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School of Medicine

Professor William Hope MBBS, FRACP, FRCPA, PhD

Professor of Therapeutics and Infectious Diseases, NIHR Clinician Scientist, and Honorary Consultant in Infectious Diseases

Room 1.810, Stopford Building, The University of Manchester, Manchester, M13 9PT

 

Role

 I run a research group with a focus on antimicrobial pharmacokinetics and pharmacodynamics.  The focus of my research is the optimisation of antimicrobial therapy.  We have a wide range of experimental models of infection, and use these to explore optimal regimens for human disease.  I use a range of mathematical modeling techniques including population pharmacokinetic modeling, PK-PD modeling and Monte Carlo simulation.  I am interested in individualisation of antimicrobial therapy for humans and am funded by NIHR to develop software so this can be achieved in clinical settings.  I am a member of the subcommittee for antifungal agents for the European Committee of Antimicrobial Susceptibility Testing (EUCAST).  My clinical interests and roles include tuberculosis, infectious diseases supportive care for solid organ transplant recipients and the care of patients with invasive fungal infections.  I am a consultant physician for the National Aspergillosis Centre.

 

Memberships of Committees and Professional Bodies

Fellow of the Royal Australasian College of Physicians, Fellow of the Royal College of Pathologists of Australasia

Research

I am an Infectious Diseases physician with a research interest in animicrobial pharmacokinetics and pharmacodynamics. I employ a wide range of experimental systems to understand drug exposure-response relationships. My work is translational in nature- there is always an attempt to address clinically relevant questions in experiemental models and bridge these results to humans.  I use a range of pharmacokinetic-pharmacodynamic modelling techniques including population PK and Monte Carlo simulation.  I am interested in the individualisation of antimicrobial therapy using stochastic control.  The diseases of interest include invasive fungal infections (invasive aspergillosis, invasive candidiasis and cryptococcal meningitis) and bacterial pneumonia.  My work is funded by the Medical Research Council and the National Institute of Health Research.  I also have a range of collaborative projects with industry.

 

Methodological Knowledge

Experimental models of invasive fungal infection and bacterial pneumonia, antimicrobial pharmacokinetics and pharmacodynamics, mathematical modelling, population pharmacokinetics, Monte Carlo simulation

 

Teaching

I am the Deputy Director of the MRES programme in Medical Sciences and Student Advisor for Year 3 Medical Students.  I am also a supervisor/ advisor to MPhil, MRES, MD and PhD students.

 

Biography


 

Qualifications

MBBS, PhD, FRCPA, FRACP

 

Collaborators and affiliated staff

Professor David Denning (The University of Manchester), Dr Peter Warn (The University of Manchester), Professor George Drusano (Ordway Research Institute), Professor Roger Jelliffe (University of Southern California), Professor Thomas Harrison (St George's London), Dr John Perfect (Duke, USA), Daniel Benjamin (Duke, USA). 

 

Publications

2011

  • 1. Paolo Manzoni, Daniel K Benjamin Jr., William Hope, Stefano Rizzollo, Paola Del Sordo, Mauro Stronati, Evelyne Jacqz-Aigrain, Elio Castagnola, Daniele Farina. (2011). The management of Candida infections in preterm neonates and the role of micafungin. J Matern Fetal Neonatal Med, eScholarID:127909
  • 12. Slater, J.L., Howard, S.J., Sharp, A., Goodwin, J, Gregson, L.M., Alastruey-Izquierdo, A., Arendrup, M. C., Warn, P.A., Perlin, D.S., Hope, W.W. (2011). Disseminated Candidiasis Caused by Candida albicans with Amino Acid Substitutions in Fks1 at Position Ser645 Cannot be Successfully Treated with Micafungin. Antimicrobial Agents and Chemotherapy, eScholarID:127912 | DOI:10.1128/AAC.01686-10
  • 13. Hope, W.W., Howard, S.J., Felton, T.W. (2011). Clinical Utility of Micafungin: Pharmacokinetics, Dosing, Use in Special Populations and Drug Interactions. Mycoses, eScholarID:127913
  • 17. Troke, P., Hockey, H., Hope W.W. (2011). The clinical efficacy of voriconazole and its relationship to plasma concentrations in patients: an observational study. Antimicrobial Agents and Chemotherapy, eScholarID:127907 | DOI:10.1128/AAC.01083-10
  • 3. Susan J. Howard, Joanne Slater, Andrew Sharp, Joanne Goodwin, Lea Gregson, A. Alastruey-Izquierdo, D.S. Perlin, Peter A. Warn, William W. Hope. (2011). Pharmacodynamics of Echinocandins against Candida glabrata: Requirement For Dosage Escalation to Achieve Maximal Antifungal Activity in Neutropenic Hosts. Antimicrobial Agents and Chemotherapy, eScholarID:127910 | DOI:10.1128/AAC.00621-11
  • Agrawal, S. Hope W.W., Sinko, J., Kibbler. (2011). Optimising Management of Invasive Mould Disease. Journal of Antimicrobial Chemotherapy, Suppl 1, i45-53. eScholarID:127911 | DOI:10.1093/jac/dkq441
  • Cohen-Wolkowiez, M., Benjamin, D., Piper, L., Cheifetz, I., Moran, C., Liu, P., Aram, J., Kashuba, A., Capparelli, E., Walsh, T., Hope, W. & Smith, P (2011). Safety and Pharmacokinetics of Multiple-Dose Anidulafungin in Infants and Neonates. CLINICAL PHARMACOLOGY & THERAPEUTICS, 89(5), 702-707. eScholarID:127901 | DOI:10.1038/clpt.2011.26
  • Howard, S., Lestner, J., Sharp, A., Gregson, L., Goodwin, J., Slater, J., Majithiya, J., Warn, P. & Hope, W (2011). Pharmacokinetics and Pharmacodynamics of Posaconazole for Invasive Pulmonary Aspergillosis: Clinical Implications for Antifungal Therapy. JOURNAL OF INFECTIOUS DISEASES, 203(9), 1324-1332. eScholarID:127895 | DOI:10.1093/infdis/jir023
  • Piper, L., Smith, P., Hornik, C., Cheifetz, I., Barrett, J., Moorthy, G., Hope, W., Wade, K., Cohen-Wolkowiez, M. & Benjamin, D (2011). Fluconazole Loading Dose Pharmacokinetics and Safety in Infants. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 30(5), 375-378. eScholarID:127889 | DOI:10.1097/INF.0b013e318202cbb3

2010

  • Benjamin, D., Smith, P., Arrieta, A., Castro, L., Sanchez, P., Kaufman, D., Arnold, L., Kovanda, L., Sawamoto, T., Buell, D., Hope, W. & Walsh, T (2010). Safety and Pharmacokinetics of Repeat-Dose Micafungin in Young Infants. CLINICAL PHARMACOLOGY & THERAPEUTICS, 87(1), 93-99. eScholarID:127900 | DOI:10.1038/clpt.2009.200
  • Denning, D. & Hope, W (2010). Therapy for fungal diseases: opportunities and priorities. TRENDS IN MICROBIOLOGY, 18(5), 195-204. eScholarID:127905 | DOI:10.1016/j.tim.2010.02.004
  • Felton, T., Baxter, C., Moore, C., Roberts, S., Hope, W. & Denning, D (2010). Efficacy and Safety of Posaconazole for Chronic Pulmonary Aspergillosis. CLINICAL INFECTIOUS DISEASES, 51(12), 1383-1391. eScholarID:127891 | DOI:10.1086/657306
  • Hope, W., Petraitis, V., Petraitiene, R., Aghamolla, T., Bacher, J. & Walsh, T (2010). The Initial 96 Hours of Invasive Pulmonary Aspergillosis: Histopathology, Comparative Kinetics of Galactomannan and (1 -> 3)-beta-D-Glucan, and Consequences of Delayed Antifungal Therapy. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(11), 4879-4886. eScholarID:127902 | DOI:10.1128/AAC.00673-10
  • Hope, W., Smith, P., Arrieta, A., Buell, D., Roy, M., Kaibara, A., Walsh, T., Cohen-Wolkowiez, M. & Benjamin, D (2010). Population Pharmacokinetics of Micafungin in Neonates and Young Infants. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(6), 2633-2637. eScholarID:127894 | DOI:10.1128/AAC.01679-09
  • Lestner, J., Howard, S., Goodwin, J., Gregson, L., Majithiya, J., Walsh, T., Jensen, G. & Hope, W (2010). Pharmacokinetics and Pharmacodynamics of Amphotericin B Deoxycholate, Liposomal Amphotericin B, and Amphotericin B Lipid Complex in an In Vitro Model of Invasive Pulmonary Aspergillosis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(8), 3432-3441. eScholarID:127898 | DOI:10.1128/AAC.01586-09
  • Roberts, J., Hope, W. & Lipman, J (2010). Therapeutic drug monitoring of beta-lactams for critically ill patients: unwarranted or essential? INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 35(5), 419-420. eScholarID:127904 | DOI:10.1016/j.ijantimicag.2010.01.022

2009

  • Hope, W (2009). Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary aspergillosis. MEDICAL MYCOLOGY, 47, S291-S298. eScholarID:127896 | DOI:10.1080/13693780802510232
  • Hope, W (2009). Rational Testing Assessing candiduria in a critically ill patient. BRITISH MEDICAL JOURNAL, 338, eScholarID:127899
  • Hope, W. & Drusano, G (2009). Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside. CLINICAL MICROBIOLOGY AND INFECTION, 15(7), 602-612. eScholarID:127890 | DOI:10.1111/j.1469-0691.2009.02913.x
  • Petraitis, V., Petraitiene, R., Hope, W., Meletiadis, J., Mickiene, D., Hughes, J., Cotton, M., Stergiopoulou, T., Kasai, M., Francesconi, A., Schaufele, R., Sein, T., Avila, N., Bacher, J. & Walsh, T (2009). Combination Therapy in Treatment of Experimental Pulmonary Aspergillosis: In Vitro and In Vivo Correlations of the Concentration- and Dose-Dependent Interactions between Anidulafungin and Voriconazole by Bliss Independence Drug Interaction Analysis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(6), 2382-2391. eScholarID:127893 | DOI:10.1128/AAC.00329-09
  • Walsh, T., Pyrgos, V., Kasai, M., Harrington, S., Hope, W., Wubneh, R., Petraitiene, R., Petraitis, V., Greene, L., Aghamolla, T., Suffredini, A., Wayne, A., Gea-Banacloche, J., Holland, S., Malech, H., Childs, R., Fahle, G., Kemp, M., Shea, Y. & Murray, P (2009). Bench to bedside: development and implementation of a clinical protocol for the early molecular detection for the improved diagnosis of invasive pulmonary aspergillosis and zygomycosis. MYCOSES, 52, 51-52. eScholarID:127888
  • Warn, P., Sharp, A., Parmar, A., Majithiya, J., Denning, D. & Hope, W (2009). Pharmacokinetics and Pharmacodynamics of a Novel Triazole, Isavuconazole: Mathematical Modeling, Importance of Tissue Concentrations, and Impact of Immune Status on Antifungal Effect. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 53(8), 3453-3461. eScholarID:127897 | DOI:10.1128/AAC.01601-08

2008

  • Hope, W., Billaud, E., Lestner, J. & Denning, D (2008). Therapeutic drug monitoring for triazoles. CURRENT OPINION IN INFECTIOUS DISEASES, 21(6), 580-586. eScholarID:127903 | DOI:10.1097/QCO.0b013e3283184611
  • Petraitiene, R., Petraitis, V., Hope, W., Mickiene, D., Kelaher, A., Murray, H., Mya-San, C., Hughes, J., Cotton, M., Bacher, J. & Walsh, T (2008). Cerebrospinal Fluid and Plasma (1 -> 3)-beta-D-Glucan as Surrogate Markers for Detection and Monitoring of Therapeutic Response in Experimental Hematogenous Candida Meningoencephalitis. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 52(11), 4121-4129. eScholarID:127892 | DOI:10.1128/AAC.00674-08

2007

  • Hope, W., Shoham, S. & Walsh, T (2007). The pharmacology and clinical use of caspofungin. Expert Opin Drug Metab Toxicol, 3(2), 263-74. eScholarID:69041

  • Gregson L., Hope W.W., Howard S.J. eScholarID:127914

Research Projects

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