Professor Malcolm Richardson PhD, FSB, FRCPath
Honorary Professor in Medical Mycology
- Email: Malcolm.Richardson@manchester.ac.uk
- Telephone: +44 161 291 5914
- Alternative Telephone: +44 754 599 4936 (Mobile)
- Fax: +44 161 291 5806
Regional Mycology Centre
Education and Research Centre
Wythenshawe Hospital
Southmoor Road
Manchester, M23 9LT, UK
Role
Director of the Regional Mycology Laboratory at the University Hospital of South Manchester, Wythenshawe Hospital and a PI within the Respiratory and Infection Research Group, School of Translational Medicine.
Editor-in Chief: Critical Reviews in Microbiology
Consultant: Biohazard Committee, European Food Safety Authority (EFSA)
Consultant: Dampness and Moulds Working Group, World Health Authority (WHO)
Member: Management and Steering GRoup, UK Clinical Mycology Network
Memberships of Committees and Professional Bodies
The Royal College of Pathologists and the Institute of Biology.
International Society for Human and Animal Mycology, British Society for Medical Mycology, European Society for Clinical Microbiology and Infectious Diseases, American Society for Microbiology
Research
My research involves investigating various aspects of the mechanisms underpinning fungal disease and allergy in humans. The work involves two groups of fungi, yeasts and moulds. Candida can cause life threatening disease in a wide variety of immuno-suppressed individuals. The incidence of candidosis has increased dramatically in recent years alongside a rise in the immunocompromised patient population. The oral cavity is a recognized reservoir of Candida and may contribute to blood stream infection and disseminated disease. Chronic rhinosinusitis is the most common chronic disease in the United States and in Europe. Although the disease is well defined clinically the aetiology and pathogenesis of chronic rhinosinusitis are unknown. Common environmental moulds are thought to be a component of chronic rhinosinusitis. In conjunction with the Institutes of Occupational Health and Dentistry we are investigating the pathogenesis of allergic fungal sinusitis by studying various biomarkers such as fungal galactomannan and glucans, interleukins and metallo-peroxidase enzymes in the sinus cavities in patients who have been exposed to allergic and toxigenic fungi.
Biography
Malcolm Richardson is the Director of the Regional Mycology Laboratory at the University Hospital of South Manchester and an honorary Professor of Medical Mycology at the University of Manchester. Prior to these positions he was the Director of the Regional Mycology Reference Laboratory, Western Infirmary, Glasgow, UK, and a Senior Clinical Lecturer in Mycology, University of Glasgow, and more recently an Associate Professor in Medical Mycology at the University of Helsinki, Finland, with an affiliate appointment at the Helsinki University Central Hospital. He is an elected Fellow of the Royal College of Pathologists and of the Institute of Biology. His clinical and laboratory investigations have focused on the pathogenicity, diagnosis and epidemiology of superficial and systemic fungal infections. More recently he has applied his diagnostic experience to investigating the role of moulds in “sick building syndrome”.
He has published over 350 original articles, book chapters and reviews and is the author or editor of fifteen mycological textbooks and handbooks, including Fungal Infection: Diagnosis and Management, 3rd Edition (2003), The Pocket Guide to Fungal infection, 2nd Edition (2006), Therapeutic Guidelines in Systemic Fungal Infection, 4th Edition (2007), and Fungal Infection and Critical Care Medicine (2008). ??Malcolm Richardson is a frequent speaker and session chair at major international conferences in the fields of clinical microbiology, infectious diseases, and medical mycology. His professional duties include being the Editor-in-Chief of Critical Reviews in Microbiology, an Editor of the Journal of Pediatric Infectious Diseases, a Member of the Editorial Board of Current Fungal Infection Reports, a member of the APMIS International Board of Co-Editors; an Executive Committee Member of the EUCAST-Antifungal Susceptibility Testing Group, and Senior Editor of an Internet Forum for Deep Fungal Infections. Currently, he is the General Secretary of the International Society of Human and Animal Mycology. Additional activities include Managing Director of MobiAir Diagnostics Ltd; and Principal Scientific Advisor: Fugenex UK; and consultant for various pharmaceutical and health care companies. Recently, Malcolm Richardson has joined the European Food Safety Authority’s Working Group on the Qualified Presumption of Safety of Yeasts, and a WHO Working Group on Dampness and Mould.
Qualifications
PhD, FSB, FRCPath
Publications
2012
- Malcolm D Richardson; David D Warnock. (2012). Fungal Infection - Diagnosis and Management. Chichester, UK: Wiley - Blackwell. eScholarID:130307
2010
- Nihtinen, A., Anttila, V., Richardson, M., Ruutu, T., Juvonen, E., Meri, T. & Volin, L (2010). Invasive Aspergillus infections in allo-SCT recipients: environmental sampling, nasal and oral colonization and galactomannan testing. Bone Marrow Transplant, 45(2), 333-8. eScholarID:80085 | PMID:19617902 | DOI:10.1038/bmt.2009.169
2009
- Richardson MD, Richardson R. (2009). How the host fights against Candida infections. Front Biosci (Schol Ed), 1, 246-57. eScholarID:1d19992
- Richardson, M (2009). The ecology of the Zygomycetes and its impact on environmental exposure. Clin Microbiol Infect, 15 Suppl 5, 2-9. eScholarID:80087 | PMID:19754749 | DOI:10.1111/j.1469-0691.2009.02972.x
- Rusanen P, Siikala E, Uittamo J, Richardson MD, Richardson R. (2009). A novel method for sampling the microbiota from the oral mucosa. Clin Oral Investig, 13( 2), 243-6. eScholarID:1d20001 | DOI:10.1007/s00784-008-0225-5
- Rusanen, P., Siikala, E., Uittamo, J., Richardson, M. & Rautemaa, R (2009). A novel method for sampling the microbiota from the oral mucosa. Clin Oral Investig, 13(2), 243-6. eScholarID:80086 | PMID:18797939 | DOI:10.1007/s00784-008-0225-5
- Suihko, M., Priha, O., Alakomi, H., Thompson, P., Mälarstig, B., Stott, R. & Richardson, M (2009). Detection and molecular characterization of filamentous actinobacteria and thermoactinomycetes present in water-damaged building materials. Indoor Air, 19(3), 268-77. eScholarID:80084 | PMID:19302504 | DOI:10.1111/j.1600-0668.2009.00591.x
- Anttila VJ, Nihtinen A, Kuutamo T, Richardson M. (2009). Air quality monitoring of HEPA-filtered hospital rooms by particulate counting. Journal of Hospital Infection, 71(4), 387-388. eScholarID:80089
- Suihko ML, Priha O, Alakomi HL, Thompson P, Mälarstig B, Stott R, Richardson M. (2009). Detection and molecular characterization of filamentous actinobacteria and thermoactinomycetes present in water-damaged building materials. Indoor Air, 19(3), 268-277. eScholarID:80090
2008
- Richardson R, Richardson MD, Pfaller M, Perheentupa J, Saxén H. (2008). Activity of amphotericin B, anidulafungin, caspofungin, micafungin, posaconazole, and voriconazole against Candida albicans with decreased susceptibility to fluconazole from APECED patients on long-term azole treatment of chronic mucocutaneous candidiasis. Diagn Microbiol Infect Dis, 62( 2), 182-5. eScholarID:1d20004 | DOI:10.1016/j.diagmicrobio.2008.05.007
- Richardson R, Richardson MD, Pfaller M, Perheentupa J, Saxen H. (2008). Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole. Scand J Infect Dis, 40( 11-12), 904-7. eScholarID:1d20002 | DOI:10.1080/00365540802275853
2007
- Richardson MD, Jones BL, Rautemaa R. (2007). Therapeutic Guidelines in Systemic Fungal Infection. London: Remedica Publishing. eScholarID:80097
- Maijala M, Richardson R, Järvensivu A, Richardson MD, Salo T, Tjäderhane L. (2007). Candida albicans does not invade carious human dentine. Oral Dis, 13( 3), 279-84. eScholarID:1d20011 | DOI:10.1111/j.1601-0825.2006.01279.x
- Richardson R, Richardson MD, Pfaller M, Koukila-Kähkölä P, Perheentupa J, Saxén H. (2007). Decreased susceptibility of Candida albicans to azole antifungals: a complication of long-term treatment in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients. J Antimicrob Chemother, 60( 4), 889-92. eScholarID:1d20009 | DOI:10.1093/jac/dkm299
2006
- Ali A, Richardson R, Hietanen J, Järvensivu A, Richardson MD, Konttinen Y. (2006). Expression of interleukin-8 and its receptor IL-8RA in chronic hyperplastic candidosis. Oral Microbiol Immunol, 21( 4), 223-30. eScholarID:1d20016 | DOI:10.1111/j.1399-302X.2006.00280.x
- Järvensivu A, Richardson R, Sorsa T, Richardson MD. (2006). Specificity of the monoclonal antibody 3H8 in the immunohistochemical identification of Candida species. Oral Dis, 12( 4), 428-33. eScholarID:1d20018 | DOI:10.1111/j.1601-0825.2006.01228.x
- Richardson R, Rusanen P, Richardson MD, Meurman J. (2006). Optimal sampling site for mucosal candidosis in oral cancer patients is the labial sulcus. J Med Microbiol, 55( Pt 10), 1447-51. eScholarID:1d20012 | DOI:10.1099/jmm.0.46615-0
2004
- Järvensivu A, Hietanen J, Richardson R, Sorsa T, Richardson MD. (2004). Candida yeasts in chronic periodontitis tissues and subgingival microbial biofilms in vivo. Oral Dis, 10( 2), 106-12. eScholarID:1d20022
- Richardson R, Järvensivu A, Kari K, Wahlgren J, DeCarlo A, Richardson MD, Sorsa T. (2004). Intracellular localization of Porphyromonas gingivalis thiol proteinase in periodontal tissues of chronic periodontitis patients. Oral Dis, 10( 5), 298-305. eScholarID:1d20021 | DOI:10.1111/j.1601-0825.2004.01021.x
2003
- Malcolm D Richardson, David D Warnock. (2003). Fungal Infection: Diagnosis and Management. Oxford: Blackwell Scientific. eScholarID:76983