Dr Tim Frank MD, MBChB, FRCGP,DCH, DRCOG.
Honorary Reader
General Practice Research Unit,
2nd Floor ERC, North West Lung Centre,
Wythenshawe Hospital,Southmoor Rd,
Manchester
M23 9LT.
Role
Principal in General Practice 1/12/96
Bowland Medical Practice,
52 Bowland Rd,
Wythenshawe,
Manchester
M23 1JX.
Trainer in General Practice: 1/8/07
Bowland Medical Practice,
52 Bowland Rd,
Wythenshawe,
Manchester
M23 1JX.
Honorary Reader (Part Time from 2009)
Faculty of Medical and Human Sciences
The University of Manchester
Director: General Practice Research Unit,
2nd Floor ERC, North West Lung Centre,
Southmoor Rd,
Manchester
M23 9LT.
Research
1.1 Wythenshawe Community Asthma Project (WYCAP)
Five surveys, each involving around 15,000 individuals, have been undertaken in two general practices in Wythenshawe over the past 12 years. Data collection for the most recent study was completed in February 2005. The surveys have studied:
• the prevalence of respiratory symptoms, obstructive airways disease and risk factors and temporal trends
• detecting airways disease using questionnaires
• health care utilisation and cost
• health related quality of life in subjects with and without respiratory symptoms and temporal changes in health related quality of life
WYCAP is a unique study showing the prevalence of respiratory symptoms, temporal changes over a 12 year period and health care utilisation in a population.
1.2 Health Related Quality of Life and Chronic illness using Wythenshawe Community Asthma Project (WYCAP)
Comparison of health related quality of life between different morbidities using a generic quality of life questionnaire (EQ-5D) in the WYCAP 2004 survey.
These analyses commenced in April 2008, with funding secured from Manchester PCT to enable the work to be undertaken by an Academic F2 doctor who was attached to this Unit, under the supervision of Dr Hazell and Dr Frank.
1.3 Manchester Community Asthma Study (MANCAS)
This study was funded by Asthma UK (formerly the National Asthma Campaign) and investigated the possible association between neonatal BCG vaccination and the subsequent development of asthma. The parents of approximately 2500 children responded to a questionnaire and were included in the study, and over 900 children had skin tests for allergies as part of the study.
This study examines the link between BCG vaccination and the development of atopic disease (asthma and allergies). The study suggests that vaccination of neonates with BCG is associated with a lower prevalence of asthma symptoms.
1.4 Manchester Community Asthma Study 2 (MANCAS2)
This study is funded by Moulton Charitable Foundation and is investigating the possible association and dose response between neonatal BCG vaccination and the subsequent development of asthma. The parents of 6734 children born at St Marys between July 1993 and March 1997 will be sent postal questionnaires regarding respiratory symptoms. These children have either had a normal dose of BCG vaccination or an intradermal dose subcutaneously (high dose) or no BCG vaccination.
This study explores whether there is a dose response relationship between BCG vaccination and the development of asthma and follows on from the MANCAS I study which suggested that vaccination of neonates with BCG is associated with a lower prevalence of asthma symptoms.
1.5 Spirometry and Cardiac Evaluation (SPACE)
This is a joint study with the Department of Cardiology at SMUHT; data collection finished in February 2006. The aims were to estimate the prevalence of COPD in patients attending a cardiology chest pain clinic.
1.6 (Avenues)Exploring the avenues to involvement in primary care research
Purpose
Aim: To explore the experiences of GPs, within NHS Manchester, in research study involvement and their perceptions of the impact of initiatives to increase this involvement.
Objective: To suggest local solutions to the long standing problem of difficulties in engaging GPs in research.
Qualifications
FRCGP London May 2008
MD Thesis “The Validation of a Screening Questionnaire for Asthma.”
Doctor of Medicine 2000
University of Leeds 1995-2000
MBChB Leeds 1989
DCH London 1993
DRCOG London 1994
MRCGP London 1994
DFFP London 1995
Collaborators and affiliated staff
Dr Hazell has been appointed Honorary Research Associate at the Faculty of Medical and Human Sciences University of Manchester.
Dr Linehan has been appointed Honorary Research Associate at the Faculty of Medical and Human Sciences University of Manchester.
Publications
2009
- Francis HH, Colecliffe W, Hazell ML, Singh SD, Niven RR M, Hagan G, Spencer M, Frank TL. (2009). Prevalence of airflow obstruction in patients attending a rapid access chest pain clinic. Respir Med, 103( 5), 736-742. eScholarID:1d19818 | DOI:10.1016/j.rmed.2008.11.016
- Isobel Heyworth, Michelle L Hazell, Mary F Linehan, Timothy L Frank. (2009). How do common chronic conditions affect health related quality of life? Br J Gen Pract, 59(568), 833-838. eScholarID:77088 | DOI:10.3399/bjgp09X453990
- Linehan MF, Frank P, Niven RR M, Hazell ML, Morris JJA, Francis HH, Frank TL. (2009). Prevalence of respiratory symptoms, features of asthma, and characteristics associated with respiratory disease, in 6-11 year olds in Manchester. Prim Care Respir J, 18(1), 21-26. eScholarID:1d19822 | DOI:10.3132/pcrj.2008.00041
- Michelle L Hazell, Julie Morris, Mary F Linehan, Peter I Frank, Timothy L Frank. (2009). Factors influencing response to postal questionnaire surveys about respiratory symptoms. Primary Care Respiratory Journal, 18(3), 165-170. eScholarID:77087 | DOI:10.3132/pcrj.2009.00001
- Michelle L Hazell, Julie Morris, Mary F Linehan, Timothy L Frank. (2009). Temporal change in health related quality of life. A longitudinal study in general practice 1999-2004. Br J Gen Pract, 59(568), 839-843. eScholarID:77089 | DOI:10.3399/bjgp09X472890
2008
- David Fishwick, Christopher Michael Barber, Lisa M Bradshaw, Joanne Harris-Roberts, Mandy Francis, Steven Naylor, Jon Ayres, Sherwood Burge, Jonathan M Corne, Paul Cullinan, Timothy Laszlo Frank, David Hendrick, Jennifer Hoyle, Maritta Jaakkola, Anthony Newman-Taylor, Paul Nicholson, Robert Niven, Tony Pickering, Roger Rawbone, Chris Stenton, Christopher Warburton, and Andrew D Curran. (2008). Standards of care for occupational asthma. Thorax, 63, 240-250. eScholarID:77091 | DOI:10.1136/thx.2007.083444
- Frank PI, Morris JA, Hazell ML, Linehan MF, Frank TL. (2008). Long term prognosis in preschool children with wheeze: longitudinal postal questionnaire study 1993-2004. BMJ, 336, 1423-1426. eScholarID:77090 | DOI:10.1136/bmj.39568.623750.BE
2007
- Frank PI, Hazell ML, Morris JA, Linehan MF, Frank TL. (2007). A longitudinal study of changes in respiratory status in young adults (1993-2001). International Journal of Tuberculosis and Lung Disease 2007; 11(3): 338-43, 11(3), 338-343. eScholarID:77095
- Frank TL, Hazell ML, Linehan MF, Morris JA, Frank PI. (2007). The estimated prevalence of chronic obstructive pulmonary disease in a general practice population. Primary Care Respiratory Journal 2007; 16(3): 169-173, 16(3), 169-173. eScholarID:77094
- Jane Upton, Hazel Madoc-Sutton, Aziz Sheikh, Timothy L Frank, Samantha Walker, Monica Fletcher. (2007). National survey on the roles and training of primary care respiratory nurses in the UK in 2006: are we making progress ?. Primary Care Respiratory Journal, 16(5), 284-290. eScholarID:77092
- Linehan G, Frank TL, Hazell ML, Francis HC, Morris JM, Baxter DB, Niven RR M. (2007). Is the prevalence of wheeze in children altered by neonatal BCG vaccination. J Allergy Clin Immunology, 119(5), 1079-1085. eScholarID:1d14600 | DOI:10.1016/j.jaci.2006.12.672
2006
- Frank P, Morris J, Hazell M, Linehan M, Frank T. (2006). Smoking, respiratory symptoms and likely asthma in young people: evidence from postal questionnaire surveys in the Wythenshawe Community Asthma Project (WYCAP). BMC Pulmonary Medicine, 6(10), eScholarID:77097
- Frank TL, Hazell ML, Linehan MF, Frank PI. (2006). The diagnostic accuracies of chronic obstructive pulmonary disease (COPD) in general practice: the results of the MAGIC (Manchester Airways Group Identifying COPD) study. Primary Care Respiratory Journal, 15(5), 286-293. eScholarID:77096
- Tavernier, G, Fletcher, G, Gee, I, Watson, A, Blacklock, G, Francis, H, Fletcher, A, Frank, TL, Frank, P, Pickering, C, Niven, RR M. (2006). IPEADAM study: indoor endotoxin exposure, family status, and some housing characteristics in English children. J Allergy Clin Immunol, 117(3), 656-662. eScholarID:1d14615 | DOI:10.1016/j.jaci.2005.12.1311
2005
- Frank PI, Wicks PD, Hazell ML, Linehan MF, Hirsch S, Hannaford PC, Frank TL. (2005). Temporal change in the prevalence of respiratory symptoms and obstructive airways disease 1993-2001. Br J Gen Pract, 55, 596-602. eScholarID:77099
- Hirsch S, Frank TL, Hazell M, Frank PI. (2005). Screening for Asthma by Population Ranking: A Validation Study. Annals of Epidemiology, 15(1), 64-70. eScholarID:77101
- Joanne Elms, Rachel O'Hara, Simon Pickvance, David Fishwick, Michelle Hazell, Tim Frank, Mandy Henson, Peter Marlow, Gareth Evans, Lisa Bradshaw, Paul Harvey, and Andrew Curran. (2005). The perceptions of occupational health in primary care. Occupational Medicine, 55, 523-527. eScholarID:77098
- M F Linehan, M L Hazell, T L Frank, and P I Frank. (2005). Prevalence of respiratory symptoms in under fives - 1993 to 2001. Arch Dis Child, 90, 516-519. eScholarID:77100
- Tavernier, G, Fletcher, G, Francis, H, Oldham, L, Fletcher, A, Blacklock, G, Stewart, L, Gee, I, Watson, A, Frank, TL, Frank, P, Pickering, C, Niven, RR M. (2005). Endotoxin exposure in asthmatic children and matched healthy controls: results of IPEADAM study. Indoor Air, 15 Suppl 10, 64-70. eScholarID:1d30709
- Travernier G, Fletcher GD, Frank TL, Frank P, Pickering CC A, Francis HC, Niven RR M. IPEADAM study, indoor pollution, endotoxin allergens and damp in asthma.. 2005. eScholarID:19d292
2004
- Frank PI, Frank TL, Hazell ML, Hirsch S. (2004). Changes in smoking habits. A longitudinal population study. Family Practice, 21(1), 33-38. eScholarID:77104
- Frank TL, Cropper JA, Hazell ML, Frank PI, Hannaford PC. (2004). Childhood Asthma: Healthcare resource utilisation in those with and without a diagnosis of the condition. Respiratory Medicine, 98, 454-463. eScholarID:77103
- Hirsch S, Frank TL, Shapiro JL, Hazell ML, Frank PI. (2004). Development of a questionnaire weighted scoring system to target diagnostic examinations for asthma in adults: a modelling study. BMC Family Practice, 5(30), eScholarID:77102
2003
- Frank TL, FrankP.I, CropperJ.A, HazellM.L, HannafordP.C, McNamee R, HirschS, PickeringC.A. (2003). Identification of adults with symptoms suggestive of obstructive airways disease: Validation of a postal respiratory questionnaire. BMC Fam. Pract, 4(5), eScholarID:1d5554
- Hazell ML, Frank TL, Frank PI. (2003). Health related quality of life in individuals with asthma like symptoms. Respiratory Medicine, 97(11), 1211-1218. eScholarID:77105
2001
- Cropper JA, Frank TL, Frank PI, Laybourn ML, Hannaford PC. (2001). Respiratory Illness and Healthcare Utilisation in Children. The Primary and Secondary Care Interface. Eur Resp J, 17(5), 892-898. eScholarID:77108
- Frank P. I, Frank TL, Cropper J, Hirsch S, Niven R. M, Hannaford P, McNamee R. (2001). The use of a screening questionnaire to identify children with likely asthma. Br J Gen Pract, 51, 463, eScholarID:1d3318
- Hazell ML, Cropper JA, Frank TL, Frank PI, Hannaford PC. (2001). The Impact of Respiratory Symptoms on healthcare utilisation: the primary and secondary care interface. Primary Care Respiratory Journal, 10(3), 61-64. eScholarID:77107
- Hirsch S, Shapiro J, Turega M, Frank TL, Niven RR M, Frank P. (2001). Using a neural network to screen a population for asthma. Ann Epidemiol, 11( 6), 369-376. eScholarID:1d28538
- Sheikh A, Frank TL, Levy ML, Dawson A. (2001). Identifying pan-European management goals for asthma: Participatory action research study. Primary Care Respiratory Journal, 10(3), 69-70. eScholarID:77106
- Copper JA, Frank TL, Frank PI, Laybourn ML, Hannaford P. Respiratory illness and healthcare utilisation in children. The primary and secondary care interface.. Vol. 17(5). 2001. 892-898. eScholarID:19d232
- Frank PI, Frank TL, Crooper J, Hirsh S, Niven RR M, Hannaford PC, McNamee R. The use of a screening questionaire to identify children with likely asthma. Vol. 51. 2001. 117-120. eScholarID:19d233
- Hirsh S, Shapiro J, Turega M, Frank TL, Niven RR M, Frank PI. Using a neurol network to screen a population for asthma. Vol. 11. 2001. 369-376. eScholarID:19d230
2000
- Frank TL. (2000). 'The Validation of a Screening Questionnaire for Asthma.'. University of Leeds. eScholarID:77140
- Cropper JA, Frank TL, Frank PI, Hannaford PC. (2000). Primary care workload and prescribing costs in children: The impact of respiratory symptoms. Prim Care Respir J, 9(1), 8-12. eScholarID:77137
1999
- Frank TL, Frank P. I, McNamee R, Wright T, Hannaford P, Morrison J, Hirsch S, Pickering C. A. (1999). Assessment of a simple scoring system applied to a screening questionnaire of asthma in children aged 5-15 yrs. Eur Respir J, 14, eScholarID:1d3314
- Frank TL, Frank PI, McNamee R, Wright T, Hannaford PC, Morrison J et al. Assessment of a simple scoring system for a screening questionaire for asthma in children age 5-15 years. Vol. 14(5). 1999. 1190-1197. eScholarID:19d235
1998
- Frank TL, Adisesh A, Pickering CA, Morrison JF, Wright T, Francis H et al. (1998). Relationship between exhaled nitric oxide and childhood asthma. Am J Resp Crit Care Med 1998; 158: 1032-6, 158, 1032-1036. eScholarID:77138