Transgenic and disease models
Animal models are being used in conjunction with in vitro methodologies to understand the cellular and molecular mechanisms of disease. In addition, state-of-the-art transgenic knock-out models are used to study genetic pathways controlling cardiac and vascular repair. Our studies focus in particular on the following:
- Heart failure
- Ageing
- Hypertension
- Diabetes
- Atherosclerosis
Principal investigators
| Name | Research area/theme | Email address |
|---|---|---|
| Caroline Abbott | Ethnic differences in neuropathy: role of microvasculature | caroline.abbott@manchester.ac.uk |
| Clare Austin | Functional vascular physiology; modulation in health and disease | clare.austin@manchester.ac.uk |
| Kennedy Cruickshank | Natural history of arterial function in children & adults; treating arterial dysfunction | clinep@manchester.ac.uk |
| Clifford Garratt | Clinical studies of atrial fibrillation in chronic heart failure | clifford@mhc.cmht.nwest.nhs.uk |
| Tony Heagerty | Small artery structure and function in diabetes and hypertension; the influence of perivascular fat on circulatory homeostasis | tony.heagerty@manchester.ac.uk |
| Cathy Holt | Atherosclerosis, animal models of cardiovascular disease, stem cells | cathy.holt@manchester.ac.uk |
| Paul Kingston | Vascular Gene Therapy: optimization of viral and non-viral gene transfer; Restenosis after coronary intervention; Biopacemaking; Models of coronary artery and vein graft injury. | paul.a.kingston@manchester.ac.uk |
| Ming Lei | Function and regulation of cardiac ion channels under physiological and pathophysiological conditions | ming.lei@manchester.ac.uk |
| Rayaz Malik | Diabetic neuropathy and cardiomyopathy in both animal models and patients | rayaz.malik@manchester.ac.uk |
| Mamas Mamas | Heart failure, diabetic heart disease, metabolomics, Interventional Cardiology | mamas.mamas@manchester.ac.uk |
| Mark T. Nelson | Ion channels and calcium signalling in smooth muscle, vascular endothelium and astrocytes; neurovascular coupling, blood vessel and lower urinary tract function | mark.nelson@manchester.ac.uk |
| Ludwig Neyses | Basic and clinical/translational research in heart failure | ludwig.neyses@cmft.nhs.uk |
| Delvac Oceandy | Novel regulator of myocardial hypertrophy | delvac.oceandy@manchester.ac.uk |
| Jacqueline Ohanian | Signalling mechanisms regulating small artery function | johanian@manchester.ac.uk |
| Andrew Trafford | Integrative patho-physiology of heart failure, ageing and atrial fibrillation: from in vivo models to molecular function | andrew.w.trafford@manchester.ac.uk |
