Professor Gillian Wallis MA PhD

2011

• Day-Williams, et al (2011). A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet, 89(3), 446-50. eScholarID:140175 | PMID:21871595 | DOI:10.1016/j.ajhg.2011.08.001
• Evangelou, et al (2011). Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis, 70(2), 349-355. eScholarID:112534 | PMID:21068099 | DOI:10.1136/ard.2010.132787
• Ha, B., Jeon, Y., Shin, S., Tatsumi, K., Komatsu, M., Tanaka, K., Watson, C., Wallis, G., Chung, C. & Kim, E (2011). Structure of Ubiquitin-fold Modifier 1-specific Protease UfSP2. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(12), 10248-10257. eScholarID:127753 | DOI:10.1074/jbc.M110.172171
• Panoutsopoulou, et al (2011). Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis, 70(5), 864-867. eScholarID:103591 | PMID:21177295 | DOI:10.1136/ard.2010.141473
• Southam, L., Panoutsopoulou, K., Rayner, N., Chapman, K., Durrant, C., Ferreira, T., Arden, N., Carr, A., Deloukas, P., Doherty, M., Loughlin, J., McCaskie, A., Ollier, W., Ralston, S., Spector, T., Valdes, A., Wallis, G., Wilkinson, J., Study, a., Marchini, J. & Zeggini, E (2011). The effect of genome-wide association scan quality control on imputation outcome for common variants. Eur J Hum Genet, 19(5), 610-614. eScholarID:118334 | PMID:21267008 | DOI:10.1038/ejhg.2010.242

2010

• Scott, J., Gabrielides, C., Davidson, R., Swingler, T., Clark, I., Wallis, G., Boot-Handford, R., Kirkwood, T., Talyor, R. & Young, D (2010). Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis, 69(8), 1502-1510. eScholarID:85253 | PMID:20511611 | DOI:10.1136/ard.2009.119966

2009

• Evangelou, E, Chapman, K, Meulenbelt, I, Karassa, F, Loughlin, J, Carr, A, Doherty, M, Doherty, S, Gómez-Reino, J, Gonzalez, A, Halldorsson, B, Hauksson, V, Hofman, A, Hart, D, Ikegawa, S, Ingvarsson, T, Jiang, Q, Jonsdottir, I, Jonsson, H, Kerkhof, H, Kloppenburg, M, Lane, N, Li, J, Lories, R, van Meurs, J, Näkki, A, Nevitt, M, Rodriguez-Lopez, J, Shi, D, Slagboom, P, Stefansson, K, Tsezou, A, Wallis, GA, Watson, C, Spector, T, Uitterlinden, A, Valdes, A, Ioannidis, J. (2009). Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum, 60(6), 1710-1721. eScholarID:1d21251 | DOI:10.1002/art.24524

2008

• Chapman, K, Takahashi, A, Meulenbelt, I, Watson, C, Rodriguez-Lopez, J, Egli, R, Tsezou, A, Malizos, K, Kloppenburg, M, Shi, D, Southam, L, van der Breggen, R, Donn, RP, Qin, J, Doherty, M, Slagboom, P, Wallis, GA, Kamatani, N, Jiang, Q, Gonzalez, A, Loughlin, J, Ikegawa, S. (2008). A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet, 17(10)(10), eScholarID:1d17068 | DOI:10.1093/hmg/ddn038
• Chapman, K., Takahashi, A., Meulenbelt, I., Watson, C., Rodriguez-Lopez, J., Egli, R., Tsezou, A., Malizos, K., Kloppenburg, M., Shi, D., Southam, L., van der Breggen, R., Donn, R., Qin, J., Doherty, M., Slagboom, P., Wallis, G., Kamatani, N., Jiang, Q., Gonzalez, A., Loughlin, J. & Ikegawa, S (2008). A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5 ' UTR of GDF5 with osteoarthritis susceptibility. HUMAN MOLECULAR GENETICS, 17(10), 1497-1504. eScholarID:127750 | DOI:10.1093/hmg/ddn038
• Hadfield, K., Rock, C., Inkson, C., Dallas, S., Sudre, L., Wallis, G., Boot-Handford, R. & Canfield, A (2008). HtrA1 inhibits mineral deposition by osteoblasts - Requirement for the protease and PDZ domains. JOURNAL OF BIOLOGICAL CHEMISTRY, 283(9), 5928-5938. eScholarID:127749 | DOI:10.1074/jbc.M709299200
• Hyde G, Boot-Handford R, Wallis GA. (2008). Col2a1 lineage tracing reveals that the meniscus of the knee joint has a complex cellular origin. J Anat, 213( 5)(5), eScholarID:1d21242 | DOI:10.1111/j.1469-7580.2008.00966.x

2007

• Hyde G, Dover S, Aszodi A, Wallis GA, Boot-Handford R. (2007). Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. Dev Biol, 304(2), eScholarID:1d21255 | DOI:10.1016/j.ydbio.2007.01.026

2006

• Greig, C, Spreckley, KB, Aspinwall, R, Gillaspy, E, Gillaspy, EE, Grant, M, Ollier, WER, John, S, Doherty, M, Wallis, GA. (2006). Linkage to nodal osteoarthritis: Quantitative and qualitative analyses of data from a whole genome screen identifies trait dependent susceptibility loci. Ann Rheum Dis, 65(9), 1131-1138. eScholarID:1d13084 | DOI:10.1136/ard.2005.048165

2005

• Gleghorn L, Ramesar R, Beighton P, Wallis GA. (2005). A mutation in the variable repeat region of the aggrecan gene (AGC1) causes a form of spondyloepiphyseal dysplasia associated with severe, premature osteoarthritis. Am J Hum Genet, 77( 3), 484-90. eScholarID:1d12131 | DOI:10.1086/444401
• Zambelli A, Mongiardini E, Villegas S, Carri N, Boot-Handford RR, Wallis GA. (2005). Transcription factor XBP-1 is expressed during osteoblast differentiation and is transcriptionally regulated by parathyroid hormone (PTH). Cell Biol Int, 29( 8)(8), eScholarID:1d13085

2003

• Newman B, Wallis GA. (2003). Skeletal dysplasias caused by a disruption of skeletal patterning and endochondral ossification. Clin Genet, 63( 4)(4), eScholarID:1d9637

2002

• Chambers D, Young D, Howard C, Thomas J, Boam D, Grant M, Wallis GA, Boot-Handford RR. (2002). An enhancer complex confers both high-level and cell-specific expression of the human type X collagen gene. FEBS Lett, 531( 3)(3), eScholarID:1d9638
• Gillaspy EE, GillaspyE, SpreckleyK, Wallis GA, DohertyM, SpectorT.D. (2002). Investigation of linkage on chromosome 2q and hand and knee osteoarthritis. Arthritis Rheum, 46, 12, 3386-3387. eScholarID:1d7326 | DOI:10.1002/art.10651
• White A, Watson REB, Newman WG, Freemont AJ, Wallis GA. (2002). Annexin VIII is differentially expressed by chondrocytes in the mammalian growth plate during endochondral ossification and in osteoarthritic cartilage. J Bone Miner Res, 17( 10)(10), eScholarID:1d9639 | DOI:10.1359/jbmr.2002.17.10.1851
• Eyre, SS, P Roby, K Wolstencroft, K Spreckley, R Aspinwall, R Bayoumi, L Al-Gazali, R Ramesar , P Beighton, Wallis, GA. (2002). Identification of a locus for a form of spondyloepiphyseal dysplasia on chromosome 15q26.1: Exclusion of aggrecan as a candidate gene. Journal Of Medical Genetics, 39, 634-638. eScholarID:17d94

2001

• Cheung J, Hillarby M, Ayad S, Hoyland JA, Jones C, Denton J, Thomas J, Wallis GA, Grant M. (2001). A novel cell culture model of chondrocyte differentiation during mammalian endochondral ossification. J Bone Miner Res, 16( 2)(2), eScholarID:1d9523
• JM Pace, M Atkinson, MC Willing, Wallis GA, PH Byers. (2001). Deletions and duplications of Gly-Xaa-Yaa triplet repeats in the triple helical domains of type I collagen chains disrupt helix formation and result in several types of osteogenesis imperfecta. Hum Mutat, 18, 319-326. eScholarID:1d3170
• Newman B, Gigout L, Sudre L, Grant M, Wallis GA. (2001). Coordinated expression of matrix Gla protein is required during endochondral ossification for chondrocyte survival. J Cell Biol, 154( 3), 659-66. eScholarID:1d9642 | DOI:10.1083/jcb.200106040

2000

• Green H, Canfield AE, Hillarby M, Grant M, Boot-Handford RR, Freemont AJ, Wallis GA. (2000). The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development. J Bone Miner Res, 15( 6)(6), eScholarID:1d9644
• Gregory C, Zabel B, Grant M, Boot-Handford RR, Wallis GA. (2000). Equal expression of type X collagen mRNA from mutant and wild typeCOL10A1 alleles in growth plate cartilage from a patient with metaphyseal chondrodysplasia type Schmid. J Med Genet, 37( 8)(8), eScholarID:1d9643

1999

• DS Marks, CA Gregory, Wallis GA, A Brass, KE Kadler, Boot-Handford RR. (1999). Metaphyseal chondrodysplasia type Schmid mutations are predicted to occur in two distinct three-dimensional clusters within type X collagen NC1 domains which retain the ability to trimerise. J. Biol. Chem, 274, 3632-3641. eScholarID:1d23871

1998

• Boot-Handford RR, TM Michaelidis, Hillarby M, A Zambeli, Denton J, Freemont AJ, Grant MM.E, Wallis GA. (1998). The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. International Journal Of Experimental Pathology, 79, eScholarID:1d25566

1996

• Hillarby M, K King, G Brady, Grant MM.E, Wallis GA, Boot-Handford RR. (1996). Localisation of gene expression during endochondral ossification. Annals of the New York Academy of Science, 785, eScholarID:1d25561