Dr Richard Booton PhD MRCP
Clinical Senior Lecturer/Consultant Respiratory Physician
- Email: richard.booton@uhsm.nhs.uk
- Telephone: +44 (0) 161 291 4297
- Fax: +44 (0) 161 291 4297
Dr Richard Booton
Clinical Senior Lecturer in Respiratory Medicine
Respiratory Research Group, School of Translational Medicine, The University of Manchester
North West Lung Centre
University Hospital of South Manchester
Southmoor Road
Manchester
M23 9LT
Memberships of Committees and Professional Bodies
European Respiratory Society
International Association for the Study of Lung Cancer
British Thoracic Oncology Group
American College of Chest Physicians
American Association for Bronchology and Interventional Pulmonology
Research
Principal Investigator (Manchester): LungSEARCH (Cancer Research UK)
Principal Investigator: Incidence, Prevalence, and Biology of Progressive Preneoplastic Bronchial Dysplasia in Two Distinct, Potential Screening Cohorts, of Patients At High Risk for Lung Cancer (The Charitable Moulton Foundation), including The Wythenshawe Respiratory Health Study (F Nordin, A Povey) and an Exon Array Analysis of Progressive Bronchial Dysplasia (L Brown/ G Landberg)
Principal Investigator (UHSM): Molecular mechanisms underlying chemotherapy resistance, therapeutic escape, efficacy and toxicity (European Union FP6 Chemores)
Principal Investigator: A Proteomic Exploration of Early Stage Lung Cancer Using Differential Analysis of Pulmonary Venous & Arterial Blood
Co-Investigator: Long non-coding RNAs and the development of lung cancer (M Lindsay/ S Griffith Jones)
Principal Investigator: An Integrative Genomic Exploration of Preinvasive and Recurrent NSCLC
Teaching
Provision and Supervision of The Foundation Programme (>70 newly qualified doctors) at the University Hospital of South Manchester (UHSM), with particular emphasis on Academic Foundation Trainees
Central/South Zonal Core Medical Training Lead for Respiratory Medicine
Respiratory Medicine Teaching Programme at UHSM
Medical Student Teaching (Out-patients/ Bronchoscopy)
Biography
After graduation from the University of Leeds in 1992 (MB ChB), Dr Booton completed general professional training in West Yorkshire (Bradford & Airedale) and Specialist Respiratory/ general Internal Medicine Training in the North West, becoming a Member of the Royal College of Physicians in 1998. He developed a sub-speciality interest in Thoracic Malignancy, working extensively at the North West Lung Centre, The Christie Hospital and The Paterson Institute for Cancer Research, Manchester and successfully completed a thoracic oncology fellowship (Supervisor: Prof N Thatcher) and a PhD thesis on the pharmacogenomics of lung cancer in 2006.
Dr Booton is a founding member of the British Thoracic Oncology Group and currently serves on the Steering Committee. He also serves on the locoregional disease sub-committee of the NCRI Lung Cancer Group. Locally, Dr Booton has played a leading role in the development of the Manchester Cancer Research Centre lung cancer strategy and the development of lung cancer services at the regional thoracic centre, University Hospital of South Manchester. He sits on the MCRC Biobank Board.
Dr Booton's is a Clinical Senior Lecturer & Honorary Consultant Respiratory Physician in the School of Translational Medicine at The University of Manchester focussing on the development of a new thoracic oncology research group and portfolio in the early detection of thoracic malignancy and leads on two national portfolio studies, employs 3 research fellows, and 2 research nurses and an NIHR Clinical Lecturer. He has active collaborations with The Wolfson Molecular Imaging Centre (Prof Whetton), The University of Manchester (Dr Lindsay/ Dr Griffiths Jones/ Prof Radford/ Dr Linton/ Dr Blackhall) and AstraZeneca Pharmaceuticals (Dr D Blowers/ Prof A Hughes)/ Allegro Diagnostics (Boston, USA). To date grant income approaches £1M.
Qualifications
Bachelor of Medicine, Bachelor of Surgery - University of Leeds 1992
Member of the Royal College of Physicians, London, UK 1998
Doctor of Philosophy PhD - University of Manchester 2006
Certificate of Completion Specialist Training (Respiratory & General Internal Medicine) 2007
Collaborators and affiliated staff
Professor Stephen Spiro, University College London
Dr Mark Lindsay, The University of Manchester
Dr Sam Griffiths-Jones, The university of Manchester
Dr Fiona Blackhall, The Christie Hospital
Professor Goran Landberg, The University of Manchester
Professor Tony Whetton, University of Manchester
Professor John Radford, The Christie Hospital
AstaZeneca Pharmaceuticals
Allegro Diagnostics
Manchester Cancer Research Centre
Publications
2011
- Booton R, Blackhall F, Kerr K. (2011). Individualised treatment in non-small cell lung cancer: precise tissue diagnosis for all? thorax, 66(4), 273-275. eScholarID:127637 | DOI:10.1136/thx.2010.138370
- Tsitsiou E, Williams AE, Moschos SA, Patel K, Rossios C, Jiang X, Adams OD, Macedo P, Booton R, Gibeon D, Chung KF, Lindsay MA. (2011). Transcriptome analysis shows activation of circulating CD8(+) T cells in patients with severe asthma. J Allergy Clin Immunol, 129(1), 95-103. eScholarID:148571 | DOI:10.1016/j.jaci.2011.08.011
- Yin M, Yan J, Voutsina A, Tibaldi C, Christiani DC, Heist RS, Rosell R, Booton R, Wei Q. (2011). No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer:a meta-analysis. Lung Cancer, 72(3), 370-377. eScholarID:127636 | DOI:10.1016/j.lungcan.2010.10.011
- Booton R, Blackhall F, Kerr K. (2011). Individualized Treatment in Non-Small Cell Lung Cancer: Precise Tissue Diagnosis for All?. Thorax, eScholarID:111113
2010
- Molassiotis A, Smith JA, Bennett MI, Blackhall F, Taylor D, Zavery B, Harle A,Booton R, Rankin EM, Lloyd-Williams M, Morice AH. (2010). Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough, 6, 6-9. eScholarID:127632 | DOI:10.1186/1745-9974-6-9
- Molassiotis, A., Smith, J., Bennett, M., Blackhall, F., Taylor, D., Zavery, B., Harle, A., Booton, R., Rankin, E., Lloyd-Williams, M. & Morice, A (2010). Clinical expert guidelines for the management of cough in lung cancer: report of a UK task group on cough. Cough, 6, 9. eScholarID:111086 | PMID:20925935 | DOI:10.1186/1745-9974-6-9
- Wheatley-Price P, Blackhall F, Lee SM, Ma C, Ashcroft L, Jitlal M, Qian W,Hackshaw A, Rudd R, Booton R, Danson S, Lorigan P, Thatcher N, Shepherd FA. (2010). The influence of sex and histology on outcomes in non-small-cell lung cancer: a pooled analysis of five randomized trials. Ann Oncol, 21(10), 2023-2028. eScholarID:127633 | DOI:10.1093/annonc/mdq067
- Yin, M., Yan, J., Voutsina, A., Tibaldi, C., Christiani, D., Heist, R., Rosell, R., Booton, R. & Wei, Q (2010). No evidence of an association of ERCC1 and ERCC2 polymorphisms with clinical outcomes of platinum-based chemotherapies in non-small cell lung cancer: A meta-analysis. Lung Cancer, eScholarID:111085 | PMID:21075476 | DOI:10.1016/j.lungcan.2010.10.011
2009
- Paul Wheatley-Price, Fiona Blackhall, Siow-Ming Lee, Clement Mark, Linda Ashcroft, Mark Jitlal, Wendi Qian, Allan Hackshaw, Robin Rudd, Richard Booton, Sarah Danson, Paul Lorigan, Nick Thatcher and Frances A. Shepherd. (2009). An Analysis of the Influence of Sex and Histology on Outcomes in Non-Small Cell Lung Cancer. Presented at World Lung Cancer Conference. San Francisco: International Association for the Study of Lung Cancer. eScholarID:84938