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School of Medicine

Dr Martin Yuille 

Photograph of Martin Yuille

Reader in Biobanking - CIGMR

Centre for Integrated Genomic Medical Research (CIGMR)
Stopford Building
Oxford Road
Manchester, M13 9PT

CIGMR - Centre for Integrated Genomic Medical Research

UDBN - UK DNA Banding Network

BBMRI - Biobanking and Biomolecular Resources Research Infrastructure

 

Role

Martin Yuille MA (Oxon), PhD (Edin), FRCPath is Reader in Biobanking in the Centre for Integrated Genomic Medical Research.

 

Memberships of Committees and Professional Bodies

He is a member of the Scientific Advisory Board of GeneLibrary Ireland, of the Steering Committee of the Confederation of Cancer Biobanks and of the Marketing Committee of the International Society for Biological and Environmental Repositories.

Research

His primary current research interest is in biobanking. This is an emerging discipline within biological sciences that takes a rigorous approach to the handling of biological resources. With the completion of the Human Genome Project, very large, high quality, accessible, sustainable resources have become essential to biomedical research translating the human genome sequence into health benefits. This then has implications for sample handling methodologies, for bioinformatics, for operational management and their setting in an appropriate collaborative, governance, ethical and societal framework. Intergovernmental bodies have advised on the need to develop global and European biological resource networks. He is actively involved in this work as Associate Coordinator for the EC-funded European Biobanking and BioMolecular Resources Infrastructure (BBMRI) Preparatory Phase and as PI for a Core Activity of Public Population Project in Genomics (P3G) work on Quantity and Quality Control (Q2C). He is also PI for the UK DNA Banking Network which is funded by the MRC. Through these activities he has many hundreds of collaborators in the UK, elsewhere in the EU and internationally.

 

Biography

Martin Yuille gained BA (Honours) Biochemistry from the University of Oxford and Doctor of Philosophy from the Department of Molecular Biology in the University of Edinburgh. He trained in molecular genetics at Stanford University, State University of New York and University of Cambridge. He led a research team at the Institute of Cancer Research, London. Previously he was Head of Research and Development in the biological services division of the MRC's UK Human Genome Mapping Project Resource Centre at The Genome Campus, Hinxton.

 

Publications

2010

2009

  • Brown, J., Donev, A.N., Aslanidis, C., Bracegirdle, P., Dixon, K.P., Foedinger, M., Gwilliam, R., Hardy, M., Illig, T., Ke, X., Krinka, D., Lagerberg, C., Laiho, P., Lewis, D.H., McArdle, W., Patton, S., Ring, S.M., Schmitz, G., Stevens, H., Tybring, G., Wichmann, H.E., Ollier, W.E. & Yuille, M.A (2009). Observational study on variability between biobanks in the estimation of DNA concentration. BMC Research Notes, 2, 8. Full text doi:10.1186/1756-0500-2-208 | PubMed entry PMID:19825187

2008

  • Yuille, MA, van Ommen, G, Bréchot, C, Cambon-Thomsen, A, Dagher, G, Landegren, U, Litton, J, Pasterk, M, Peltonen, L, Taussig, M, Wichmann, H, Zatloukal, K. (2008). Biobanking for Europe. Brief Bioinform, 9(1), 14-24. Full text doi:10.1093/bib/bbm050

2007

  • JonssonV, TjonnfjordG, SamuelsenS.O, JohannesenT, OlsenJ, SellickG, HoulstonR, Yuille MA, CatovskyD. (2007). Birth order pattern in the inheritance of chronic lymphocytic leukaemia and related lymphoproliferative disease. Leuk.Lymphoma, 48, 12, 2387-2396.

2006

  • deTute R, Yuille MA, CatovskyD, HoulstonR.S, HillmenP, RawstronA.C. (2006). Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults. Leukemia, 20, 4, 728-729.

2005

  • Jonsson,V., Houlston,R.S., Catovsky,D., Yuille, MA, Hilden,J., Olsen,J.H., Fajber,M., Brandt,B., Sellick,G., Allinson,R., Wiik,A. (2005). CLL family 'Pedigree 14' revisited: 1947-2004. Leukemia, 19, 6, 1025-1028.
  • Sellick,G.S., Webb,E.L., Allinson,R., Matutes,E., Dyer,M.J., Jonsson,V., Langerak,A.W., Mauro,F.R., Fuller,S., Wiley,J., Lyttelton,M., Callea,V., Yuille, MA, Catovsky,D., Houlston,R.S. (2005). A high-density SNP genomewide linkage scan for chronic lymphocytic leukemia-susceptibility loci. Am. J. Hum. Genet, 77, 3, 420-429.

2004

  • Yuille MA, KornB, MooreT, FarmerA.A, CarrinoJ, PrangeC, HayashizakiY. (2004). The responsibility to share: sharing the responsibility. Genome Res, 14, 10B, 2015-2019.

2003

  • HoulstonR.S, SellickG, Yuille MA, MatutesE, CatovskyD. (2003). Causation of chronic lymphocytic leukemia--insights from familial disease. Leuk.Res, 27, 10, 871-876.

2002

  • BenzowK.A, KoobM.D, CondieA, CatovskyD, MatutesE, Yuille MA, HoulstonR.S. (2002). Instability of CAG-trinucleotide repeats in chronic lymphocytic leukemia. Leuk.Lymphoma, 43, 10,
  • BradshawP.S, CondieA, MatutesE, CatovskyD, Yuille MA. (2002). Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif. Oncogene, 21, 3, 483-487.
  • CondieA, PowlesR.L, HudsonC.D, ShepherdV, BevanS, Yuille MA, HoulstonR.S. (2002). Analysis of the Fanconi anaemia complementation group A gene in acute myeloid leukaemia. Leuk.Lymphoma, 43, 9, 1849-1853.
  • HoulstonR.S, CatovskyD, Yuille MA. (2002). Genetic susceptibility to chronic lymphocytic leukemia. Leukemia, 16, 6, 1008-1014.
  • Rawstron,A.C., Yuille, MA, Fuller,J., Cullen,M., Kennedy,B., Richards,S.J., Jack,A.S., Matutes,E., Catovsky,D., Hillmen,P., Houlston,R.S. (2002). Inherited predisposition to CLL is detectable as subclinical monoclonal B-lymphocyte expansion. Blood, 100, 7, 2289-2290.
  • Reddy,A., Yuille, MA, Sullivan,A., Repellin,C., Bell,A., Tidy,J.A., Evans, DDGR, Farrell,P.J., Gusterson,B., Gasco,M., Crook,T. (2002). Analysis of CHK2 in vulval neoplasia. Br.J.Cancer, 86, 5, 756-760.
  • SodhaN, HoulstonR.S, WilliamsR, Yuille MA, MangionJ, EelesR.A. (2002). A robust method for detecting CHK2/RAD53 mutations in genomic DNA. Hum.Mutat, 19, 2, 173-177.
  • Sullivan,A., Yuille, MA, Repellin,C., Reddy,A., Reelfs,O., Bell,A., Dunne,B., Gusterson,B.A., Osin,P., Farrell,P.J., Yulug,I., Evans,A., Ozcelik,T., Gasco,M., Crook,T. (2002). Concomitant inactivation of p53 and Chk2 in breast cancer. Oncogene, 21, 9, 1316-1324.
  • SummersgillB, ThorntonP, AtkinsonS, MatutesE, ShipleyJ, CatovskyD, HoulstonR.S, Yuille MA. (2002). Chromosomal imbalances in familial chronic lymphocytic leukaemia: a comparative genomic hybridisation analysis. Leukemia, 16, 7, 1229-1232.
  • Yuille MA, CondieA, HudsonC, Kote-JaraiZ, StoneE, EelesR, MatutesE, CatovskyD, HoulstonR. (2002). Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Blood, 99, 11, 4216-4218.
  • Yuille MA, CondieA, HudsonC.D, BradshawP.S, StoneE.M, MatutesE, CatovskyD, HoulstonR.S. (2002). ATM mutations are rare in familial chronic lymphocytic leukemia. Blood, 100, 2, 603-609.
  • SodhaN, HoulstonR.S, BullockS, Yuille MA, ChuC, TurnerG, EelesR.A. (2002). Increasing evidence that germline mutations in CHEK2 do not cause Li-Fraumeni syndrome. Hum.Mutat, 20, 6, 460-462.

2001

  • LuY, CondieA, BennettJ.D, FryM.J, Yuille MA, ShipleyJ. (2001). Disruption of the ATM gene in breast cancer. Cancer Genet.Cytogenet, 126, 2, 97-101.
  • MeloJ.V, KumberovaA, van DijkA.G, GoldmanJ.M, Yuille MA. (2001). Investigation on the role of the ATM gene in chronic myeloid leukaemia. Leukemia, 15, 9, 1448-1450.
  • Yuille MA, CondieA, StoneE.M, WilsherJ, BradshawP.S, BrooksL, CatovskyD. (2001). TCL1 is activated by chromosomal rearrangement or by hypomethylation. Genes Chromosomes.Cancer, 30, 4, 336-341.
  • StankovicT, TaylorA.M, Yuille MA, VorechovskyI. (2001). Recurrent ATM mutations in T-PLL on diverse haplotypes: no support for their germline origin. Blood, 97, 5, 1517-1518.

2000

  • Bevan,S., Catovsky,D., Matutes,E., Antunovic,P., Auger,M.J., Ben-Bassat,I., Bell,A., Berrebi,A., Gaminara,E.J., Junior,M.E., Mauro,F.R., Quabeck,K., Rassam,S.M., Reid,C., Ribeiro,I., Stark,P., van Dongen,J.J., Wimperis,J., Wright,S., Marossy,A., Yuille, MA, Houlston,R.S. (2000). Linkage analysis for major histocompatibility complex-related genetic susceptibility in familial chronic lymphocytic leukemia. Blood, 96, 12, 3982-3984.
  • De SchouwerP.J, DyerM.J, Brito-BabapulleV.B, MatutesE, CatovskyD, Yuille MA. (2000). T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation. Br.J.Haematol, 110, 4, 831-838.
  • SorourA, Brito-BabapulleV, SmedleyD, Yuille MA, CatovskyD. (2000). Unusual breakpoint distribution of 8p abnormalities in T-prolymphocytic leukemia: a study with YACS mapping to 8p11-p12. Cancer Genet.Cytogenet, 121, 2, 128-132.
  • Yuille MA, MatutesE, MarossyA, HilditchB, CatovskyD, HoulstonR.S. (2000). Familial chronic lymphocytic leukaemia: a survey and review of published studies. Br.J.Haematol, 109, 4, 794-799.
  • BradshawP.S, HoulstonR.S, HamoudiR, Yuille MA. (2000). A proposed BAT-26 germline polymorphism. Am.J.Pathol, 156, 2, 733-734.
  • HoulstonR.S, CatovskyD, Yuille MA. (2000). Pseudoautosomal linkage in chronic lymphocytic leukaemia. Br.J.Haematol, 109, 4, 899-900.
  • SodhaN, WilliamsR, MangionJ, BullockS.L, Yuille MA, EelesR.A. (2000). Screening hCHK2 for mutations. Science, 289, 5478, 359.

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