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School of Medicine

Professor Rayaz Malik BSc (hons)., MSc., MBChB, FRCP, PhD

Photograph of Rayaz Malik

Professor of Medicine

Cardiovascular Research Group
School of Clinical & Laboratory Sciences
Core Technology Facility (3rd Floor)
University of Manchester
46 Grafton Street
Manchester
M13 9NT

 

Role

He is a consultant with responsibility for unselected general acute medicine admissions to Manchester Royal Infirmary and does a general medical and diabetes outpatient clinic weekly.

His research focuses on diabetic neuropathy and cardiomyopathy in both animal models and most importantly at a translational level in patients.

He is an expert in the pathogenesis, assessment and treatment of diabetic neuropathy and has published and presented extensively on this. His research is currently funded by the NIH, JDRF, MRC, DUK and BHF and he is currently supervising 6 PhD’s and 4 MD’s.

 

Memberships of Committees and Professional Bodies

  • Diabetes UK
  • European Association for the Study of Diabetes
  • American Diabetes Association
  • Peripheral Nerve Society
  • Executive Committe for Neurodiab, the Neuropathy study group of the EASD

Research

Light and electron microscopic morphometry to quantify pathology and apoptosis in relation to the severity and symptoms of peripheral neuropathy and the pathophysiology of: diabetic amyotrophy, Insulin neuritis, IGT neuropathy, Carpal Tunnel syndrome.

Atrial appendage material has been collected from diabetic and non-diabetic patients undergoing either valve replacement or CABG in the Manchester Heart Centre for defining the expression of key angiogenic molecules: VEGF, VEGFr, HIF-1, in relation to atrial cardiomyocyte and vascualr morphology to help define the molecular basis of diabetic cardiomyopathy.

We have performed sequential biopsies from chronic non-healing foot ulcers and acute wounds in the upper arm to define the genomic differences between human acute and chronic wounds employing tissue genomic profiling using micro array ‘chip’ technology in collaboration with Renovo Limited, Manchester Incubator Building, University of Manchester.

 

Methodological Knowledge

Techniques.

In-vivo studies.

State of the art facilities employing quantitative sensory testing, electrophysiology, corneal confocal microscopy and iontophoresis with scanning laser Doppler imaging to conduct in-vivo physiological studies characterising the severity of neuro-vascular damage in diabetic patients.

In-vitro studies.

A fully functional laboratory to perform both gluteal subcutaneous, and foot skin biopsies and in-vitro myography on resistance arteries in patients is established.

Laboratory based studies.

In 1993, I established the protocol to carry out tissue processing and detailed light and electronmicroscopy with quantitative assessment of nerve and cardiac tissue pathology in the electronmicroscope unit. This has now been further developed to combine morphometry with immunohistological studies.

 

Teaching

  • Teach 3rd-5th year Medical students bed side clinical teaching
  • Teach F1-F2 and registrars
  • Supervise MD's and PhD's
 

Biography

Rayaz Malik is a Professor of Medicine & Consultant Physician in the Division of Cardiovascular Medicine, Manchester Royal Infirmary & University of Manchester, Manchester.

He obtained his BSc., MSc. and MB ChB from the University of Aberdeen and his PhD from the University of Manchester .

His clinical work includes consultant responsibility for unselected general acute medicine admissions to Manchester Royal Infirmary and a general medical and diabetes outpatient clinic weekly.

His research focuses on diabetic neuropathy and cardiomyopathy in both animal models and at a translational level in patients. He is an expert in the pathogenesis, assessment and treatment of diabetic neuropathy and has published and presented extensively on this. His research is currently funded by the NIH, JDRF, MRC, DUK and BHF and he is currently supervising 6 PhD’s and 4 MD’s.

He won the young clinical investigator prize for clinical science for the neuropathy study group of the European association for the study of diabetes in 1999, and the North West of England Medical Society Prize in 2000. He has been an invited lecturer for the American Diabetes Association, European Association for the Study of Diabetes and Diabetes UK.

He was appointed to the Executive committee of the Neurodiab (The neuropathy study group of the European association for the study of diabetes) in September 2007.

He is the associate editor for Diabetic Medicine and Journal of Brachial Plexus and Peripheral Nerve Injury. He is a JDRF Medical and Research Committee grant reviewer 2005-2010. He also undertaeks adhoc reviews for DUK, MRC and the Wellcome Trust and reviews for nine medical journals, including Neurology, Diabetes, Diabetologia, and the Lancet.

He is a member of the Curriculum and Progress Committees and the Interview committee for medical undergraduates in the Manchester Medical School . He is the Heart Lung and Blood lead for year 3 and is also the Final year exam lead for Manchester Royal Infirmary.

 

Qualifications

  • B.Sc. (Hons) July 1986.
  • M.Sc. Jan. 1990.
  • MB. ChB. July 1991.
  • MRCP (UK) Oct. 1996.
  • Ph.D. Oct. 1997.
  • USMLE April 1998.
  • FRCP (London) October 2007
 

Collaborators and affiliated staff

  • Professor David Tomlinson, Faculty of Life Sciences, University of Manchester
  • Dr Maria Jeziorska, Division of Regenerative Medicine, University of Manchester
  • Professor Solomon Tesfaye, Royal Hallamshire Hospital, Sheffield, UK
  • Dr Gerry Rayman, Ipswich Hospital, UK
  • Professor Nathan Efron, Brisbane, Australia
  • Professor D Zochodne, University of Calgary, Canada
  • Professor L Dahlin, University of Malmao, Sweden
  • Professor D Ziegler, Dusseldorf, Germany
  • Professor D Yue, Sydney, Australia
 

Publications

2012

  • Banerjee, M., Anderson, S., Malik, R., Austin, C. & Cruickshank, J (2012). Small artery function 2 years postpartum in women with altered glycaemic distributions in their preceding pregnancy. Clin Sci (Lond), 122(2), 53-61. eScholarID:153467 | PMID:21745185 | DOI:10.1042/CS20110033
  • Lynch, F., Izzard, A., Austin, C., Prendergast, B., Keenan, D., Malik, R. & Heagerty, A (2012). Effects of diabetes and hypertension on structure and distensibilty of human small coronary arteries. J Hypertens, 30(2), 384-9. eScholarID:153461 | PMID:22124179 | DOI:10.1097/HJH.0b013e32834e38a0
  • Paranthaman R, Greenstein A, Burns AS, Heagerty AM, Malik RA, Baldwin RC. (2012). Relationship of endothelial function and atherosclerosis to treatment response in late-life depression. Int J Geriatr Psychiatry, (doi: 10.1002/gps.2811.), eScholarID:153450

2011

  • Abbott, C., Malik, R., van Ross, E., Kulkarni, J. & Boulton, A (2011). Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K. Diabetes Care, 34(10), 2220-4. eScholarID:153464 | PMID:21852677 | DOI:10.2337/dc11-1108
  • Dabbah, M., Graham, J., Petropoulos, I., Tavakoli, M. & Malik, R (2011). Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Med Image Anal, 15(5), 738-47. eScholarID:153458 | PMID:21719344 | DOI:10.1016/j.media.2011.05.016
  • Malik, R., Veves, A., Tesfaye, S., Smith, G., Cameron, N., Zochodne, D., Lauria, G. & . (2011). Small Fiber Neuropathy: Role in the diagnosis of Diabetic Sensorimotor Polyneuropathy. Diabetes Metab Res Rev, eScholarID:153468 | PMID:21695760 | DOI:10.1002/dmrr.1222
  • Pritchard, N., Edwards, K., Shahidi, A., Sampson, G., Russell, A., Malik, R. & Efron, N (2011). Corneal markers of diabetic neuropathy. Ocul Surf, 9(1), 17-28. eScholarID:153456 | PMID:21338566 | DOI:10.1097/OPX.0b013e3181fd6188
  • Tavakoli, M. & Malik, R (2011). Corneal confocal microscopy: a novel non-invasive technique to quantify small fibre pathology in peripheral neuropathies. J Vis Exp, (47), eScholarID:153455 | PMID:21248693 | DOI:10.3791/2194
  • Tavakoli, M., Boulton, A., Efron, N. & Malik, R (2011). Increased Langerhan cell density and corneal nerve damage in diabetic patients: role of immune mechanisms in human diabetic neuropathy. Cont Lens Anterior Eye, 34(1), 7-11. eScholarID:153462 | PMID:20851037 | DOI:10.1016/j.clae.2010.08.007
  • Withers, S., Agabiti-Rosei, C., Livingstone, D., Little, M., Aslam, R., Malik, R. & Heagerty, A (2011). Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler Thromb Vasc Biol, 31(4), 908-13. eScholarID:153463 | PMID:21273560 | DOI:10.1161/ATVBAHA.110.221705
  • Wo, J., Ejskjaer, N., Hellström, P., Malik, R., Pezzullo, J., Shaughnessy, L., Charlton, P., Kosutic, G. & McCallum, R (2011). Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting--randomised clinical study subset data. Aliment Pharmacol Ther, 33(6), 679-88. eScholarID:153465 | PMID:21214610 | DOI:10.1111/j.1365-2036.2010.04567.x

2010

  • Alam, U., Asghar, O. & Malik, R (2010). Diabetic gastroparesis: Therapeutic options. Diabetes Ther, 1(1), 32-43. eScholarID:153454 | PMID:22127672 | DOI:10.1007/s13300-010-0010-8
  • Dabbah, M., Graham, J., Petropoulos, I., Tavakoli, M. & Malik, R (2010). Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Med Image Comput Comput Assist Interv, 13(Pt 1), 300-7. eScholarID:153460 | PMID:20879244 | DOI:10.1007/978-3-642-15705-9_37
  • Efron, N., Edwards, K., Roper, N., Pritchard, N., Sampson, G., Shahidi, A., Vagenas, D., Russell, A., Graham, J., Dabbah, M. & Malik, R (2010). Repeatability of measuring corneal subbasal nerve fiber length in individuals with type 2 diabetes. Eye Contact Lens, 36(5), 245-8. eScholarID:153466 | PMID:20724854 | DOI:10.1097/ICL.0b013e3181eea915
  • Greenstein, A., Paranthaman, R., Burns, A., Jackson, A., Malik, R., Baldwin, R. & Heagerty, A (2010). Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries. Hypertension, 56(4), 734-40. eScholarID:153453 | PMID:20713917 | DOI:10.1161/HYPERTENSIONAHA.110.152801
  • Pritchard, N., Edwards, K., Vagenas, D., Shahidi, A., Sampson, G., Russell, A., Malik, R. & Efron, N (2010). Corneal sensitivity as an ophthalmic marker of diabetic neuropathy. Optom Vis Sci, 87(12), 1003-8. eScholarID:153457 | PMID:21037498 | DOI:10.1097/OPX.0b013e3181fd6188
  • Tesfaye, S., Boulton, A., Dyck, P., Freeman, R., Horowitz, M., Kempler, P., Lauria, G., Malik, R., Spallone, V., Vinik, A., Bernardi, L., Valensi, P. & . (2010). Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care, 33(10), 2285-93. eScholarID:153459 | PMID:20876709 | DOI:10.2337/dc10-1303

2009

  • Greenstein, AS, Kaivan Khavandi, Withers, SB, Sonoyama, KK, olivia clancy, Jeziorska, M, Laing, II, Yates, A, Pemberton, P, Malik, RA, Heagerty, AM. (2009). Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation, 119( 12), eScholarID:1d18910 | DOI:10.1161/CIRCULATIONAHA.108.821181
  • Greenstein, AS, Price, A, Sonoyama, K, Paisley, A, Khavandi, K, Withers, SB, Shaw, LM, Paniagua, O, Malik, RA, Heagerty, AM. (2009). Eutrophic Remodeling of Small Arteries in Type 1 Diabetes Mellitus Is Enabled by Metabolic Control. A 10-Year Follow-Up Study. Hypertension, eScholarID:1d19271 | DOI:10.1161/HYPERTENSIONAHA.109.129718
  • Khavandi K, Khavandi A, Asghar O, Greenstein AS, Withers SB, Heagerty AM, Malik RA. (2009). Diabetic cardiomyopathy--a distinct disease? Best Pract Res Clin Endocrinol Metab, 23( 3), eScholarID:1d19304 | DOI:10.1016/j.beem.2008.10.016

2008

  • Khavandi K, Greenstein AS, Sonoyama KK, Withers SB, Price A, Malik RA, Heagerty AM. (2008). Myogenic tone and small artery remodelling: insight into diabetic nephropathy. Nephrol Dial Transplant, eScholarID:1d18337 | DOI:10.1093/ndt/gfn583
  • Mitra Tavakoli, Parwez Hossain, Rayaz Malik. (2008). Clinical Applications of Corneal Confocal Microscopy. Journal of Clinical Ophthalmology, 2, 435-445. eScholarID:1d15996 | PMID:19668734
  • Quattrini C, Jeziorska M, Boulton AJM, Malik RA. (2008). Reduced vascular endothelial growth factor expression and intra-epidermal nerve fiber loss in human diabetic neuropathy. Diabetes Care, 31( 1), eScholarID:1d19432 | DOI:10.2337/dc07-1556
  • QuattriniC, Jeziorska M, Tavakoli M, Begum P, Boulton AJM, Malik RA. (2008). The Neuropad: A visual indicator test for human diabetic neuropathy. Diabetologia, 51(6), 1046-50. eScholarID:1d17014 | PMID:18368386 | DOI:10.1007/s00125-008-0987-y
  • Tavakoli M, Fadavi HH, Malik RA. (2008). Advances in the diagnosis and treatment of painful diabetic neuropathy. Journal of European Endocrinology, 6th edition, 48-51. eScholarID:1d17601
  • Tavakoli M, Malik RA. (2008). Management of painful diabetic neuropathy. Expert Opinion on Pharmacotherapy, 9(17), 2969-78. eScholarID:1d18104
  • Tavakoli M, Mojaddidi M, Fadavi H, Malik RA. (2008). Pathophysiology and treatment of painful diabetic neuropathy. Curr Pain Headache Rep, 12(3), 192-197. eScholarID:1d19439 | PMID:18796269 | DOI:10.1007/s11916-008-0034-1
  • Tavakoli M, Mojaddidi M, Fadavi HH, Malik RA. (2008). Pathophysiology of painful diabetic neuropathy and its treatment. Current Pain and Headache Reports, 12(3), 192-7. eScholarID:1d17012
  • Tavakoli M, Malik RA. Management of painful diabetic neuropathy. 2008. eScholarID:19d375

2007

  • Bevilacqua NJ, Rogers LC, Malik RA, Armstrong D. (2007). Technique of the sural nerve biopsy. J Foot Ankle Surg, 46(2), 139-42. eScholarID:1d27875
  • Greenstein AS, Mojaddidi M, Al-Sunni A, Tavakoli M, Malik RA. (2007). Chronic complications of diabetes: Risk factors and interventions. MIMS Cardiovascular, 2, 28-31. eScholarID:1d15997
  • Greenstein AS, Tavakoli M, Mojaddidi M, Al-Sunni A, Matfin G, Malik RA. (2007). Microvascular complications: evaluation and monitoring, relevance to clinical practice, clinical trials, and drug development. British J Diabetes Vasc Dis, 7, eScholarID:1d27873
  • Greenstein AS, Tavakoli M, Mojaddidi M, Al-Sunni A, Mutfin G, Malik RA. (2007). Microvascular complications: evaluation and monitoring relevance to clinical practice, clinical trials, and drug development. The British Journal of Diabetes and Vascular Disease, eScholarID:1d15995
  • Joy T, Cao H, Black GCM, Malik RA, Charlton-Menys V, Hegele R, Durrington PN. (2007). Alstrom syndrome (OMIM 203800): a case report and literature review. Orphanet J Rare Dis, 2, eScholarID:1d19754 | DOI:10.1186/1750-1172-2-49
  • Mehra S, Tavakoli M, Kallinikos PA, Efron N, Boulton AJM, Augustine T, Malik RA. (2007). Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation. Diabetes Care, e-pub ahead of print, eScholarID:1d15994
  • Quattrini C, Harris ND, Malik RA, Tesfaye S. (2007). Impaired skin microvascular reactivity in painful diabetic neuropathy. Diabetes Care, 30(3), 655-9. eScholarID:1d27877
  • Quattrini C, Jeziorska M, Boulton AJM, Malik RA. (2007). Reduced VEGF expression and intra-epidermal nerve fiber loss in human diabetic neuropathy. Diabetes Care, eScholarID:1d28002
  • Quattrini, C, Tavakoli, M, Jeziorska, M, Kallinikos, P, Tesfaye, S, Finnigan, J, Marshall, A, Boulton, AJM, Efron, N, Malik, RA. (2007). Surrogate Markers of Small Fiber Damage in Human Diabetic Neuropathy. Diabetes, 56, 2148-54. eScholarID:1d15990
  • Rogers LC, Armstrong D, Boulton AJM, Freemont AJ, Malik RA. (2007). Malignant melanoma misdiagnosed as a diabetic foot ulcer. Diabetes Care, 30(2), 444-5. eScholarID:1d27879
  • Sanjay Mehra, Mitra Tavakoli, Nathan Efron, Andrew J Boulton, Titus Augustine, Rayaz A Malik. (2007). Corneal Confocal Microscopy Detects Early Nerve Regeneration After Pancreas Transplantation in Patients with Type 1 Diabetes. Diabetes Care, 30(10), 2608-12. eScholarID:1d32881 | PMID:17623821
  • Tavakoli M, Kallinikos PA, Efron N, Boulton AJM, Malik RA. (2007). Corneal Sensitivity is Reduced in Diabetic patients and Relates to the Severity of Neuropathy in Patients with Diabetes. Diabetes Care, 30, 1895-7. eScholarID:1d15992
  • Veves A, Backonja M, Malik RA. (2007). Painful diabetic neuropathy: epidemiology, natural history, early diagnosis and treatment options. Pain Medicine, 9, 660-674. eScholarID:1d33720

2006

  • Asghar O, Greenstein AS, Malik RA. (2006). Glycaemic control in South Asian patients during feasting and fasting. Br. J. Hosp. Med, 67(10), 523-6. eScholarID:1d27881
  • Cruickshank (K, Malik RA. (2006). Pregnancy as the prodrome to vascular dysfunction and cardiovascular risk. Nature Clin Pract Cardiovasc Med, 3, 596-603. eScholarID:1d27385
  • Dang C, Anwar R, Thomas G, Prasad YD, Boulton AJM, Malik RA. (2006). The Biogun: A novel way of eradicating methicillin-resistant Staphylococcus aureus colonization in diabetic foot ulcers. Diabetes Care, 29(5), eScholarID:1d27550
  • Malik RA, Veves A, Tesfaye S. (2006). Ameliorating human diabetic neuropathy: lessons from implanting hemotopoietic mononuclear cells. Experimental Neurology, 201(1), 7-14. eScholarID:1d27882

2005

  • Akbani MK, Saleem M, Gadit WU, Basit A, Malik RA. (2005). Fasting and feasting safely during Ramadan in the diabetic patient. Pract Diab Int, 22, 100-104. eScholarID:1d27872
  • Boulton, AJM, Vinik, A, Arezzo, J, Bril, V, Feldman, E, Freeman, R, Malik, RA, Maser, R, Sosenko, J, Ziegler, D, NULL. (2005). Diabetic neuropathies: a statement by the American Diabetes Association. Diabetes Care, 28( 4), 956-62. eScholarID:1d29481
  • Hossain P, Sachdev A, Malik RA. (2005). Early detection of diabetic peripheral neuropathy with corneal confocal microscopy. Lancet, 366( 9494), 1340-3. eScholarID:1d29849
  • Malik RA, Schofield I, Izzard AS, Austin CE, Bermann G, Heagerty AM. (2005). Effects of angiotensin Type-1 receptor antagonism on small artery function in patients with type 2 diabetes mellitus. Hypertension, 45, 264-269.. eScholarID:1d26111 | DOI:10.1161/01.HYP.0000153305.50128.a1
  • Malik, RA, Li, C, Aziz, W, Olson, J, Vohra, A, McHardy, K, Forrester, J, Boulton, AJM, Wilson, P, Liu, D, McLeod, D-, Kumar, S. (2005). Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy. J Cell Mol Med, 9( 3), 692-7. eScholarID:1d11630
  • Malik, RA, Tesfaye, S, Newrick, P, Walker, D, Rajbhandari, S, Siddique, I, Sharma, A, Boulton, AJM, King, R, Thomas, P, Ward, J. (2005). Sural nerve pathology in diabetic patients with minimal but progressive neuropathy. Diabetologia, 48( 3), 578-85. eScholarID:1d11632
  • Mojaddidi M, Quattrini C, Tavakoli M, Malik RA. (2005). Recent developments in the assessment of efficacy in clinical trials of diabetic neuropathy. Current Diabetes Reports, 417-22, eScholarID:1d15052 | PMID:16316591

2004

  • Boulton AJM, Malik RA, Arezzo JC, JM Sosenko. (2004). Diabetic somatic neuropathies. Diabetes Care, 27, 1458-86. eScholarID:1d25815
  • Hayat S, Patel B, Malik RA. (2004). Diabetic cardiomyopathy. Clinical Science, 107(6), 539-557. eScholarID:1d26122
  • Kallinkos P, Berhanu M, O'Donnell C, Boulton AJM, Efron N, Malik RA. (2004). Corneal nerve tortuosity in diabetic patients with neuropathy. Investigative Ophthalmology and Vision Sciences, 45, 418-22. eScholarID:1d25817
  • Quattrini C, Jeziorska M, Malik RA. (2004). Small fiber neuropathy in diabetes: clinical consequence and assessment. Int J Low Extrem Wounds, 16-21, eScholarID:1d27571
  • Quattrini C, Jeziorska M, Malik RA. (2004). Small fiber neuropathy in diabetes: clinical consequence and assessment. Int J Low Extrem Wounds, 3( 1), 16-21. eScholarID:1d30719

2003

  • Malik RA, P Kallnikos, Abbott CA, van Schie CH M, P Morgan, N Efron, Boulton AJM. (2003). Corneal confocal microscopy: a non-invasive surrogate of nerve fibre damage and repair in diabetic patients. Diabetologia, 46(5), 683-688. eScholarID:1d25527
  • Malik RA. (2003). Current and future strategies for the management of diabetic neuropathy. Treat Endocrinol, 2( 6), 389-400. eScholarID:1d29688
  • S Thrainsdottir, Malik RA, B Dahlin, P Wiksell, J Petersson, I Rosen, D Green, G Sundkvist. (2003). Endoneurial capillary abnormalities presage deterioration of glucose tolerence and accompany peripheral neuropathy in man. Diabetes, 52, 2615-2622. eScholarID:1d25528

2002

  • C Charalambous, S Cleanthous, I Siddique, D Keenan, Malik RA, Heagerty AM. (2002). Secondary prevention in patients awaiting CABG in the North West of England. B J Cardiol, 9, 488-490. eScholarID:1d3179
  • Knowles EA, Armstrong DG, Hayat SA, Khwaja KI, Malik RA, Boulton AJM. (2002). Offloading diabetic foot wounds using the scotchcast boot: a retrospective study. Ostomy Wound Management, 48, 50-53. eScholarID:1d7049
  • Malik RA, Tomlinson D. (2002). Angiotensin-converting enzyme inhibitors: are there credible mechanism beneficial effects in diabetic neuropathy? Int Rev Neurobiol, 50, 415-30. eScholarID:1d25822
  • Malik RA, Tomlinson D. (2002). Angiotensin-converting enzyme inhibitors: are there credible mechanisms for beneficial effects in diabetic neuropathy? Int Rev Neurobiol, 50, 415-30. eScholarID:1d29214
  • Malik RA. (2002). Focal and multifocal neuropathies. Curr Diab Res, 2, 489-94. eScholarID:1d25818
  • Malik RA. (2002). No morbidity-mortality. Commentary. Diabetic Medicine, 19, 7-8. eScholarID:1d25820
  • NA Tramboo, K Iqbal, MA Dar, Malik RA, BA Naikoo, MA Andrabi. (2002). Unusual dysmorphic features in five patients with Nooman's syndrome: a brief review. Journal Of Paediatrics & Child Health, 38, 521-5. eScholarID:1d25819
  • Schofield I, Malik RA, Izzard AS, Austin CE, Heagerty AM. (2002). Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the role of abnormal myogenic responsiveness and dyslipidemia. Circulation, 106, 3037-3043. eScholarID:1d2346 | DOI:10.1161/01.CIR.0000041432.80615.A5

2001

  • C Charalambous, Malik RA, Davies M, Heagerty AM. (2001). Atrial flutter: the dangers of cardioversion. Int J Cardiol, 81( 1), 93-5. eScholarID:1d19387
  • C Charalambous, Malik RA, H Mamtora, R Aslam, RJ Young. (2001). Sub-acute presentation of emphysematous cholecystitis in a diabetic patient. Int J Diabetes and Metabolism, 8, 11-113. eScholarID:1d25028
  • D Walker, I Siddique, H Anderson, TA Gardner, DA Archer, Boulton AJM, Malik RA. (2001). Nerve pathology in the type 1 diabetic dog: effects of treatment with Sulindac. J Peripheral N System, 6, 219-226. eScholarID:1d3177
  • Malik RA, Veves A, Walker D, Siddique I, Lye RH, Schady W, Boulton AJM. (2001). Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology. Acta Neuropathol, 101, 367-374. eScholarID:1d2867

2000

  • K Iqbal, NA Tramboo, Malik RA, MA Dar, BA Naikoo. (2000). Mixed connective-tissue disease presenting with transient coplete heart block. American Journal Of Medicine, 109, 259-60. eScholarID:1d25823
  • KI Khawaja, D Walker, SA Hyat, Boulton AJM, Malik RA. (2000). Clinico-pathological features of postural hypotension in diabetic autonomic neuropathy. Diabetic Medicine, 17, 163-166. eScholarID:1d33529
  • Malik RA. (2000). Can diabetic neuropathy be prevented by angiotensin-converting enzyme inhibitors? Ann Med, 32, 1-5. eScholarID:1d25824

1999

  • D Walker, A Carrington, SA Cannan, I Sawick, J Sredy, Boulton AJM, Malik RA. (1999). Structural abnormalities do not explain the early functional abnormalities in the peripheral nerves of the streptozotocin diabetic rat. J. Anatomy, 195, 419-427. eScholarID:1d33766
  • GL Pittenger, Malik RA, N Burcus, Boulton AJM, AI Vinik. (1999). Polyneuropathy corresponds to cytotoxicity against neuroblastoma cells of sera from patients with diabetes. Diabetes Care, 22, 1839-1844. eScholarID:1d33880
  • GL Pittenger, Malik RA, N Burcus, Boulton AJM, AI Vinik. (1999). Specific Fibre Deficits in Sensorimotor diabetic polyneuropathy correspond to cytotoxicity of sera from patients with diabetes on neuroblastoma cells. Diabetes Care, 22, 1839-1844. eScholarID:1d3175
  • M Ghani, Malik RA, D Walker, AK Sharma, CT Lowrie, WD Schall, Boulton AJM. (1999). Perineurial abnormalities in the spontaneously diabetic dog. Acta Neuropathol, 97, 98-102. eScholarID:1d3172
  • Malik RA, S Williamson, Abbott CA, A L Carrington, J Iqbal, Boulton AJM, W Schady. (1999). Effect of the angiotensin-converting-enzyme inhibitor trandolapril on diabetic peripheral and autonomic neuropathy: a randomised double-blind controlled trial. Lancet, 352, 1978-1981. eScholarID:1d3100

1998

  • B Abuaisha, S Kumar, Malik RA, Boulton AJM. (1998). Relationship of elevated urinary albumin excretion to components of the metabolic syndrome in non-insulin-dependent diabetes mellitus. Diabetes Research and Clinical Practice, 39, 93-99. eScholarID:1d24460
  • Boulton AJM, Malik RA. (1998). Diabetic neuropathy. Medical Clinics Of North America, 82, 909-929. eScholarID:1d24396

1997

  • Malik RA. (1997). The pathology of human diabetic neuropathy. Diabetes, 46, S50-S53. eScholarID:1d24458

1996

  • S Tesfaye, Malik RA, N Harris, J Jakubowski, C Mody, IG Rennie, JD Ward. (1996). Painful and severe autonomic neuropathy following insulin treatment. Diabetologia, 39, 329-335. eScholarID:1d24457

1995

  • AK Sharma, Malik RA, P Dhar, RD Mehra, I Ahmed, CT Lowrie, WD Schall. (1995). Peripheral nerve abnormalities in spontaenously diabetic dog. Int. J. Diabetes, 3, 130-139. eScholarID:1d33642
  • G Rayman, Malik RA, J Metcalfe, AK Sharma, J Day. (1995). Microvascular response to tissue injury and capillary ultrastructure in the foot skin of type 1 diabetic patients. Clinical Science, 89, 467-474. eScholarID:1d24456
  • Malik RA, S Kumar, Boulton AJM. (1995). Clues to the aetiology of human diabetic neuropathy. Journal Of Neurology,neurosurgery And Psychiatry, 58, 493-495. eScholarID:1d24455

1994

  • AS Bansal, B Abdul-Karim, Malik RA, P Goulding, RSH Pumphrey, Boulton AJM. (1994). IgM anti-ganglioside GM1 antibodies in normals, patients with autoimmune disease and those with neuropathy. 47, 300-302. eScholarID:1d4588
  • Malik RA, S Tesfaye, SD Thompson, A Veves, A Hunter, AK Sharma, JD Ward, Boulton AJM. (1994). Transperineurial capillary abnormalities in the sural nerve of patients with diabetic neuropathy. Microvascular Research, 48, 236-245. eScholarID:1d24453

1993

  • AS Bansal, Malik RA, Boulton AJM, PB Wilson, RSH Pumphrey. (1993). Pumphrey RSH cellular and humoral immunity in patients with insulin dependent diabetes. Lancet, 342, eScholarID:1d24451
  • Malik RA, S Tesfaye, SD Thompson, A Veves, Boulton AJM, JD Ward. (1993). Endoneurial localisation of microvascular damage in human diabetic neuropathy. Diabetologia, 36, 454-459. eScholarID:1d24449

1992

  • I Ford, Malik RA, PG Newrick, EF Preston, JD Ward, M Greaves. (1992). Relationship between haemostatic factors and capillary morphology in human diabetic neuropathy. Thrombosis And Haemostasis, 68, 628-633. eScholarID:1d24447
  • Malik RA, A Veves, EA Massson, AK Sharma, AK Ah-See, Schady WW, Boulton AJM. (1992). Endoneurial capillary abnormalities in mild human diabetic neuropathy. Journal Of Neurology,neurosurgery And Psychiatry, 55, 557-561. eScholarID:1d24446
  • Malik RA, G Rayman, J Metcalfe, AK Sharma, JL Day. (1992). Skin epidermal thickness and vascular density in type 1 diabetes. Diabetic Medicine, 9, 263-267. eScholarID:1d24444

1991

  • C Rodriguez-Sanchez, M Medina Sanchez, Malik RA, AK Ah-See, AK Sharma. (1991). The relationship between sural nerve morphometric findings and meansures of peripheral vascular disease. Histology Histopathology, 6, 63-71. eScholarID:1d24443

1990

  • Malik RA, EA Masson, AK Sharma, RH Lye, AK Ah-See, AM Compton, DR Tomlinson, SP Hanley, Boulton AJM. (1990). Hypoxic neuropathy: relevance to human diabetic neuropathy. Diabetologia, 33, 311-318. eScholarID:1d24442

1989

  • Malik RA, PG Newrick, AK Sharma, AK Ah-See, TM Mayhew, J Jakubowski, Boulton AJM, JD Ward. (1989). Macroangiopathy in human diabetic neuropathy: relationship between capillary abnormalities and the severity of neuropathy. Diabetologia, 32, 92-102. eScholarID:1d24440

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