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School of Medicine

Dr Steve Hopkins PhD

Consultant Healthcare Scientist / Honorary Reader

  • Email: Steve.Hopkins@manchester.ac.uk
  • Telephone: +44 (0)161 206 4269
  • Alternative Telephone: +44 (0)161 206 4270 (Laboratory Group phone)
  • Fax: +44 (0)161 206 4368
 

Role

Principal Scientist Injury Research at Salford Royal Foundation Trust. I lead the Cytokine and Inflammation Research Lab in Research & Development at Salford Royal. Our primary collaborations within the Clinical Neurosciences Group but we also have collaborations with other clinical groups within and external to Manchester University in the area of cytokine and inflammation research.

 

Research

Cytokines, Inflammation and Immunity

The principal aim of our research is to identify the role of cytokines in the regulation of inflammatory and immune responses, both in peripheral tissues and the central nervous system. Particular interests include the relationship between cytokine expression and disease and how cytokines regulate associated systemic responses. Our studies have involved collaborations with a number of clinical and experimental biology groups, both locally and internationally. Current activity is focused in the area of stroke, head injury and Alzheimer's disease.

 

Methodological Knowledge

We have developed a range of biological, immunological and molecular techniques to identify expression of cytokines in both clinical disease and experimental situations, including biological and immunoassays for cytokines, as well and quantitative molecular techniques.This expertise is being used to develop a multiplex assay for diagnosis of pre-eclampsia in collaboration with the Maternal & Fetal Health Research Centre at St. Mary's Hospital, Manchester.

 

Collaborators and affiliated staff

Professor Nancy Rothwell (School of Life Sciences, University of Manchester)

Dr Pippa Tyrrell (Clinical Neurosciences Group, University of Manchester)

Professor Alistair Burns (Professor of Old Age Psychiatry, University of Manchester)

Dr Peter Hutchinson (Academic Unit of Neurosurgery, Department of Clinical Neurosciences, University of Cambridge)

Dr Ian Crocker (Maternal & Fetal Health Research Centre, St. Mary's Hospital Manchester)

 

Publications

2011

  • Binymin, K., Herrick, A., Carlson, G. & Hopkins, S (2011). The effect of disease activity on body composition and resting energy expenditure in patients with rheumatoid arthritis Journal: Journal of Inflammation Research. 4(1), 61-66. eScholarID:126063 | DOI:10.2147/JIRS16508
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., Proctor, S., Russell, J., Hopkins, S., Tyrrell, P., Rothwell, N. & Allan, S (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain, Behavior, and Immunity, In Press, Accepted Manuscript, eScholarID:126068 | DOI:10.1016/j.bbi.2011.02.008
  • Galea, J., Ogungbenro, K., Hulme, S., Greenhalgh, A., Aarons, L., Scarth, S., Hutchinson, P., Grainger, S., King, A., Hopkins, S., Rothwell, N. & Tyrrell, P (2011). Intravenous anakinra can achieve experimentally effective concentrations in the central nervous system within a therapeutic time window: results of a dose-ranging study. J Cereb Blood Flow Metab, 31(2), 439-447. eScholarID:126062 | DOI:10.1038/jcbfm.2010.103
  • Selvarajah, J., Smith, C., Hulme, S., Georgiou, R., Sherrington, C., Staniland, J., Illingworth, K., Jury, F., Payton, A., Ollier, W., Vail, A., Rothwell, N., Hopkins, S. & Tyrrell, P (2011). Does inflammation predispose to recurrent vascular events after recent transient ischaemic attack and minor stroke? The North West of England transient ischaemic attack and minor stroke (NORTHSTAR) study. International Journal of Stroke, 6(3), 187-194. eScholarID:126061 | DOI:10.1111/j.1747-4949.2010.00561.x

2010

  • Parry-Jones, A., Boutin, H., Denes, A., McColl, B., Hopkins, S., Allan, S. & Tyrrell, P (2010). Interleukin-1 Receptor Antagonist in Animal Models of Stroke: A Fair Summing Up? Journal of Stroke and Cerebrovascular Diseases, 19(6), 512-513. eScholarID:126067 | DOI:10.1016/j.jstrokecerebrovasdis.2010.01.005

2008

  • Clark S, McMahon C, Gueorguieva I, Rowland M, Scarth S, Georgiou R, Tyrrell PJ, Hopkins SJ, Rothwell NJ. (2008). Interleukin-1 receptor antagonist penetrates human brain at experimentally therapeutic concentrations. J Cereb Blood Flow Metab, 28( 2), 387-94. eScholarID:1d16879
  • Emsley H, Hopkins SJ. (2008). Acute ischaemic stroke and infection: recent and emerging concepts. Lancet Neurol, 7( 4), 341-53. eScholarID:1d17150 | DOI:10.1016/S1474-4422(08)70061-9
  • Emsley, H., Smith, C., Tyrrell, P. & Hopkins, S (2008). Inflammation in acute ischaemic stroke and its relevance to stroke critical care. Neurocritical Care, 9, 125-138. eScholarID:132965 | DOI:10.1007/s12028-007-9035-x
  • Gueorguieva I, Clark SR, McMahon CJ, Scarth S, Rothwell NJ, Tyrrell PJ, Hopkins SJ, Rowland M. (2008). Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. Br J Clin Pharmacol, 65(3), 317-25. eScholarID:1d16891
  • Gueorguieva, I., Clark, S., McMahon, C., Scarth, S., Rothwell, N., Tyrell, P., Hopkins, S. & Rowland, M (2008). Pharmacokinetic modelling of interleukin-1 receptor antagonist in plasma and cerebrospinal fluid of patients following subarachnoid haemorrhage. British Journal of Clinical Pharmacology, 65(3), 317-325. eScholarID:126060 | DOI:10.1111/j.1365-2125.2007.03026.x
  • Emsley H, Smith CJ, Hopkins SJ. (2008). Infection and brain-induced immunodepression after acute ischemic stroke. Stroke, 39( 1), e7; author reply e8. eScholarID:17d708

2007

  • Emsley HC, Smith CJ, Tyrrell PJ, Hopkins SJ. (2007). Inflammation in Acute Ischemic Stroke and its Relevance to Stroke Critical Care. Neurocrit Care, eScholarID:1d16877
  • Emsley, HCA, Smith, CJ, Gavin, CCM, Georgiou, R, Vail, A, Barberan, EM, Illingworth, K, Scarth, S, Wickramasinghe, V, Hoadley, M, Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2007). Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production. BMC Neurol, 7, eScholarID:1d16883
  • Hopkins SJ. (2007). Central nervous system recognition of peripheral inflammation: a neural, hormonal collaboration. Acta Biomed, 78 Suppl 1, 231-47. eScholarID:1d16892
  • Hutchinson, P, O'Connell, M, Rothwell, NJ, Hopkins, SJ, Nortje, J, Carpenter, K, Timofeev, I, Al-Rawi, P, Menon, D, Pickard, J. (2007). Inflammation in human brain injury: intracerebral concentrations of IL-1alpha, IL-1beta, and their endogenous inhibitor IL-1ra. J Neurotrauma, 24( 10), 1545-57. eScholarID:1d16889
  • Hutchinson, P., O'Connell, M., Rothwell, N., Hopkins, S., Nortje, J., Carpenter, K., Timofeev, I., Al-Rawi, P., Menon, D. & Pickard, J (2007). Inflammation in human brain injury: Intracerebral concentrations of IL-1 alpha, IL-1 beta, and their endogenous inhibitor IL-1ra. Journal of Neurotrauma, 24(10), 1545-1557. eScholarID:126069

2006

  • Gunji H, Scarth S, Carlson GL, Warhurst G, Little RA, Hopkins SJ. (2006). Variability of bacterial translocation in the absence of intestinal mucosal damage following injury and the influence of interleukin-6. Pathophysiology, 13( 1), 39-49. eScholarID:1d16896
  • Hoadley M, Hopkins SJ. (2006). Comparison of 'real-time' and immunometric RT-PCR: RNA interference of reverse transcriptase-PCR. J Immunol Methods, 312( 1-2), 40-4. eScholarID:1d16894
  • Smith CJ, Emsley HCA, Vail A, Georgiou R, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2006). Variability of the systemic acute phase response after ischemic stroke. J Neuro Sci, 251(1-2), eScholarID:1d27471 | DOI:10.1016/j.jns.2006.09.011

2005

  • Di Napoli, M, Schwaninger, M, Cappelli, R, Ceccarelli, E, Di Gianfilippo, G, Donati, C, Emsley, HCA, Forconi, S, Hopkins, SJ, Masotti, L, Muir, K, Paciucci, A, Papa, F, Roncacci, S, Sander, D, Sander, K, Craig Smith, Stefanini, A, Weber, D. (2005). Evaluation of C-reactive protein measurement for assessing the risk and prognosis in ischemic stroke: a statement for health care professionals from the CRP Pooling Project members. Stroke, 36( 6), 1316-29. eScholarID:1d16898
  • Emsley C A, Smith CJ, Georgiou R, Vail A, Hopkins SJ, Rothwell NJ, Tyrrell PJ. (2005). A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. Journal of Neurol. Neurosurg. Psychiatry, 76, 1366-1372. eScholarID:1d11509 | DOI:10.1136/jnnp.2004.054882
  • Emsley H, Smith CJ, Georgiu R, Vail A, Barberan EM, Rothwell NJ, Tyrrell PJ, Hopkins SJ. (2005). Interleukin-6 and acute ischaemic stroke. Acta Neurol Scand, 112( 4), 273-4; author reply. eScholarID:17d688
  • Emsley, HCA, Smith, CJ, Georgiou, R, Vail, A, Tyrrell, PJ, Barberan, EM, Rothwell, NJ, Hopkins, SJ, Audebert, H, Haberl, RL. (2005). Correlation of systemic inflammatory response with infarct volume in acute ischemic stroke patients. Stroke, 36( 2), 228-9; author reply. eScholarID:17d789

2004

  • Smith, CJ, Emsley, HCA, Gavin, C, Georgiou, R, Vail, A, Barberan, EM, Del Zoppo, G, Hallenbeck, J, Rothwell, NJ, Hopkins, SJ, Tyrrell, PJ. (2004). Peak Plasma Interleukin-6 and Other Periperhal Markers of Inflammation in tne first week of Ischaemic Stroke Correlate with Brain Infarct Volume, Stroke Severity and Long-term Outcome. BMC Neurology, Jan 15; 4:2, eScholarID:1d7415 | DOI:10.1186/1471-2377-4-2

2003

  • Emsley, HCA, Smith, CJ, Gavin,C.M., Georgiou, R, Vail, A, Barberan,E.M., Hallenbeck,J.M., del Zoppo,G.J., Rothwell, NJ, Tyrrell, PJ, Hopkins, SJ. (2003). An early and sustained peripheral inflammatory response in acute ischaemic stroke: relationships with infection and atherosclerosis. Journal of Neuroimmunology, 139, 1-2, 93-101. eScholarID:1d5583 | DOI:10.1016/S0165-5728(03)00134-6
  • Hoadley M, Hopkins SJ. (2003). Simple, quantitative measurement of cytokine gene expression using an immunometric reverse transcriptase-polymerase chain reaction. J Immunol Methods, 282( 1-2), 135-45. eScholarID:1d16900
  • Hopkins SJ. (2003). The pathophysiological role of cytokines. Leg Med (Tokyo), 5 Suppl 1, S45-57. eScholarID:1d16901
  • Turnbull A, Prehar S, Kennedy AA.R, Little R, Hopkins SJ. (2003). Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice. Endocrinology, 144( 5), 1894-906. eScholarID:1d16903

2002

  • Hopkins SJ, Loudon AA. (2002). Remember the null hypothesis. J.Biol.Rhythms, 17, 410-412. eScholarID:1d6851
  • Soop, M, Duxbury, H, Agwunobi, A, Gibson, JM, Hopkins, SJ, Childs, C, Cooper, RG, Maycock, PF, Little, RA, Carlson, GL. (2002). Euglycemic hyperinsulinemia augments the cytokine and endocrine responses to endotoxin in humans. Am J Physiol Endocrinol Metab, 282( 6), E1276-85. eScholarID:1d14221
  • Zhou S, Cagampang FRA, Stirland JA, Loudon ASI, Hopkins SJ. (2002). Different photoperiods affect proliferation of lymphocytes but not expression of cellular, humoral, or innate immunity in hamsters. J. Biol. Rhythms, 17, 392-405. eScholarID:1d2571

2001

  • Cartmell T, Luheshi GG, Hopkins SJ, Rothwell NJ, Poole S. (2001). Role of endogenous interleukin-1 receptor antagonist in regulating fever induced by localised inflammation in the rat. J Physiol, 531( Pt 1), 171-80. eScholarID:1d7832

2000

  • Hope JC, Campbell F, Hopkins SJ. (2000). Deficiency of interleukin-2 or interleukin-6 reduces lymphocyte proliferation, but only interleukin-6 deficiency decreases the contact hypersensitivity response. Eur. J. Immunol, 30, 197-203. eScholarID:1d2510
  • Zampronio A, Hoadley M, Luheshi GG, Rothwell NJ, de Souza G, Hopkins SJ. (2000). Interleukin (IL)-6 release and fever induced by a pre-formed pyrogenic factor (PFPF) derived from LPS-stimulated macrophages. Eur Cytokine Netw, 11( 4), 589-96. eScholarID:1d16905

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