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School of Medicine

Dr Alexander Heazell MBChB(Hons) PhD

NIHR Clinical Lecturer in Obstetrics

5th floor (Research), St Mary's Hospital, Oxford Road, Manchester, M13 9WL.

 

Role

I am a Clinical Lecturer in Obstetrics, spending 50% of my time in clinical practice and 50% research and teaching within the Maternal and Fetal Health Research Centre, School of Biomedicine. I am closely involved in stillbirth research theme at the Maternal and Fetal Health Research Centre, leading projects in understanding the reasons for stillbirth, and prevention of perinatal mortality and improving care for parents whose babies die before or shortly after birth.

I am on the board of the International Stillbirth Association, and work with the Scientific Advisory Committee within ISA to improve information for parents and direct effective research. I am also involved in the Confidential Enquiry into Perinatal Deaths in Cumbria (2009-2010).

 

 

Memberships of Committees and Professional Bodies

Member of the Royal College of Obstetricians and Gynaecologists since 2008

Teaching

MBChB 1st and 2nd Year - Academic advisor

MBChB 4th Year - Obstetrics and Gynaecology module - tutorials

MBChB 4th Year - Project Option

MBChB 3rd, 4th, 5th Year - Student Selected Components

Intercalated BSc Students via Faculty of Life Sciences

MRes Translational Medicine - Tutorial

MRes Maternal and Fetal Health - Tutorials, Workshops, Student Supervision.

 

Biography

Dr Alexander Heazell is a clinical lecturer working at the Maternal and Fetal Health Research Centre, University of Manchester. After graduation from the University of Birmingham Medical School in 2000, he commenced clinical training in Obstetrics and Gynaecology. After completing his PhD thesis on placenta dysfunction in preeclampsia, he has focused his research interests around stillbirth and fetal growth restriction. He is particularly interested in the role that placental dysfunction plays in these conditions, and whether understanding the nature of such placental failure can be used to identify pregnancies most at risk of stillbirth. He has also led qualitative research projects to explore professionals and parents’ experiences after stillbirth, with a particular focus on investigations following a stillbirth.

Dr Alexander Heazell has recieved over £350,000 in grant income from Tommy's - the baby charity, Sands, Peel Medical Research Trust, Manchester Wellcome Trust Clinical Research facility, and the Manchester Biomedical Research Centre. He has over 50 peer-reviewed publications and has co-written the RCOG green-top guidelines for the management of reduced fetal movements. In collaboration with Sands he has initiated the development of a national consent form for perinatal post-mortem and a care pathway for parents who experience a perinatal death.
 

 

Qualifications

MBChB (Hons) University of Birmingham, 2000

PhD University of Manchester, 2008

 

Publications

2011

  • Acharya, G., Albrecht, C., Benton, S., Cotechini, T., Dechend, R., Dilworth, M., Duttaroy, A., Grotmol, T., Heazell, A., Jansson, T., Johnstone, E., Jones, H., Jones, R., Lager, S., Laine, K., Nagirnaja, L., Nystad, M., Powell, T., Redman, C., Sadovsky, Y., Sibley, C., Troisi, R., Wadsack, C., Westwood, M. & Lash, G (2011). IFPA meeting 2011 workshop report I: Placenta: Predicting future health; roles of lipids in the growth and development of feto-placental unit; placental nutrient sensing; placental research to solve clinical problems - A translational approach. Placenta, eScholarID:144593 | PMID:22154691 | DOI:10.1016/j.placenta.2011.11.015
  • Ackerman, et al (2011). IFPA meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta, eScholarID:144592 | PMID:22154501 | DOI:10.1016/j.placenta.2011.11.022
  • Goodfellow LR, Batra G, Hall V, McHale E, Heazell AE. (2011). A case of confined placental mosaicism with double trisomy associated with stillbirth. Placenta, 32(9), 699-703. eScholarID:144587 | DOI:10.1016/j.placenta.2011.06.008
  • Heazell AE, Riches J, Hopkins L, Myers JE. (2011). A Review of Fetal Blood Sampling in Practice. BJOG, 118(7), 849-855. eScholarID:134113
  • Heazell, A., Brown, M., Worton, S. & Dunn, W (2011). Review: The effects of oxygen on normal and pre-eclamptic placental tissue--insights from metabolomics. Placenta, 32 Suppl 2, S119-24. eScholarID:144590 | PMID:21195475 | DOI:10.1016/j.placenta.2010.12.001
  • Heazell, A., Sharp, A., Baker, P. & Crocker, I (2011). Intra-uterine growth restriction is associated with increased apoptosis and altered expression of proteins in the p53 pathway in villous trophoblast. Apoptosis, 16(2), 135-44. eScholarID:144589 | PMID:21052841 | DOI:10.1007/s10495-010-0551-3
  • Rowland, J., Heazell, A., Melvin, C. & Hill, S (2011). Auscultation of the fetal heart in early pregnancy. Arch Gynecol Obstet, 283 Suppl 1, 9-11. eScholarID:144588 | PMID:20617441 | DOI:10.1007/s00404-010-1563-5
  • Warrander, L. & Heazell, A (2011). Identifying placental dysfunction in women with reduced fetal movements can be used to predict patients at increased risk of pregnancy complications. Med Hypotheses, 76(1), 17-20. eScholarID:144591 | PMID:20826059 | DOI:10.1016/j.mehy.2010.08.020

2009

  • Heazell A, Sahasrabudhe N, Grossmith A, Martindale E, Bhatia K. (2009). A case of intrauterine growth restriction in association with placental mesenchymal dysplasia with abnormal placental lymphatic development. Placenta, 30( 7), 654-7. eScholarID:1d21607 | DOI:10.1016/j.placenta.2009.04.004
  • Heazell A, Taylor N, Greenwood SL, Baker PN, Crocker IP. (2009). Does altered oxygenation or reactive oxygen species alter cell turnover of BeWo choriocarcinoma cells? Reprod Biomed Online, 18( 1), 111-9. eScholarID:1d20119

2008

  • Frøen J, Tveit J, Saastad E, Børdahl P, Stray-Pedersen B, Heazell A, Flenady V, Fretts R. (2008). Management of decreased fetal movements. Semin Perinatol, 32( 4), 307-11. eScholarID:1d17770 | DOI:10.1053/j.semperi.2008.04.015
  • Heazell A, Buttle H, Baker PN, Crocker IP. (2008). Altered expression of regulators of caspase activity within trophoblast of normal pregnancies and pregnancies complicated by preeclampsia. Reprod Sci, 15( 10), 1034-43. eScholarID:1d20121 | DOI:10.1177/1933719108322438
  • Heazell A, Crocker I. (2008). Live and let die - regulation of villous trophoblast apoptosis in normal and abnormal pregnancies. Placenta, 29( 9), 772-83. eScholarID:1d17769 | DOI:10.1016/j.placenta.2008.07.003
  • Heazell A, Green M, Wright C, Flenady V, Frøen J. (2008). Midwives' and obstetricians' knowledge and management of women presenting with decreased fetal movements. Acta Obstet Gynecol Scand, 87( 3), 331-9. eScholarID:1d17773 | DOI:10.1080/00016340801902034
  • Heazell A, Lacey HA, Jones CJP, Huppertz B, Baker PN, Crocker IP. (2008). Effects of oxygen on cell turnover and expression of regulators of apoptosis in human placental trophoblast. Placenta, 29(2), 175-86. eScholarID:1d17300 | DOI:10.1016/j.placenta.2007.11.002
  • Heazell AEP, Brown M, Dunn WB, Worton SA, Crocker IP, Baker PN, Kell DB. (2008). Analysis of the Metabolic Footprint and Tissue Metabolome of Placental Villous Explants Cultured at Different Oxygen Tensions Reveals Novel Redox Biomarkers. Placenta, 29(8), 691-698. eScholarID:134114 | DOI:10.1016/j.placenta.2008.05.002

2007

  • Heazell A, Moll S, Jones C, Baker PN, Crocker I. (2007). Formation of syncytial knots is increased by hyperoxia, hypoxia and reactive oxygen species. Placenta, 28 Suppl A, S33-40. eScholarID:1d20821 | DOI:10.1016/j.placenta.2006.10.007
  • Moll S, Jones CJP, Crocker IP, Baker PN, Heazell A. (2007). Epidermal growth factor rescues trophoblast apoptosis induced by reactive oxygen species. Apoptosis, Jun 19; [Epub ahead of print], eScholarID:1d27792

2006

  • Heazell A, Moll S, Jones CJP, Baker PN, Crocker IP. (2006). Formation of Syncytial Knots is Increased by Hyperoxia, Hypoxia and Reactive Oxygen Species. Placenta, Nov 29, eScholarID:1d15077
  • Myers JE, Heazell A, Jones RL, Baker PN. (2006). Obstetric management of teenage pregnancy. Maternal & Fetal Medicine Review, 17 (4), eScholarID:1d15204

2005

  • Heazell A, Sumathi G, Bhatti N. (2005). What investigation is appropriate following maternal perception of reduced fetal movements? J Obstet Gynaecol, 25( 7), 648-50. eScholarID:1d21614 | DOI:10.1080/01443610500278303

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