Stem cells in cardiovascular medicine
Stem and progenitor cells are gaining increasing interest from clinicians, basic researchers and the general public for their potential for clinical use. Although bone marrow derived stem cells have shown a limited effect to date in human studies, alternative approaches and sources of multi-potent and pluripotent cells are being investigated. Progress is being made in the isolation and culture of progenitor cells derived from adult tissue, as well as adult peripheral and cord blood progenitor cells. Our goal is to understand the regulation of the differentiation of these cells towards specific lineages.
Principal investigators
| Name | Research area/theme | Email address |
|---|---|---|
| Yvonne Alexander | Endothelial dysfunction, cell differentiation and vascular calcification | yvonne.alexander@manchester.ac.uk |
| Ann Canfield | Molecular and cellular basis of vascular calcification; cell-matrix biology of vascular progenitor cells | ann.canfield@manchester.ac.uk |
| Cathy Holt | Atherosclerosis, animal models of cardiovascular disease, stem cells | cathy.holt@manchester.ac.uk |
| Andrew Trafford | Integrative patho-physiology of heart failure, ageing and atrial fibrillation: from in vivo models to molecular function | andrew.w.trafford@manchester.ac.uk |
