Cardiovascular bioimaging
Clinical-led research interfacing with basic scientists uses state-of-the-art imaging techniques to study heart and vessel wall disease status. Researchers also study normal and diseased vasculature and heart using a range of techniques such as calcium imaging, immunofluorescence, epi-fluorescence measurements and confocal imaging of various ion-sensitive dyes loaded into cardiac and smooth muscle myocytes, transmission electron microscopy to study cell structure and individual proteins for 3D reconstruction of ion channels. Imaging and modelling methods are combined to reconstruct the architecture of the heart’s pacemaker.
Sub-themes
- Non-invasive clinical diagnostic imaging
- Molecular and cellular imaging
Principal investigators
| Name | Research area/theme | Email address |
|---|---|---|
| Caroline Abbott | Ethnic differences in neuropathy: role of microvasculature | caroline.abbott@manchester.ac.uk |
| Yvonne Alexander | Endothelial dysfunction, cell differentiation and vascular calcification | yvonne.alexander@manchester.ac.uk |
| Mark Boyett | Electrophysiology of the cardiac conduction system | mark.boyett@manchester.ac.uk |
| Ann Canfield | Molecular and cellular basis of vascular calcification; cell-matrix biology of vascular progenitor cells | ann.canfield@manchester.ac.uk |
| Kennedy Cruickshank | Natural history of arterial function in children and adults; treating arterial dysfunction | clinep@manchester.ac.uk |
| Katharine Dibb | Atrial electrophysiology and intracellular Ca2+ homeostasis in the healthy heart as well as remodeling in age, heart failure and atrial fibrillation | katharine.dibb@manchester.ac.uk |
| Halina Dobrzynski | Cardiac conduction system in health, aging and disease: anatomy, histology, immunohistochemistry and molecular biology approach | halina.dobrzynski@manchester.ac.uk |
| David Eisner | Control of calcium signaling in cardiac muscle | eisner@manchester.ac.uk |
| Clifford Garratt | Clinical studies of atrial fibrillation in chronic heart failure | clifford@mhc.cmht.nwest.nhs.uk |
| Tony Heagerty | Small artery structure and function in diabetes and hypertension; the influence of perivascular fat on circulatory homeostasis | tony.heagerty@manchester.ac.uk |
| Cathy Holt | Atherosclerosis, animal models of cardiovascular disease, stem cells | cathy.holt@manchester.ac.uk |
| Ashraf Kitmitto | Molecular basis of heart failure and cardiac arrhythmias; cardiac spectroscopy and imaging | ashraf.kitmitto@manchester.ac.uk |
| Rayaz Malik | Diabetic neuropathy and cardiomyopathy in both animal models and patients | rayaz.malik@manchester.ac.uk |
| Mamas Mamas | Heart failure, diabetic heart disease, metabolomics, Interventional Cardiology | mamas.mamas@manchester.ac.uk |
| Charles McCollum | Clinical trials in vascular surgery and venous thromboembolism. Cerebral perfusion and embolisation in dementia and migraine. Blood transfusion strategies for surgery and risk prediction models in vascular surgery and venous disease | cnmcc@manchester.ac.uk |
| Ludwig Neyses | Basic and clinical/translational research in heart failure | ludwig.neyses@cmft.nhs.uk |
| Delvac Oceandy | Novel regulator of myocardial hypertrophy | delvac.oceandy@manchester.ac.uk |
| Jacqueline Ohanian | Signalling mechanisms regulating small artery function | johanian@manchester.ac.uk |
| Vasken Ohanian | Cell signalling in vascular smooth muscle | vasken.ohanian@manchester.ac.uk |
| Stephen O'Neill | The effects of Omega-3 fatty acids on Cardiac Excitation-Contraction Coupling and the mechanisms of cardiac systolic alternans | mdssssco@manchester.ac.uk |
| Andrew Trafford | Integrative patho-physiology of heart failure, ageing and atrial fibrillation: from in vivo models to molecular function | andrew.w.trafford@manchester.ac.uk |
