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School of Medicine

Professor Gus McGrouther 

Photograph of Gus McGrouther

Professor of Plastic And Reconstructive Surgery Research

 

Research

From a background of surgery and bioengineering, Gus has pursued research with a general theme of understanding how physical influences (tension, strain) affect repair processes in the healing of various tissues. Studies have ranged from anatomy, to cell culture and molecular biology. Specific areas of current laboratory activity are tendon repair, skin graft incorporation and revascularisation, skin wound healing focussing on the partial thickness injury as in burns or skin grafting, and peripheral nerve repair in collaboration with Professor Terenghi.

The organised structure of tendon facilitates the tracking of cell movements, proliferation, apoptosis and gene expression, while simultaneously allowing the mathematical modelling of the strain environment of individual cells. The interactions between physical forces and growth factors in modifying repair processes can be assessed and the lessons learned can be applied to repair in more complex structures such as skin. Large human volunteer studies are in place to look at partial thickness skin injuries comparing scarring (deeper) and non-scarring (more-superficial) wounds.

Several clinical trials have commenced including: the use of anti-scarring agents in the excision of benign skin lesions from the head and neck; surgical scar revisions; repair of large nerves in the wrist and forearm with an implantable biodegradable conduit.

A National Wound Care Evaluation and Research Unit is planned at Wythenshawe Hospital to facilitate translational research in clinical wound treatment trials.

 

Biography

Gus qualified in surgery, MBChB, MD(Honours) at Glasgow, and in Bioengineering (M.Sc) at Strathclyde. He is a FRCS (England, Glasgow and Edinburgh). He was appointed to the first UK chair of Plastic and Reconstructive Surgery and was recruited from UCL to develop the University Plastic and Reconstructive Surgery Research Group.

Gus has an active surgical practice at the University of South Manchester Hospital which facilitates two-way translation of knowledge between laboratory and patients. He has developed a large laboratory activity, recruiting the Blond McIndoe Research group and Professor Giorgio Terenghi, with whom Gus jointly supervises several fields of tissue repair research relevant to reconstructive surgery. Gus provides a national ‘research hub’ acting as mentor or adviser for Reconstructive Surgery research fellows at many centres: RESTORE and Plastic Surgery Research Trust, University of Oxford and UCL. He is active in fundraising and research direction for numerous national charities.

He is a Fellow of the Academy of Medical Sciences and held a personal research merit award from the Royal Society. HRH Philip, Duke of Edinburgh attended his public lectures, 1989, 1995 and 2002. He has delivered numerous public lectures and acted as a media spokesman on issues such as ‘Disfigurement-The Last Bastion of Discrimination. Gus is Clinical Director of MIMIT (Manchester Integrating Medicine and Innovative Technology). He is a Council Member and Trustee of the Royal College of Surgeons.
 

 

Publications

2011

  • Bagabir, R., Syed, F., Rautemaa, R., McGrouther, D., Paus, R. & Bayat, A (2011). UP-REGULATION OF TOLL-LIKE RECEPTORS (TLR) 6, 7 AND 8 IN KELOID SCARS: DOES KELOID DISEASE REFLECT AN ABNORMAL INNATE IMMUNE RESPONSE TO VIRAL INFECTION? WOUND REPAIR AND REGENERATION, 19(2), A11-A11. eScholarID:126727
  • Bella, H., Bayat, A., Black, G. & McGrouther, K (2011). The evidence for a genetic link in keloid scarring: A British-African collaboration. BRITISH JOURNAL OF SURGERY, 98(6), E15-E15. eScholarID:126716
  • Bella, H., Bayat, A., Black, G., Yagi, K. & McGrouther, G (2011). The evidence for a genetic link in keloid scarring: The phenotype-genotype link. BRITISH JOURNAL OF SURGERY, 98(6), E12-E12. eScholarID:126771
  • Bella, H., Heise, M., Yagi, K., Black, G., McGrouther, D. & Bayat, A (2011). A Clinical Characterization of Familial Keloid Disease in Unique African Tribes Reveals Distinct Keloid Phenotypes. PLASTIC AND RECONSTRUCTIVE SURGERY, 127(2), 689-702. eScholarID:126680 | DOI:10.1097/PRS.0b013e3181fed645
  • Branford, O., Brown, R., McGrouther, D., Grobbelaar, A. & Mudera, V (2011). Shear-aggregated fibronectin with anti-adhesive properties. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 5(1), 20-31. eScholarID:126705 | DOI:10.1002/term.284
  • Mac Raighne, A., Fernandez, G., Maneuski, D., McGrouther, D. & O'Shea, V (2011). Medipix2 as a highly flexible scanning/imaging detector for transmission electron microscopy. JOURNAL OF INSTRUMENTATION, 6, eScholarID:126697
  • Payraudeau, N., McGrouther, D. & O'Kelly, K (2011). Quantification of Subsurface Damage in a Brittle Insulating Ceramic by Three-Dimensional Focused Ion Beam Tomography. MICROSCOPY AND MICROANALYSIS, 17(2), 240-245. eScholarID:126704 | DOI:10.1017/S1431927610094523
  • Payraudeau, N., McGrouther, D. & O'Kelly, K (2011). Quantification of Subsurface Damage in a Brittle Insulating Ceramic by Three-Dimensional Focused Ion Beam Tomography. MICROSCOPY AND MICROANALYSIS, 17(2), 240-245. eScholarID:126759 | DOI:10.1017/S1431927610094523
  • Rutkowski, D., Farhatullah, S., Watson, R., McGrouther, D., Ray, D., Mathews, L. & Bayat, A (2011). UNDERSTANDING STEROID RESPONSIVENESS IN KELOID PATIENTS: LASER DOPPLER AND SIASCOPY IMAGING PLUS LABORATORY EVALUATION OF TEMPORAL PUNCH BIOPSIES SHOW ABNORMALITIES IN THE GLUCOCORTICOID RECEPTOR IN STEROID RESISTANT KELOID SCARS. WOUND REPAIR AND REGENERATION, 19(2), A47-A47. eScholarID:126725
  • Sebastian, A., Syed, F., McGrouther, D., Colthurst, J., Paus, R. & Bayat, A (2011). A novel in vitro assay for electrophysiological research on human skin fibroblasts: Degenerate electrical waves downregulate collagen I expression in keloid fibroblasts. EXPERIMENTAL DERMATOLOGY, 20(1), 64-68. eScholarID:126679 | DOI:10.1111/j.1600-0625.2010.01150.x
  • Syed, F., Ahmadi, E., Iqbal, S., Singh, S., McGrouther, D. & Bayat, A (2011). Fibroblasts from the growing margin of keloid scars produce higher levels of collagen I and III compared with intralesional and extralesional sites: clinical implications for lesional site-directed therapy. BRITISH JOURNAL OF DERMATOLOGY, 164(1), 83-96. eScholarID:126691 | DOI:10.1111/j.1365-2133.2010.10048.x
  • Tan, K., McGrouther, D., Day, A., Milner, C. & Bayat, A (2011). Characterization of hyaluronan and TSG-6 in skin scarring: differential distribution in keloid scars, normal scars and unscarred skin. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 25(3), 317-327. eScholarID:126682 | DOI:10.1111/j.1468-3083.2010.03792.x
  • Taylor, S., Al-Youha, S., Van Agtmael, T., Lu, Y., Wong, J., McGrouther, D. & Kadler, K (2011). Tendon Is Covered by a Basement Membrane Epithelium That Is Required for Cell Retention and the Prevention of Adhesion Formation. PLOS ONE, 6(1), eScholarID:126765 | DOI:10.1371/journal.pone.0016337

2010

  • Al-Youha, S., McGrouther, D., Kadler, K. & Wong, J (2010). Investigating the mechanisms of 'Acellular Zone' formation after suturing mouse tendon. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 91(6), A41-A41. eScholarID:126696
  • Brown, B., McKenna, S., Solomon, M., Wilburn, J., McGrouther, D. & Bayat, A (2010). The Patient-Reported Impact of Scars Measure: Development and Validation. PLASTIC AND RECONSTRUCTIVE SURGERY, 125(5), 1439-1449. eScholarID:126724 | DOI:10.1097/PRS.0b013e3181d4fd89
  • Brown, B., McKenna, S., Solomon, M., Wilburn, J., McGrouther, D. & Bayat, A (2010). The Patient-Reported Impact of Scars Measure: Development and Validation. PLASTIC AND RECONSTRUCTIVE SURGERY, 125(5), 1439-1449. eScholarID:126776 | DOI:10.1097/PRS.0b013e3181d4fd89
  • Brown, B., Moss, T., McGrouther, D. & Bayat, A (2010). Skin scar preconceptions must be challenged: Importance of self-perception in skin scarring. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 63(6), 1022-1029. eScholarID:126706 | DOI:10.1016/j.bjps.2009.03.019
  • Guimberteau, J., Delage, J., McGrouther, D. & Wong, J (2010). The microvacuolar system: how connective tissue sliding works. J Hand Surg Eur Vol, 35(8), 614-22. eScholarID:105677 | PMID:20571142 | DOI:10.1177/1753193410374412
  • Guimberteau, J., Delage, J., McGrouther, D. & Wong, J (2010). THE MICROVACUOLAR SYSTEM: HOW CONNECTIVE TISSUE SLIDING WORKS. JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 35E(8), 614-622. eScholarID:126721 | DOI:10.1177/1753193410374412
  • Hickey, M., Ngo, D., Lepadatu, S., Atkinson, D., McGrouther, D., McVitie, S. & Marrows, C (2010). Spin-transfer torque efficiency measured using a Permalloy nanobridge. APPLIED PHYSICS LETTERS, 97(20), eScholarID:126708 | DOI:10.1063/1.3520144
  • Hollywood, K., Maatje, M., Shadi, I., Henderson, A., McGrouther, D., Goodacre, R. & Bayat, A (2010). Phenotypic profiling of keloid scars using FT-IR microspectroscopy reveals a unique spectral signature. ARCHIVES OF DERMATOLOGICAL RESEARCH, 302(10), 705-715. eScholarID:126702 | DOI:10.1007/s00403-010-1071-2
  • Iqbal, S., Syed, F., McGrouther, D., Paus, R. & Bayat, A (2010). Differential distribution of haematopoietic and nonhaematopoietic progenitor cells in intralesional and extralesional keloid: do keloid scars provide a niche for nonhaematopoietic mesenchymal stem cells? BRITISH JOURNAL OF DERMATOLOGY, 162(6), 1377-1383. eScholarID:126687 | DOI:10.1111/j.1365-2133.2010.09738.x
  • Kim, J., De Wit, T., Hovius, S., McGrouther, D. & Walbeehm, E (2010). What is the significance of tendon suture purchase? (vol 34E, pg 497, 2009). JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 35E(7), 601-601. eScholarID:126783
  • Narinesingh, S., Wong, J., McGrouther, D. & Babar, A (2010). Descending the reconstructive ladder with tube pedicles. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 63(2), E217-E219. eScholarID:126685 | DOI:10.1016/j.bjps.2009.06.017
  • Ougazzaden, A., Rogers, D., Teherani, F., Orsal, G., Moudakir, T., Gautier, S., Sandana, E., Jomard, F., Abid, M., Molinari, M., Troyon, M., Voss, P., McGrouther, D. & Chapman, J (2010). Epitaxial MOVPE growth of highly c-axis oriented InGaN/GaN films on ZnO-buffered Si (111) substrates. OXIDE-BASED MATERIALS AND DEVICES, 7603, eScholarID:126692 | DOI:10.1117/12.846664
  • Ougazzaden, A., Rogers, D., Teherani, F., Orsal, G., Moudakir, T., Gautier, S., Sandana, E., Jomard, F., Abid, M., Molinari, M., Troyon, M., Voss, P., McGrouther, D. & Chapman, J (2010). Epitaxial MOVPE growth of highly c-axis oriented InGaN/GaN films on ZnO-buffered Si (111) substrates. OXIDE-BASED MATERIALS AND DEVICES, 7603, eScholarID:126746 | DOI:10.1117/12.846664
  • Parmar, V., Bhatti, W., Hutchinson, C., Muir, L., Mcgrouther, D. & Bayat, A (2010). Staging of Dupuytren's Disease: Novel Use of 3T MR Scanning Validated with Immunohistochemistry Measures Disease Extent and Activity. AMERICAN JOURNAL OF ROENTGENOLOGY, 194(5), eScholarID:126707
  • Perry, D., Colthurst, J., Giddings, P., McGrouther, D., Morris, J. & Bayat, A (2010). Treatment of symptomatic abnormal skin scars with electrical stimulation. J Wound Care, 19(10), 447-53. eScholarID:105676 | PMID:20948493
  • Perry, D., McGrouther, D. & Bayat, A (2010). Current tools for noninvasive objective assessment of skin scars. Plast Reconstr Surg, 126(3), 912-23. eScholarID:105669 | PMID:20811225 | DOI:10.1097/PRS.0b013e3181e6046b
  • Perry, D., McGrouther, D. & Bayat, A (2010). Current Tools for Noninvasive Objective Assessment of Skin Scars. PLASTIC AND RECONSTRUCTIVE SURGERY, 126(3), 912-923. eScholarID:126739 | DOI:10.1097/PRS.0b013e3181e6046b
  • Power, K., Turkmen, A. & McGrouther, D (2010). Response to letter: Gravitational retrograde venous perfusion - a technique for limb extremity salvage when microvascular arterial repair is not possible. J Plast Reconstr Aesthet Surg 2010;63:e422-e423. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 63(7), E582-E583. eScholarID:126703 | DOI:10.1016/j.bjps.2009.12.017
  • Tan, K., Shah, N., Pritchard, S., McGrouther, D. & Bayat, A (2010). The influence of surgical excision margins on keloid prognosis. Ann Plast Surg, 64(1), 55-8. eScholarID:79818 | PMID:20010410 | DOI:10.1097/SAP.0b013e31819b6c3a
  • Tan, K., Shah, N., Pritchard, S., McGrouther, D. & Bayat, A (2010). The Influence of Surgical Excision Margins on Keloid Prognosis. ANNALS OF PLASTIC SURGERY, 64(1), 55-58. eScholarID:126720 | DOI:10.1097/SAP.0b013e31819b6c3a
  • Trompetter, W., Hyland, M., McGrouther, D., Munroe, P. & Markwitz, A (2010). The Effect of Substrate Surface Oxides on the Bonding of NiCr Alloy Particles HVAF Thermally Sprayed onto Aluminum Substrates. JOURNAL OF THERMAL SPRAY TECHNOLOGY, 19(5), 1024-1031. eScholarID:126715 | DOI:10.1007/s11666-010-9506-z
  • Trompetter, W., Hyland, M., McGrouther, D., Munroe, P. & Markwitz, A (2010). The Effect of Substrate Surface Oxides on the Bonding of NiCr Alloy Particles HVAF Thermally Sprayed onto Aluminum Substrates. JOURNAL OF THERMAL SPRAY TECHNOLOGY, 19(5), 1024-1031. eScholarID:126768 | DOI:10.1007/s11666-010-9506-z
  • Turkmen, A., Graham, K. & McGrouther, D (2010). Therapeutic applications of the larvae for wound debridement. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 63(1), 184-188. eScholarID:126723 | DOI:10.1016/j.bjps.2008.08.070
  • Wong, J., Alyouha, S., Kadler, K., Ferguson, M. & McGrouther, D (2010). The cell biology of suturing tendons. MATRIX BIOLOGY, 29(6), 525-536. eScholarID:126764 | DOI:10.1016/j.matbio.2010.06.002

2009

  • Atkins SE, Logan B, McGrouther D. (2009). The deep (motor) branch of the ulnar nerve: A detailed examination of its course and the clinical significance of its damage. J Hand Surg Eur Vol, eScholarID:1d18611 | DOI:10.1177/1753193408097489
  • Atkins, S., Logan, B. & Mcgrouther, D (2009). THE DEEP (MOTOR) BRANCH OF THE ULNAR NERVE: A DETAILED EXAMINATION OF ITS COURSE AND THE CLINICAL SIGNIFICANCE OF ITS DAMAGE. JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 34E(1), 47-57. eScholarID:126713 | DOI:10.1177/1753193408097489
  • Bisson, M., Beckett, K., McGrouther, A., Grobbelaar, A. & Mudera, V (2009). Transforming Growth Factor-beta 1 Stimulation Enhances Dupuytren's Fibroblast Contraction in Response to Uniaxial Mechanical Load Within a 3-Dimensional Collagen Gel. JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 34A(6), 1102-1110. eScholarID:126726 | DOI:10.1016/j.jhsa.2009.02.008
  • Bogart, L., Atkinson, D., O'Shea, K., McGrouther, D. & McVitie, S (2009). Dependence of domain wall pinning potential landscapes on domain wall chirality and pinning site geometry in planar nanowires. PHYSICAL REVIEW B, 79(5), eScholarID:126686 | DOI:10.1103/PhysRevB.79.054414
  • Brown, B., McKenna, S., Solomon, M., Wilburn, J., McGrouther, D. & Bayat, A (2009). Patient-reported impact of scars measure (PRISM): development and validation of a new skin scar patient-reported outcome measure. BRITISH JOURNAL OF DERMATOLOGY, 161, 17-17. eScholarID:126701
  • Brown, B., Moss, T., McGrouther, D. & Bayat, A (2009). Skin scar pre-conceptions must be challenged: Importance of self-perception in skin scarring. J Plast Reconstr Aesthet Surg, eScholarID:79823 | PMID:19501559 | DOI:10.1016/j.bjps.2009.03.019
  • Durani, P., McGrouther, D. & Ferguson, M (2009). Current scales for assessing human scarring: A review. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 62(6), 713-720. eScholarID:126684 | DOI:10.1016/j.bjps.2009.01.080
  • Durani, P., McGrouther, D. & Ferguson, M (2009). The Patient Scar Assessment Questionnaire: A Reliable and Valid Patient-Reported Outcomes Measure for Linear Scars. PLASTIC AND RECONSTRUCTIVE SURGERY, 123(5), 1481-1489. eScholarID:126722 | DOI:10.1097/PRS.0b013e3181a205de
  • Hindocha S, McGrouther D, Bayat A. (2009). Epidemiological Evaluation of Dupuytren's Disease Incidence and Prevalence Rates in Relation to Etiology. Hand (N Y), eScholarID:1d18490 | DOI:10.1007/s11552-008-9160-9
  • Kim, J., De Wit, T., Hovius, S., McGrouther, D. & Walbeehm, E (2009). WHAT IS THE SIGNIFICANCE OF TENDON SUTURE PURCHASE? JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 34E(4), 497-502. eScholarID:126730 | DOI:10.1177/1753193408104555
  • O'Brien, E., McGrouther, D., Hardingham, T., Clegg, P. & Kielty, C (2009). The influence of exogenous mesenchymal stromal cells (MSCs) on the tensile properties of injured tendon. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 90(2), A124-A125. eScholarID:126719
  • Power, K., Giannas, J. & McGrouther, D (2009). Distal revascularisation/replantation using the reversed radial artery. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 62(12), 1688-1691. eScholarID:126690 | DOI:10.1016/j.bjps.2008.06.065
  • Rogers, D., Teherani, F., Moudakir, T., Gautier, S., Jomard, F., Molinari, M., Troyon, M., McGrouther, D., Chapman, J., Razeghi, M. & Ougazzaden, A (2009). Microstructural compositional, and optical characterization of GaN grown by metal organic vapor phase epitaxy on ZnO epilayers. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 27(3), 1655-1657. eScholarID:126700 | DOI:10.1116/1.3137967
  • Rogers, D., Teherani, F., Moudakir, T., Gautier, S., Jomard, F., Molinari, M., Troyon, M., McGrouther, D., Chapman, J., Razeghi, M. & Ougazzaden, A (2009). Microstructural compositional, and optical characterization of GaN grown by metal organic vapor phase epitaxy on ZnO epilayers. JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 27(3), 1655-1657. eScholarID:126754 | DOI:10.1116/1.3137967
  • Russell C, Bush J, Russell G, Thorlby A, McGrouther D, Lees VV. (2009). Dynamic skin tension in the forearm: effects of pronation and supination. J Hand Surg Am, 34( 3), eScholarID:1d19882 | DOI:10.1016/j.jhsa.2008.10.029
  • Russell, C., Bush, J., Russell, G., Thorlby, A., McGrouther, D. & Lees, V (2009). Dynamic Skin Tension in the Forearm: Effects of Pronation and Supination. JOURNAL OF HAND SURGERY-AMERICAN VOLUME, 34A(3), 423-431. eScholarID:126689 | DOI:10.1016/j.jhsa.2008.10.029
  • Theopold, C., Pritchard, S., McGrouther, D. & Bayat, A (2009). Keloid scar harbouring malignant blue naevus emphasises the need for excision biopsy and routine histology. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 62(1), 93-95. eScholarID:126695 | DOI:10.1016/j.bjps.2007.11.035
  • Walbeehm E, De Wit T, Hovius S, McGrouther D. (2009). Influence of core suture geometry on tendon deformation and gap formation in porcine flexor tendons. J Hand Surg Eur Vol, 34( 2), 190-5. eScholarID:1d19881 | DOI:10.1177/1753193408098479
  • Walbeehm, E., De Wit, T., Hovius, S. & Mcgrouther, D (2009). INFLUENCE OF CORE SUTURE GEOMETRY ON TENDON DEFORMATION AND GAP FORMATION IN PORCINE FLEXOR TENDONS. JOURNAL OF HAND SURGERY-EUROPEAN VOLUME, 34E(2), 190-195. eScholarID:126693 | DOI:10.1177/1753193408098479
  • Wilburn, J., McKenna, S., Brown, B., Solomon, M., McGrouther, D. & Bayat, A (2009). DEVELOPMENT AND VALIDATION OF THE PATIENT-REPORTED IMPACT OF SCARS MEASURE (PRISM). VALUE IN HEALTH, 12(7), A459-A459. eScholarID:126688 | DOI:10.1016/S1098-3015(10)75273-6
  • Wong, J., Lui, Y., Kapacee, Z., Kadler, K., Ferguson, M. & McGrouther, D (2009). The Cellular Biology of Flexor Tendon Adhesion Formation An Old Problem in a New Paradigm. AMERICAN JOURNAL OF PATHOLOGY, 175(5), 1938-1951. eScholarID:126712 | DOI:10.2353/ajpath.2009.090380
  • Wong, J., Lui, Y., Kapacee, Z., Kadler, K., Ferguson, M. & McGrouther, D (2009). The cellular biology of flexor tendon adhesion formation: an old problem in a new paradigm. Am J Pathol, 175(5), 1938-51. eScholarID:79820 | PMID:19834058 | DOI:10.2353/ajpath.2009.090380

2008

  • Al-Nuaimi Y, McGrouther D, Bayat A. (2008). Modernising medical careers and factors influencing career choices of medical students. Br J Hosp Med (Lond), 69( 3), 163-6. eScholarID:1d18489
  • Branford O, Mudera V, Brown R, McGrouther D, Grobbelaar A. (2008). A novel biomimetic material for engineering postsurgical adhesion using the injured digital flexor tendon-synovial complex as an in vivo model. Plast Reconstr Surg, 121( 3), 781-93. eScholarID:1d18599 | DOI:10.1097/01.prs.0000299373.25294.65
  • Brown, B., McKenna, S., Siddhi, K., McGrouther, D. & Bayat, A (2008). The hidden cost of skin scars: quality of life after skin scarring. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 61(9), 1049-1058. eScholarID:126717 | DOI:10.1016/j.bjps.2008.03.020
  • Bush J, Ferguson M, Mason T, McGrouther D. (2008). Skin tension or skin compression? Small circular wounds are likely to shrink, not gape. J Plast Reconstr Aesthet Surg, 61( 5), 529-34. eScholarID:1d18604 | DOI:10.1016/j.bjps.2007.06.004
  • Caulfield R, Tyler M, Austyn J, Dziewulski P, McGrouther D. (2008). The relationship between protease/anti-protease profile, angiogenesis and re-epithelialisation in acute burn wounds. Burns, 34( 4), 474-86. eScholarID:1d18601 | DOI:10.1016/j.burns.2007.07.012
  • Foong D, Babar A, McGrouther D, Wong JKF. (2008). Key points in technique: Split thickness skin grafting to bare skull as a single stage procedure. J Plast Reconstr Aesthet Surg, 61( 10), 1260-3. eScholarID:1d18534 | DOI:10.1016/j.bjps.2008.01.032
  • Foong, D., Babar, A., McGrouther, D. & Wong, J (2008). Key points in technique: Split thickness skin grafting to bare skull as a single stage procedure. JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY, 61(10), 1260-1263. eScholarID:126698 | DOI:10.1016/j.bjps.2008.01.032
  • Fox A, Smythe J, Fisher N, Tyler M, McGrouther D, Watt S, Harris A. (2008). Mobilization of endothelial progenitor cells into the circulation in burned patients. Br J Surg, 95( 2), 244-51. eScholarID:1d18602 | DOI:10.1002/bjs.5913
  • Lees V, McGrouther D. (2008). The Postgraduate Diploma in Hand Surgery: training hand surgeons of the future in the UK. J Hand Surg Eur Vol, 33( 2), 98-102. eScholarID:1d18598 | DOI:10.1177/1753193408088461
  • Leuchter, A., Cook, I., DeBrota, D., Hunter, A., Potter, W., McGrouther, C., Morgan, M., Abrams, M. & Siegman, B (2008). Changes in Brain Function During Administration of Venlafaxine or Placebo to Normal Subjects. CLINICAL EEG AND NEUROSCIENCE, 39(4), 175-181. eScholarID:126681
  • Witt E, Maliri A, McGrouther D, Bayat A. (2008). RAC Activity in Keloid Disease: Comparative Analysis of Fibroblasts from Margin of Keloid to its Surrounding Normal Skin. Eplasty, 8, eScholarID:1d18499

2007

  • Bayat A, Cunliffe E, McGrouther D. (2007). Assessment of clinical severity in Dupuytren's disease. Br J Hosp Med (Lond), 68( 11), 604-9. eScholarID:1d18503
  • Bush J, Ferguson M, Mason T, McGrouther D. (2007). The dynamic rotation of Langer's lines on facial expression. J Plast Reconstr Aesthet Surg, 60( 4), 393-9. eScholarID:1d18608 | DOI:10.1016/j.bjps.2006.06.008
  • O'Ceallaigh S, Herrick SE, Bennett W, Bluff J, Ferguson M, McGrouther D. (2007). Perivascular cells in a skin graft are rapidly repopulated by host cells. J Plast Reconstr Aesthet Surg, 60( 8), 864-75. eScholarID:1d18605 | DOI:10.1016/j.bjps.2006.03.036
  • Power K, Giannas J, Babar Z, McGrouther D. (2007). Management of massive lower limb plexiform neurofibromatosis--when to intervene? Ann R Coll Surg Engl, 89( 8), W3-5. eScholarID:1d18600 | DOI:10.1308/147870807X238230
  • Taylor B, McGrouther D, Bayat A. (2007). Use of a non-contact 3D digitiser to measure the volume of keloid scars: a useful tool for scar assessment. J Plast Reconstr Aesthet Surg, 60( 1), 87-94. eScholarID:1d18606 | DOI:10.1016/j.bjps.2005.12.051
  • Wagstaff M, Shah M, McGrouther D, Latchman D. (2007). The heat shock proteins and plastic surgery. J Plast Reconstr Aesthet Surg, 60( 9), 974-82. eScholarID:1d18603 | DOI:10.1016/j.bjps.2006.03.065
  • Dunkin C, Pleat J, Gillespie P, Tyler M, Roberts A, McGrouther D. (2007). Scarring occurs at a critical depth of skin injury: precise measurement in a graduated dermal scratch in human volunteers. ( 119( 6), ). United States: Academic Press. eScholarID:5d75 | DOI:10.1097/01.prs.0000258829.07399.f0

2006

  • Wong JKF, Bennett WWR, Ferguson MW.J, McGrouther D. (2006). A genetically tractable model for the investigation of flexor tendon injury using mice. Academic Press. eScholarID:2d2447
  • A Roberts, C Dunkin, MPH Tyler, McGrouther D, J Pleat. (2006). The Dermal Scratch- a Volunteer study of partial thickness wound healing. Plastic and Reconstructive Surgery, eScholarID:1d13110
  • Al-Nuaimi Y, McGrouther D, Bayat A. (2006). Modernizing medical careers in the UK and plastic surgery as a possible career choice: undergraduate opinions. J Plast Reconstr Aesthet Surg, 59( 12), 1472-4. eScholarID:1d18609 | DOI:10.1016/j.bjps.2006.04.026
  • Bayat A, McGrouther D. (2006). Management of Dupuytren's disease--clear advice for an elusive condition. Ann R Coll Surg Engl, 88( 1), eScholarID:1d12979
  • Bayat A, McGrouther D. (2006). Spectrum of abnormal skin scars and their clinical management. Br J Hosp Med (Lond), 67( 10), 527-32. eScholarID:1d18610
  • Henderson J, Terenghi G, McGrouther D, Ferguson M. (2006). The reinnervation pattern of wounds and scars may explain their sensory symptoms. J Plast Reconstr Aesthet Surg, 59( 9), 942-50. eScholarID:1d13763
  • O'Ceallaigh S, Herrick SE, Bluff J, McGrouther D, Ferguson M. (2006). Quantification of total and perfused blood vessels in murine skin autografts using a fluorescent double-labeling technique. Plast Reconstr Surg, 117( 1), 140-51. eScholarID:1d12981
  • Wong JKF, Bennett W, Ferguson M, McGrouther D. (2006). Microscopic and histological examination of the mouse hindpaw digit and flexor tendon arrangement with 3D reconstruction. J Anat, 209( 4), 533-45. eScholarID:1d14572
  • Wong JKF, Cerovac S, Ferguson MW.J, McGrouther D. (2006). The Cellular effect of a single interrupted suture on tendon. Journal of Hand Surgery, 31B, 358-367. eScholarID:1d13109 | DOI:10.1016/j.jhsb.2006.03.162

2005

  • Bayat A, Arscott G, Ollier WER, McGrouther D, Ferguson M. (2005). Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg, 58( 1), 28-37. eScholarID:1d11726
  • Bayat A, McGrouther D. (2005). Clinical management of skin scarring. Skinmed, 4( 3), 165-73. eScholarID:1d12982
  • Bulstrode N, Mudera V, McGrouther D, Grobbelaar A, Cambrey A. (2005). 5-fluorouracil selectively inhibits collagen synthesis. Plast Reconstr Surg, 116( 1), 209-21; discussion 2. eScholarID:1d12128 | DOI:10.1097/01.PRS.0000169701.16509.D6
  • Cheema U, Brown R, Mudera V, Yang S, McGrouther D, Goldspink G. (2005). Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle. J Cell Physiol, 202( 1), 67-75. eScholarID:1d12127 | DOI:10.1002/jcp.20107

2004

  • Bayat A, Arscott G, Ollier WER, Ferguson M, McGrouther D. (2004). Description of site-specific morphology of keloid phenotypes in an Afrocaribbean population. Br J Plast Surg, 57( 2), 122-33. eScholarID:1d8124
  • Bulstrode N. W, Bisson M, Jemec B, Pratt A. L, McGrouther D, Grobbelaar A. O. (2004). A prospective randomised clinical trial of the intra-operative use of 5-Fluorouracil on the outcome of dupuytren's disease. J Hand Surg [Br], 29, 1, eScholarID:1d22236
  • Cano S, Browne J, Lamping D, Roberts A, McGrouther D, Black N. (2004). The Patient Outcomes of Surgery-Hand/Arm (POS-Hand/Arm): a new patient-based outcome measure. J Hand Surg [Br], 29( 5), 477-85. eScholarID:1d31491
  • Khan A, Banwell P, Bakker M, Gillespie P, McGrouther D, Roberts A. (2004). Topical radiant heating in wound healing: an experimental study in a donor site wound model*. Int Wound J, 1( 4), 233-40. eScholarID:1d18607 | DOI:10.1111/j.1742-4801.2004.00065.x

2003

  • Ardy Bayat, Arscott G, Ollier WER, Ferguson M. W, McGrouther D. (2003). 'Aggressive keloid': a severe variant of familial keloid scarring. J R Soc Med, 96, 11, 554-555. eScholarID:1d7364
  • Ardy Bayat, McGrouther D, Ferguson M. W. (2003). Skin scarring. Bmj, 326, 7380, 88-92. eScholarID:1d7365
  • Bisson M. A, McGrouther D, Mudera V, Grobbelaar A. O. (2003). The different characteristics of Dupuytren's disease fibroblasts derived from either nodule or cord: expression of alpha-smooth muscle actin and the response to stimulation by TGF-beta1. J Hand Surg [Br], 28, 4, 351-6. eScholarID:1d7366
  • Durrani A, McGrouther D, Hill M. (2003). Molecular genetic investigation of the role of fibronectin in wound healing and fibrotic disease. J Hand Surg [Am], 28 Suppl 1, eScholarID:1d7367
  • Greig A. V, James S. E, McGrouther D, Terenghi G, Burnstock G. (2003). Purinergic receptor expression in the regeneration epidermis in a rat model of normal and delayed wound healing. Exp Dermatol, 12, 6, 860-71. eScholarID:1d7613
  • Greig A. V, Linge C, Healy V, Lim P, Clayton E, Rustin M. H, McGrouther D, Burnstock G. (2003). Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. J Invest Dermatol, 121, 2, 315-27. eScholarID:1d7368
  • Greig A. V, Linge C, Terenghi G, McGrouther D, Burnstock G. (2003). Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. J Invest Dermatol, 120, 6, 1007-15. eScholarID:1d7369
  • Harrison R. K, Mudera V, Grobbelaar A. O, Jones M. E, McGrouther D. (2003). Synovial sheath cell migratory response to flexor tendon injury: an experimental study in rats. J Hand Surg [Am], 28, 6, eScholarID:1d22241
  • Hormbrey E, Han C, Roberts A, McGrouther D, Harris A. L. (2003). The relationship of human wound vascular endothelial growth factor (VEGF) after breast cancer surgery to circulating VEGF and angiogenesis. Clin Cancer Res, 9, 12, 4332-9. eScholarID:1d7371
  • Jones M. E, Mudera V, Brown R. A, Cambrey A. D, Grobbelaar A. O, McGrouther D. (2003). The early surface cell response to flexor tendon injury. J Hand Surg [Am], 28, 2, 221-30. eScholarID:1d7372
  • Ragoowansi R, Khan U, Brown R. A, McGrouther D. (2003). Differences in morphology, cytoskeletal architecture and protease production between zone II tendon and synovial fibroblasts in vitro. J Hand Surg [Br], 28, 5, 465-70. eScholarID:1d7374
  • Ross G. L, Price R. D, Fletcher-Williams G, McGrouther D. (2003). Manoeuvring a-head in plastic surgery. Br J Plast Surg, 56, 8, 812-4. eScholarID:1d7375

2002

  • Chrysopoulo MT, McGrouther D, Jeschke MG, Kaufman BR. (2002). Cleland's ligaments: an anatomic study. Plast Reconstr Surg, 109(2), 566-72. eScholarID:1d4461
  • Hormbrey E, Gillespie P, Turner K, Han C, Roberts A, McGrouther D, Harris A. L. (2002). A critical review of vascular endothelial growth factor (VEGF) analysis in peripheral blood: is the current literature meaningful? Clin Exp Metastasis, 19, 8, 651-63. eScholarID:1d7370

2001

  • Cerovac S, Afoke A, Akali A, McGrouther D. (2001). Early breaking strength of repaired flexor tendon treated with 5-fluorouracil. J Hand Surg [Br], 26, 3, eScholarID:1d22217
  • Ng RL, James SE, Philip B, Floyd D, Ross DA, Butler PE, Brough MD, McGrouther D. (2001). The Soho nail bomb: the UCH experience.University College Hospital. Ann R Coll Surg Engl, 83(5), 297-301. eScholarID:1d4462
  • Ragoowansi R, Khan U, Brown R. A, McGrouther D. (2001). Reduction in matrix metalloproteinase production by tendon and synovial fibroblasts after a single exposure to 5-fluorouracil. Br J Plast Surg, 54, 4, 283-7. eScholarID:1d7373
  • Tyler MP, Watts AM, Perry ME, Roberts AH, McGrouther D. (2001). Dermal cellular inflammation in burns. an insight into the function of demal microvascular anatomy. Burns, 27(5), 433-8. eScholarID:1d4464
  • Uppal RS, khan U, Kakar S, Talas G, Chapman P, McGrouther D. (2001). The effects of a single dose of 5-flourouracil on keliod scars: a clinincal trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg, 108(5), 1218-24. eScholarID:1d4463
  • Watts A. M, Tyler M. P, Perry M. E, Roberts A. H, McGrouther D. (2001). Burn depth and its histological measurement. Burns, 27, 2, 154-60. eScholarID:1d7376

2000

  • Deng J, Newton N. M, Hall-Craggs M. A, Shirley R. A, Linney A. D, Lees W. R, Rodeck C. H, McGrouther D. (2000). Novel technique for three-dimensional visualisation and quantification of deformable, moving soft-tissue body parts. Lancet, 356, 9224, eScholarID:1d22238
  • Jemec B, Linge C, Grobbelaar A. O, Smith P. J, Sanders R, McGrouther D. (2000). The effect of 5-fluorouracil on Dupuytren fibroblast proliferation and differentiation. Chir Main, 19, 1, eScholarID:1d22245
  • Jones M. E, Ladhani K, Mudera V, Grobbelaar A. O, McGrouther D, Sanders R. (2000). Flexor tendon blood vessels. J Hand Surg [Br], 25, 6, eScholarID:1d22246
  • Khan U, Kakar S, Akali A, Bentley G, McGrouther D. (2000). Modulation of the formation of adhesions during the healing of injured tendons. J Bone Joint Surg Br, 82, 7, eScholarID:1d22248
  • Mudera V. C, Pleass R, Eastwood M, Tarnuzzer R, Schultz G, Khaw P, McGrouther D, Brown R. A. (2000). Molecular responses of human dermal fibroblasts to dual cues: contact guidance and mechanical load. Cell Motil Cytoskeleton, 45, 1, eScholarID:1d22251
  • Murphy J. V, Banwell P. E, Roberts A. H, McGrouther D. (2000). Frostbite: pathogenesis and treatment. J Trauma, 48, 1, eScholarID:1d22252

1999

  • Akali A, Khan U, Khaw P. T, McGrouther D. (1999). Decrease in adhesion formation by a single application of 5-fluorouracil after flexor tendon injury. Plast Reconstr Surg, 103, 1, eScholarID:1d22233
  • Banwell P. E, Tyler M. P, Watts A. M, Roberts A. H, McGrouther D. (1999). Burn depth estimation: use of laser doppler flowmetry. Plast Reconstr Surg, 103, 1, eScholarID:1d22234
  • Ioannides C, Fossion E, McGrouther D. (1999). Reconstruction for large defects of the scalp and cranium. J Craniomaxillofac Surg, 27, 3, eScholarID:1d22242
  • Jemec B, Grobbelaar A. O, Wilson G. D, Smith P. J, Sanders R, McGrouther D. (1999). Is Dupuytren's disease caused by an imbalance between proliferation and cell death? J Hand Surg [Br], 24, 5, eScholarID:1d22244
  • Richards A. M, Floyd D. C, Terenghi G, McGrouther D. (1999). Cellular changes in denervated tissue during wound healing in a rat model. Br J Dermatol, 140, 6, eScholarID:1d22253
  • Talas G, Brown R. A, McGrouther D. (1999). Role of phenytoin in wound healing--a wound pharmacology perspective. Biochem Pharmacol, 57, 10, eScholarID:1d22254

1998

  • Afoke A, Meagher P. J, Starley I, McGrouther D, Bailey A. J, Brown R. A. (1998). Biomechanical characterization of tissues in Dupuytren's disease. J Hand Surg [Br], 23, 3, eScholarID:1d22232
  • Brown R. A, Prajapati R, McGrouther D, Yannas I. V, Eastwood M. (1998). Tensional homeostasis in dermal fibroblasts: mechanical responses to mechanical loading in three-dimensional substrates. J Cell Physiol, 175, 3, eScholarID:1d22235
  • Clark M. P, Greenfield B, Hunt N, Hall-Craggs M, McGrouther D. (1998). Function of the nasal muscles in normal subjects assessed by dynamic MRI and EMG: its relevance to rhinoplasty surgery. Plast Reconstr Surg, 101, 7, eScholarID:1d22237
  • Eastwood M, McGrouther D, Brown R. A. (1998). Fibroblast responses to mechanical forces. Proc Inst Mech Eng [H], 212, 2, eScholarID:1d22239
  • Eastwood M, Mudera V. C, McGrouther D, Brown R. A. (1998). Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes. Cell Motil Cytoskeleton, 40, 1, eScholarID:1d22240
  • Iwuagwu F. C, McGrouther D. (1998). Early cellular response in tendon injury: the effect of loading. Plast Reconstr Surg, 102, 6, eScholarID:1d22243
  • Kakar S, Khan U, McGrouther D. (1998). Differential cellular response within the rabbit tendon unit following tendon injury. J Hand Surg [Br], 23, 5, eScholarID:1d22247
  • Khan U, Occleston N. L, Khaw P. T, McGrouther D. (1998). Differences in proliferative rate and collagen lattice contraction between endotenon and synovial fibroblasts. J Hand Surg [Am], 23, 2, eScholarID:1d22249
  • McGrouther D, Ahmad F. S. (1998). A preliminary report: the changes in the neuropeptide containing epidermal innervation in response to inflammatory reactions elicited in human breast skin. J R Coll Surg Edinb, 43, 1, eScholarID:1d22250
  • Tarlton J. F, Meagher P, Brown R. A, McGrouther D, Bailey A. J, Afoke A. (1998). Mechanical stress in vitro induces increased expression of MMPs 2 and 9 in excised Dupuytren's disease tissue. J Hand Surg [Br], 23, 3, eScholarID:1d22255

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