Examples of research projects within the University of Manchester, AstraZeneca or Greater Manchester Teaching Hospitals
- Using silk as a biomaterial for nerve regeneration
- Species variability in metabolism as a translational factor influencing susceptibility to adverse drug reactions in man
- The function of Notch signalling in vascular smooth muscle cell differentiation from mouse embryonic stem cells
- Statins in translational cerebral ischemia: systematic review and meta-analysis of pre-clinical studies
- Parallel gene expression profiling and histological analysis of tumour tissue microarrays
- Effects of differentiating agents on breast cancer stem cells and their sensitivity to DNA-damaging therapies
- The role of Notch receptors in the radio and chemo-resistance of breast cancer stem cells
- Molecular characterisation of prostate cancer
- Identifying novel monotherapy and combination therapies for the treatment of Glioma
- Metabonomic profiling of tumour-bearing mice
- Analysis of key growth factor and survival signalling pathways in preclinical xenograft models
- Effect of Interleukin-1 Receptor Antagonist on induction of cytokines by lipopolysaccharide after stroke or sub-arachnoid haemorrhage
- Inhibitors of IAPP Aggregation and Toxicity. New Therapies for Type II Diabetes
- 3D anatomical reconstruction and molecular mapping of the atrioventricular ring tissues in human embryonic heart and adult rat heart
- Escherichia coli is responsible for a number of extra-intestinal life threatening infections including septicaemia, pyelonephritis and neonatal meningitis.
- In vivo mechanistic analysis of cancer drug combination therapies
- Translation of in vitro to in vivo: investigating the utility of in vitro drug transporter assays to predict inductive effects in the clinic
- Identification of the genetic basis of disorders associated with the presence of intracranial calcification
- Establishing the influence of dietary fat on the intestinal epithelium through nutrigenomics
- Regulation of skin barrier function by urocanic acid
- Identification of genetic variants predisposing to autoimmune idiopathic inflammatory myopathies
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