Mr Andrew Sharp 

2011

• Howard, S., Lestner, J., Sharp, A., Gregson, L., Goodwin, J., Slater, J., Majithiya, J., Warn, P. & Hope, W (2011). Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy. Journal of Infectious Diseases, 203(9), 1324. eScholarID:137218 | DOI:10.1093/infdis/jir023
• Howard, S., Livermore, J., Sharp, A., Goodwin, J., Gregson, L., Alastruey-Izquierdo, A., Perlin, D., Warn, P. & Hope, W (2011). Pharmacodynamics of Echinocandins against Candida glabrata: Requirement for Dosage Escalation To Achieve Maximal Antifungal Activity in Neutropenic Hosts. Antimicrobial Agents and Chemotherapy, 55(10), 4880-4887. eScholarID:137217 | DOI:10.1128/AAC.00621-11
• Slater, J., Howard, S., Sharp, A., Goodwin, J., Gregson, L., Alastruey-Izquierdo, A., Arendrup, M., Warn, P., Perlin, D. & Hope, W (2011). Disseminated candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin. Antimicrobial agents and chemotherapy, 55(7), 3075-3083. eScholarID:137189 | DOI:10.1128/AAC.01686-10

2010

• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2010). Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and-resistant strains of Aspergillus fumigatus. International journal of antimicrobial agents, 35(2), 146-151. eScholarID:137192 | DOI:10.1016/j.ijantimicag.2009.09.029

2009

• Majithiya JB, Sharp AD, Parmar AA, Denning DW, Warn PA. (2009). Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. J Antimicrob Chemother, 63( 1), eScholarID:1d19806 | DOI:10.1093/jac/dkn431
• Majithiya, J., Sharp, A., Parmar, A., Denning, D. & Warn, P (2009). Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. Journal of antimicrobial chemotherapy, 63(1), 161. eScholarID:137197 | DOI:10.1093/jac/dkn431
• Warn PA, Sharp AD, Parmar AA, Majithiya JB, Denning DW, Hope WW. (2009). Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, the importance of tissue concentrations and the impact of immune status on the antifungal effect. Antimicrob Agents Chemother, 53, 3453. eScholarID:1d19802 | DOI:10.1128/AAC.01601-08
• Warn, P., Sharp, A., Parmar, A., Majithiya, J., Denning, D. & Hope, W (2009). Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, the importance of tissue concentrations and the impact of immune status on the antifungal effect. Antimicrobial agents and chemotherapy, eScholarID:137216 | DOI:10.1128/AAC.01601-08

2008

• Majithiya, J., Sharp, A., Parmar, A., Denning, D. & Warn, P (2008). Correlation of in vitro MIC and MFC against isavuconazole, voriconazole, and amphotericin B of Aspergillus with in vivo outcome in mice with disseminated Aspergillosis. Programs and abstracts of the 18th ECCMID meeting. Barcelona, P1915. eScholarID:137193
• Warn, P., Parmar, A., Sharp, A. & Denning, D (2008). Dose response in neutropenic mice with disseminated infection of multiple strains of Aspergillus fumigatus with widely varying MIC and MFC values treated with isavuconazole. Programs and abstracts of the 17th ECCMID meeting. Munich, eScholarID:137190

2007

• Hope, W., Warn, P., Sharp, A., Reed, P., Keevil, B., Louie, A., Walsh, T., Denning, D. & Drusano, G (2007). Optimization of the dosage of flucytosine in combination with amphotericin B for disseminated candidiasis: a pharmacodynamic rationale for reduced dosing. Antimicrobial agents and chemotherapy, 51(10), 3760. eScholarID:137207
• Warn, P., Parmar, A., Sharp, A. & Denning, D (2007). P1951 Dose response in neutropenic mice with disseminated infec-tion of multiple strains of Aspergillus fumigatus with widely varying MIC and MFC values treated with isavuconazole. International Journal of Antimicrobial Agents, 29, S560-S560. eScholarID:137214
• Warn, P., Parmar, A., Sharp, A., Heep, M., Spickermann, J. & Denning, D (2007). P1950 In vivo efficacy of the triazole BAL8557 against disseminated Candida albicans in mice assessed by survival and tissue bur-den in temporarily and persistently neutropenic mice treated with 1-7 doses of drug over a dose range of 20-80\% of Emax. International Journal of Antimicrobial Agents, 29, S560-S560. eScholarID:137213

2006

• Hope, W., Drusano, G., Moore, C., Sharp, A., Louie, A., Walsh, T., Denning, D. & Warn, P (2006). The effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis. Antimicrobial agents and chemotherapy, eScholarID:137206
• Hope, W., Warn, P., Sharp, A., Howard, S., Kasai, M., Louie, A., Walsh, T., Drusano, G. & Denning, D (2006). The derivation of an in vivo drug-exposure breakpoint for flucytosine against Candida albicans and the impact of the minimum inhibitory concentration, growth rate and resistance genotype on the antifungal effect. Antimicrobial agents and chemotherapy, eScholarID:137212
• Warn, P., Sharp, A. & Denning, D (2006). In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp. Journal of Antimicrobial Chemotherapy, 57(1), 135. eScholarID:137199
• Warn, P., Sharp, A., Anderson, M. & Denning, D (2006). Single-spore cultures of the sequences strain of Aspergillus fumigatus (Af293) have significantly different mortality rates in a murine model of IPA. 2nd Advances Against Aspergillosis Meeting Syllabus P, 31, eScholarID:137215
• Warn, P., Sharp, A., Mosquera, J., Spickermann, J., Schmitt-Hoffmann, A., Heep, M. & Denning, D (2006). Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus. Journal of Antimicrobial Chemotherapy, 58(6), 1198. eScholarID:137191

2005

• Hope, W., Warn, P., Sharp, A., Reed, P., Keevil, B., Louie, A., Denning, D. & Drusano, G (2005). MAJOR ARTICLES AND BRIEF REPORTS-FUNGI-Surface Response Modeling to Examine the Combination of Amphotericin B Deoxycholate and 5-Fluorocytosine for Treatment of Invasive Candidiasis. Journal of Infectious Diseases, 192(4), 673-680. eScholarID:137205
• Hope, W., Warn, P., Sharp, A., Reed, P., Keevil, B., Louie, A., Denning, D. & Drusano, G (2005). Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis. Journal of Infectious Diseases, 192(4), 673. eScholarID:137209
• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2005). Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis. Journal of Antimicrobial Chemotherapy, 56(3), 590. eScholarID:137194

2004

• Warn, P., Sharp, A., Guinea, J. & Denning, D (2004). Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. Journal of Antimicrobial Chemotherapy, 53(5), 743. eScholarID:137196

2003

• Warn, P., Brampton, M., Sharp, A., Morrissey, G., Steel, N., Denning, D. & Priest, T (2003). Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections. Laboratory animals, 37(2), 126-131. eScholarID:137201

2002

• WARN, P., ORTEGA, J., SHARP, A., DENNING, D. & . (2002). Microaerophilic MICs and MFCs of Amphotericin B and Itraconazole with Aspergillus spp. Compared with air. eScholarID:137203
• Mosquera, J., Sharp, A., Moore, C., Warn, P. & Denning, D (2002). In vitro interaction of terbinafine with itraconazole, fluconazole, amphotericin B and 5-flucytosine against Aspergillus spp. Journal of Antimicrobial Chemotherapy, 50(2), 189. eScholarID:137208
• Warn, P., Sharp, A., Clark, E. & Denning, D (2002). IN VITRO MODEL OF THE TRANSLOCATION OF CANDIDA SPP. ACROSS THE GUT WALL. Mycoses, 45(S2), 68-68. eScholarID:137200
• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2002). In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis. Journal of Antimicrobial Chemotherapy, 50(6), 1071. eScholarID:137202

2001

• Warn, P., Sharp, A., Denning, D. & . (2001). In Vitro Activity of the Echinocandin HMR3270 against Aspergillus spp. eScholarID:137198

• MAJITHIYA, J., SHARP, A., PARMAR, A., DENNING, D. & WARN, P Efficacy of Isavuconazole, voriconazole and. fluconazole in a neutropenic mice murine model of Candida krusei. eScholarID:137195
• WARN, P., PARMAR, A., SHARP, A., HEEP, M., SCHMITT-HOFFMANN, A., SPICKERMANN, J. & DENNING, D In Vivo Efficacy of Isavuconazole against Disseminated Candida albicans in Mice Assessed by Survival and Tissue Burden in Temporarily and Persistently Neutropenic Mice Treated with 107 Doses of Drug over a Dose Range of 20080\% of Emax. eScholarID:137204