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School of Medicine

Professor Nicola Tirelli PhD, FRSC

Photograph of Nicola Tirelli

Professor of Polymers and Biomaterials

Stopford building, Oxford Road, Manchester M13 (School of Biomedicine)

Materials Science Centre, Grosvenor Street, M1 7HS (School of Materials)

 

Role

Editor-in-chief of Reactive and Functional Polymers

Member of the Executive Advisory Board of the Wiley-VCH Macromolecular journals, specifically dealing with Macromolecular Bioscience

 

Memberships of Committees and Professional Bodies

Fellow of the Royal Society of Chemistry

Member of the American Chemical Society

Research

Our research focus is on the molecular design and processing of polymeric materials for biomedical applications, what we generally call 'biomaterials'. Specifically, we are interested in the molecular design of (nano)materials that interact with a biological environment in responsive fashion: responsive release of active principles (drugs) from nanocarriers, bioresponsive formation of tissue engineering matrices.

To know more, visit the web site of the Laboratory of Polymers and Biomaterials.

 

Teaching

Clinical Applications in Biomaterials (3rd year BSc in Biomedical Materials, 4th year MEng in Biomedical Materials)

Anatomy & Physiology (1st year BSc and MEng in Biomedical Materials)

DTC in Nanotechnology

MRes in Tissue Regeneration

 

Biography

Since August 2010, Professor Nicola Tirelli has held  a joint appointment as a Professor of Polymers and Biomaterials in the School of Biomedicine (MHS) and the School of Materials (EPS). He joined The University of Manchester in December 2004 as a Senior Lecturer in the School of Pharmacy & Pharmaceutical Sciences. He was promoted  to Chair of Polymers and Biomaterials in the School of Pharmacy and Pharmaceutical Sciences in 2006. Previously, he was Oberassistent, a position largely analogous to that of a Lecturer, at the ETH Zurich, Department of Materials, Institute of Biomedical Engineering headed at the time by Jeff Hubbell (12/98-12/02).

 Awards

2005: EPSRC Advanced Research Fellow

2004: Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation (endowed by the German Federal Ministry of Education and Research). 

 

Qualifications

1996 – PhD in Industrial Chemistry, University of Pisa (Italy)

1992 – Italian “Laurea” (cum laude) – Master in Chemistry, University of Pisa (Italy)

 

Collaborators and affiliated staff

Affiliated staff

 

Selected publications

2011

  • Ping Hu, Nicola Tirelli. (2011). Inter-micellar dynamics in block copolymer micelles: FRET experiments of macroamphiphile and payload exchange. Reactive & Functional Polymers, 71, eScholarID:103632 | DOI:10.1016/j.reactfunctpolym.2010.10.010
  • Wilda Helen, Piero de Leonardis, Rein Ulijn, Julie Gough, Nicola Tirelli. (2011). Mechanosensitive peptide gelation: mode of agitation controls mechanical properties and nano-scale morphology. Soft Matter, 7, 1732-1740. eScholarID:103618 | DOI:10.1039/C0SM00649A

2010

  • N.M. Zaki, N. Tirelli. (2010). Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting. Expert Opinion on Drug Delivery, 7(8), 895-913. eScholarID:95665 | DOI:10.1517/17425247.2010.501792

2009

  • Liu R, De Leonardis P, Cellesi F, Tirelli N, Saunders BR. (2009). Temperature-Triggered Gelation of Aqueous Laponite Dispersions Containing a Cationic Poly(N-isopropyl acrylamide) Graft Copolymer. Langmuir, 25, 1, 490-496. eScholarID:1d17629 | DOI:10.1021/la802941h
  • R. Liu, Cellesi F, Tirelli N, B.R. Saunders. (2009). A study of thermoassociative gelation of aqueous cationic poly(N-isopropyl acrylamide) graft copolymer solutions. Polymer, 50, 6, 1456-1462. eScholarID:1d18896 | DOI:10.1016/j.polymer.2009.01.035
  • Vo Cong Duan, Kilcher G, Tirelli N. (2009). Polymers and Sulfur: what are OrganicPolysulfides Good For? Preparative Strategiesand Biological Applications. Macromolecular Rapid Communications, 30, 299-315. eScholarID:1d19785 | DOI:10.1002/marc.200800740

2008

  • Liu R, De Leonardis P, Cellesi F, Tirelli N, Saunders B.R. (2008). Cationic temperature-responsive poly(N-isopropyl acrylamide) graft copolymers: from triggered association to gelation. Langmuir, 24(14), 7099-7106. eScholarID:1d18239 | DOI:10.1021/la8002756

2007

  • Kilcher G, Wang L, Duckham C, Tirelli N. (2007). Polysulfide networks. In situ formation and characterisation of the elastomeric behaviour. Macromolecules, 40, 5141 - 5149. eScholarID:1d16184

2006

  • MissirlisD, HubbellJ.A, Tirelli N. (2006). Thermally - induced glass formation from hydrogel nanoparticles. Soft Matter, 2, 1067 - 1075. eScholarID:1d14174
  • TaglientiA, Cellesi F, CrescenziV, SequiP, ValentiniM, Tirelli N. (2006). Investigating the Interactions of Hyaluronan Derivatives with Biomolecules. The Use of Diffusional NMR Techniques. Macromolecular Bioscience, 6, 611 - 622. eScholarID:1d13582 | DOI:10.1002/mabi.200600041
  • Tirelli N. (2006). (Bio)Responsive nanoparticles. Current Opinion in Colloid and Interface Science, 11, 210 - 216. eScholarID:1d14175

2004

  • Napoli A, Massimiliano Valentini, Tirelli N, Muller M, Hubbell J.A. (2004). Oxidation-responsive polymeric vesicles. Nature Materials, 183 - 189. eScholarID:1d7827 | DOI:10.1038/nmat1081
  • ValentiniM, Vaccaro A, Rehor A, Napoli A, Hubbell J, Tirelli N. (2004). Diffusion NMR spectroscopy for the characterisation of size and interactions of colloidal matter: the case of vesicles and nanoparticles. Journal of the American Chemical Society, 6, 2142 - 2147. eScholarID:1d7794 | DOI:10.1021/ja037247r

2003

  • Hubbell JA, Bearinger J.P, Terrettaz S, MichelR, Tirelli N, VogelH, Textor M. (2003). Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions. Nature Materials, 2, 259 - 264. eScholarID:1d4368 | DOI:10.1038/nmat851
  • Park Y.D, Tirelli N, Hubbell J.A. (2003). Photopolymerized Hyaluronic Acid-Based Hydrogels and InterPenetrating Networks. Biomaterials, 24, 893 - 900. eScholarID:1d4261 | DOI:10.1016/S0142-9612(02)00420-9

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