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School of Medicine

Mr Nizar Yonan 

Consultant Cardiothoracic Surgeon/ Director of Transplant

 

Research

Mr. Nizar Yonan ‘s main academic work is related to relations between clinical heart and lung transplantation and basic, applied and clinical immunology. This is the heart of translational research. He is also pioneered, researched, and developed few clinical advances in thoracic transplantation that is applied routinely not only in UK, but in Europe and internationally namely the clinical development of the bicaval Wythenshawe technique for heart transplantation, the use of pulmonary vein gas analysis in assessing donor lung function and the use of retrograde pulmonary perfusion in lung donation. More recently, he developed the finger prick testing for cyclosporine and use of postal delivery of samples in the that simplified monitoring of transplant patients. Mr Yonan has authored and co-authored nearly 120 articles in peer reviewed journals and contributed to a chapter in books on lung transplantation. He has delivered more than fifty invited lectures as well as presentation of major work at national and international meetings.

 

Methodological Knowledge

Key words

  • Heart transplant
  • Lung transplant
  • Rejection, immunosuppression (IS)
  • Organ retrieval, donor preservation
  • Cytokines, chemokines, growth factors
     
 

Biography

Mr Nizar Yonan is the Director of Transplant program and a Consultant Cardiothoracic Surgeon at the Transplant Centre, Wythenshawe Hospital , Manchester and an Honorary Senior Lecturer within the Division of Translational Medicine at the University of Manchester . He is also the director of the Transplant Research Laboratory, which is a centre of excellence for translational research, leading to an average of 20 international presentations per year and over 200 peer reviewed publications in the last 10 years. Mr Yonan undertook his MD degree within this facility and also at the Department of Immunology (who he is closely linked with) at Manchester University . During his time at the transplant centre and research lab, Mr Yonan has personally contributed to over 115 peer reviewed experimental and review articles. He reviews regularly for several journals, and he is a member of the editorial board for the Journal of Cardiac Surgery. Mr Yonan is also a member of the reviewing panel for the Society of Cardiothoracic surgery for and , and examiner for the Royal College of Surgeons of Edinburgh, a member of the cardiac and pulmonary councils for the International Society for Heart and lung transplantation and an invited advisor for the Department of Health and UK Transplant. Since the start of his medical career, Mr Yonan has always been attracted to clinical an basic science research, which he sees as a major vocational aspect of his clinical daily work. Research with major international impact includes the development of the bi-caval technique for heart transplantation, his group were the first to design and use retrograde pulmonplegia in clinical transplantation and the use of pulmonary vein gas in assessment of individual donor lungs. A more recent work including the development and advancement of the concept of tailoring immunosuppressive treatment that he enhanced by using IS drug monitoring namely C2 and MPA and tacrolimus. Mr Yonan is a member of UKT advisory committee, national VAD forum, and helped developing national guidelines in heart and lung transplantation and temporary ventricular assist devices. He is the transplant and university representative at the north-west deanery training committee for CT surgery. He plays a very active role in undergraduate and postgraduate teaching. He is a trustee for the New Start charity.

 

Publications

2009

  • Fildes JE, Shaw SM, Williams SG, Yonan NN A. (2009). Potential immunologic effects of statins in cancer following transplantation. Cancer Immunol Immunother, 58, 461-7. eScholarID:1d17633 | DOI:10.1007/s00262-008-0541-2
  • Shaw SM, Fildes JE, Yonan NN A, Williams SG. (2009). Pleiotropic Effects and Cholesterol-Lowering Therapy. Cardiology, 112( 1), 4-12. eScholarID:1d17631

2008

  • Fildes JE, Shaw S, Mitsidou A, Rogacev K, Leonard C, Williams S, Yonan NN A. (2008). HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation. Transpl Immunol, 19( 2), 152-7. eScholarID:1d17634
  • Fildes JE, Shaw S, Yonan NN A, Williams S. (2008). Non-specific immunomodulation in chronic heart failure. Lancet, 371( 9630), eScholarID:1d17632
  • Fildes JE, Walker A, Williams S, Yonan NN A, Leonard C. (2008). CMV infection is associated with the depletion but lack of activation of peripheral blood natural killer cells in a lung transplant cohort. Transpl Immunol, 19( 3-4), 235-7. eScholarID:1d17630
  • Fildes JE, Yonan NN A, Leonard C. (2008). Natural killer cells and lung transplantation, roles in rejection, infection, and tolerance. Transpl Immunol, 19( 1), 1-11. eScholarID:1d17635
  • Fildes JE, Yonan NN A, Tunstall K, Walker A, Griffiths-Davies L, Bishop P, Leonard C. (2008). Natural killer cells in peripheral blood and lung tissue are associated with chronic rejection after lung transplantation. J Heart Lung Transplant, 27( 2), 203-7. eScholarID:1d17636

2007

  • Bittar M, Khasati N, Deiraniya A, Yonan NN A. (2007). Interleukin-4 C-590T polymorphism has no role in coronary artery bypass surgery. Asian Cardiovasc Thorac Ann, 15( 3), 214-7. eScholarID:1d32162
  • Fildes JE, Williams S, Yonan NN A. (2007). Large population sizes are a prerequisite for genetic association studies. J Heart Lung Transplant, 26( 1), eScholarID:1d17638
  • Hummel M, Yonan NN A, Ross H, Miller L, Sechaud R, Balez S, Koelle E, Gerosa G. (2007). Pharmacokinetics and variability of mycophenolic acid from enteric-coated mycophenolate sodium compared with mycophenolate mofetil in de novo heart transplant recipients. Clin Transplant, 21( 1), 18-23. eScholarID:1d31962
  • Khan N, Al-Aloul M, Khasati N, Machaal A, Leonard CT, Yonan NN A. (2007). Extracorporeal membrane oxygenator as a bridge to successful surgical repair of bronchopleural fistula following bilateral sequential lung transplantation: a case report and review of literature. J Cardiothorac Surg, 2, eScholarID:1d31750
  • Khasati N, Machaal A, Barnard J, Yonan NN A. (2007). Donor heart selection: the outcome of "unacceptable" donors. J Cardiothorac Surg, 2, eScholarID:1d32079
  • Shaw S, Fildes JE, Yonan NN A, Williams S. (2007). Does brain natriuretic peptide interact with the immune system after cardiac transplantation? Transplantation, 84( 11), 1377-81. eScholarID:1d17637

2006

  • Barnard J, Richardson S, Sheldon S, Fildes JE, Pravica V, Hutchinson I, Leonard CT, Yonan NN A. (2006). The MDR1/ABCB1 gene, a high-impact risk factor for cardiac transplant rejection. Transplantation, 82( 12), 1677-82. eScholarID:1d16805
  • Barnard J, Thekkudan J, Richardson S, Bittar M, Martyszczuck R, Hasan J, Khasati N, Keevil B, Yonan NN A. (2006). Cyclosporine profiling with C2 and C0 monitoring improves outcomes after heart transplantation. J Heart Lung Transplant, 25( 5), 564-8. eScholarID:1d32361
  • Bittar M, Carey J, Barnard J, Pravica V, Deiraniya A, Yonan NN A, Hutchinson I. (2006). Tumor necrosis factor alpha influences the inflammatory response after coronary surgery. Ann Thorac Surg, 81( 1), 132-7. eScholarID:1d32134
  • Grimm, M, Rinaldi, M, Yonan, NN A, Arpesella, G, Arizón Del Prado, J, Pulpón, L, Villemot, J, Frigerio, M, Rodriguez Lambert, J, Crespo-Leiro, M, Almenar, L, Duveau, D, Ordonez-Fernandez, A, Gandjbakhch, J, Maccherini, M, Laufer, G. (2006). Superior prevention of acute rejection by tacrolimus vs. cyclosporine in heart transplant recipients--a large European trial. Am J Transplant, 6( 6), 1387-97. eScholarID:1d31894
  • Kobashigawa, J, Renlund, D, Gerosa, G, Almenar, L, Eisen, H, Keogh, A, Lehmkuhl, H, Livi, U, Ross, H, Segovia, J, Yonan, NN A, NULL. (2006). Similar efficacy and safety of enteric-coated mycophenolate sodium (EC-MPS, myfortic) compared with mycophenolate mofetil (MMF) in de novo heart transplant recipients: results of a 12-month, single-blind, randomized, parallel-group, multicenter study. J Heart Lung Transplant, 25( 8), 935-41. eScholarID:1d31963
  • Yonan NN A, Martyszczuk R, Machaal A, Baynes A, Keevil B. (2006). Monitoring of cyclosporine levels in transplant recipients using self-administered fingerprick sampling. Clin Transplant, 20( 2), 221-5. eScholarID:1d32362

2005

  • Allen D, Fildes JE, Yonan NN A, Leonard CT. (2005). Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients. J Heart Lung Transplant, 24( 1), 88-91. eScholarID:1d29755
  • Azzawi M, Kan S, Hillier V, Yonan NN A, Hutchinson I, Hasleton P. (2005). The distribution of cardiac macrophages in myocardial ischaemia and cardiomyopathy. Histopathology, 46( 3), 314-9. eScholarID:1d29681
  • Bittar M, Carey J, Barnard J, Fildes JE, Pravica V, Yonan NN A, Hutchinson I. (2005). Interleukin 6 G-174C polymorphism influences outcome following coronary revascularization surgery. Heart Surg Forum, 8( 3), E140-5; discussion E145. eScholarID:1d29287
  • Densem C, Ray M, Hutchinson I, Yonan NN A, Brooks N. (2005). Interleukin-6 polymorphism: a genetic risk factor for cardiac transplant related coronary vasculopathy? J Heart Lung Transplant, 24( 5), 559-65. eScholarID:1d29615
  • Fildes JE, Walker A, Densem C, Deiraniya A, Hutchinson I, Leonard CT, Yonan NN A. (2005). Angiotensin converting enzyme insertion/deletion polymorphism does not influence postcardiac transplantation hypertension onset or progression. J Heart Lung Transplant, 24( 4), 406-10. eScholarID:1d29616
  • Fildes JE, Walker A, Howlett R, Bittar M, Hutchinson I, Leonard CT, Yonan NN A. (2005). Donor CCR5 Delta32 polymorphism and outcome following cardiac transplantation. Transplant Proc, 37( 5), 2247-9. eScholarID:1d28898
  • Fildes JE, Walker A, Keevil B, Hutchinson I, Leonard CT, Yonan NN A. (2005). The effects of ACE inhibition on serum angiotensin II concentration following cardiac transplantation. Transplant Proc, 37( 10), 4525-7. eScholarID:1d16804
  • Khasati N, Barnard J, Bittar M, Machaal A, Waterworth P, Yonan NN A. (2005). Donor heart selection: Wythenshawe experience. Transplant Proc, 37( 2), 1331-2. eScholarID:1d28905
  • Khasati N, MacHaal A, Thekkudan J, Kumar S, Yonan NN A. (2005). An aberrant donor pulmonary vein during lung transplant: a surgical challenge. Ann Thorac Surg, 79( 1), 330-1. eScholarID:1d30713
  • Polster K, Walker A, Fildes JE, Entwistle G, Yonan NN A, Hutchinson I, Leonard CT. (2005). CD4-veCD8-ve CD30+ve T cells are detectable in human lung transplant patients and their proportion of the lymphocyte population after in vitro stimulation with donor spleen cells correlates with preservation of lung physiology. Transplant Proc, 37( 5), 2257-60. eScholarID:1d11257

2004

  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (2004). Donor and recipient-transforming growth factor-beta 1 polymorphism and cardiac transplant-related coronary artery disease. Transpl Immunol, 13( 3), 211-7. eScholarID:1d28854
  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (2004). Influence of IFN-gamma polymorphism on the development of coronary vasculopathy after cardiac transplantation. Ann Thorac Surg, 77( 3), 875-80. eScholarID:1d29464
  • Densem C, Mutlak A, Pravica V, Brooks N, Yonan NN A, Hutchinson I. (2004). A novel polymorphism of the gene encoding furin, a TGF-beta1 activator, and the influence on cardiac allograft vasculopathy formation. Transpl Immunol, 13( 3), 185-90. eScholarID:1d29463
  • Densem C, Wassel J, Cooper A, Yonan NN A, Brooks N, Keevil B. (2004). Haptoglobin phenotype correlates with development of cardiac transplant vasculopathy. J Heart Lung Transplant, 23( 1), 43-9. eScholarID:1d28855
  • Walker A, Fildes JE, Leonard CT, Yonan NN A. (2004). The influence of donor age on transplant coronary artery disease and survival post heart transplantation: is it safe to extend donor age? Transplant Proc, 36( 10), 3139-41. eScholarID:1d30712

2003

  • Aziz T, Burgess M, Haselton P, Yonan NN A, Hutchinson I. (2003). Transforming growth factor beta and diastolic left ventricular dysfunction after heart transplantation: echocardiographic and histologic evidence. J Heart Lung Transplant, 22( 6), 663-73. eScholarID:1d28570
  • Burgess M, Bright-Thomas R, Yonan NN A, Ray S. (2003). Can the index of myocardial performance be used to detect acute cellular rejection after heart transplantation? Am J Cardiol, 92( 3), 308-11. eScholarID:1d28554
  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (2003). Influence of interleukin-10 polymorphism on the development of coronary vasculopathy following cardiac transplantation. Transpl Immunol, 11( 2), 223-8. eScholarID:1d29957

2002

  • Aziz T, El-Gamel A, Saad R, Migliore M, Campbell C, Yonan NN A. (2002). Pulmonary vein gas analysis for assessing donor lung function. Ann Thorac Surg, 73( 5), 1599-604; discussion 1604-5. eScholarID:1d28499
  • Aziz T, Saad R, Burgess M, Campbell C, Yonan NN A. (2002). Clinical significance of tricuspid valve dysfunction after orthotopic heart transplantation. J Heart Lung Transplant, 21( 10), 1101-8. eScholarID:1d29899
  • Bridgewater B, Hooper T, Campbell C, Jones M, Carey J, Waterworth P, Deiraniya A, Yonan NN A. (2002). Performance league tables. Publication of league tables needs to be open and accurate. BMJ, 324( 7336), eScholarID:1d28985
  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (2002). Tumour necrosis factor alpha gene polymorphism: a predisposing factor to non-ischaemic myocardial dysfunction? Heart, 87( 2), 153-5. eScholarID:1d32164
  • Egan J, Carroll K, Yonan NN A, Woodcock A, Crisp A. (2002). Valacyclovir prevention of cytomegalovirus reactivation after heart transplantation: a randomized trial. J Heart Lung Transplant, 21( 4), 460-6. eScholarID:1d31965
  • Haider Y, Yonan NN A, Mogulkoc N, Carroll K, Egan J. (2002). Bronchiolitis obliterans syndrome in single lung transplant recipients--patients with emphysema versus patients with idiopathic pulmonary fibrosis. J Heart Lung Transplant, 21( 3), 327-33. eScholarID:1d32163
  • Howell J, Yonan NN A, Dunn P, Aslan T. (2002). Performance league tables. League tables are unreasonably simple. BMJ, 324( 7336), eScholarID:1d32088
  • Keevil B, Tierney D, Cooper D, Morris M, Machaal A, Yonan NN A. (2002). Simultaneous and rapid analysis of cyclosporin A and creatinine in finger prick blood samples using liquid chromatography tandem mass spectrometry and its application in C2 monitoring. Ther Drug Monit, 24( 6), 757-67. eScholarID:1d30091
  • Patel N, Grayson A, Jackson M, Au J, Yonan NN A, Hasan R, Fabri B. (2002). The effect off-pump coronary artery bypass surgery on in-hospital mortality and morbidity. Eur J Cardiothorac Surg, 22( 2), 255-60. eScholarID:1d28984
  • Walker A, Keevil B, Yonan NN A. (2002). An investigation of the correlation between C-reactive protein, serum amyloid a concentration, and cardiac allograft rejection. Transplant Proc, 34( 4), 1279-80. eScholarID:1d31895

2001

  • Aziz T, Burgess M, Hasleton PP S, Yonan NN A, Deiraniya A, Hutchinson I. (2001). Transforming growth factor-beta: association with arteriosclerosis and left ventricular dysfunction after heart transplantation. Transplant Proc, 33( 3), 2334-6. eScholarID:1d28426
  • Aziz T, Burgess M, Rahman A, Campbell C, Yonan NN A. (2001). Cardiac transplantation for cardiomyopathy and ischemic heart disease: differences in outcome up to 10 years. J Heart Lung Transplant, 20( 5), 525-33. eScholarID:1d31896
  • Aziz T, El-Gamel A, Yonan NN A. (2001). Pulmonary vein gas analysis for assessing of donor lung function. J Heart Lung Transplant, 20( 2), eScholarID:1d32595
  • Aziz T, Saad R, Burgess M, Yonan NN A, Hasleton P, Hutchinson I. (2001). Transforming growth factor beta and myocardial dysfunction following heart transplantation. Eur J Cardiothorac Surg, 20( 1), 177-86. eScholarID:1d29081
  • Azzawi M, Hasleton P, Turner D, Yonan NN A, Deiraniya A, Sinnott P, Hutchinson I. (2001). Tumor necrosis factor-alpha gene polymorphism and death due to acute cellular rejection in a subgroup of heart transplant recipients. Hum Immunol, 62( 2), 140-2. eScholarID:1d32142
  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (2001). Influence of tumor necrosis factor-alpha gene-308 polymorphism on the development of coronary vasculopathy after cardiac transplantation. J Heart Lung Transplant, 20( 12), 1265-73. eScholarID:1d32089
  • Densem C, Hutchinson IV, Yonan NN A, Brooks NH. (2001). Tumour necrosis factor- a A2 polymorphism; a predisposing factor to non-ischaemic myocardial dysfunction? J Heart Lung Transplant, 20( 2), 159-160. eScholarID:1d32471
  • Densem CG, Wassel J, Brooks NH, Yonan NN A, Keevil B. (2001). Haptoglobin polymorphism influences the development of cardiac transplant vasculopathy. J Heart Lung Transplant, 20( 2), eScholarID:1d32596

2000

  • Aziz T, Burgess M, Rahman A, Campbell C, Deiraniya A, Yonan NN A. (2000). Early and long-term results of heart transplantation after previous cardiac surgery. Eur J Cardiothorac Surg, 17( 4), 349-54. eScholarID:1d32143
  • Aziz T, Hasleton P, Hann A, Yonan NN A, Deiraniya A, Hutchinson I. (2000). Transforming growth factor beta in relation to cardiac allograft vasculopathy after heart transplantation. J Thorac Cardiovasc Surg, 119( 4 Pt 1), 700-8. eScholarID:1d32597
  • Barber L, Egan J, Lomax J, Haider Y, Yonan NN A, Woodcock A, Turner A, Fox A. (2000). A prospective study of a quantitative PCR ELISA assay for the diagnosis of CMV pneumonia in lung and heart-transplant recipients. J Heart Lung Transplant, 19( 8), 771-80. eScholarID:1d32369
  • Burgess M, Aziz T, Ray S, Yonan NN A, Brooks N. (2000). Value of echocardiography in predicting long term outcome after heart transplantation. Heart, 83( 1), 105-6. eScholarID:1d32472
  • Densem C, Hutchinson I, Cooper A, Yonan NN A, Brooks N. (2000). Polymorphism of the transforming growth factor-beta 1 gene correlates with the development of coronary vasculopathy following cardiac transplantation. J Heart Lung Transplant, 19( 6), 551-6. eScholarID:1d32370

1999

  • Awad M, Pravica V, Perrey C, El Gamel A, Yonan NN A, Sinnott P, Hutchinson I. (1999). CA repeat allele polymorphism in the first intron of the human interferon-gamma gene is associated with lung allograft fibrosis. Hum Immunol, 60( 4), 343-6. eScholarID:1d31967
  • Aziz T, Burgess M, Acladious N, Campbell C, Rahman A, Yonan NN A, Deiraniya A. (1999). Heart transplantation for peripartum cardiomyopathy: a report of three cases and a literature review. Cardiovasc Surg, 7( 5), 565-7. eScholarID:1d32135
  • Aziz T, Burgess M, Deiraniya A, Yonan NN A. (1999). Orthotopic heart transplantation: which technique? A comment on the prospective randomised trial of CAVT by Bainbridge et al. J Heart Lung Transplant, 18( 12), 1253-4. eScholarID:1d31897
  • Aziz T, Burgess M, El-Gamel A, Campbell C, Rahman A, Deiraniya A, Yonan NN A. (1999). Orthotopic cardiac transplantation technique: a survey of current practice. Ann Thorac Surg, 68( 4), 1242-6. eScholarID:1d32165
  • Aziz T, Burgess M, Khafagy R, Wynn Hann A, Campbell C, Rahman A, Deiraniya A, Yonan NN A. (1999). Bicaval and standard techniques in orthotopic heart transplantation: medium-term experience in cardiac performance and survival. J Thorac Cardiovasc Surg, 118( 1), 115-22. eScholarID:1d31898
  • Aziz T, Burgess M, Rahman A, Campbell C, Deiraniya A, Yonan NN A. (1999). Risk factors for tricuspid valve regurgitation after orthotopic heart transplantation. Ann Thorac Surg, 68( 4), 1247-51. eScholarID:1d32090
  • Aziz T, Burgess M, Rahman A, Campbell C, Deiraniya A, Yonan NN A. (1999). Zonal allocation for thoracic organs in the united kingdom: Has it been successful? A single-center view. J Thorac Cardiovasc Surg, 118( 4), 733-9. eScholarID:1d32473
  • Barber L, Egan J, Turner A, Guiver M, Woodcock A, Yonan NN A, Deiraniya A, Fox A. (1999). The development of a quantitative PCR ELISA to determine HCMV DNAaemia levels in heart, heart/lung and lung transplant recipients. J Virol Methods, 82( 1), 85-97. eScholarID:1d32172
  • Burgess M, Aziz T, Yonan NN A. (1999). Clinical relevance of subclinical tricuspid regurgitation after orthotopic cardiac transplantation. J Am Soc Echocardiogr, 12( 2), eScholarID:1d32474
  • Densem C, Hutchinson I, Yonan NN A, Brooks N. (1999). TGF-beta gene polymorphism does not influence the rise in creatinine following cardiac transplantation. Transpl Immunol, 7( 4), 247-9. eScholarID:1d32598
  • El-Gamel, A, Awad, M, Hasleton, P, Yonan, NN A, Hutchinson, J, Campbell, C, Rahman, A, Deiraniya, A, Sinnott, P, Hutchinson, I. (1999). Transforming growth factor-beta (TGF-beta1) genotype and lung allograft fibrosis. J Heart Lung Transplant, 18( 6), 517-23. eScholarID:1d31964
  • El-Gamel, A, Sim, E, Hasleton, P, Hutchinson, J, Yonan, NN A, Egan, J, Campbell, C, Rahman, A, Sheldon, S, Deiraniya, A, Hutchinson, I. (1999). Transforming growth factor beta (TGF-beta) and obliterative bronchiolitis following pulmonary transplantation. J Heart Lung Transplant, 18( 9), 828-37. eScholarID:1d32091
  • Sheldon S, Yonan NN A, Aziz T, Hasleton P, Rahman A, Deiraniya A, Campbell C, Dyer P. (1999). The influence of histocompatibility on graft rejection and graft survival within a single center population of heart transplant recipients. Transplantation, 68( 4), 515-9. eScholarID:1d32470
  • Tang A, El-Gamel A, Keevil B, Yonan NN A, Deiraniya A. (1999). The effect of 'renal-dose' dopamine on renal tubular function following cardiac surgery: assessed by measuring retinol binding protein (RBP). Eur J Cardiothorac Surg, 15( 5), 717-21; discussion 721-2. eScholarID:1d31966

1998

  • Aziz T, el-Gamel A, Keevil B, Krysiak P, Campbell C, Rahman A, Deiraniya A, Yonan NN A. (1998). Clinical impact of Neoral in thoracic organ transplantation. Transplant Proc, 30( 5), 1900-3. eScholarID:1d32173
  • Aziz T, el-Gamel A, Keevil B, Martyszczuk R, Campbell C, Rahman A, Deiraniya A, Yonan NN A. (1998). Clinical impact of Neoral in heart transplantation. Transplant Proc, 30( 4), 1152-3. eScholarID:1d32599
  • Aziz T, el-Gamel A, Krysiak P, Rahman A, Campbell C, Yonan NN A, Deiraniya A. (1998). Risk factors for early mortality, acute rejection, and factors affecting first-year survival after heart transplantation. Transplant Proc, 30( 5), 1912-4. eScholarID:1d31975
  • Aziz T, el-Gamel A, Krysiak P, Rahman A, Campbell C, Yonan NN A, Deiraniya A. (1998). Ten year experience in orthotopic heart transplantation: single center result. Transplant Proc, 30( 5), 1915-6. eScholarID:1d32475
  • Aziz T, Krysiak P, el-Gamel A, Campbell C, Rahman A, Deiraniya A, Isalska B, Yonan NN A. (1998). Bacteremia and endocarditis following endomyocardial biopsy. Transplant Proc, 30( 5), 2112-3. eScholarID:1d31905
  • Aziz T, Sheldon S, el-Gamel A, Krysiak P, Campbell C, Rahman A, Dyer P, Yonan NN A, Deiraniya A. (1998). Implication of HLA mismatch in the clinical outcome of orthotopic heart transplantation. Transplant Proc, 30( 5), 1917-9. eScholarID:1d31968
  • Azzawi M, Hasleton P, Geraghty P, Yonan NN A, Krysiak P, El-Gammal A, Deiraniya A, Hutchinson I. (1998). RANTES chemokine expression is related to acute cardiac cellular rejection and infiltration by CD45RO T-lymphocytes and macrophages. J Heart Lung Transplant, 17( 9), 881-7. eScholarID:1d32145
  • Egan, J, Lomax, J, Barber, L, Lok, S, Martyszczuk, R, Yonan, NN A, Fox, A, Deiraniya, A, Turner, A, Woodcock, A. (1998). Preemptive treatment for the prevention of cytomegalovirus disease: in lung and heart transplant recipients. Transplantation, 65( 5), 747-52. eScholarID:1d31906
  • El Gamel A, Yonan NN A, Hassan R, Jones M, Campbell C, Deiraniya A, Lawson R. (1998). Treatment of mediastinitis: early modified Robicsek closure and pectoralis major advancement flaps. Ann Thorac Surg, 65( 1), 41-6; discussion 46-7. eScholarID:1d32379
  • el Gamel, A, Grant, S, Yonan, NN A, Keevil, B, Aziz, T, Deiraniya, A, Campbell, C, Rahman, A, Haselton, P, Hutchinson, I. (1998). Interleukin-10 and cellular rejection following cardiac transplantation. Transplant Proc, 30( 5), 2387-8. eScholarID:1d32371
  • El-Gamel A, Awad M, Sim E, Hasleton P, Yonan NN A, Egan J, Deiraniya A, Hutchinson I. (1998). Transforming growth factor-beta1 and lung allograft fibrosis. Eur J Cardiothorac Surg, 13( 4), 424-30. eScholarID:1d32098
  • el-Gamel A, Doran H, Aziz T, Rahman A, Deiraniya A, Campbell C, Yonan NN A. (1998). Natural history and the clinical importance of early and late grade 2 cellular rejection following cardiac transplantation. Transplant Proc, 30( 4), 1143-6. eScholarID:1d32483
  • el-Gamel A, Evans C, Keevil B, Aziz T, Rahman A, Campbell C, Deiraniya A, Yonan NN A. (1998). Effect of allopurinol on the metabolism of azathioprine in heart transplant patients. Transplant Proc, 30( 4), 1127-9. eScholarID:1d32600
  • el-Gamel, A, Awad, M, Yonan, NN A, Keevil, B, Egan, J, Campbell, C, Rahman, A, Haselton, P, Deiraniya, A, Hutchinson, I. (1998). Does cyclosporin promote the secretion of transforming growth factor-beta 1 following pulmonary transplantation? Transplant Proc, 30( 4), 1525-7. eScholarID:1d32174
  • Lok S, Smith E, Doran H, Sawyer R, Yonan NN A, Egan J. (1998). Idiopathic pulmonary fibrosis and cyclosporine: a lesson from single-lung transplantation. Chest, 114( 5), 1478-81. eScholarID:1d32144
  • Yonan NN A, Aziz T, el-Gamel A, Campbell C, Rahman A, Deiraniya A. (1998). Long-term safety and efficacy of Neoral in heart transplantation. Transplant Proc, 30( 5), 1906-9. eScholarID:1d32092
  • Yonan NN A, Bishop P, el-Gamel A, Hutchinson I. (1998). Tracheal allograft transplantation in rats: the role of immunosuppressive agents in development of obliterative airway disease. Transplant Proc, 30( 5), 2207-9. eScholarID:1d32372
  • Yonan NN A, el-Gamel A, Egan J, Kakadellis J, Rahman A, Deiraniya A. (1998). Single lung transplantation for emphysema: predictors for native lung hyperinflation. J Heart Lung Transplant, 17( 2), 192-201. eScholarID:1d32373

1997

  • el Gamel A, Keevil B, Rahman A, Campbell C, Deiraniya A, Yonan NN A. (1997). Cardiac allograft rejection: do trough cyclosporine levels correlate with the grade of histologic rejection? J Heart Lung Transplant, 16( 3), 268-74. eScholarID:1d32484
  • El Gamel A, Yonan NN A, Keevil B, Warbuton R, Kakadellis J, Woodcock A, Campbell C, Rahman A, Deiraniya A. (1997). Significance of raised natriuretic peptides after bicaval and standard cardiac transplantation. Ann Thorac Surg, 63( 4), 1095-100. eScholarID:1d32147
  • Turner D, Grant S, Yonan NN A, Sheldon S, Dyer P, Sinnott P, Hutchinson I. (1997). Cytokine gene polymorphism and heart transplant rejection. Transplantation, 64( 5), 776-9. eScholarID:1d32146

1996

  • Azzawi M, Grant S, Hasleton P, Yonan NN A, Campbell C, Deiraniya A, Rahman A, Hutchinson I. (1996). TNF alpha mRNA and protein in cardiac transplant biopsies: comparison with serum TNF alpha levels. Cardiovasc Res, 32( 3), 551-6. eScholarID:1d32485
  • Barber L, Egan J, Lomax J, Yonan NN A, Deiraniya A, Turner A, Woodcock A, Fox A. (1996). Comparative study of three PCR assays with antigenaemia and serology for the diagnosis of HCMV infection in thoracic transplant recipients. J Med Virol, 49( 2), 137-44. eScholarID:1d32099
  • Egan J, Lowe L, Yonan NN A, Rahman A, Campbell C, Deiraniya A, Carroll K, Woodcock A. (1996). Pulmonary diffusion impairment following heart transplantation: a prospective study. Eur Respir J, 9( 4), 663-8. eScholarID:1d32100
  • Egan J, Martin N, Hasleton P, Yonan NN A, Rahman A, Campbell C, Deiraniya A, Carroll K, Woodcock A. (1996). Pulmonary interstitial fibrosis and haemosiderin-laden macrophages: late following heart transplantation. Respir Med, 90( 9), 547-51. eScholarID:1d31907
  • Egan J, Stewart J, Hasleton P, Yonan NN A, Bishop P, Arrand J, Rahman A, Carroll K, Woodcock A. (1996). Epstein-Barr virus associated graft failure following heart/lung transplantation. Thorax, 51( 11), 1160-2; discussion 1164-5. eScholarID:1d32087
  • Egan J, Yonan NN A, Carroll K, Deiraniya A, Webb A, Woodcock A. (1996). Allergic bronchopulmonary aspergillosis in lung allograft recipients. Eur Respir J, 9( 1), 169-71. eScholarID:1d31977
  • El Gamel A, Campbell C, Yonan NN A, Keevil B, Warbuton R, Woodcock A, Deiraniya A. (1996). Atrial natriuretic peptide release after cardiac transplantation. J Thorac Cardiovasc Surg, 112( 4), 1128-9. eScholarID:1d32602
  • el Oakley R, Yonan NN A, Simpson B, Deiraniya A. (1996). Extended criteria for cardiac allograft donors: a consensus study. J Heart Lung Transplant, 15( 3), 255-9. eScholarID:1d31976
  • el-Gamel A, Bridgewater B, Doran H, Yonan NN A, Campbell C, Hooper T. (1996). Severe mitral valve dysfunction due to unsuspected granulomatous myocarditis: successful cardiac transplantation following attempted mitral valve repair. Eur J Cardiothorac Surg, 10( 8), 702-4. eScholarID:1d32486
  • el-Gamel A, Deiraniya A, Rahman A, Campbell C, Yonan NN A. (1996). Orthotopic heart transplantation hemodynamics: does atrial preservation improve cardiac output after transplantation? J Heart Lung Transplant, 15( 6), 564-71. eScholarID:1d32175
  • el-Gamel A, Doran H, Rahman A, Deiraniya A, Campbell C, Yonan NN A. (1996). Clinical importance of grade 2 cellular heart rejection. J Heart Lung Transplant, 15( 3), 319-21. eScholarID:1d32176
  • el-Gamel A, Egan J, Rahman A, Deiraniya A, Yonan NN A. (1996). Application of pulmonary vein gas analysis: a novel approach which may increase the pool of potential lung transplant donors. J Heart Lung Transplant, 15( 3), 315-6. eScholarID:1d31908
  • Hasleton P, Woodcock A, Yonan NN A, Deiraniya A. (1996). Should cryptogenic organizing pneumonia be included in the classification of pulmonary allograft rejection? J Heart Lung Transplant, 15( 12), 1268-9. eScholarID:1d32601

1995

  • Egan J, Hasleton P, Yonan NN A, Rahman A, Deiraniya A, Carroll K, Woodcock A. (1995). Necrotic, ulcerative bronchitis, the presenting feature of lymphoproliferative disease following heart-lung transplantation. Thorax, 50( 2), 205-7. eScholarID:1d31909
  • Egan, J, Barber, L, Lomax, J, Fox, A, Yonan, NN A, Rahman, A, Campbell, C, Deiraniya, A, Carroll, K, Craske, J. (1995). Detection of human cytomegalovirus antigenaemia: a rapid diagnostic technique for predicting cytomegalovirus infection/pneumonitis in lung and heart transplant recipients. Thorax, 50( 1), 9-13. eScholarID:1d32177
  • el Gamel A, Yonan NN A, Grant S, Deiraniya A, Rahman A, Sarsam M, Campbell C. (1995). Orthotopic cardiac transplantation: a comparison of standard and bicaval Wythenshawe techniques. J Thorac Cardiovasc Surg, 109( 4), 721-9; discussion 729-30. eScholarID:1d31979
  • el Gamel A, Yonan NN A, Rahman A, Deiraníya A, Campbell C, Sarsam M. (1995). The clinical benefit of the bicaval technique for cardiac transplantation. J Thorac Cardiovasc Surg, 109( 6), 1257-9. eScholarID:1d31978
  • el Gamel A, Yonan NN A, Rahman A, Deiraniya A, Campbell C, Sarsam M. (1995). Alternative heart transplantation technique. Ann Thorac Surg, 59( 1), 258-60. eScholarID:1d32101
  • el-Gamel A, Yonan NN A, Egan J, Smith K, Campbell C, Rahman A, Deiraniya A. (1995). The histological grade of rejection does not relate to intracardiac pressures. Transplant Proc, 27( 3), 1947-9. eScholarID:1d32167
  • el-Gamel A, Yonan NN A, Keevil B, Nicholls S, Smith K, Campbell C, Rahman A, Deiraniya A. (1995). Measurement of microalbumin and retinol binding protein in cardiac and lung transplant recipients. Transplant Proc, 27( 3), 1969-72. eScholarID:1d32381
  • Grant S, Khan M, Faragher E, Yonan NN A, Brooks N. (1995). Atrial arrhythmias and pacing after orthotopic heart transplantation: bicaval versus standard atrial anastomosis. Br Heart J, 74( 2), 149-53. eScholarID:1d32380
  • Grant S, Lamb W, Yonan NN A, Hutchinson I, Brenchley P. (1995). Antithymocyte globulin preparations after heart transplantation. Cytokine responses in vivo and in vitro. Transplantation, 60( 7), 684-9. eScholarID:1d32166
  • Yonan NN A, Egan J, Deiraniya A, Rahman A. (1995). Right lower lobe herniation after domino heart-lung transplantation. Ann Thorac Surg, 59( 5), 1223-6. eScholarID:1d32487

1994

  • Egan J, Stewart J, Yonan NN A, Arrand J, Woodcock A. (1994). Non-Hodgkin lymphoma in heart/lung transplant recipients. Lancet, 343( 8895), eScholarID:1d32603
  • el Gamel A, Yonan NN A, Rahman A, Deiraniya A, Campbell C. (1994). Thrombotic complications after heart transplantation. J Heart Lung Transplant, 13( 6), 1146-7. eScholarID:1d32184
  • el-Gamel A, Yonan NN A, Rahman A, Deiraniya A, Campbell C. (1994). Donor lung procurement. Ann Thorac Surg, 58( 1), 276-7. eScholarID:1d32494
  • Sheldon S, Hasleton P, Yonan NN A, Rhaman A, Deiraniya A, Campbell C, Brooks N, Dyer P. (1994). Rejection in heart transplantation strongly correlates with HLA-DR antigen mismatch. Transplantation, 58( 6), 719-22. eScholarID:1d32102

1993

  • Egan J, Kalra S, Yonan NN A, Hasleton P, Brooks N, Woodcock A. (1993). Pulmonary diffusion abnormalities in heart transplant recipients. Relationship to cytomegalovirus infection. Chest, 104( 4), 1085-9. eScholarID:1d31910
  • Sarsam M, Campbell C, Yonan NN A, Deiraniya A, Rahman A. (1993). An alternative surgical technique in orthotopic cardiac transplantation. J Card Surg, 8( 3), 344-9. eScholarID:1d32604
  • Sarsam M, Yonan NN A, Beton D, McMaster D, Deiraniya A. (1993). Early pulmonary vein thrombosis after single lung transplantation. J Heart Lung Transplant, 12( 1 Pt 1), 17-9. eScholarID:1d32168
  • Sarsam M, Yonan NN A, Deiraniya A, Rahman A. (1993). Retrograde pulmonaryplegia for lung preservation in clinical transplantation: a new technique. J Heart Lung Transplant, 12( 3), 494-8. eScholarID:1d32495

1991

  • Hasan R, Deiranyia A, Yonan NN A. (1991). Effect of intra-aortic balloon counterpulsation on right-left shunt following right ventricular infarction. Int J Cardiol, 33( 3), 439-42. eScholarID:1d32169
  • Hasan R, Yonan NN A, Lawson R. (1991). Adrenal insufficiency due to bilateral metastases from oat cell carcinoma of the oesophagus. Eur J Cardiothorac Surg, 5( 6), 336-7. eScholarID:1d32382

1990

  • Hasan R, Yonan NN A, Moussalli H. (1990). Technique of dissecting the internal mammary after using the Moussalli bar. Eur J Cardiothorac Surg, 4( 10), 571-2. eScholarID:1d32383

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