Electrophysiology
Research in this area is focused on understanding the electrophysiology of the heart in both normal and diseased conditions. Work spans the entire spectrum from molecular studies of ion expression, through single cell electrophysiology to studies on patients in a clinical setting. Examples of the areas being addressed include:
- The function of the sinoatrial and atrioventricular nodes and, in particular, the link between ion channel expression and function
- The nature of the changes in atrial fribrillation
- Alteration of ion channels in heart failure
Principal investigators
| Name | Research area/theme | Email address |
|---|---|---|
| Mark Boyett | Electrophysiology of the cardiac conduction system | mark.boyett@manchester.ac.uk |
| Katharine Dibb | Atrial electrophysiology and intracellular Ca2+ homeostasis in the healthy heart as well as remodeling in age, heart failure and atrial fibrillation | katharine.dibb@manchester.ac.uk |
| Halina Dobrzynski | Cardiac conduction system in health, aging and disease: anatomy, histology, immunohistochemistry and molecular biology approach | halina.dobrzynski@manchester.ac.uk |
| David Eisner | Control of calcium signaling in cardiac muscle | eisner@manchester.ac.uk |
| Clifford Garratt | Clinical studies of atrial fibrillation in chronic heart failure | clifford@mhc.cmht.nwest.nhs.uk |
| Paul Kingston | Vascular Gene Therapy: optimization of viral and non-viral gene transfer; Restenosis after coronary intervention; Biopacemaking; Models of coronary artery and vein graft injury. | paul.a.kingston@manchester.ac.uk |
| Ming Lei | Function and regulation of cardiac ion channels under physiological and pathophysiological conditions | ming.lei@manchester.ac.uk |
| Stephen O'Neill | The effects of Omega-3 fatty acids on Cardiac Excitation-Contraction Coupling and the mechanisms of cardiac systolic alternans | mdssssco@manchester.ac.uk |
| Andrew Trafford | Integrative patho-physiology of heart failure, ageing and atrial fibrillation: from in vivo models to molecular function | andrew.w.trafford@manchester.ac.uk |
