Translational radiobiology
Led by Professor Catharine West
With the advent of high-throughput techniques, this group is interested in the characterisation of molecular profiles that reflect relevant biological phenotypes and predict tumour and normal tissue response to radiation.
For further information, see:
- Hypoxia
The group has a long interest in evaluating methods for assessing tumour hypoxia. Many cancers are treated with radiotherapy and the presence of hypoxic cells in these tumours makes them harder to cure. - Intrinsic radiosensitivity
Individual radiosensitivity is considered to be an inherited complex trait dependent on interactions between multiple genes / gene products. Completion of the Human Genome Project has been accompanied by the development of new high-throughput techniques, which provide extensive capabilities for the analysis of a large number of genes or the whole genome. - Non-invasive imaging
The use of imaging (MRI, PET) to measure biologically relevant phenotypes is important for exploring mechanisms underlying radiotherapy resistance such as hypoxia and impaired blood flow.
Staff members
| Name | Job title | Email address |
|---|---|---|
| Stephanie Donaldson | Postgraduate Student | stephanie.donaldson@postgrad.manchester.ac.uk |
| Rebecca Elliot | Scientific Administrator | rebecca.m.elliott@manchester.ac.uk |
| John Hall | Postdoctoral Research Associate | JHall@picr.man.ac.uk |
| Rohan Iype | MRes Student | Riype@picr.man.ac.uk |
| Joely Irlam-Jones | Research Associate | jirlam@picr.man.ac.uk |
| Navin Mani | Clinical Research Fellow | navin.mani@manchester.ac.uk |
| Sophie Perry | Research Project Manager | sophie.perry@manchester.ac.uk |
| Helen Valentine | Research Associate | hvalentine@picr.man.ac.uk |
| Catharine West | Professor of Radiation Biology | catharine.west@manchester.ac.uk |
| Amanda Williamson | Postdoctoral Research Associate | amanda.williamson@picr.man.ac.uk |