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School of Medicine

Dr Helen Young 

Photograph of Helen Young

Senior Lecturer

 

Role

Clinical Senior Lecturer, my roles are split between 3 areas:

Consultant Dermatologist, Salford Royal Hospitals: 50%

Research: 30%

  • Current funding from NIHR, British Skin Foundation and The Psoriasis Association
  • National Research Committee: British Society for Investigative Dermatology

Teaching: 20%

  • Programme Director for MRes in Medical Sciences course
  • Clinical teaching and supervision

 

 

Memberships of Committees and Professional Bodies

Research Committee: British Society for Investigative Dermatology
Specialist Training Committee for Dermatology, North West Deanery

Royal College of Physicians
British Association of Dermatologists
 

Research

Current research interests are focused on taking forward research questions that arise from direct patient care particularly in the field of psoriasis and addressing these with modern laboratory techniques. My work is based around the recognition of molecular targets for therapy of inflammatory skin disease and exploration of the emerging evidence that cardiovascular disease is an important co-morbidity of psoriasis.
The management of chronic disease, of which psoriasis is the commonest inflammatory disease in the UK, is a key point of current health strategy.
Research is currently funded by NIHR, The British Skin Foundation and The Psoriasis Association.
 

 

Teaching

Teaching has been a significant component of my work, largely undertaken within Manchester Medical School:
Programme Director MRes Medical Sciences (Intercalated Medical Students)
Clinical teaching and lectures
Year 4 project option
SSC tutor
Academic Advisor
Medical School Admissions Interviews
 

 

Biography

Helen Young, MB, ChB, PhD, MRCP(UK), is Senior Lecturer in Dermatology at The University of Manchester and Honorary Consultant Dermatologist at Salford Royal Hospital, Manchester. She received her MB, ChB and PhD degrees from The University of Manchester. She trained in dermatology on the North West Regional Dermatology Training Scheme (Manchester) and at Harvard Medical School where she was a Research Fellow in Dermatology at the Cutaneous Biology Research Center, Massachusetts General Hospital, Boston, USA. She is one of the four Consultant Dermatologists who lead the Manchester Psoriasis Service – a multidisciplinary clinic for patients with severe psoriasis – which was awarded Hospital Doctor Dermatology Team of the Year Award in 2002. Her Higher Education Funding Council for England (HEFCE) funded Clinical Senior Lectureship was awarded in September 2008 and she is the first dermatologist to have received this award.

Her research interests include cutaneous angiogenesis and lymphangiogenesis, particularly as they relate to psoriasis pathogenesis. Her research has received many awards at national and international meetings including the British Association of Dermatologists, British Society for Investigative Dermatology and American Academy of Dermatology Annual Meetings. In 2006 she was presented with the Eugene M. Farber Research in Psoriasis Award by the American Society of Investigative Dermatology and she was awarded the Gold Medal for PhD Student of the Year at The University of Manchester. In 2007 she was The Medical Research Society, the Academy of Medical Sciences and the Royal College of Physicians Young Investigator of the Year runner-up.
 

 

Qualifications

MB ChB University of Manchester 1994
PhD University of Manchester 2006
MRCP(UK) London 1997
CCT Dermatology 2006
 

 

Publications

2012

  • Crawshaw A, Griffiths CEM, Young HS. (2012). Investigational VEGF antagonists for psoriasis. Expert Opinion on Investigational Drugs, 21(1), 33-43. eScholarID:149115 | DOI:10.1517/13543784.2012.636351
  • Langan EA, Mansoor W, Brabant G, Jamieson LA, Young HS. (In-press). A painful blistering rash on the lower legs and perineum. Clinical and Experimental Dermatology, eScholarID:149136

2011

  • Weidmann AK, Young HS. (2011). Azathioprine in the 21st Century. Current Medical Literature - Dermatology, 16(3), 61-67. eScholarID:149130
  • Weidmann AK, Young HS. (2011). Topical Calcineurin Inhibitors: An Update on Their Use. Clinical Medicine Insights: Dermatology, 4, 17-25. eScholarID:149125

2010

  • Laws PM, Young HS. (2010). Topical treatment of psoriasis. Expert Opinion On Pharmacotherapy, eScholarID:83818
  • Laws PM, Young HS. (2010). Update of the management of chronic psoriasis: new approaches and emerging treatment options. Clinical Cosmetic and Investigational Dermatology, 3, 25-37. eScholarID:79703
  • Strange et al. (2010). A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nature Genetics, 42(11), 985-989. eScholarID:95123 | DOI:10.1038/ng.694
  • Young HS. (2010). The HEFCE / NHS Clinical Senior Lectureship Awards. The British Association of Dermatologists Newsletter, 13(2), eScholarID:83593
  • Young HS. (In-press). Psoriasis as a systemic disease: considerations for the dermatologist when treating psoriasis. Advances in Psoriasis and Inflammatory Skin Diseases, eScholarID:83817

2008

  • Capon, F, Bijlmakers, M, Wolf, N, Quaranta, M, Huffmeier, U, Allen, M, Timms, K, Abkevich, V, Gutin, A, Smith, R, Warren, RB, Young, H, Worthington, J, Burden, A, Griffiths, C, Hayday, A, Nestle, F, Reis, A, Lanchbury, J, Barker, J, Trembath, R. (2008). Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene. Hum Mol Genet, 17( 13), 1938-45. eScholarID:1d17544 | DOI:10.1093/hmg/ddn091
  • El-Rachkidy R, Young H, Griffiths C, Camp R. (2008). Humoral autoimmune responses to the squamous cell carcinoma antigen protein family in psoriasis. J Invest Dermatol, 128( 9), 2219-24. eScholarID:1d18486 | DOI:10.1038/jid.2008.71
  • Filer C, Ho PY, Smith R, Griffiths CEM, Young H, Worthington J, Bruce IN, Barton A. (2008). Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Arthritis Rheum, 58 (12), 3705-9. eScholarID:1d18217 | DOI:10.1002/art.24128
  • Ho PY, Barton A, Worthington J, Plant D, Griffiths C, Young H, Bradburn P, Thomson, Silman AJ, Bruce IN. (2008). Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. Annals of the Rheumatic Diseases, 67, 677-682. eScholarID:21073 | DOI:10.1136/ard.2007.071399
  • Smith RL, Eyre S, Warren RB, Young H, Griffiths CE, Worthington J. (2008). No Association between Polymorphisms in the Interleukin-15 Gene and Early-Onset Psoriasis in a UK Cohort Suggests Heterogeneity for this Susceptibility Locus Identified in Chinese Psoriasis Patients. J Invest Dermatol, eScholarID:1d17542
  • Smith RL, Warren RB, Eyre S, Ke X, Young HS, Gittins MP, Barker JNWN, Griffiths CEM, Worthington J. (2008). Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. Br J Dermatol, 158, 962-968. eScholarID:79702 | DOI:10.1111/j.1365-2133.2008.08482.x
  • Smith RL, Warren RB, Eyre S, Ke X, Young HS, Griffiths C, Worthington J. (2008). Polymorphisms in the IL-12beta and IL-23R genes are associated with psoriasis of early onset in a UK cohort. Journal of Investigative Dermatology, 128, 1325-1327. eScholarID:21089 | DOI:10.1038/sj.jid.5701140

2007

  • El-Rachkidy R, Hales J, Freestone P, Young H, Griffiths C, Camp R. (2007). Increased blood levels of IgG reactive with secreted Streptococcus pyogenes proteins in chronic plaque psoriasis. J Invest Dermatol, 127( 6), 1337-42. eScholarID:1d18487 | DOI:10.1038/sj.jid.5700744

2006

  • Young H, Coulson IH. (2006). Erythema elevatum diutinum. Treatment of Skin Disease: Comprehensive therapeutic strategies. 2nd Edition. Elsevier Science. eScholarID:3d918
  • E Campalani, MH Allen, D Fairhurst, Young, H, CO Mendonca, AD Buren, Griffiths, CEM, MA Crook, JN Barker, CH Smith. (2006). Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin. British Journal of Dermatology, 154, 345-352. eScholarID:1d12875
  • Marie Cumberbatch, M Singh, Rebecca Dearman, Young H, I Kimber, Griffiths CEM. (2006). Impaired Langerhans' cell migration in psoriasis. The Journal of Experimental Medicine, 203, 953-960. eScholarID:1d12906 | DOI:10.1084/jem.20052367
  • Plant D, Watson REB, Young H, Worthington J, Griffiths CEM. (2006). The CX3CL1-CX3CR1 system and psoriasis. Experimental Dermatology, 15 (11), 900-903. eScholarID:1d13538
  • Young, H, Angela M Summers, Ian Read, David A Fairhurst, Plant, D, Emanuela Campalani, Catherine H Smith, Jonathan NWN Barker, Michael J Detmar, Brenchley, PEC, Griffiths, CEM. (2006). Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis. Journal of investigative dermatology, 126, 453-459. eScholarID:1d26801 | DOI:10.1038/sj.jid.5700096

2005

  • Ho, PY, Bruce, IN, Silman, AJ, Symmons, D, Newman, WG, Young, H, Griffiths, CEM, John, S, Worthington, J, Barton, A. (2005). Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis. Arthritis Rheum, 52( 11), 3596-3602. eScholarID:1d11751
  • Young H, Griffiths CEM. (2005). Efalizumab: a viewpoint. Americal Journal of Clinical Dermatology, 6, 119-20. eScholarID:1d10938

2004

  • Young H, Beck MH. (2004). Post-coital contact dermatitis from methyldibromo glutaronitrile. Contact Dermatitis, 50( 1), eScholarID:1d11956
  • Young H, Ferguson J, Beck MH. (2004). Contact dermatitis from 2-n-octyl-4-isothiazolin-3-one in a PhD student. Contact Dermatitis, 50( 1), 47-8. eScholarID:1d11958
  • Young H, Summers AM, Bhushan M, Brenchley PEC, Griffiths CEM. (2004). Single-Nucleotide Polymorphisms of Vascular Endothelial Growth Factor (VEGF) in Psoriasis of Early Onset. Journal of Investigative Dermatology, 122, 209-215. eScholarID:1d7611 | DOI:10.1046/j.0022-202X.2003.22107.x
  • Young H, Wilson N, Winter J, Beck MH. (2004). Contact dermatitis from Diazald. Contact Dermatitis, 50( 5), 315-6. eScholarID:1d11953

2003

  • Batchelor R, Young H, Beck MH. (2003). The role of patch teating in perineal disorders. Exogenous Dermatology, 2, eScholarID:1d20263
  • Young H, Griffiths CEM. (2003). Immunotherapy in Psoriasis. Giornale Italiano di Dermatologia e Venereologia, 138, 349-354. eScholarID:1d7609
  • Young H, Griffiths CEM. (2003). New biological response modifiers for inflammatory skin disease. Postgraduate Doctor Caribbean, 19, eScholarID:83589
  • Young H, Griffiths CEM. (2003). Treatment resistance in psoriasis. Doctor, eScholarID:83591
  • Young H, Khan A, Power S, Ehrhardt P, Coulson I. (2003). Case 4. Transient symptomatic zinc deficiency in a breast-fed premature infant: an acrodermatitis enteropathica-like eruption. Clin Exp Dermatol, 28( 1), 109-10. eScholarID:1d20260

2002

  • Young H, Coulson IH. (2002). Erythema elevatum diutinum. Treatment of Skin Disease: Comprehensive therapeutic strategies. 1st Edition. eScholarID:3d917
  • Bhushan M, Young H, Brenchley PEC, Griffiths CEM. (2002). Recent advances in cutaneous angiogenesis. Br J Dermatol, 147, 418-25. eScholarID:1d3764
  • Young H, Chalmers RJG, Griffiths CEM, August P. (2002). CO2 laser vaporization for disfiguring lupus pernio. J Cosmet Laser Ther, 4( 3-4), 87-90. eScholarID:1d11987

2001

  • Young H, Kirby B, Stewart EJC. (2001). Aggressive, extensive, vasculitic leg ulceration associated with hydroxyurea therapy and a fatal outcome. Clin Exp Dermatol, 26, 664-7. eScholarID:1d3774

2000

  • Young H, Coulson I. (2000). Granuloma annulare following waxing induced pseudofolliculitis-resolution with isotretinoin. Clin Exp Dermatol, 25( 4), 274-6. eScholarID:1d20256
  • Young H, Coulson IH. (2000). Linear IgA Disease: successful treatment with cyclosporin. British Journal Of Dermatology, 143, 204-5. eScholarID:1d32764
  • Young H, Khan ASA, Kendra JR, Coulson IH. (2000). The cutaneous side-effects of hydroxyurea. Clin Lab Haem, 22, 229-32. eScholarID:1d3775

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