Skip to main content Skip to navigation

[University home]

School of Medicine

Dr Jacky Smith MB, ChB, MRCP, PhD

Photograph of Jacky Smith

MRC Clinician Scientist/Reader/Honorary Consultant

2nd Floor Education and Research Centre, Respiratory Research Group,

University Hospital of South Manchester, Southmoor Road, Wythenshawe, Manchester, M23 9LT

 

Role

Dr Jacky Smith holds an MRC Clinician Scientist Award, is a Reader and Honorary Consultant in Respiratory Medicine based at University Hospital Manchester NHS Foundation Trust. She runs a multi-disciplinary research team studying the symptom of cough; this team includes research doctors, a clinical engineer, a pulmonary physiologist, post doctoral scientists and research assistants. She has also developed a specialist clinic investigating and diagnosing patients with chronic cough, through close collaborations with colleagues in Neurogastroenterology, ENT Surgery and GI Surgery.

 

Memberships of Committees and Professional Bodies

Member of the Royal College Physicians (London)
Member of British Thoracic Society
Member European Respiratory Society
Member of the European Task Force for the Assessment of Cough
Member of the International Society for the Study of Cough

Research

Research interests include:

Measurement of cough and the cough reflex

The role of gastro-oesophageal reflux in chronic cough

Mechanisms of sensitisation of the cough reflex

Testing of novel anti-tussive agents

 

Methodological Knowledge

Clinical research skills: bronchial challenge testing, cough reflex sensitivity testing, pulmonary function testing, exhaled nitric oxide measurement, sputum induction, endo-bronchial biopsy, brushing and lavage, optico-electronic plethysmography, intra-oesophageal and gastric balloon pressure measurements

Clinical trials experience: design, applying for ethical approval, patient recruitment, data collection and analysis, including clinical trials of investigational medicinal products for the treatment of cough.
Statistics and data analysis skills: I have an interest in advanced statistical techniques such as factor analysis, cluster analysis and recently structural equation modelling.
Signal Processing Skills: I have a basic understanding of acoustic signal processing and speech recognition techniques from a close collaboration with computer scientists and engineers
 

Biography

Jacky graduated in Medicine from Manchester University in 1992 and continued her training around the North West region in General and Respiratory Medicine. She only undertook research in her final year of specialist registrar training, taking time out to study for a PhD in the 'Measurement of Cough', awarded in 2004. This involved close collaboration with computer scientists and fuelled an interest in acoustics and signal processing. After completing specialist training she returned to research and was funded by a Stepping Stones Award from Manchester University.

In collaboration with Mr Kevin McGuinness (Clinical engineer) she has developed a novel method for automated cough detection. She is an inventor on a patent owned by the University Hospital of South Manchester, covering novel concepts for automated detection of cough from sound signals. This patent is the subject of a license agreement with a medical device company with which she has been collaborates.

Whilst she continues to work on developing other endpoints in cough monitoring, her main research interests are in mechanisms of cough reflex hypersensitivity and analogies to pain hypersensitivity and also the testing of novel anti-tussive therapies.

 

 

Qualifications

MB ChB Manchester 1992

MRCP London 1996

PhD Manchester 2004

 

Collaborators and affiliated staff

Affiliated Staff
Prof Ashley Woodcock (Clinician Scientist Award Mentor)
Ms Danielle Yuill (Research Project Co-ordinator)
Dr Angela Kelsall (Post doctoral Pulmonary Physiologist)
Dr Kevin McGuinness (Senior Clinical Engineer)
Dr Peter West (Research Associate)
Dr Demi Valdramidou (Research Associate)
Dr Emma Young (MRC Clinical Research Fellow and PhD student)
Dr Saif Khalid (Clinical Research Fellow and PhD student)
Dr Rayid Abdulqawi (Clinical Research Fellow and PhD student)
Ms Helen Sumner (Research Associate)
Ms Rachel Dockry (Research Assisstant)
Ms Kimberly Holt (Research Assistant)
Ms Fran Solari (MPhil Student)
 
 
Academic Collaborators
Prof Lesley Houghton, Mayo Clinic, Florida, US
Prof Doug Corfield, University of Manchester
Mr Andy Camilleri, ENT Surgery, UHSM
Mr Simon Galloway, GI Surgery, UHSM
Professor Peter Calverley and Dr John Earis, University Hospital Aintree, University of Liverpool
Professor Neil Thomson, Division of Immunology, Infection & Inflammation, University of Glasgow
Prof Jeff Pearson and Dr Chris Ward, School of Clinical Medical Sciences, Newcastle University
Dr Andrea Aliverti, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy
Prof Maria Belvisi, National Heart and Lung Institute, Imperial College, London
Dr Brendan Canning, Johns Hopkins Medical Institutions, Balitmore, Maryland
 
Industrial Collaborators
Vitalograph Ltd, Maids Moreton, Buckingham, UK
GlaxoSmithKilne, Discovery Medicine, Respiratory CEDD, Stevenage, UK
Schering Plough Corp., Kenilworth, New Jersey, USA
Procter & Gamble, UK
Pfizer, NY, USA
 

Publications

2011

  • Denning DW, Park S, Lass-Florl C, Fraczek MG, Kirwan M, Gore R, Smith J, Bueid A, Moore CB, Bowyer P, Perlin DS. (2011). High-frequency triazole resistance found In nonculturable Aspergillus fumigatus from lungs of patients with chronic fungal disease. Clin Infect Dis, 52(9), 1123-1129. eScholarID:123571 | DOI:10.1093/cid/cir179
  • E. Young, J.A.Smith. (2011). Pharmacologic Therapy for Cough. Current Opinion in Pharmacology, 11, 224-230. eScholarID:126463 | DOI:10.1016/j.coph.2011.06.003
  • J Ellis, R Wagland, C Bailey, J Haines, A Caress, M Lloyd Williams, P Lorigan, J Smith, C Tishelman, R Booton, F Blackhall, A Molassiotis. (In-press). Considerations in developing and delivering a non-pharmacological intervention for symptom management in lung cancer: the views of patients and informal caregivers. Journal of Pain and Symptom Management, eScholarID:145456
  • J.A. Smith, E. Young, L. Saulsberry, B.J. Canning. (2011). The anti-tussive effects of memantine in guinea pigs. Chest, eScholarID:135037 | DOI:10.1378/chest.11-0554
  • Kelsall A, Houghton LA, Jones H, Decalmer S, McGuinness K, Smith JA. (2011). A Novel Approach to Studying the Relationships between Subjective and Objective Measures of Cough. Chest, 139(3), 569-575. eScholarID:93073 | DOI:10.1378/chest.10-0438
  • Molassiotis A, Lowe M, Ellis J, Wagland R, Bailey C, Lloyd-Williams M, Tishelman C, Smith J. (2011). The experience of cough in patients diagnosed with lung cancer. Support Care Cancer, 19(12), 1997-2004. eScholarID:107375 | DOI:10.1007/s00520-010-1050-3
  • Richard Wagland, Jackie Ellis, Chris D Bailey, Jemma Haines, Ann Caress, Mari Lloyd-Williams, Paul Lorigan, Jaclyn Smith, Carol Tishelman, Richard Booton, Karen Luker, Fiona Blackhall, Alex Molassiotis. (In-press). Considerations in developing and delivering a non-pharmacological intervention for symptom management in lung cancer: the views of health care professionals. Supportive Care in Cancer, eScholarID:145457 | DOI:10.1007/s00520-011-1362-y
  • Smith JA, Abdulqawi R, Houghton LA. (2011). GERD-Related Cough: Pathophysiology and Diagnostic Approach. Curr Gastroenterol Rep, 13(3), 247-256. eScholarID:123572 | DOI:10.1007/s11894-011-0192-x
  • Smith JA, Aliverti A, Quaranta M, McGuinness K, Kelsall A, Earis J, Calverley P. (2011). Chest Wall Dynamics During Voluntary and Induced Cough in Healthy Volunteers. J Physiol, eScholarID:142391 | DOI:10.1113/jphysiol.2011.213157
  • Smith JA. (In-press). Cough Recording Technologies. Current Respiratory Medicine Reviews, 7(1), 34-39. eScholarID:83609 | DOI:10.2174/157339811794109318
  • Susana Marinho, Angela Simpson, Paul Marsden, Jacky A Smith, Adnan Custovic. (2011). Quantification of atopy, lung function and airway hypersensitivity in adults. Clinical and Translational Allergy, 1(16), eScholarID:145459 | DOI:10.1186/2045-7022-1-16

2010

  • A. Key, K. Holt, A Hamilton, J.A. Smith, J.E. Earis. (2010). Objective Cough Frequency in Idiopathic Pulmonary Fibrosis. Cough, 6(1), 4. eScholarID:83606 | DOI:10.1186/1745-9974-6-4
  • Bailey CD, Wagland R, Dabbour R, Caress A, Smith J, Molassiotis A. (2010). An integrative review of systematic reviews related to the management of breathlessness in respiratory illnesses. BMC Pulm Med, 10, 63. eScholarID:107374
  • Jaclyn A. Smith, Samantha Decalmer, Angela Kelsall, Kevin McGuinness, Helen Jones, Simon Galloway, Ashley Woodcock, Lesley A. Houghton. (2010). Acoustic Cough–Reflux Associations in Chronic Cough: Potential Triggers and Mechanisms. Gastroenterology, 139(3), 754-762. eScholarID:83603 | DOI:10.1053/j.gastro.2010.06.050
  • Jaclyn Smith, Ashley Woodcock and Lesley Houghton. (2010). New Developments in Reflux-Associated Cough. Lung, 188(supp 1), 81-86. eScholarID:83602 | DOI:10.1007/s00408-009-9210-2
  • Molassiotis A, Bailey C, Caress A, Brunton L, Smith J. (2010). Interventions for cough in cancer. Cochrane Database Syst Rev, 8(9), eScholarID:93074
  • Molassiotis A, Bryan G, Caress A, Bailey C, Smith J. (2010). Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature. Respiratory Medicine, eScholarID:83595 | DOI:10.1016/j.rmed.2010.02.010
  • Molassiotis A, Smith JA, Bennett MI, Blackhall F, Taylor D, Zavery B, Harle A, Booton R, Rankin EM, Lloyd-Williams M, Morice AH. (2010). Clinical expert guidelines for the management of cough in lung cancer: report of a UK Task Group on Cough. Cough, 6(1), 9. eScholarID:93071
  • Smith J. (2010). Monitoring chronic cough: current and future techniques. Expert Rev Respir Med, 4(5), 673-683. eScholarID:93072 | DOI:10.1586/ers.10.63
  • Smith JA. (2010). Assessing efficacy of therapy for cough. Otolaryngol Clin North Am, 43(1), 157-166. eScholarID:83597 | DOI:10.1016/j.otc.2009.11.014
  • Smith JA. (2010). Interrupting the cough reflex in asthma. Curr Opin Allergy Clin Immunol, 10(1), 77-81. eScholarID:83599 | DOI:10.1097/ACI.0b013e328334e75f
  • Woodcock A, McLeod RL, Sadeh J, Smith JA. (2010). The Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough. Lung, 188(supp 1), 47-52. eScholarID:83601
  • Woodcock A, Young EC, Smith JA. (2010). New insights in cough. Br Med Bull, 96, 61-73. eScholarID:107431 | DOI:10.1093/bmb/ldq034
  • Young EC, Smith JA. (2010). Quality of life in patients with chronic cough. Ther Adv Respir Dis, 4(1), 49-55. eScholarID:83598 | DOI:10.1177/1753465809358249

2009

  • Al-Shair K, Kolsum U, Berry P, Smith J, Caress A, Singh D, Vestbo J. (2009). Development, dimensions, reliability and validity of the novel Manchester COPD-fatigue scale. Thorax, eScholarID:20294
  • Kelsall AAA, Decalmer S, McGuinness K, Woodcock AA, Smith JA. (2009). Sex differences and predictors of objective cough frequency in chronic cough. Thorax, 64(5), 393-398. eScholarID:1d19285 | DOI:10.1136/thx.2008.106237
  • Roy K, Smith JA, Kolsum UU, Borrill Z, Vestbo J, Singh SD. (2009). COPD phenotype description using principal components analysis. Respir Res, 10(41), eScholarID:1d19584 | DOI:10.1186/1465-9921-10-41
  • Smith JA, Albert P, Bertella E, Lester J, Jack S, Calverley P. (2009). Qualitative aspects of breathlessness in health and disease. Thorax, 64(8), 713-718. eScholarID:1d19874 | DOI:10.1136/thx.2008.104869
  • Young EC, Brammar C, Owen E, Brown N, Lowe J, Johnson C, Calam R, Jones S, Woodcock A, Smith JA. (2009). The Effect of Mindfulness Meditation on Cough Reflex Sensitivity. Thorax -London-, eScholarID:20289 | DOI:10.1136/thx.2009.116723

2008

  • Heil M, Hazel A, Smith JA. (2008). The mechanics of airway closure. Respir Physiol Neurobiol, 163(1-3), 214-221. eScholarID:1d19875 | DOI:10.1016/j.resp.2008.05.013
  • Kelsall A, Decalmer S, Webster D, Brown N, McGuinness K, Woodcock AA, Smith JA. (2008). How to quantify coughing? Correlations with quality of life in chronic cough. Eur Respir J, 32(1), 175-179. eScholarID:1d17351 | DOI:10.1183/09031936.00101307
  • Marsden, PA, Smith, JA, Kelsall, AA, Owen, E, Naylor, J, Webster, D, Sumner, H, Alam, U, McGuinness, K, Woodcock, AA. (2008). A comparison of objective and subjective measures of cough in asthma. J Allergy Clin Immunol, 122(5), 903-907. eScholarID:1d19287 | DOI:10.1016/j.jaci.2008.08.029
  • Smith, JA, Drake, R, Simpson, A, Woodcock, A, Pickles, A, Custovic, A. (2008). Dimensions of Respiratory Symptoms in Pre-school Children: Population-based Birth Cohort Study. Am J Respir Crit Care Med, 177(12), 1358-1363. eScholarID:1d17152 | DOI:10.1164/rccm.200709-1419OC
  • McGuinness K, Morice A, Woodcock AA, Smith JA. (2008). The Leicester Cough Monitor: a semi-automated, semi-validated cough detection system? Eur Respir J, 32(2), 529-530. eScholarID:17d527 | DOI:10.1183/09031936.00052008

2007

  • 9. A.H. Morice, G.A. Fontana, M.G. Belvisi, S.S. Birring, K.F. Chung, P.V. Dicpinigaitis, J.A. Kastelik, L.P. McGarvey, J.A. Smith, M Tatar, J Widdicombe. (2007). European Respiratory Society Guidelines on the Assessment of Cough. Eur Respir J, 29(6), 1256-1276. eScholarID:93075
  • Decalmer S, Woodcock AA, Greaves M, Howe M, Smith JA. (2007). Airway abnormalities at flexible bronchoscopy in patients with chronic cough. Eur Respir J, 30(6), 1138-1142. eScholarID:1d16810
  • Decalmer SC, Webster D, Kelsall AA, McGuinness K, Woodcock AA, Smith JA. (2007). Chronic Cough: How Do Cough Reflex Sensitivity And Subjective Assessments Correlate With Objective Cough Counts During Ambulatory Monitoring? Thorax, 62(4), 329-334. eScholarID:1d14441 | DOI:10.1136/thx.2006.067413
  • Smith JA, Woodcock AA. (2007). New Developments in the Objective Assessment of Cough. Lung, 186(Supp 1), S48-S54. eScholarID:1d16809
  • Smith JA. (2007). Ambulatory methods for recording cough. Pulm Pharmacol Ther, 20(4), 313-318. eScholarID:1d16812
  • Stovold, R, Forrest, I, Corris, P, Murphy, D, Smith, JA, Decalmer, S, Johnson, G, Dark, J, Pearson, J, Ward, C. (2007). Pepsin, a biomarker of gastric aspiration in lung allografts: a putative association with rejection. Am J Respir Crit Care Med, 175(12), 1298-1303. eScholarID:1d16811
  • Decalmer S, Woodcock A, Smith JA. (2007). Patient misreporting may lead to underestimation of cough events. Chest, 132(1), 358-359. eScholarID:17d959

2006

  • Smith JA, Ashurst H, Jack S, Woodcock AA, Earis J. (2006). The description of cough sounds by healthcare professionals. Cough, 2(1), eScholarID:1d14445
  • Smith JA, Earis J, Woodcock A. (2006). Establishing a gold standard for manual cough counting: video versus digital audio recordings. Cough, 2(6), eScholarID:1d14596
  • Smith JA, Owen E, Earis J, Woodcock AA. (2006). Cough in COPD: correlation of objective monitoring with cough challenge and subjective assessments. Chest, 130(2), 379-385. eScholarID:1d14442 | DOI:10.1378/chest.130.2.379
  • Smith JA, Owen E, Jones AM, Dodd M, Webb Ak, Woodcock AA. (2006). Objective measurement of cough during pulmonary exacerbations in adults with cystic fibrosis. Thorax, 61(5), 425-429. eScholarID:1d14440 | DOI:10.1136/thx.2005.050963
  • Smith JA, Owen EC, Earis JE, Woodcock AA. (2006). The Effect of Codeine on Objective Measuremnet of Cough in Chronic Obstructive Pulmonary Disease. J Allergy Clin Immunology, 117(4), 831-835. eScholarID:1d14599 | DOI:10.1016/j.jaci.2005.09.055
  • Smith JA, Woodcock AA. (2006). Cough and its importance in COPD. Int J Chron Obstruct Pulmon Dis, 1(3), 305-314. eScholarID:1d16808
  • Smith JA. (2006). Cough frequency and patterns of cough in cystic fibrosis. J R Soc Med, 99 Suppl 46, 17-22. eScholarID:1d17352
  • Borrill Z, Smith JA, Naylor J, Woodcock A, Singh SD. (2006). The effect of gas standardisation on exhaled breath condensate pH. Eur Respir J, 28(1), 251-252. eScholarID:17d423

2005

  • Smith JA. (2005). Analysis of the Cough Sound. Acute and Chronic Cough, Lung Biology in Health and Disease Series. ( 205, pp. -). Taylor & Francis. eScholarID:3d854

2004

  • Smith JA, Calverley P. (2004). Cough in chronic obstructive pulmonary disease. Pulm Pharmacol Ther, 17( 6), 393-8. eScholarID:1d16813

1999

  • Smith JA, Redman P, Woodhead M. (1999). Antibiotic use in patients admitted with acute exacerbations of chronic obstructive pulmonary disease. Eur Respir J, 13(4), 835-838. eScholarID:1d16814

Top of page

| Skip to main content | Skip to navigation | Skip to Search |