Skip to main content Skip to navigation

[University home]

School of Medicine

Professor Anthony Jones 

Photograph of Anthony Jones

Professor of Neuro-Rheumatology

Human Pain Research Group
School of Translation Medicine
University of Manchester
Clinical Sciences Building
Salford Royal NHS Foundation Trust
Salford
M6 8HD

Hon. Professor of Rehabilitation Science, Salford University

Human Pain Research Group

Human Pain Research

 

Memberships of Committees and Professional Bodies

  • Royal College of Physicians
  • British Society for Rheumatology
  • Pain Society
  • International Association for the Study of Pain (IASP)
  • European Federation of the International Association for the Study of Pain - (EFIC)
  • British Neuroscience Association
  • Psychophysiology Association
  • Euroscience
  • Trigeminal Neuralgia Association
  • Trustee & Director – ARMA (the Arthritis and Musculoskeletal Alliance

Research

  • Previous research has concentrated on the development of new techniques to identify the network of brain structures in the human brain that is involved in nociceptive processing and some of the endogenous pharmacological processes that may modify this. We were the first group to achieve these two goals. The main applications have been in musculoskeletal and post-stroke pain. Candidate mechanisms for fibromyalgia and post-stoke pain have been identified by recent PET studies; funded by our Arthritis Research Campaign program grant and previous MRC grants.
  • Future research will be focused on establishing a causal relationship between some of these candidate mechanisms and different types of chronic musculoskeletal pain. Having identified these, our long-term goal is to identify new therapeutic targets for modifying such abnormal brain mechanisms.
 

Teaching

Current university teaching activities include regular undergraduate and post-graduate teaching. Over the last five years the work from our group and those of our colleagues, and the seminars that we have given nationally and internationally, have resulted in a slow but substantial shift of interest to pain physiology and pain management issues in the European Rheumatology and Neurology Communities. This has resulted in the Group being commissioned by the British Society for Rheumatology and the International Society for the Study of Pain (IASP) to develop “Integrated Guidelines for the Management of Musculoskeletal Pain”.

Specialist registrars in rheumatology are taught in the multidisciplinary musculoskeletal pain and inflammatory arthritis clinics that I have set up in parallel to the formal teaching they get on the ward and in the Rheumatology MSc course.

Now that the ARC programme grant has been established we have plans, which are at an early stage, to develop a teaching website on the principles of pain physiology and musculoskeletal pain management. We would plan to do this in conjunction with our colleagues in the Dept of Anatomy, ARC Epidemiology Unit and the Royal College of Physicians and IASP. Chairman of IASP Musculoskeletal Pain Taskforce. This is an international group which is focussed on developing and promoting the guidelines - driven management of Musculoskeletal Pain workshops and seminars at international and national meetings. We plan to do this at the same time as holding a number of National and International meetings to develop and promote the “Integrated Guidelines for the Management of Musculoskeletal Pain”.

 

Biography

Anthony Jones is professor of Neuro-rheumatology at Manchester University and leads the Human Pain Research Group. Whilst at the Hammersmith Hospital he pioneered the development of techniques to image neurochemical and metabolic brain responses to pain using Positron Emission Tomography. Over the last twenty years he has used a number of functional brain imaging techniques to understand that the normal and abnormal mechanisms of pain perception. There is now the exciting prospect of using some of the insights gained in these studies to develop new approaches to pharmacological and cognitive interventions for chronic pain. He also leads the International Association of Pain Musculoskletal Pain Taskforce and is leading the development of National and International Guidelines on the Integrated Management of Musculoskeletal Pain (jointly sponsored by the BSR and the IASP).

 

Qualifications

  • M.A 1975 - Oxford
  • MB BS 1978 - London
  • MRCP 1981 - UK
  • MD 1992 - London
  • FRCP 1996 - UK
 

Collaborators and affiliated staff

Collaborators

  • Carlo Porro
    University of Udine, Italy
    Collaborator in grant applications and research
  • Irene Tracey
    University of Oxford
    Collaborator in grant applications and research
  • Peter Bandettini
    NIMH, USA
    collaborator on HFSP grant
  • Dr Pippa Tyrrell
    Salford Royal Hospitals NHS Trust
    collaborator
  • Professor Alan R Crossman
    University of Manchester
    current collaborator
  • Professor Bill Deakin
    University of Manchester
    grant collaborator
  • Professor Francis Creed
    University of Manchester
    collaborator on research
  • Professor Terence King
    University of Manchester
    collaborator on arc programme grant
 

Publications

2011

  • Brown C, Watson A, Morton D, Power A, El-Deredy W, Jones AKP. (2011). Role of the central neurophysiological systems in placebo analgesia and their relationship to cognitive processes mediating placebo responding. Future Neurology, 6(3), 389-398. eScholarID:124110 | DOI:10.2217/fnl.11.21

2010

  • Brown C, Jones AKP. (2010). Cortical Interactions between pain-related anxiety and selective attention to pain. Presented at IASP 2010. MONTREAL. eScholarID:80891
  • Brown C, Jones AKP. (2010). Differences between patients with osteoarthritis and fibromyalgia in their anticipation of future pain events: a behavioural and EEG study. Presented at IASP 2010. MONTREAL. eScholarID:80892
  • El-Deredy W, Trujillo-Barreto NJ, Watson A, Jones AKP. (2010). Bayesian model comparison of placebo analgesia: parameterisation of prior information and expection. Presented at IASP 2010. Montreal. eScholarID:80886
  • Watson A, Power A, Lenton A, El-Deredy W, Morais S, Jones AKP. (2010). A behavioural and electrophysiological study of distraction and attention to a painful laser stimulus in fibromyalgia, arthritis and healthy volunteers. Presented at IASP 2010. MONTREAL. eScholarID:80890
  • Brown A, Jones AKP. (2010). Meditation experience predicts less negative appraisal of pain: electrophysiological evidence for the involvement of anticipatory neural responses. Pain, eScholarID:80910 | DOI:10.1016/j.pain.2010.04.017
  • Morton D, El-Deredy W, Morton A, Elliott R, Jones AKP. (2010). Optimism facilitates the utilization of prior cues. European Journal of Personality, eScholarID:124109
  • Morton D, El-Deredy W, Watson A, Jones AKP. (2010). Placebo Analgesia as a case of a cognitive style driven by prior expectation. Brain Research, 1359, 137-141. eScholarID:103202 | DOI:10.1016/j.brainres.2010.08.046
  • Morton DL, Brown CA, Watson A, El-Deredy W, Jones AKP. (2010). Cognitive changes as a result of a single exposure to placebo. Neuropsychologia, eScholarID:80909

2009

  • Brown C, Jones AKP. (2009). Experimental modification of expectations and beliefs about pain in patients with fibromyalgia and healthy controls. Presented at BSR 2009. eScholarID:80898
  • Morton D, Watson A, El-Deredy W, Jones AKP. (2009). The reproducibility of placebo analgesia. Presented at BSR 2009. eScholarID:80897
  • -Ray M, Tom BDM, Morais S, Watson A, Bentley D, Boyle Y, Jones AKP. (2009). Identifying fibromyalgia and osteoarthritis patients subgroups at most risk of psychological distress. Presented at The British Pain Society Annual Scientific Meeting 2009. eScholarID:80894
  • Watson A, Morais S, Bentley D, Boger E, Boyle Y, Kulkarni B, Jones AKP. (2009). Behavioural study of distraction and attention to a painful laser stimulus in fibromyalgia, arthritis and healthy volunteers. Presented at BSR Conference 2009. eScholarID:80895
  • McMunn V, Bedwell C, Neilson J, Jones AKP, Dowswell T, Lavender T. (2009). A national survery of the use of TENS in labour. British Journal of Midwifery, 17(8), 492-495. eScholarID:80906
  • Morton D, Watson A, El-Deredy W, Jones AKP. (2009). Reproducibility of placebo analgesia: Effect of dispositional optimism. PAIN, 146(1-2), 194-198. eScholarID:80903 | DOI:10.1016/j.pain.2009.07.026
  • Watson A, El-Deredy W, Iannetti G I, Lloyd D, Tracey I, Vogt B A, Nadeau V, Jones AKP. (2009). Placebo conditioning and placebo analgesia modulate a common brain network during pain anticipation and perception. Pain, 145, 24-30. eScholarID:80908 | DOI:10.1016/j.pain.2009.04.003

2008

  • Boyle Y, El-Deredy W, Martínez Montes E, Bentley DE, Jones AK P. (2008). Selective modulation of nociceptive processing due to noise distraction. Pain, 138( 3), eScholarID:1d18359 | DOI:10.1016/j.pain.2008.02.020
  • Brown CA, Jones AKP. (2008). A role for midcingulate cortex in the interruptive effects of pain anticipation on attention. Clinical Neurophysiology, 119(10), 2370-9. eScholarID:1d18694 | DOI:10.1016/j.clinph.2008.06.014
  • Brown CCA, Seymour B, El-Deredy W, Jones AK P. (2008). Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula. Pain, 139(2), 324-32. eScholarID:1d18358 | DOI:10.1016/j.pain.2008.04.028
  • Christopher A. Brown, Ben Seymour, Yvonne Boyle, El-Deredy W, Jones AK P. (2008). Modulation of pain ratings by expectation and uncertainty: Behavioral characteristics and anticipatory neural correlates. Pain, 135, 240-250. eScholarID:1d16033 | DOI:DOI:10.1016/j.pain.2007.05.022
  • JA Clark, Brown CA, Jones AKP. (2008). Dissociating nociceptive modulation by the duration of pain anticipation from unpredictability in the timing of pain. Clinical Neurophysiology, 119(12), 2870-8. eScholarID:1d18213 | DOI:10.1016/j.clinph.2008.09.022
  • Jones AKP. (2008). Is Pain All in The Brain. Manchester Evening News, eScholarID:80913
  • Jones AKP. (2008). New research to harness the power of placebo effect. Arthritis Today, eScholarID:80911

2007

  • Jones AK P, Watson A. (2007). A functional imaging of pain: A cortical model of allodynia in poststroke pain and fibromyalgia. eScholarID:2d2175
  • Bhavna Kulkarni, D E Bentley, Elliott R, PJ Julyan, E Boger, A Watson, Y Boyle, El-Deredy W, Jones AK P. (2007). Arthritic pain is processed in brain areas concernedwith emotions and fear. Arthritis and Rheumatism, 56 (4), 1345-1354. eScholarID:1d12953 | DOI:10.1002/art.22460
  • Langley G, Evans T, Holgate S, Jones AK P. (2007). Replacing animal experiments: choices, chances and challenges. Bioessays, 918-926. eScholarID:1d17108
  • Langley G, Evans T, Holgate ST, Jones AKP. (2007). Replacing animal experiments: choices, chances and challenges. Bioessays, eScholarID:80916
  • Porro C, Martinig M, Facchin P, Maieron M, Jones AK P, Luciano F. (2007). Parietal cortex involvement in the localisation of tactile and noxious mechanical stimuli: A transcranial magnetic stimulation study. Behavioural Brain Research, 178, 183-189. eScholarID:1d17107
  • Watson A, El-Deredy W, Vogt BA, Jones AK P. (2007). Placebo analgesia is not due to compliance or habituation: EEG and behavioural evidence. NeuroReport, 18, 771-775. eScholarID:1d27649
  • Zampini M, El-Deredy W, Bentley DE, Vogt B, Jones AK P, Spence C. (2007). Attention speeds the perceptual processing of painful stimuli. Behavioral Brain Research, 414, 75 - 79. eScholarID:1d17106
  • Jones AKP. (2007). New insights into managing musculoskeltal pain. MD Conference Express, eScholarID:80914

2006

  • Bentley DE, Baumgartner U, Watson A, G Barrett, Kulkarni B, Youell P, Schlereth T, Jones AK P, R Detlef-Treede. (2006). The time-course of sensory and affective pain processing: evidence from laser-evoked potentials. eScholarID:2d2057
  • Boyle Y, Bentley DE, Watson A, Jones AK P. (2006). Acoustic noise in functional magnetic resonance imaging reduces pain unpleasantness ratings. Neuroimage, 31, 1278-1283. eScholarID:1d13016 | DOI:10.1016/j.neuroimage.2006.01.025
  • Jones AKP, Georgiou G. (2006). Probing Pain. Biological Science Review - Philip Allan Updates, eScholarID:80917
  • Watson A, El-Deredy W, Bentley DE, Brent A Vogt, Jones AK P. (2006). Categories of placebo response in the absence of site-specific expectation of analgesia. Pain, 126, 115-122. eScholarID:1d13634
  • Jones AKP. (2006). A new approach to pain. Arthritis Today, eScholarID:80915

2005

  • Bentley DE, Ulf Baumgartner, Watson A, Geoff Barrett, Kulkarni B, Youell P, Jones AK P. (2005). Early involvement of right operculo-insular cortex cortex in processing pain unpleasantness : evidence from laser evoked potentials. Brain Topography. ( 17(3), ). eScholarID:3d1043
  • Jones AK P. (2005). The role of the cerebral cortex in pain perception. Proceedings of the 11th World Congress on Pain, IASP, Sydney, Australia 2005. eScholarID:3d225
  • Watson A, El-Deredy W, Bentley DE, Boyle Y, Brent Vogt, Jones AK P. (2005). Placebo-induced reductions in pain ratings & laser evoked potentials. Poster 11th World congress on Pain IASP, Sydney 2005. eScholarID:3d423
  • Boyle Y, Bentley DE, Watson A, Jones AK P. (2005). Modulation of pain affect, spatial discrimination and laser evoked potentials by distraction. eScholarID:2d2222
  • Boyle Y, Bentley DE, Watson A, Jones AK P. (2005). The differential effects of distraction from pain localisation versus pain unpleasantness on laser-evoked potentials. eScholarID:2d1770
  • Chris Brown, Bentley DE, Boyle Y, Watson A, Kulkarni B, Emma Boger, Jones AK P. (2005). The expectancy of pain in fibromyalgia, osteoarthritis & healthy volunteers. eScholarID:2d1903
  • Chris Brown, Boyle Y, Watson A, Bentley DE, Jones AK P. (2005). The expectancy of pain: Modulation by intensity and uncertainty. eScholarID:2d1906
  • El-Deredy W, Boyle Y, Bentley DE, Jones AK P. (2005). Modulation of laser evoked potentials frequency response to pain localisation, affect and distraction. eScholarID:2d2225
  • N Trujilli-Barreto, Boyle Y, El-Deredy W, Bentley DE, Jones AK P. (2005). Modulation of medial and lateral pain systems by noise distraction. eScholarID:2d2224
  • Nadeau VJ, A Abraham, Watson A, Bentley DE, Boyle Y, Jones AK P. (2005). Ability to localise a heat stimulus is dependent on stimulus intensity. eScholarID:2d1860
  • Nadeau VJ, AD Abraham, Watson A, Bentley DE, Jones AK P. (2005). Does the intensity of a painful heat stimulus affect the ability to localize it?. eScholarID:2d2217
  • Watson A, Jones AK P, Bentley DE, Brent Vogt, Carlo Porro. (2005). Placebo-induced reduction of pain intensity and unpleasantness ratings of a laser stimulus. eScholarID:2d1747
  • Kulkarni B, Bentley D, Elliott R, Youell P, Watson A, Derbyshire S, Frackowiak R, Friston K, Jones AK P. (2005). Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems. Eur J Neurosci, 21( 11), 3133-42. eScholarID:1d29913

2004

  • T N Hoang, El-Deredy W, Bentley DE, Jones AK P, P J Lisboa, Francis P McGlone. (2004). Dipole source localisation using independent component analysis: Single trial localisation of laser evoked pain. eScholarID:2d1201
  • Bentley DE, Alison Watson, Rolf-Detleff Treede, Geoff Barrett, Youell P, Kulkarni B, Jones AK P. (2004). Differential effects on the Laser Evoked Potential of Selectively Attending to Pain Localisation versus Pain Unpleasantness. Clinical Neurophysiology, 115, 1846 - 1856. eScholarID:1d7757
  • Youell P, Richard G Wise, Bentley DE, Mark D Dickinson, King T, Irene Tracey, Jones AK P. (2004). Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. Neuroimage, eScholarID:1d7748
  • Youell P, Wise R, Bentley D, Dickinson M, King T, Tracey I, Jones AK P. (2004). Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. Neuroimage, 23( 3), 1068-77. eScholarID:1d9037 | DOI:10.1016/j.neuroimage.2004.07.004

2003

  • Bentley DE, Stuart W G Derbyshire, Youell P, Jones AK P. (2003). Caudal cingulate cortex involvement in pain processing: An inter-individual laser evoked potential source localisation study using realistic head models. Pain, 102:3, 265-271. eScholarID:1d7078

2002

  • Kulkarni B, Jones AK P, Elliott R, Bentley DE, Stuart Derbyshire, Youell P. (2002). Cortical processing of affective versus sensory-discriminative aspects of pain - a PET study. eScholarID:2d1278
  • Lampros Stergioulas, M Reoullas, Costas S Xydeas, E Baltas, Bentley DE, Youell P, Jones AK P. (2002). Coherence pattern classification using LVQs for pain detection. eScholarID:2d1574
  • Bentley DE, Youell P, Jones AK P. (2002). Anatomical localisation and intra-subject reproducibility of laser evoked potential source in cingulate cortex, using a realistic head model. Clin Neurophysiol, 113, 1351-1356. eScholarID:1d3945
  • Derbyshire SWG, Jones AK P, Creed FH, Starz T, Meltzer CC, Townsend DW, Peterson AM, Firestone L. (2002). Cerebral responses to noxious thermal stimulation in chronic low back pain patients and normal controls. Neuroimage, 16(1), 158-168. eScholarID:1d24126 | DOI:10.1006/nimg.2002.1066
  • Spence C, Bentley DE, Phillips N, McGlone FP, Jones AK P. (2002). Selective attention to pain: a psychophysical investigation. Exp Brain Res, 145, 395-402. eScholarID:1d3946

2001

  • Bentley DE, Jones AK P. (2001). Consistent localisation of hig-density pain evoked potential recordings in cingulate cortex, using realistic head models. eScholarID:2d1490
  • Bentley DE, Youell P, Crossman AA.R, Jones AK P. (2001). Source localisation of 62-electrode human laser pain evoked potential data using a realistic head model. Int J Psychophysiol, 41/2, 187-193. eScholarID:1d6717

2000

  • Bentley DE, Youell P, Crossman AA.R, Jones AK P. (2000). Evidence for a movement suppression component of human pain evoked potentials. eScholarID:2d1978
  • Bentley DE, Youell P, Crossman AA.R, Jones AK P. (2000). Pain evoked potentials: possible evidence for a movement suppression component? 3rd Congress of the European Federation of IASP Chapters, Nice, France, eScholarID:1d33829
  • Youell P, Bentley DE, King TA, Jones AK P. (2000). manipulation of the affective components of the pain experience using laser stimulation. Eur. J. Neuro, 12(11), eScholarID:1d33576

1999

  • Bentley DE, Youell P, Carson KI, Crossman AA.R, Jones AK P. (1999). Spatial and temporal localisation of pain processing in the human brain. eScholarID:2d2259
  • Youell P, Bentley DE, Clark S, Dickinson MR, King TA, Jones AK P. (1999). laser pain stimulation. eScholarID:2d1795

Top of page

| Skip to main content | Skip to navigation | Skip to Search |