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School of Medicine

Professor Dave Singh 

Photograph of Dave Singh

Professor of clinical pharmacology and respiratory medicine

PRIMARY ADDRESS:

Medicines Evaluation Unit (MEU)

Langley Building

University Hospital Of South Manchester NHS Foundation Trust

Southmoor Road, Manchester, M23 9QZ

SECONDARY ADDRESS:

2nd Floor Education & Research Centre

  University Hospital Of South Manchester NHS Foundation Trust

  Southmoor Road, Manchester M23 9LT 

 

Role

 

  • Head of airway pharmacology group, using human lung tissue models to study inflammation in asthma and COPD
  • Medical Directorfor early phase clinical trials in the Medicines evaluation unit (MEU)
 

Memberships of Committees and Professional Bodies

 

Member of:-

  • University Of Manchester representative on CHOP (Committee of Heads and Professors of Clinical Pharmacology and Therapeutics)
  • British Pharmacology Society
  • British Association of Lung Research
  • British Thoracic Society
  • Royal College of Physicians
  • American Thoracic Society
  • European Respiratory Society
  • British Society of Immunology 

Research

I lead a translational airway pharmacology group investigating inflammation in asthma and COPD. My interests span from basic pharmacological studies using primary cells concerning corticosteroid insensitivity and novel molecular targets, through to early phase proof of concept clinical trials. The close links between my laboratory and clinical research enable proper translational studies to be performed. 

 

 

 

Teaching

TEACHING & TRAINING

  • Undergraduate training – I have supervised 5 medical student 10 week research project options.
  • I contribute every year to undergraduate examinations, and medical student teaching.
  • I have acted as Mres tutor for year 4 medical students for the last 3 years, delivering seminars on asthma

 

 

Biography

 

After graduating in Medicine from Cambridge University, I trained in respiratory medicine and clinical pharmacology. This included an industrial placement for phase 1 experience. I completed an MD at the University of Manchester, and then was appointed as senior lecturer in respiratory pharmacology based in the University Hospital of South Manchester in 2003. My research interests are the pharmacotherapy of Asthma and COPD with studies spanning from basic pharmacology investigations of anti-inflammatory drug action to clinical trials. I am medical director of the Medicines Evaluation Unit performing proof of concept studies in obstructive lung diseases.
 

 

Qualifications

 

BA (Hons) Medical Sciences 2:1 (1989) Cambridge University
MB, B.Chir. (1991) Cambridge University
MA (Hon) (1992) Cambridge University
MRCP (1996)
MD (2002)
 

 

Collaborators and affiliated staff

Current Research Staff
6 post-docs
1 research assistant

2 research technicians
3 clinical fellows (PhD registered)
3 non-clinical PhD students

INTERNATIONAL COLLABORATIONS

  • EvA – FP7 COPD consortium investigating genetics and gene expression in emphysema vs airway disease
  • ECLIPSE – GSK funded, largest ever COPD longitudinal cohort study.  
 

Publications

2011

  • 2. Ibrahim B, Basanta M, Cadden P, Singh D, Douce D, Woodcock A, Fowler SJ. (2011). Non-invasive phenotyping using exhaled volatile organic compounds in asthma. THORAX, 66, 804-809. eScholarID:142930 | DOI:10.1136/thx.2010.156695
  • Al-shair, K., Kolsum, U., Dockry, R., Morris, J., Singh, D. & Vestbo, J (2011). Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD. Respir Res, 12, 3. eScholarID:127917 | PMID:21208443 | DOI:10.1186/1465-9921-12-3
  • Armstrong, J., Harbron, C., Lea, S., Booth, G., Cadden, P., Wreggett, K. & Singh, D (2011). Synergistic effects of p38 MAPK inhibition with a corticosteroid in alveolar macrophages from COPD patients. J Pharmacol Exp Ther, eScholarID:127920 | PMID:21610141 | DOI:10.1124/jpet.111.180737
  • Donohue, J., Singh, D., Kornmann, O., Lawrence, D., Lassen, C. & Kramer, B (2011). Safety of indacaterol in the treatment of patients with COPD. Int J Chron Obstruct Pulmon Dis, 6, 477-92. eScholarID:142934 | PMID:22003293 | DOI:10.2147/COPD.S23816
  • Eustace, A., Smyth, L., Mitchell, L., Williamson, K., Plumb, J. & Singh, D (2011). Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD. Chest, 139(5), 1089-100. eScholarID:127916 | PMID:20864612 | DOI:10.1378/chest.10-0779
  • Gibbs, J., Blaikley, J., Beesley, S., Matthews, L., Simpson, K., Boyce, S., Farrow, S., Else, K., Singh, D., Ray, D. & Loudon, A (2011). The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A, eScholarID:142938 | PMID:22184247 | DOI:10.1073/pnas.1106750109
  • Halpin, D., Gray, J., Edwards, S., Morais, J. & Singh, D (2011). Budesonide/formoterol vs. salmeterol/fluticasone in COPD: a systematic review and adjusted indirect comparison of pneumonia in randomised controlled trials. Int J Clin Pract, 65(7), 764-74. eScholarID:127919 | PMID:21676119 | DOI:10.1111/j.1742-1241.2011.02685.x
  • Kay, P., Schlossmacher, G., Matthews, L., Sommer, P., Singh, D., White, A. & Ray, D (2011). Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS One, 6(10), e24839. eScholarID:142937 | PMID:21984896 | DOI:10.1371/journal.pone.0024839
  • Plumb, J., Gaffey, K., Kane, B., Malia-Milanes, B., Shah, R., Bentley, A., Ray, D. & Singh, D (2011). Reduced glucocorticoid receptor expression and function in airway neutrophils. Int Immunopharmacol, eScholarID:142935 | PMID:22032841 | DOI:10.1016/j.intimp.2011.10.006
  • Qiu, W., Cho, M., Riley, J., Anderson, W., Singh, D., Bakke, P., Gulsvik, A., Litonjua, A., Lomas, D., Crapo, J., Beaty, T., Celli, B., Rennard, S., Tal-Singer, R., Fox, S., Silverman, E., Hersh, C. & . (2011). Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One, 6(9), e24395. eScholarID:142933 | PMID:21949713 | DOI:10.1371/journal.pone.0024395
  • Singh, D., Collarini, S., Poli, G., Acerbi, D., Amadasi, A. & Rusca, A (2011). Effect of AeroChamber Plus™ on the lung and systemic bioavailability of beclometasone dipropionate/formoterol pMDI. Br J Clin Pharmacol, 72(6), 932-9. eScholarID:142936 | PMID:21615456 | DOI:10.1111/j.1365-2125.2011.04024.x
  • Singh, D., Fox, S., Tal-Singer, R., Plumb, J., Bates, S., Broad, P., Riley, J., Celli, B. & . (2011). Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers. Thorax, 66(6), 489-95. eScholarID:127918 | PMID:21441172 | DOI:10.1136/thx.2010.153767

2010

  • Basanta, M., Jarvis, R., Xu, Y., Blackburn, G., Tal-Singer, R., Woodcock, A., Singh, D., Goodacre, R., Thomas, C. & Fowler, S (2010). Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst, 135(2), 315-20. eScholarID:79215 | PMID:20098764 | DOI:10.1039/b916374c
  • Berry, A., Matthews, L., Jangani, M., Plumb, J., Farrow, S., Buchan, N., Wilson, P., Singh, D., Ray, D. & Donn, R (2010). Interferon-inducible factor 16 is a novel modulator of glucocorticoid action. FASEB J, eScholarID:79214 | PMID:20086048 | DOI:10.1096/fj.09-139998
  • Kent, L., Fox, S., Farrow, S. & Singh, D (2010). The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages. Int Immunopharmacol, 10(1), 57-64. eScholarID:79210 | PMID:19818417 | DOI:10.1016/j.intimp.2009.09.021
  • Nicholas, B., Skipp, P., Barton, S., Singh, D., Bagmane, D., Mould, R., Angco, G., Ward, J., Guha-Niyogi, B., Wilson, S., Howarth, P., Davies, D., Rennard, S., O'Connor, C. & Djukanovic, R (2010). Identification of Lipocalin and Apolipoprotein A1 as Biomarkers of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med, eScholarID:79217 | PMID:20110559 | DOI:10.1164/rccm.200906-0857OC
  • Singh, D., Smyth, L., Borrill, Z., Sweeney, L. & Tal-Singer, R (2010). A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol, 50(1), 94-100. eScholarID:79209 | PMID:19880675 | DOI:10.1177/0091270009347873

2009

  • Al-shair, K., Dockry, R., Mallia-Milanes, B., Kolsum, U., Singh, D. & Vestbo, J (2009). Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD. Respir Med, 103(10), 1572-9. eScholarID:79213 | PMID:19560330 | DOI:10.1016/j.rmed.2008.11.021
  • Al-shair, K., Kolsum, U., Berry, P., Smith, J., Caress, A., Singh, D. & Vestbo, J (2009). Development, dimensions, reliability and validity of the novel Manchester COPD fatigue scale. Thorax, 64(11), 950-5. eScholarID:79212 | PMID:19720608 | DOI:10.1136/thx.2009.118109
  • Armstrong, J., Sargent, C. & Singh, D (2009). Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol, 158(1), 74-83. eScholarID:79211 | PMID:19737233 | DOI:10.1111/j.1365-2249.2009.03986.x
  • Borrill Z, Roy K, Kolsum U, Southworth T, Vestbo J, Singh SD. (2009). Seretide withdrawal increases airway inflammation in moderate COPD patients. Eur J Clin Pharmacol, eScholarID:1d20857 | DOI:10.1007/s00228-009-0697-5
  • Francis HH, Colecliffe W, Hazell MML, Singh SD, Niven RR M, Hagan G, Spencer M, Frank TL. (2009). Prevalence of airflow obstruction in patients attending a rapid access chest pain clinic. Respir Med, 103( 5), 736-42. eScholarID:1d19819 | DOI:10.1016/j.rmed.2008.11.016
  • Gibbs J, Beesley S, Plumb J, Singh SD, Farrow S, Ray DW, Loudon A. (2009). Circadian timing in the lung; a specific role for bronchiolar epithelial cells. Endocrinology, 150( 1), 268-76. eScholarID:1d20316 | DOI:10.1210/en.2008-0638
  • Kane B, Borrill Z, Southworth TTW, Woodcock AA, Singh SD. (2009). Reduced exhaled breath condensate pH in asthmatic smokers using inhaled corticosteroids. Respirology, 14( 3), 419-23. eScholarID:1d32490
  • Kane B, Kolsum UU, Southworth TTW, Armstrong JJ, Woodcock AA, Singh SD. (2009). The Effects of Smoking on the Lipopolysaccharide Response and Glucocorticoid Sensitivity of Alveolar Macrophages From Asthmatics. Chest, eScholarID:1d32311 | DOI:10.1378/chest.08-2633
  • Kane, B., Kolsum, U., Southworth, T., Armstrong, J., Woodcock, A. & Singh, D (2009). The effects of smoking on the lipopolysaccharide response and glucocorticoid sensitivity of alveolar macrophages of patients with asthma. Chest, 136(1), 163-70. eScholarID:79218 | PMID:19225056 | DOI:10.1378/chest.08-2633
  • Kent L, Smyth L, Plumb J, Clayton C, Fox SM, Ray DW, Farrow S, Singh SD. (2009). Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 mitogen-activated protein kinase inhibitor N-cyano-N'-(2-{[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7-oxo-7,8-dihydropyrido[2,3-d] pyrimidin-2-yl]amino}ethyl)guanidine (SB706504). J Pharmacol Exp Ther, 328, 458-468. eScholarID:1d19146 | DOI:10.1124/jpet.108.142950
  • Kolsum UU, Borrill Z, Roy K, Starkey C, Vestbo J, Houghton C, Singh SD. (2009). Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes. Respir Med, 103( 1), 136-43. eScholarID:1d19610 | DOI:10.1016/j.rmed.2008.07.014
  • Kolsum UU, Roy K, Starkey C, Borrill Z, Truman N, Vestbo J, Singh SD. (2009). The repeatability of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein in COPD patients over one year. Int J Chron Obstruct Pulmon Dis, 4( 1), 149-56. eScholarID:1d19587
  • Lewis S, Singh SD, Evans C. (2009). Cyclic hydrostatic pressure and cotton particles stimulate synthesis by human lung macrophages of cytokines in vitro. Respir Res, 10, eScholarID:1d20856 | DOI:10.1186/1465-9921-10-44
  • Moretto N, Facchinetti F, Southworth T, Singh SD, Civelli M, Singh SD, Patacchini R. (2009). alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases. Am J Physiol Lung Cell Mol Physiol, 296( 5), L839-48. eScholarID:1d19928 | DOI:10.1152/ajplung.90570.2008
  • Plumb JJ, Smyth LLJ, Adams HR, Vestbo J, Bentley AAM, Singh SD. (2009). Increased T regulatory cells within lymphocyte follicles in moderate COPD. Eur Respir J, eScholarID:1d19600 | DOI:10.1183/09031936.00100708
  • Plumb, J., Smyth, L., Adams, H., Vestbo, J., Bentley, A. & Singh, S (2009). Increased T-regulatory cells within lymphocyte follicles in moderate COPD. Eur Respir J, 34(1), 89-94. eScholarID:127923 | PMID:19196820 | DOI:10.1183/09031936.00100708

2008

  • Borrill Z, Houghton C, Tal-Singer R, Vessey S, Faiferman I, Langley S, Singh SD. (2008). The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD. Br J Clin Pharmacol, 65( 2), 244-52. eScholarID:1d32577
  • Borrill Z, Roy K, Singh SD. (2008). Exhaled breath condensate biomarkers in COPD. Eur Respir J, 32( 2), 472-86. eScholarID:1d20858 | DOI:10.1183/09031936.00116107
  • Borrill Z, Roy K, Vessey R, Woodcock AA, Singh SD. (2008). Non-invasive biomarkers and pulmonary function in smokers. Int J Chron Obstruct Pulmon Dis, 3( 1), 171-83. eScholarID:1d31816
  • Kent, L, Smyth, L, Clayton, C, Scott, L, Cook, T, Stephens, R, Fox, S, Hext, P, Farrow, S, Singh, SD. (2008). Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages. Cytokine, 42( 2), 205-16. eScholarID:1d32576 | DOI:10.1016/j.cyto.2008.02.001
  • Kirkham SS, Kolsum UU, Rousseau K, Singh SD, Vestbo J, Thornton DD.J. (2008). MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 178( 10), 1033-9. eScholarID:1d19608 | DOI:10.1164/rccm.200803-391OC
  • Singh SD, Brooks J, Hagan G, Cahn T, O'Connor B. (2008). Triple therapy with salmeterol/fluticasone propionate and tiotropium bromide versus individual components in moderate to severe COPD. Thorax, eScholarID:1d32105 | DOI:10.1136/thx.2007.087213
  • Singh SD, Fairwood J, Murdoch R, Weeks A, Russell P, Roy K, Langley S, Woodcock A, Woodcock AA. (2008). The reproducibility of adenosine monophosphate bronchial challenges in mild, steroid-naive asthmatics. Br J Clin Pharmacol, eScholarID:1d32326
  • Singh SD, Piccinno A, Borrill Z, Poli G, Acerbi D, Meuleners L, Woodcock AA. (2008). Tolerability of high cumulative doses of the HFA modulite beclomethasone dipropionate/formoterol combination inhaler in asthmatic patients. Pulm Pharmacol Ther, 21( 3), 551-7. eScholarID:1d32276
  • Smyth LLJ, Starkey C, Gordon F, Vestbo J, Singh SD. (2008). CD8 chemokine receptors in chronic obstructive pulmonary disease. Clin Exp Immunol, 154( 1), 56-63. eScholarID:1d19613 | DOI:10.1111/j.1365-2249.2008.03729.x

2007

  • Basanta M, Koimtzis T, Singh SD, Wilson I, Thomas C. (2007). An adaptive breath sampler for use with human subjects with an impaired respiratory function. Analyst, 132( 2), 153-63. eScholarID:1d32277
  • Basanta M, Singh SD, Fowler S, Wilson I, Dennis R, Thomas C. (2007). Increasing analytical space in gas chromatography-differential mobility spectrometry with dispersion field amplitude programming. J Chromatogr A, 1173( 1-2), 129-38. eScholarID:1d31874
  • Borrill Z, Starkey R, Singh SD. (2007). Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients. Int J Chron Obstruct Pulmon Dis, 2( 1), 71-6. eScholarID:1d32325
  • Borrill, Z., Starkey, R. & Singh, S (2007). Variability of exhaled breath condensate leukotriene B4 and 8-isoprostane in COPD patients. Int J Chron Obstruct Pulmon Dis, 2(1), 71-6. eScholarID:127925 | PMID:18044068
  • Houghton C, Lawson N, Borrill Z, Wixon C, Yoxall S, Langley S, Woodcock A, Singh SD. (2007). Comparison of the effects of salmeterol/fluticasone propionate with fluticasone propionate on airway physiology in adults with mild persistent asthma. Respir Res, 8, eScholarID:1d31915
  • Roy K, Borrill Z, Starkey C, Hazel A, Morris J, Vestbo J, Singh SD. (2007). Use of different exhaled nitric oxide multiple flow rate models in COPD. Eur Respir J, 29( 4), 651-9. eScholarID:1d31432
  • Singh SD, Richards D, knowles R, Schwartz S, Woodcock AA, Langley SJ, O'Connor BJ. (2007). Selective INOS inhibition has no effect on allergen chalenge in Asthma. Am J Respir Crit Care Med, in press, eScholarID:1d16147
  • Singh SD, Tutuncu A, Lohr I, Carlholm M, Polanowski T. (2007). Budesonide administered using chlorofluorocarbon and hydrofluoroalkane pressurized metered-dose inhalers: pharmacokinetics, pharmacodynamics and clinical equivalence. Int J Clin Pharmacol Ther, 45( 9), 485-95. eScholarID:1d32106
  • Singh, S (2007). Salmeterol/fluticasone propionate combination in the treatment of COPD. Expert Rev Respir Med, 1(1), 25-33. eScholarID:127924 | PMID:20477262 | DOI:10.1586/17476348.1.1.25
  • Smyth L, Starkey C, Vestbo J, Singh SD. (2007). CD4-regulatory cells in COPD patients. Chest, 132( 1), 156-63. eScholarID:1d31384

2006

  • Borrill Z, Clough D, Truman N, Morris J, Langley S, Singh SD. (2006). A comparison of exhaled nitric oxide measurements performed using three different analysers. Respir Med, 100( 8), 1392-6. eScholarID:1d31822
  • Singh, SD, Tal-Singer, R, Faiferman, I, Lasenby, S, Henderson, A, Wessels, D, Goosen, A, Dallow, N, Vessey, R, Goldman, M. (2006). Plethysmography and impulse oscillometry assessment of tiotropium and ipratropium bromide; a randomized, double-blind, placebo-controlled, cross-over study in healthy subjects. Br J Clin Pharmacol, 61( 4), 398-404. eScholarID:1d31922

2005

  • Borrill Z, Houghton C, Woodcock AA, Vestbo J, Singh SD. (2005). Measuring bronchodilation in COPD clinical trials. Br J Clin Pharmacol, 59( 4), 379-84. eScholarID:1d30706
  • Borrill Z, Starkey C, Vestbo J, Singh SD. (2005). Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease. European Respiratory Journal, 25, 269-274. eScholarID:1d26706 | DOI:10.1183/09031936.05.00085804
  • Houghton C, Woodcock AA, Singh SD. (2005). A comparison of plethysmography, spirometry and oscillometry for assessing the pulmonary effects of inhaled ipratropium bromide in healthy subjects and patients with asthma. Br J Clin Pharmacol, 59( 2), 152-9. eScholarID:1d28843
  • Langley S, Houghton C, Singh SD. (2005). Bronchoprotective and bronchodilator effects of an HFA pMDI vs. a CFC pMDI and a DPI containing formoterol in asthma patients. Respiration, 72 Suppl 1, 35-7. eScholarID:1d29438

2004

  • Houghton C, Langley S, Singh SD, Holden J, Monici Preti A, Acerbi D, Poli G, Woodcock AA. (2004). Comparison of bronchoprotective and bronchodilator effects of a single dose of formoterol delivered by hydrofluoroalkane and chlorofluorocarbon aerosols and dry powder in a double blind, placebo-controlled, crossover study. Br J Clin Pharmacol, 58( 4), 359-66. eScholarID:1d29137
  • Houghton C, Woodcock AA, Singh SD. (2004). A comparison of lung function methods for assessing dose-response effects of salbutamol. Br J Clin Pharmacol, 58( 2), 134-41. eScholarID:1d28723
  • Singh SD, Alexander J, Owen A, Rustom R, Bone M, Hammad A, Roberts N, Park K, Pirmohamed M. (2004). Whole-blood cultures from renal-transplant patients stimulated ex vivo show that the effects of cyclosporine on lymphocyte proliferation are related to P-glycoprotein expression. Transplantation, 77( 4), 557-61. eScholarID:1d9385

2003

  • Singh SD, Whale C, Houghton N, Daley-Yates P, Kirby S, Woodcock A. (2003). Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease. Br J Clin Pharmacol, 55( 4), 375-81. eScholarID:1d28524
  • Singh, S., Whale, C., Houghton, N., Daley-Yates, P., Kirby, S. & Woodcock, A (2003). Pharmacokinetics and systemic effects of inhaled fluticasone propionate in chronic obstructive pulmonary disease. Br J Clin Pharmacol, 55(4), 375-81. eScholarID:127922 | PMID:12680886

2002

  • Singh SD, Booth C. (2002). Tuberculin-induced lymphocyte proliferation in whole blood: an antigen specific method for assessing immunosuppressive agents. J Immunol Methods, 260( 1-2), 149-56. eScholarID:1d28525

2000

  • Singh SD, Allen D. (2000). Intravenous montelukast. Thorax, 55( 12), eScholarID:1d28844

1999

  • Singh SD, Williams A. (1999). The prevalence and incidence of medical conditions in healthy pharmaceutical company employees who volunteer to participate in medical research. Br J Clin Pharmacol, 48( 1), 25-31. eScholarID:1d28852

  • Singh, D., Petavy, F., Macdonald, A., Lazaar, A. & O'Connor, B The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma. Respir Res, 11, 26. eScholarID:79216 | PMID:20193079 | DOI:10.1186/1465-9921-11-26

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