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School of Medicine

Dr Colm Leonard MB, BCh, BAO, BA, MRCP, MD

Consultant Respiratory Physician and Honorary Senior Lecturer

University Hospital of South Manchester NHS Foundation Trust,

North West Lung centre, SouthMoor Road, Wythenshawe, Manchester, M23 9LT

 

Role

Consultant Thoracic Physician with an interest inTransplantation, University Hospital Of South manchester NHS Foundation Trust, October 2000 to present.

Honorary Clinical Senior Lecturer, Universty of Manchester.

Clinical Director for thoracic medicicne February 2002 - may 2005

 

Research

My research involves looking at immune determinants of outcome following lung transplantation and in the interstitial lung disease (ILD) arena I am heavily involved in clinical trials of new therapies but also looking at mechanisms of steroid sensitivity in ILD. I have several collaborations (Prof Holt, Perth, Australia; Prof Soderberg-Naucler, Karolinska Institute in Stockholm

 

Qualifications

MB BCh BAO BA- 1991 Universit of Dublin, Trinity College

MRCP- 1991 Irland

MD- 1998 Universty of Dublin, Trinity College

 

Publications

2007

  • Khan N, Al-Aloul M, Khasati N, Machaal A, Leonard CT, Yonan NN A. (2007). Extracorporeal membrane oxygenator as a bridge to successful surgical repair of bronchopleural fistula following bilateral sequential lung transplantation: a case report and review of literature. J Cardiothorac Surg, 2, eScholarID:1d31750

2006

  • Barnard J, Richardson S, Sheldon S, Fildes JE, Pravica V, Hutchinson I, Leonard CT, Yonan NN A. (2006). The MDR1/ABCB1 gene, a high-impact risk factor for cardiac transplant rejection. Transplantation, 82( 12), 1677-82. eScholarID:1d16805

2005

  • Allen D, Fildes JE, Yonan NN A, Leonard CT. (2005). Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients. J Heart Lung Transplant, 24( 1), 88-91. eScholarID:1d29755
  • Fildes JE, Walker A, Densem C, Deiraniya A, Hutchinson I, Leonard CT, Yonan NN A. (2005). Angiotensin converting enzyme insertion/deletion polymorphism does not influence postcardiac transplantation hypertension onset or progression. J Heart Lung Transplant, 24( 4), 406-10. eScholarID:1d29616
  • Fildes JE, Walker A, Howlett R, Bittar M, Hutchinson I, Leonard CT, Yonan NN A. (2005). Donor CCR5 Delta32 polymorphism and outcome following cardiac transplantation. Transplant Proc, 37( 5), 2247-9. eScholarID:1d28898
  • Fildes JE, Walker A, Keevil B, Hutchinson I, Leonard CT, Yonan NN A. (2005). The effects of ACE inhibition on serum angiotensin II concentration following cardiac transplantation. Transplant Proc, 37( 10), 4525-7. eScholarID:1d16804
  • Polster K, Walker A, Fildes JE, Entwistle G, Yonan NN A, Hutchinson I, Leonard CT. (2005). CD4-veCD8-ve CD30+ve T cells are detectable in human lung transplant patients and their proportion of the lymphocyte population after in vitro stimulation with donor spleen cells correlates with preservation of lung physiology. Transplant Proc, 37( 5), 2257-60. eScholarID:1d11257

2004

  • Leonard CT, Brown J, Price T, Queen S, Mikhailenok E. (2004). Comparison of surface electromyography and myotonometric measurements during voluntary isometric contractions. J Electromyogr Kinesiol, 14( 6), 709-14. eScholarID:1d29504
  • Walker A, Fildes JE, Leonard CT, Yonan NN A. (2004). The influence of donor age on transplant coronary artery disease and survival post heart transplantation: is it safe to extend donor age? Transplant Proc, 36( 10), 3139-41. eScholarID:1d30712

2003

  • Leonard CT, Deshner W, Romo J, Suoja E, Fehrer S, Mikhailenok E. (2003). Myotonometer intra- and interrater reliabilities. Arch Phys Med Rehabil, 84( 6), 928-32. eScholarID:1d28436
  • Leonard CT. (2003). Childhood motor disorders. Pediatrics, 112( 6 Pt 1), 1462-3; author reply 1462-3. eScholarID:1d29162

2002

  • Leonard CT, Soccal P, Berry G, Doyle R, Theodore J, Duncan S, Rosen G. (2002). PG490-88, a derivative of triptolide, attenuates obliterative airway disease in a mouse heterotopic tracheal allograft model. J Heart Lung Transplant, 21( 12), 1314-8. eScholarID:1d28496
  • Duncan SR, Leonard CT, Theodore J, Lega M, Grigis RE, Rosen GD, Theofilopoulos AN. Oligoclonal CD4(+) T cellexpansions in lung transplant recipients with obliterative bronchiolitis.. Vol. 165. 2002. 1439-44. eScholarID:19d267

2001

  • Leonard CT, Berry G, Ruoss S. (2001). Nasal-pulmonary relations in allergic fungal sinusitis and allergic bronchopulmonary aspergillosis. Clin Rev Allergy Immunol, 21( 1), 5-15. eScholarID:1d28982
  • Leonard CT, Stephens J, Stroppel S. (2001). Assessing the spastic condition of individuals with upper motoneuron involvement: validity of the myotonometer. Arch Phys Med Rehabil, 82( 10), 1416-20. eScholarID:1d28563
  • Leonard CT, Weinacker A, Berry G, Whyte R. (2001). A cystic upper lobe lesion in a healthy nonsmoking man. Chest, 120( 5), 1725-7. eScholarID:1d28981

2000

  • Leonard CT, Faul J, Raffin T. (2000). Optimizing the utilization of Advance Directives. Crit Care Med, 28( 9), 3352-4. eScholarID:1d31700
  • Leonard CT, Soccal P, Singer L, Berry G, Theodore J, Holt P, Doyle R, Rosen G. (2000). Dendritic cells and macrophages in lung allografts: A role in chronic rejection? Am J Respir Crit Care Med, 161( 4 Pt 1), 1349-54. eScholarID:1d31699
  • Leonard CT, Whyte R, Lillington G. (2000). Primary non-small-cell lung cancer: determining the suitability of the patient and tumor for resection. Curr Opin Pulm Med, 6( 4), 391-5. eScholarID:1d31694
  • Lillington G, Leonard CT, Sachs D. (2000). Smoking cessation. Techniques and benefits. Clin Chest Med, 21( 1), 199-208, xi. eScholarID:1d31749
  • Soccal P, Jani A, Chang S, Leonard CT, Pavlakis M, Doyle R. (2000). Inducible nitric oxide synthase transcription in human lung transplantation. Transplantation, 70( 2), 384-5. eScholarID:1d31695

1999

  • Leonard CT, Doyle R, Raffin T. (1999). Do-not-resuscitate orders in the face of patient and family opposition. Crit Care Med, 27( 6), 1045-7. eScholarID:1d31748
  • Leonard CT, Sachs D. (1999). Environmental tobacco smoke and lung cancer incidence. Curr Opin Pulm Med, 5( 4), 189-93. eScholarID:1d31706

1998

  • Faul J, Leonard CT, Burke C, Tormey V, Poulter L. (1998). Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time. Thorax, 53( 9), 753-61. eScholarID:1d31651

Research Projects

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