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School of Medicine

Dr Harbans Sharma MSc, PhD, DSc

Photograph of Harbans Sharma

Senior Lecturer


 

Role

Teaching: Director of Pre-medical/Pre-Dental (Year0 of the MBChB/BDS Programmes) Course: This is 'Problem Based Learning' course to prepare students with none or partial background in Science subjects for entry into Year1 of the MBChB and BDS programmes of The University. 

Research: Radioisotopes and Radiopharmaceuticals; Their production and applications in Biological, Pharmaceutical and Medical Research.

 

Memberships of Committees and Professional Bodies

  • Society of Nuclear Medicine
  • European Association of Nuclear Medicine

Research

The development of novel radiotracers for myocardial perfusion imaging based on Tc-99m-carbonyl complexes.

Pharmacokinetics and organ distribution of Polysan Polysulphate (PPS): A potential drug against vCJD

Radiolabelling polypeptides specifically synthesised to target amyloid plaques in Alzheimer's disease.

Measuring uptake of non-blood derived lung perfusion agents in the animal model.

 

Methodological Knowledge

  • Production of radioisotopes, the nuclear reaction yields, radiochemical separations and the quality control
  • Radiolabelling cells (Red blood cells, lymphocytes, lymphoid cells, epithelial cells etc.)
  • Synthesis of radiolabelled compounds (Pt-based antitumour compounds, Au-antiarthritic drugs, Tc-99m-compounds, Co-Bleomicine etc.
  • Preparation and in vivo imaging of pharmaceutical formulations
  • Pharmacokinetics of radiolabelled compounds in animal models
 

Teaching

Course Tutor: Pre-Medical/Pre-Dental (year0 of MBChB/BDS Programmes). 

Lectures: 3rd. year Physics in Medicine and Biology students.

Lectures: MSc students taking Nuclear Medicine Module. 

 

Biography

Following graduation in 1964, Harbans went on to do an MSc in Nuclear Physics, obtaining a First class First (and a gold medal) in the University. Harbans worked as a University lecturer in India for 4 years. In July 1970 Harbans went to USA, funded by Fulbright Scholarship, for further studies and research leading to PhD in Nuclear Physics in 1974. He came to Manchester as a research associate in Nuclear Research Group in the Physics Department. In 1975, Harbans developed an interest in the Application of Nuclear Physics to Medicine and contacted Prof. B R Pullan, then the Head of the Department of Medical Biophysics (predecessor of ISBE) and embarked upon a collaborative research programme of producing novel radioisotopes for diagnostic nuclear medicine and other research projects. Success of the pilot programme led to a funding for a three year Research Associateship for Harbans by the NHS in the Department of Medical Biophysics. A number of new research programmes were established during this period and their continuity was supported by the NHS by providing funding for a tenured lecturership for Harbans in 1979. He was promoted to a Senior Lecturership in 1985. Expansion of the research programme and numerous publications in refereed journals prompted Harbans to submit a compilation of some of these for the Doctor of Science degree, which he received from the University of Manchester in 1993. In 1997, Harbans took responsibility of the Pre-Medical/Pre-Dental course and has transferred it to a Problem Based Learning (PBL) format, to be in line with the other Medical and Dental courses, and expanded it from ~12 students in 1996 to 34 in 2007.

 

Collaborators and affiliated staff

  • Mrs Anne-Marie Smith: Research collaborator and Laboratory Manager for all of my research activity
  • Anti-cancer research: Prof. D Crowther, Prof B W Fox, Prof. N thacher, Dr R Cowan
  • Synthesis of anti-tumour agents: Prof. C J Mcauliffe
  • Epethelial cell kinetics: Prof M G Walker
  • Radioisotope uptake and effects on the gonads: Prof J Hendry, Dr P Hoyes
  • PET Isotopes: Prof. D Townsend (Geneva, now at Pittsburg)
 

Publications

2006

  • Ellis, BL, Gorshkov, NI, alexander lumpov, Alexander Miroslavov, Anatoly Yalfimov, Dmitrii Suglobov, Rattana Braddock, Adams, J, Smith, A, Prescott, MC, Sharma, HL. (2006). Pre-clinical evaluation of 99mTc-tricarbonyl complexes as potential myocardial perfusion agents. eScholarID:2d1961
  • Gorshkov, NI, A.A. Lumpov, A.E. Miroslavov, Ellis, BL, Rattana Braddock, Adams, J, Smith, A, Prescott, MC, Sharma, HL, A.N. Yalfimov, D.N. Suglobov. (2006). Technetium-99m and rhenium tricarboyl 2+1 complexes as potential myocardial perfusion agents. eScholarID:2d2514
  • Frances Stops, Fell JT, Collett JH, Martini L.G, Sharma HL, SmithA.M. (2006). Citric acid prolongs the gastro-retention of a floating dosage form and increases bioavailabiliy of riboflavn in the fasted state. International Journal of Pharmaceutics, 308, 14 - 24. eScholarID:1d12712 | DOI:10.1016/j.ijpharm.2005.09.039
  • Sharma HL, Smith A. (2006). Citric acid prolongs the gastro-retention of a floating dosage form and incresaes bioavailability of riboflavin in thefasted state. Int. J. of Pharmaceutics, 308, 14-24. eScholarID:1d13415
  • Stops F, Fell J, Collett J, Martini L, Sharma HL, Smith A. (2006). The use of citric acid to prolong the in vivo gastro-retention of a floating dosage form in the fasted state. Int J Pharmaceutics, 308( 1-2), 8-13. eScholarID:1d13416

2005

  • Gorshkov, NI, Miroslavob, Suglobov, Yalfimov, Ellis, BL, Prescott, MC, Braddock, R, Lumpov, Smith, A, Sharma, HL. (2005). Techneium-99m Pentacarbonyl as Promising Lung Perfusion Agent. European Journal of Nuclear Medicine, eScholarID:1d26588

2004

  • Braddock R, Denney O, Ellis BL, Prescott M, Dealler S, Pepper DS, Sharma HL. (2004). Preparation and Characterisation of 125I-labelled tyrosyl-Pentosan Polysulpahte derivative. eScholarID:2d1284
  • Braddock R, Ellis BL, Prescott M, Dealler S, Pepper DS, Sharma HL. (2004). The Uptake and Organ Distribution of Radioiodinated Pentosan polsulphate derivative in the mouse following intravenous, subcutaneous and oral administration. eScholarID:2d1285
  • Sharma HL, Livens FR, K.Morris, Ellis BL, Bryan N, Lloyd JR. (2004). Biogeochemical controls on technetium mobility in FRC sediments. eScholarID:2d1603
  • Stops Frances, Fell JT, Collett JH, Martini Luigi, Sharma HL, Smith A. (2004). Floating dosage forms for gastro retention - A gamma scintigraphy and bioavailability study. eScholarID:2d1282
  • Chan Henry B S, Ellis BL, Sharma HL, Frost William, Caps Valerie, Shields RR A, Tsang Shik Chi. (2004). Carbon-Encapsulated Radioactive 99mTc Nanoparticles. Advanced Materials, 16 (2), 144-149. eScholarID:1d7775
  • Ofori-KwakyeK, Fell JT, Sharma HL, Smith A. (2004). Gamma scintigraphic evaluation of film-coated tablets intended for colonic or biphasic release. International Journal of Pharmaceutics, 270, 307 - 313. eScholarID:1d7682
  • Sharma HL, Smith A, Stops F. (2004). Floating dosage forms to prolong gastro retention - An in vivo study in the fasted state. British Pharmaceutical Conference, eScholarID:17d169

2002

  • Cowan RA, Murby B, Gunton D, Owens SE, Hoyes KP, Sharma, HL, Smith, A, Chang J, van Kessel B, Nuttall PM, Crowther D. (2002). Autologous lymphocytes as vectors to target therapeutic radiation, using indium-114m, in patients with lymphoid cell malignancy. British Journal Of Haematology, 119, 459-466. eScholarID:1d4034

2001

  • BL Ellis, Sharma HL, Smith A, SK Shukla. (2001). Ovarian uptake of 67Ga: A study of the effect of sodium citrate concentration. eScholarID:2d726
  • Hoyes KP, Wadeson PJ, Murby B, Sharma HL, Cowan RA, Lord BI. (2001). Bone marrow toxicity in mice treated with Indium-114m-La belled blood cells. J. Exp. Clin. Cancer Res, 505-510. eScholarID:1d4033

1999

  • B Ellis, Sharma HL. (1999). Co,Fe and Ga-chelates for cell labelling:a potential use in PET imaging. Nuclear Med.Comm, 20, 1017-1021. eScholarID:1d1418
  • GS Macleod, JT Fell, JH Collett, Sharma HL, Smith A. (1999). Selective drug delivery to the colon using pectin:Chitosan:hydroxypropyl methylcellulose film coated tablets. Int. J. Pharmaceutics, 187, 251-257. eScholarID:1d23368

1998

  • Sharma HL, NC Jackson, H Jackson, Smith A, SK Shukla. (1998). Selective splenic targeting of In-114m by heat treated red blood cells. eScholarID:2d714
  • KP Hoyes, PJ Wadeson, Sharma HL, JH Hendry, ID Morris. (1998). Mutation studies in lac I transgenic mice after exposure to radiation or cyclophosphamide. Mutagenesis, 13, 607-612. eScholarID:1d1416
  • L Whitehead, JT Fell, JH Collett, Sharma HL, Smith A. (1998). Floating dosage forms:an in vivo study demonstrating prolonged gastric retention. J. Controlled Release, 55, 3-12. eScholarID:1d23366
  • O Munjero, JH Collett, JT Fell, Sharma HL, Smith A. (1998). In vivo behaviour of Hydrogel beads based on amidated pectins. Drug Delivery, 5, 239-241. eScholarID:1d23367

1997

  • BL Ellis, Sharma HL. (1997). Evaluation of Co-oxine, Co-tropalonate and Fe-oxine as potential cell labelling agents for PET Imaging. eScholarID:2d725
  • JM Wright, Sharma HL, CA McAuliffe, P Ackrill. (1997). Augmentation of ura and electrolyte removal induced by excess thermal sweating. eScholarID:2d713
  • Sharma HL, RA Cowan, B Murby, S Owens, PM Nuttall, D Gunton, Smith A, J Cheng, D Crowther. (1997). Treatment of lymphoid cell malignancy with In-114m labelled autologous lymphocytes. eScholarID:2d963
  • Sharma HL, Smith A. (1997). Uptake and localisation of radiopharmaceuticals in mouse ovaries. eScholarID:2d964
  • M Ramli, Sharma HL. (1997). Radiochemical separation of 101mPh via 101Pd from a Rhodium target. Int.J.Appl.Rad & Isotopes, 48, 327-31. eScholarID:1d1413
  • PB Geraghty, D Atwood, JH Collett, Sharma HL, Y Dandiker. (1997). An investigation of the parameters influencing the bioadhesive properties of myverol 18-99/water gels. Biomaterials, 18, 63-67. eScholarID:1d23364
  • PI Bates, Sharma HL, B Murrer, CFJ Barnard, CA McAuliffe. (1997). The synthesis of 191Pt labelled JM 216, an orally active platinum anti-tumour agent. Int.J.Appl.Radiat.Isotopes, 48, 469-476. eScholarID:1d1412
  • Sharma HL, RA Cowan, B Murby, S Owens, D Gunton, Smith A, J Chang, D Crowther. (1997). Treatment of lymphoid cell malignancy with In-114m labelled autologous lymphocytes. Anti-cancer Res, 17, 1815-1822. eScholarID:1d23365

1996

  • PB Geraghty, D Atwood, JH Collett, Sharma HL, Y Dandikar. (1996). An investigation into the bioadhesive nature of myverol 18-99. eScholarID:2d1327
  • F Atyabi, Sharma HL, HAH Mohammad, JT Fell. (1996). Controlled drug release from floating ion exchange resin beads. J. Controlled Release, 42, 25-28. eScholarID:1d23362
  • F Atyabi, Sharma HL, HAH Mohammad, JT Fell. (1996). In vivo evaluation of a novel gastric retentive formulation based on Ion exchange resins. J. Controlled Release, 42, 105-113. eScholarID:1d23361
  • HMH Carr, R Vohra, Sharma HL, JV Smyth, OB Rooney, PD Dodd, Walker MG. (1996). Endothelial cell seeding kinetics under chronic flow in prosthetic grafts. Annals of Vascular Surgery, 10, 469-475. eScholarID:1d1408
  • KP Hoyes, D Bingham, JH Hendry, JD Harrison, Sharma HL, ID Morris. (1996). Transferin-mediated uptake of plutonium by spermatogenic tubules. International J.of Radiation Biology, 70, 467-471. eScholarID:1d1410
  • KP Hoyes, ID Morris, JH Hendry, Sharma HL. (1996). Transferrin-mediated uptake of radionuclides by the testes. Journal Of Nuclear Medicine, 37, 36-340. eScholarID:1d23359
  • PI Bates, Sharma HL, BA Murrer, CA McAuliffe. (1996). The tissue distribution in balb/C mice of C-14 labelled JM216,an orally active Pt-antitumour compound. Cancer Chemotherapy and Pharmacology, 39, 170-175. eScholarID:1d23363

1995

  • H.A.H. Mohammad, Fell JT, Sharma HL, F.Atyabi. (1995). A novel floating preparation based on ion exchange resins. eScholarID:2d1529
  • KP Hoyes, JH Hendry, Sharma HL, ID Morris. (1995). Testicular localisation of radionuclides via the transferrin pathway. eScholarID:2d533
  • KP Hoyes, Sharma HL, ID Morris, JH Hendry. (1995). Effects of dietary vitamin C on radiation induced damage to the testis. eScholarID:2d804
  • KP Hoyes, Sharma HL, ID Morris, JH Hendry. (1995). Lack of protection by vitamin C against radiation-induced testicular damage. eScholarID:2d962
  • M Ramli, Sharma HL. (1995). Radiochemical separation of Rh-101m via Pd-101 with Rh target. eScholarID:2d534
  • PI Bates, Sharma HL, BA Murror, CA McAuliffe. (1995). Synthesis of Pt-191 labelled JM216, an orally active anti-tumour Compound. eScholarID:2d757
  • PI Bates, Sharma HL, BA Murror, CA McAuliffe. (1995). The tissue distribution in mice of C-14 labelled JM216 an orally active anti-tumour compound. eScholarID:2d758
  • Sharma HL, ND Tinker, Smith A, CA McAuliffe. (1995). Conversion of CBDCA to Cis-DDP in in vitro incubations of CBDCA in rat plasma. eScholarID:2d756
  • Sharma HL. (1995). A novel mechanism for selective testicular toxicity of environmentally important radioisotopes. eScholarID:2d1345
  • H Jackson, M Bock, NC Jackson, F Barnett, Sharma HL. (1995). A turnover study in the male rat of plasma bound 59Fe,114mIn and 109Cd with particular reference to the gonad. Nucl.Medicine Communications, 16, 112-120. eScholarID:1d1398
  • HMH Carr, JV Smyth, OB Rooney, PD Dodd, Sharma HL, Walker MG. (1995). Limitations of in vitro labelling of endothelial cell with In-111 oxine. Cell Transplant, 4, 291-296. eScholarID:1d1402
  • KP Hayes, C Johnston, RE Johnson, RG Lendon, JH Hendry, Sharma HL, ID Morris. (1995). Testicular toxicity of the transferrin binding radionuclide 114m in adult and neonate rats. Reproductive Toxicology, 9, 297-305. eScholarID:1d1388
  • KP Hoyes, ID Morris, Sharma HL, JH Hendry. (1995). Lack of protection by Vitamin C against radiation-induced damage to the testes. Journal of Radiological Protection, 15, 143-150. eScholarID:1d1389

1994

  • KP Hoyes, NC Jackson, H Jackson, Sharma HL, JH Hendry, ID Morris. (1994). Genotoxic consequences of testicular localisation of In-114m. Male Mediated development Toxicity. New York. eScholarID:3d495
  • H.A.H. Mohammad, Fell JT, Sharma HL, F.Atyabi. (1994). A novel floating system using ion exchange resins. eScholarID:2d1563
  • K Sano, T Kanri, Sharma HL, Smith A, JP Rood. (1994). The influence of Lignocaine and Adrenaline on Peripheral blood flow: An animal study. eScholarID:2d532
  • KP Hoyes, RE Johnson, JH Hendry, Sharma HL, ID Morris. (1994). Radionuclide uptake in the testis via the receptor mediated endocytosis of transferrin. eScholarID:2d802
  • L Radwan, Sharma HL, CA McAuliffe. (1994). Oxine conjugates of Co-55, Ga-66 and Cu-64 as potential cell labels for PET scanning. eScholarID:2d1344
  • N Shiel, O Cassidy, Sharma HL, JM Braganza. (1994). Pancreatic uptake of potentionally therapeutic antioxidents in caerulein - induced experimental pancreatitis. eScholarID:2d755
  • O Cassidy, N Shiel, J Fell, Sharma HL, JM Braganza. (1994). Pilot study of 14C-5 amino salycylic acid distribution in caerulein pancreatitis. eScholarID:2d803
  • Sharma HL. (1994). The tissue distribution in mice of C-14 labelled JM 216, an orally active Platinum Antitumour Agent. eScholarID:2d724
  • SK Shukla, C Cipriani, Sharma HL, G Argiro, G Atezei, S Boemi, GS Limouris, M Cristalli. (1994). Advanced Lung cancer therapy with Y-90 or In-114m species. eScholarID:2d712
  • J Bowen, Sharma HL, DCS Gough. (1994). Chronic hydronephrosis:renographic drainage patterns and renal morphology in an animal model. British Journal Of Urology, 74, 26-30. eScholarID:1d23354
  • KP Hoyes, Sharma HL, H Jackson, JH Hendry, ID Morris. (1994). Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m. Radiation Research, 139, 185-193. eScholarID:1d1387
  • O Cassidy, JT Fell, Sharma HL, N Sheil, JM Braganza. (1994). Action of 5-amino salicylic acid(5-ASA)in caerulein-induced acute pencreatits. Clinical Science, 86, eScholarID:1d23348
  • RE Wilson, KP Hoyes, ID Morris, Sharma HL, JH Hendry, GP Margison. (1994). In vivo induction of O6-alkyl guanine DNA alkyl transferase in response to In-114m. Radiation Research, 138, 26-33. eScholarID:1d1385

1993

  • Sharma, HL, GS Limouris, RA Cowan, SK Shukla, M Drayson, B Murby, S Owens, PM Nutall, J Chang, DP Deakin, D Crowther. (1993). Selective targeting of In-114m for the treatment of lymphoid cell malignancy; from laboratory to the clinic. Radionuclides for Therapy. Athens. eScholarID:3d321
  • SK Shukla, GS Limouris, S Cipriani, SK Shukla, G Argiro, R Hermes, GS Limouris, K Shomacker, N Baziotis, Sharma, HL. (1993). Biochemical nature of cancer studied with radionuclide pure species in aqueous solution. Radionuclides for Therapy. Athens. eScholarID:3d115
  • A Grady, Smith A, NC Jackson, PM Nuttall, Sharma HL. (1993). Gonadal uptake and localisation of Ga-67, In-111 and Tc-99m-HMPAO in a rodent model. eScholarID:2d722
  • KP Hoyes, ID Morris, JH Hendry, Sharma HL. (1993). Mutagenic effects of In-114m in the rat. eScholarID:2d711
  • KP Hoyes, ID Morris, Sharma HL, H Jackson, JH Hendry. (1993). Distribution and Radiobiological effects of b and g emitting radionuclides in the rodent testes. eScholarID:2d721
  • KP Hoyes, J Hendry, ID Morris, H Jackson, Sharma HL. (1993). Mutagenic consequences of testicular radionuclide localisation. eScholarID:2d1343
  • KP Hoyes, Sharma HL, JH Hendry, H Jackson, ID Morris. (1993). Male fertility in rats after internal radiation with 114mIn, a transferrin binding isotope. eScholarID:2d723
  • KP Hoyes, SL Taylor, ID Morris, Sharma HL, JH Hendry, GP Margison, RE Wilson. (1993). IN vivo induction of O6-alkyguanine-DNA-alkyltransferase by In-114m. eScholarID:2d767
  • MR Rose, MC Prescott, Smith A, Sharma HL. (1993). Testicular uptake of In-111 in patients from In-111 labelled platelets. eScholarID:2d754
  • M Ashford, JT Fell, D Atwood, Sharma HL, PJ Woodhead. (1993). An evaluation of pectin as a carrier for drug targeting to the colon. J. Controlled Release, 26, 213-220. eScholarID:1d23347
  • M Ashford, JT Fell, D Atwood, Sharma HL, PJ Woodhead. (1993). An in vivo investigation into the suitability of pH dependent polymers for colonic targeting. Int. J. Pharmaceutics, 95, 193-199. eScholarID:1d23346

1992

  • HMH Carr, R Vohra, M Welch, Sharma HL, OB Rooney, Walker MG. (1992). Fibronectin binding to gelatin-impregnated Dacron (Gelseal) prostheses. eScholarID:2d801
  • HMH Carr, R Vohra, M Welch, Sharma HL, OB Rooney, Walker MG. (1992). The durability of seeded endothelial cell monolayers. eScholarID:2d531
  • HMH Carr, R Vohra, Sharma HL, OB Rooney, M Welch, Walker MG. (1992). The effect of prolonged shear stress on seeded endothelial cell retention on precoated expanded polytetrafluoroethylene and gelatin impregnated Dacron. eScholarID:2d753
  • KP Hoyes, M Cox, C Jackson, H Jackson, Sharma HL, ID Morris, JH Hendry. (1992). Localisation of In-114m in the rodent testis. eScholarID:2d720
  • KP Hoyes, M Cox, NC Jackson, Sharma HL, ID Morris, JH Hendry. (1992). Localisation of 114m In in the rodent testes. eScholarID:2d520
  • KP Hoyes, NC Jackson, H Jackson, Sharma HL, JH Hendry, ID Morris. (1992). Genotoxic consequences of testicular localisation of Indium-114m. eScholarID:2d799
  • M Ashford, JT Fell, A Atwood, Sharma HL, PJ Woodhead. (1992). In vivo assessment of colonic drug delivery systems. eScholarID:2d1340
  • R Cowan, B Murby, S Owens, P Nuttall, M Drayson, Sharma HL, J Chang, D Deakin, D Crowther. (1992). Autologous lymphocytes to target therapeutic radiation in patients with chronic lymphocytic leukaemia. eScholarID:2d960
  • Sharma HL, NC Jackson, H Jackson. (1992). Testicular localisation of radionuclides and potential hazard. eScholarID:2d961
  • Sharma HL, NC Jackson, M Bock, H Jackson. (1992). Treatment of on acute rat lymphoblastic leukaemia by combined drug and cell targeted radiotherapy. eScholarID:2d798
  • Sharma HL, R Cowan, M Drayson, S Owens, P Nuttall, D Deakin, D Crowther. (1992). Selective lymphoid tissue irradiation using autologous lymphocytes in patients with chronic lymphocytic leukaemia. eScholarID:2d1342
  • Sharma HL, Smith A, R Kumar, V Kaushik, NC Jackson, H Jackson. (1992). Radiopharmaceuticals and the rat testis. eScholarID:2d1341
  • SK Shukla, C Cipriani, G Argiro, N Baziotis, D Kateveni, G Limours, K Schomacker, H Xie, Sharma, HL, M Cristalli, A Muller. (1992). Pure radionuclide (Ga-67, Tc-99m, In-111, Y-90) species in the study of the biochemical nature of cancer and in its diagnosis and therapy. eScholarID:2d652
  • SK Shukla, Sharma HL, C Ciprinani, G Argiro, U Tarantino. (1992). A study of the factors which can eliminate cisplatin toxicity during tumour therapy. eScholarID:2d1339
  • A Perera, H Jackson, Sharma HL, CA McAuliffe, BW Fox. (1992). A Comparative binding of platinum anti-tumour compounds to plasma proteins in the rat(in vivo)and in mouse(in vitro). Chem-Biol. interactions, 85, 199-213. eScholarID:1d1378
  • DH Woods, SA Woods, MJ Woods, JL Makepeace, CWA Downey, D Smith, AS Munster, S Lucas, Sharma HL. (1992). The standardisation and measurement of decay scheme data of 124I. Int.J.of Appl.Radiat.Isotopes, 43, 551-564. eScholarID:1d1372
  • HMH Carr, R Vohra, M Welch, OB Rooney, Sharma HL, Walker MG. (1992). Fibronectin binding to gel impregnated Dacron(gelseal)prostheses. Artificial Organs, 16, 342-345. eScholarID:1d1380
  • J Zweit, R Goodall, JW Babich, Sharma HL, RJ Ott. (1992). Cerium-134/Lanthanum-134,a new radionuclides generator system for positron emission tomgraphy. Journal of Labelled Comp. and Radiopharmaceuticals, 32, 480-482. eScholarID:1d1374
  • J Zweit, R Goodall, M Cox, JW Babich, GA Potter, Sharma HL, RJ Ott. (1992). Development of a high performance 62Zn-62Cu radionuclide generator for positron emission tomography. European Journal of Nuclear Medicine, 19, 418-425. eScholarID:1d23343
  • NC Jackson, H Jackson, M Bock, C Ramsden, Sharma HL. (1992). Cell tageted In-114m and drug (BCNU) combination therapy in a rat acute lymphoblastic leukaemia. Nucl.Med.Communications, 13, 614-619. eScholarID:1d1373
  • R Vohra, GJ L Thompson, HMH Carr, Sharma HL, Walker MG. (1992). The response of rapidly formed adult human endothelial-cell monolayers to shear stress of flow:A comparison of fibronectin-coated Teflon and gelatin-impregnated Dacron grafts. Surgery, 111, 210-220. eScholarID:1d23345

1991

  • FR Hartley, CA McAuliffe, Sharma HL, ND Tinker. (1991). Cancer chemotherapy involving platinum and other platinum group complexes. Chemistry of the platinum group metals. eScholarID:3d114
  • AG Filler, BA Bell, FA Howe, JR Griffiths, M Flower, Sharma HL, HR Winn, TW Deacon. (1991). Imaging of axonal transport: is the axoplasmic flow clinically relevant?. eScholarID:2d797
  • DJ Murphy, MJ Lind, Sharma HL, N Tinker, Smith A, CA McAuliffe, D Crowther. (1991). Comparative intraperitonal pharmacokinetics of Cis-DDP, CHIP and CBDCA. eScholarID:2d518
  • G Westera, HW Reist, F Buchegger, CH Heusser, N Hardman, A Pfeiffer, Sharma HL, GK Von Schultress, JP Mach. (1991). Radioimmuno positron emission tomography with monoclonal antibodies: A new approach for quantifying in vivo tumour concentration and biodistribution of therapeutic radionuclides. eScholarID:2d709
  • HMH Carr, R Vohra, M Welch, OB Rooney, Sharma HL, Walker MG. (1991). Does indium-111 oxine labelling of human adult endothelial cells adversely affect their viability?. eScholarID:2d522
  • HMH Carr, R Vohra, M Welch, Sharma HL, Walker MG. (1991). Fibronectin binding to gelatin impregnated Dacron (Gelseal). eScholarID:2d749
  • HMH Carr, R Vohra, M Welch, Sharma HL, Walker MG. (1991). Fibronectin binding to gelatin impregnated Dacron (Gelseal). eScholarID:2d795
  • J Zweit, JW Babich, MA Bakir, Sharma HL, RJ Ott. (1991). Production of no-carrier added 86Y for radioimmuno-imaging using positron emission tomography (PET). eScholarID:2d710
  • J Zweit, Sharma HL, R Goodall, M Cox, MA Bakir, RJ Ott. (1991). Excitation functions of proton induced reactions in natural tellurium: production of no carrier added I-124 for PET applications. eScholarID:2d719
  • KP Hayes, M Cox, NC Jackson, H Jackson, Sharma HL, ID Morris, JH Hendry. (1991). Localisation of 114mIn in the rodent testes. eScholarID:2d519
  • M Ashford, JT Fell, D Atwood, Sharma HL, PJ Woodhead. (1991). Colonic drug delivery via the use of pH dependent polymers. eScholarID:2d794
  • M Oliveira, N Tinker, Sharma HL, CA McAuliffe, J Miller. (1991). Synthesis and characterisation of platinum fluorinated dicarboxyklate ligands. eScholarID:2d793
  • ND Tinker, Sharma HL, Smith A, CA McAuliffe. (1991). The tissue distribution and pharmacokinetics following oral administration of 195mPt-CHIP. eScholarID:2d1338
  • O Cassidy, JT Fell, Sharma HL, JM Braganza, OL Arouma. (1991). Action of 5-ASA on the inactivation of alpha-antiprotease protein by oxygen derived species. eScholarID:2d650
  • R Cowan, B Murby, S Owens, P Nuttall, M Drayson, Sharma HL, J Chang, D Deakin, D Crowther. (1991). Autologous lymphocytes to target therapeutic radiation in patients with chronic lymphocytic leukaemia. eScholarID:2d651
  • C Jackson, H Jackson, ID Morris, Sharma HL. (1991). Metal radionuclides and the testis. Int.J.Appl.Ratiat.Biology, 60, 851-858. eScholarID:1d1363
  • DE Snook, G Rowlinson-Busza, Sharma HL, AA Epenetos. (1991). Preparation and in vivo study of 124I-labelled monoclonal antibody H17E2 in a human tumour xenograft model.A prelude to positrion emission tomography.(PET). British Journal Of Cancer, 62, 89-91. eScholarID:1d23341
  • G Westera, HW Reist, F Buchegger, CH Heussen, N Hardman, A Pfeiffer, Sharma HL, GK Von Schulttess, JP Mach. (1991). Radioimmuno PET with MoAB:A new approach to quantifying in vivo tumour concentration and biodistribution for radioimmunotherapy. Nuclear Medicine Communications, 12, 429-437. eScholarID:1d1371
  • H Jackson, CA McAuliffe, A Perera, Sharma HL. (1991). An imprved methed for the preparation of 195mPt-labelled anti-tumour complexes. J Labell.Comp. and Radiopharmaceuticals, 29, 1121-1130. eScholarID:1d1364
  • J Zweit, S Downey, Sharma HL. (1991). Production of no carrier added Zirconium-89 for positron emission tomography. Int.J.Appl.Ratiat.Isotopes, 42, 199-201. eScholarID:1d1362
  • J Zweit, Smith A, S Downey, Sharma HL. (1991). Excitation functions for deuteron induced reactions in natural nickel: production of no carrier added 64Cu from enriched 64Ni targets for positron emission tomography. Int.J.Appl.Radiat.Isotopes, 42, 193-197. eScholarID:1d1361
  • MJ Lind, DJ Murphy, Sharma HL, N Tinker, Smith A, CA McAuliffe, D Crowther. (1991). Comparative intraperitoneal pharmacokinetics of three platinum analogues. Cancer Chemotherapy and Pharmacology, 28, 315-317. eScholarID:1d23338
  • ND Tinker, J ZWeit, Sharma HL, S Downey, C McAuliffe. (1991). Production of no carrier added 191Pt, a radiolabel for the synthesis and biological investigations of Pt-anti-tumour compounds. Radiocheimica Acta, 54, 29-34. eScholarID:1d1368
  • O Cassidy, JT Fell, Sharma HL, JM Braganza, OI Aruoma, B Halliwell. (1991). Action of 5-ASA on the inactivation of X-anti protease protein by oxygen derived species. J. Pharm. Pharmacol, 43, eScholarID:1d23337
  • R Vohra, GJL Thompson, HMH Carr, Sharma HL, M Welch, Walker MG. (1991). In vitro adherence and kinetic studies of adult human endothelial cell seeded ePTFE and gelatin impregnated dacron grafts. Eur.J.Vasc.Surg, 5, 93-103. eScholarID:1d1360
  • R Vohra, GJL Thompson, HMH Carr, Sharma HL, Walker MG. (1991). Comparison of different vascular prosthesis and matrices in relation to endothelial seeding. British Journal of Surgery, 78, 417-426. eScholarID:1d23340
  • R Vohra, GJL Thompson, Sharma HL, HMH Carr, Walker MG. (1991). The effect of varying fibronecritin concentration on the attachment of endothelial cells to ePTFE vascular grafts. Journal of Vascular Surgery, 14, eScholarID:1d1382
  • Sharma HL, J Zweit, S Downey. (1991). Production of medium half-litre positron emitting radionuclides using a cyclotron. Acta Radiologica (including Supplements), 376, 66-67. eScholarID:1d23342

1990

  • R Vohra, GJL Thompson, Sharma HL. (1990). Comparison of different vascular prosthesis grafts and matrices in relation to endothelial seeding. eScholarID:2d718
  • R Vohra, GJL Thompson, Sharma HL. (1990). Effect of shear stress of flow on rapidly formed endothelial cell monolayers on fibronectin coated Teflon and gelatin impregnated dacron. eScholarID:2d792
  • R Vohra, GJL Thompson, WF Tait, HMH Carr, Sharma HL, Walker MG. (1990). Effect of shear stress on rapidly formed endothelial cell monolayers on fibronectin-coated ePTFE and dacron grafts. eScholarID:2d692
  • R Vohra, Sharma HL. (1990). In vitro adherence and kinetic studies of adult human endothelial cell seeded ePTFE and Gelseal grafts. eScholarID:2d748
  • Sharma HL. (1990). Survey of radiopharmaceuticals. eScholarID:2d791
  • Sharma HL. (1990). Use of radioactive isotopes. eScholarID:2d647
  • Sharma HL. (1990). Use of radiolabelled pt-complexes for pharmacokinetics and metabolism studies. eScholarID:2d648
  • Vohra, Sharma HL. (1990). The Role of fibronectin in endothelial seeding of vascular prostheses. eScholarID:2d649
  • D Harris, JT Fell, DC Taylor, J Lynch, Sharma HL. (1990). GI-transit of potential bioadhesive systems in the rat. J. Controlled Release, 12, 55-65. eScholarID:1d23327
  • D Harris, JT Fell, Sharma HL, DC Taylor. (1990). GI-transit of potential bioadhesive formulations in man: A scintigraphic study. J. Controlled Release, 12, 45-53. eScholarID:1d23326
  • DE Snook, G Rowlinson-Busza, Sharma HL, AA Epenetos. (1990). Preparation and in vivo study of I-124 labelled monoclonal anti body H17E2 in human tumour xenografts model. British Journal Of Cancer, 10, 89-91. eScholarID:1d23334
  • GM Cleator, PE Klapper, AG Lewis, Sharma HL, Smith A. (1990). Measurement of renal blood flow by 131I-labelled sodium iodohippuran in a rat model of Herpes Encephalits. Acta Radiologica (including Supplements), 538-539. eScholarID:1d23336
  • H Jackson, NC Jackson, ID Morris, Sharma HL. (1990). Intratesticular radionuclide and spermatogenic damage. British Medical Journal, 300, 1014-1015. eScholarID:1d23335
  • H Jackson, NC Jackson, M Bock, A Perera, C Ramsden, Sharma HL. (1990). Experimental investigation into the clearance, targeting and stability of In-114m labelled lymphoid cell. Clin. Biol. Res, 355, 219-228. eScholarID:1d1353
  • MA Flower, AT Irvine, RJ Ott, F Kabir, VR McReady, CL Hammer, Sharma HL, AG Smith. (1990). Thyroid imaging using a PET a comparison with ultrasound imaging and conventional scintigraphy in throtoxicosis. British Journal of Radiology, 63, 325-330. eScholarID:1d23333
  • ND Tinker, B Speigeleer, Sharma HL, H Jackson, CA McAuliffe, JP Reman. (1990). The tissue distribution in rats of 195mPt carboplatin following IV,IP and oral administration. Nucl.Med.Biol, 17, 427-436. eScholarID:1d1356
  • ND Tinker, Sharma HL, CA McAuliffe. (1990). [82Br] Cisplatin derivative:A potential biological model for cisplatin. J. Labelled compounds and radiopharmaceuticals, 28, 971-976. eScholarID:1d1351
  • RK Vohra, GJL Thompson, Sharma HL, HMH Carr, Walker MG. (1990). Effects on shear stress on endothelical cell monolayers on ePTFE grafts using preclot and fibronectin matrices. European Journal of vascular surgery, 4, 33-41. eScholarID:1d1342
  • RK Vohra, GJL Thompson, Sharma HL, HMH Carr, Walker MG. (1990). Fibronectin coating of ePTFE grafts and its role in endotherial seeding. Artificial organs, 14, 41-45. eScholarID:1d1349
  • WL Hill, CA McAuliffe, Sharma HL, A Zaki. (1990). Sythesis characterization and antitumor testing of some platinum(II)amine complexes containing 1,1 and 1,2-cyclobutane dicarboxylate ligands. Chemico-Biological Interactions, 73, 337-351. eScholarID:1d1352

1989

  • B Casey, PH Bach, EA Lock, S McGuinness, I Pratt, MP Ryan, CA McAuliffe, Sharma HL, ND Tinker. (1989). Uptake of cis-platin(195Pt)into LLCPK cells in the presence of DDTC,MESNA and amiloride. Nephrotoxicity. eScholarID:3d320
  • PH Bach, T Ormond, EA Lock, S McGuinness, I Pratt, MP Ryan, CA McAuliffe, Sharma HL, ND Tinker. (1989). The effect of amiloride on renal uptake of cisplatin(195Pt)in male wistar rats. Nephrotoxixity. eScholarID:3d371
  • D Snook, G Rawlinson-Busza, Sharma HL, AA Epenetos. (1989). Preparations and in vivo study of Iodine-124 labelled monoclonal antibody H17E2 in a human tumour xenograft model. eScholarID:2d788
  • H Jackson, NC Jackson, M Bock, Sharma HL. (1989). Experimental Investigation into the clearance, targeting and stability of In-114m labelled lymphocytes. eScholarID:2d646
  • R Vohra, GJL Thompson, Sharma HL, Walker MG. (1989). The effect of shear stress imposed by flow on endothelial cell monolayers on ePTFE comparing Prectol and Fibronectin matrices. eScholarID:2d716
  • R Vohra, GJL Thompson, Sharma HL, Walker MG. (1989). The role of fibronectin in endothelial reading of vascular prostheses. eScholarID:2d789
  • R Vohra, GJL Thomson, Sharma HL, Walker MG. (1989). The Role of fibronectin in endothelial seeding. eScholarID:2d787
  • R Vohra, Sharma HL, Walker MG. (1989). Effect of shear stress on endothelialized grafts. eScholarID:2d1334
  • RA Cowan, M Drayson, SE Owens, Sharma HL, P Nuttall, D Deakin, D Crowther. (1989). Autologous lymphocytes as vectors to target Indium-114m to sites of disease in Non-Hodgkin's lymphoma. eScholarID:2d1337
  • Sharma HL, AG Smith, J Zweit, R Goodall, D Bonnett, T Saxton, G Lawrence. (1989). Potential for the production of medically useful radionuclides at the Clatterbridge Cyclotron. eScholarID:2d1336
  • Sharma HL, D Hamilton, R Cowan, P Cummins, P Nuttall, M Drayson, D Crowther. (1989). Selective internal lymphoid irradiation with In-114m labelled lymphocytes: A preliminary report. eScholarID:2d517
  • Sharma HL, H Jackson, NC Jackson, M Bock. (1989). Radiotherapy by 114mIn-labelled lymphocytes combined with chemotherapy in rat leukaemia model. eScholarID:2d645
  • Sharma HL, J Zweit, S Downey. (1989). Production of medium half-life, positron emitting radionuclides using a cyclotron. eScholarID:2d747
  • D Harris, JT Fell, DC Taylor, J Lynch, Sharma HL. (1989). The oral availability of a poorly absorbed drug, hydrochlorothiazide,from a bio-adhesive formulation,in the rat. Int. J. Pharmaceutics, 56, 97-102. eScholarID:1d23323
  • D Harris, JT Fell, Sharma HL, DC Taylor, J Lynch. (1989). Studies on potential bioadhesives systems for oral drug delivery. Sciences techniques et pratiques pharmaceutiques, 5, 852-856. eScholarID:1d1338
  • GM Cleator, AG Lewis, PE Klapper, Sharma HL, Smith A. (1989). HM-PAO-imaging and herpes encephalitis. Archives Of Virology, 109, 263-268. eScholarID:1d23324
  • SM Cotterill, Sharma HL, DB Dyson, RV Parish, CA McAuliffe. (1989). The role of ligand in Chrysotherapy; a kinetic study of 199Au and 35S labelled Myocrisin and Auronofin. J. Chem. Soc., Perkin Trans, 2, 53-58. eScholarID:1d23322

1988

  • PE Cummings, HAE Schmidt, GL Buraggi, D Hamilton, R Cowan, Sharma HL, P Nuttall, M Drayson, D Crowther. (1988). Treatment of lymphoid cell malignancy using In-114m labelled lymphocytes. Nuclear Medicine:Trends and possibilities in Nuclead Medicine. eScholarID:3d974
  • B Spiegeleer, ND Tinker, Sharma HL, H Jackson, M Bock, CA McAuliffe. (1988). Study of IV, IP and oral administration of carboplatin in rats. eScholarID:2d1333
  • J Zweit, Sharma HL, Smith A, S Downey. (1988). Production of carrier-free 64Cu: A positron emitting radionuclide. eScholarID:2d643
  • JT Fell, D Harris, Sharma HL, J Lynch, DC Taylor. (1988). Muco-adhesive polymers and G I transit of oral dosage forms. eScholarID:2d644
  • JT Fell, D Harris, Sharma HL, J Lynch, DC Taylor. (1988). Muco-adhesive polymers and gastro-intestinal transit of oral pharmaceutical formulations. eScholarID:2d1331
  • ND Ticker, A Perera, Sharma HL, CA McAuliffe. (1988). Synthesis of 195mPt-labelled CBDCA, an active anti-tumour drug and its use in metabolic investigations. eScholarID:2d691
  • ND Tinker, MP Ryan, I Pratt, CA McAuliffe, Sharma HL, BA Casey. (1988). Uptake of (195mPt-Cis-platin into LLCPK and MDCK Renal Epitheliel Cell lines. eScholarID:2d715
  • PE Cummings, D Hamilton, R Cowan, Sharma HL, P Nuttal, M Drayson, D Crowther. (1988). Treatment of lymphoid cell malignancy using In-114m labelled lymphocytes. eScholarID:2d1330
  • RV Parish, Sharma HL, SM Cottrill, CA McAuliffe. (1988). Single dose pharmacokinetics of 199Au myocrisin and 199Au and 35S-Auronofin in rats. eScholarID:2d1325
  • Sharma HL, AK Gupta, Smith A, ND Tinker, CA McAuliffe. (1988). IP vs IV Pharmacokinetics of carboplatin, an anti-tumour drug, using 195mPt as a radioactive tracer. eScholarID:2d785
  • Sharma HL, J Zweit, S Downey, Smith A, AG Smith. (1988). Production of 124I for positron-emission tomography. eScholarID:2d1332
  • Sharma HL, RC Saxena, AK Gupta, TK Gupta, Smith A, VS Saxena, ND Tinker, CA McAuliffe. (1988). Pharmacokinetics of carboplatin, using 195mPt as a radioactive tracer. eScholarID:2d527
  • Sharma HL, Smith A, JT Fell, JM Braganza. (1988). A Gamma-Scintigraphic Technique for investigation of esophageal transit, retention and reflux of a new cimetidine formulation. eScholarID:2d515
  • SK Shukla, C Cipriani, M Cristalli, G Politana, A Muller, Sharma HL. (1988). Tumour-specific chemotherapy of melanoma with platinum complexes. eScholarID:2d516
  • C Ewen, A Perera, JH Hendry, CA McAuliffe, Sharma HL, B Fox. (1988). An auto-radiographic study of the intra-renal localisation and retention of cisplatin,iproplatin and paraplatin. Cancer Chemotherapy and Pharmacology, 22, 241-245. eScholarID:1d23319
  • D Hamilton, R Cowan, M Drayson, Sharma HL, P Cummins, P Nuttall, D Deakin, J Wagstaff, D Crowther. (1988). 114mIn-Oxide labelled lymphocytes-therapeutic applications. Journal Of Nuclear Medicine, 9, 797-802. eScholarID:1d23321
  • D Hamilton, RA cowan, Sharma HL, M Drayson, J Wagstaff, DP Deakin, D Crowther. (1988). The behaviour of autologus In-114m labelled lymphocytes in patients with lymphoid cell malignancy. Journal Of Nuclear Medicine, 29, 485-493. eScholarID:1d23318
  • GM Cleator, PE Klapper, AG Lewis, Sharma HL, M Longson. (1988). Specific neuro-radiological diagnosis of herpes encephalitis in an animal model. Archives Of Virology, 101, 1-12. eScholarID:1d23320
  • J Zweit, S Downey, Sharma HL. (1988). A method for the production of Iron-52 with a very low Iron-55 contamination. Int.J.Appl.Radiation Isotopes, 39, 1197-1201. eScholarID:1d1331

1987

  • B Casey, S McGuiness, I Pratt, MP Ryan, CA McAuliffe, Sharma HL, ND Tinker. (1987). Uptake of Cis-platin (195mPt) into LLCPK cells in the presence of DDTC, MESNA and Amiloride. eScholarID:2d746
  • D Harris, Sharma HL, Smith A, JT Fell, D Taylor. (1987). The assessment of muco-adhesive agents for delaying gastro-intestinal transit in human volunteers using gamma-scintigraphy. eScholarID:2d689
  • J Zweit, Sharma HL, S Downey. (1987). Production of Ga-66, a positron emitting radionuclide as a potential label for monoclonal antibodies. eScholarID:2d686
  • J Zweit, Sharma HL, S Downey. (1987). Production of Iron-52 for bone marrow imaging. eScholarID:2d685
  • JT Fell, D Harris, Sharma HL, DC Taylor. (1987). The use of muco-adhesive polymers to modify the gastro-intestinal transit of oral pharmaceutical formulations. eScholarID:2d687
  • M. Nicolini, Sharma HL. (1987). Qualitative investigation,both in vivo and in vitro of the metabolites formed by cisplatin and paraplatin involving high performance liquid chromatography analysis. eScholarID:2d742
  • NC Jackson, H Jackson, Sharma HL. (1987). Distribution patterns and clearance of radioactive material following injection of In-114m-oxine labelled cells into normal and leukaemic rats. eScholarID:2d529
  • ND Tinker, Sharma HL, CA McAuliffe. (1987). A qualitative investigation both in vivo and in vitro of the metabolites formed by cisplatin and paraplatin involving high performance liquid chromatography. eScholarID:2d688
  • Sharma HL, ND Tinker, CA McAuliffe, MJ Lind, DB Smith, D Crowther, M Nicolini. (1987). IP vs IV pharmacokinetics in patients using radiolabelled paraplatin. eScholarID:2d706
  • SM Cottrill, Sharma HL, RV Parish, CA McAuliffe. (1987). Single dose pharmacokinetics of 199Au-myocrism, 199Au-auronofin and 35S-auronofin in rats. eScholarID:2d690
  • T Ormond, S McGuiness, I Pratt, MP Ryan, CA McAuliffe, Sharma HL, ND Tinker. (1987). The effect of amiloride on renal uptake of Cis-platin (195mPt) in male wistar rats. eScholarID:2d784
  • D Harris, JT Fell, Sharma HL, DC Taylor. (1987). Assessment of gastric emptying using gamma-scintigraphy. Journal of Clinical Pharmacy and Therapeutics, 12, 34-346. eScholarID:1d23316
  • GM Cleator, PE Klapper, Sharma HL, M Longsom. (1987). A rat model of herpes encephalitis with special reference to its potential for the development of diagnostic brain imaging. Journal of the Neurological Sciences, 79, 55-56. eScholarID:1d1324
  • J Zweit, Sharma HL, S Downey. (1987). Production of Gallium-66, a short lived positron emitting radionuclide. Int.J.App.Rad.and Isotopes, 38, 499-501. eScholarID:1d1327
  • P Bedford, MC Walker, Sharma HL, A Perera, CA McAuliffe, JRW Master, BT Hill. (1987). Factors influencing the sensitivity of two human bladder carcinoma cell lines to cis-diammino-dichloroplatinum(II). Chem.Biol.Interactions, 61, 1-15. eScholarID:1d1325
  • RJ Ott, V Barry, S Webb, MA Flower, MO Leach, R Clack, PK Marsden, VR McCready, JE Bateman, Sharma, HL, A Smith. (1987). Measurement of radiation dose to the thyroid using positron emission tomography. British Journal of Radiology, 60, 245-251. eScholarID:1d23317

1986

  • Sharma HL, TF McAinsh, BR Pullan. (1986). Radionuclide Imaging. Physics In Medicine And Biology. eScholarID:3d196
  • C Ewen, A Perera, JH Hendry, CA McAuliffe, Sharma HL, BW Fox. (1986). Autoradiographic analysis of the intra-renal localization of Cis-platin and Iproplatin. eScholarID:2d642
  • C Ewen, JH Hendry, Sharma HL, A Perera, CA McAuliffe. (1986). Autoradiographic analysis of the intra-renal localisation of Cis-platin. eScholarID:2d514
  • D Hamilton, R Cowan, Sharma HL, PM Nuttall, D Crowther. (1986). The pharmacokinetics of In-114m labelled lymphocytes: A potential agent for Selective Internal Irradiation of Lymphoid Tissue. eScholarID:2d783
  • P Frey, G Schaller, D Townsend, A Christin, JS Lacroix, A Reverdin, JE Rysler, A Donath, A Jeavons, Sharma, HL, Smith, A. (1986). Co-55-Bleomycin in detecting malignant tumour disease of the neck and brain using positron emission tomography. eScholarID:2d528
  • S Cottrill, Sharma HL, LS Moore, CA McAuliffe, RV Parish. (1986). 199Au and 35S. Isotope distribution studies of Myocrisin and Auronofin in the rat. eScholarID:2d782
  • Sharma HL, Smith A, CJ Tait, J Collett, D Atwood. (1986). The In vivo release of 99mTc-labelled solutes from polymeric controlled release systems. eScholarID:2d684
  • Sharma HL. (1986). Annual Conf of Controlled Release Soc. eScholarID:2d1329
  • Sharma HL. (1986). Pharmacology of In-114m labelled lymphocytes. eScholarID:2d745
  • D Hamilton, R Cowan, Sharma HL, PM Nuttall, D Crowther. (1986). The pharmacokinetics of In-114m labelled lymphocytes: A potential agent for selective internal irradiation of lymphoid tissue. Nucl.Med.Comm, 7, 288-289. eScholarID:1d1316
  • LC Kaus, JT Fell, Sharma HL, DC Taylor. (1986). Representation of the path of a non-disintegrating capsule in the gastro intestinal tract using external scintigraphy and computer graphics. Nucl.Med.Comm, 7, 587-591. eScholarID:1d1319
  • M Birch, Sharma HL, EB Bell, WL Ford. (1986). The carriage and delivery of substances to lymphatic tissues by recirculating lymphocytes;II. Long term selective irradiation of the spleen and lymphnodes by deposition of In-114m. Immunology, 58, 359-364. eScholarID:1d1320
  • RB Akbari, RJ Ott, NG Trott, Sharma HL, AG Smith. (1986). Radionuclide purity and radiation dosimetry of Iodine-124 used in positron tomography of the thyroid. Physics In Medicine And Biology, 31, 789-791. eScholarID:1d23314
  • RJ Ott, JE Bateman, V Batty, R Clack, MA Flower, MO Leach, PK Marsden, VR McCready, S Webb, Sharma, HL, Smith, A. (1986). 3D positron emission tomography:preliminary results. British Journal of Radiology, 59, 419-422. eScholarID:1d23315
  • Sharma HL, J Zweit, Smith A, S Downey. (1986). Production of cobalt-55, ashort lived positron emitting radiolabel for bleomycin. International journal of applied radiation isotopes, 37, 105-109. eScholarID:1d1317
  • Sharma HL, Smith A, CJ Trait, J Collett, D Atwood. (1986). The in vivo release of TC-99m labelled solutes from polymeric controlled release systems. Nucl. Medicine Comm, 7, eScholarID:1d1318

1985

  • JH Collett, CJ Tait, D Atwood, Sharma HL, Smith A. (1985). In vivo evaluation of poloxamer gels as controlled release systems using gamma-scintigraphy. eScholarID:2d683
  • J Baer, R Harrison, C McAuliffe, A Zaki, Sharma HL, Smith A. (1985). Microscale synthesis of anti-tumour platinum compounds labelled with Pt-191. Int.J.Appl.Rad.Isotopes, 36, 675-680. eScholarID:1d1314
  • SE Owens, N Thatcher, Sharma, HL, R Harrison, Smith, A, A Zaki, J Baer, CA McAuliffe, D Crowther, BW Fox. (1985). In vivo distribution studies of radioactively labelled platinum complexes in patients with malignant disease, using a gamma-camera. Cancer Chemotherapy and Pharmacology, 14, 253-257. eScholarID:1d23313
  • WL Ford, AJS Davis, M Birch, JA Forrester, D McIntosh, Sharma HL, S Sparshott, C Wood. (1985). Exploiting lymphocyte traffic to deliver radioactivity or Ricin to lymphatic tissues. Advances in Exp.Med.and Biology, 186, 675-680. eScholarID:1d1315

1984

  • M Birch, Sharma HL, WL Ford. (1984). Exploiting lymphocyte traffic to produce irradiation of lymphatic tissue by Indium-114m. eScholarID:2d781
  • M Birch, Sharma HL, WL Ford. (1984). Selective Irradiation of lymphoid tissue produced by In-114m labelled lymphocytes. eScholarID:2d513
  • LC Kaus, JT Fell, Sharma HL, D Taylor. (1984). On the intestinal transit of a single non-disintegrating object. Int. J. Pharmaceutics, 20, 315-323. eScholarID:1d23312
  • LC Kaus, Sharma HL, JT Fell. (1984). Stimultanous measurement of gastric emptying of the soluble and insoluble components of a formation using a dual isotope,gamma scintigraphic technique. J. Pharm. Pharmacol, 36, 136-138. eScholarID:1d23311
  • LC Klaus, JT Fell, Sharma HL, D Taylor. (1984). Gastric emptying and intestinal transit of non-disintegrating capsules-the influence of metoclopramide. Int. J. Pharmaceutics, 99-103. eScholarID:1d23309
  • M Flower, R Ott, S Webb, MO Leach, P Marsden, O Khan, V McCready, J Bateman, A Fletcher, Sharma, HL, Smith, A. (1984). A clinical evaluation of a prototype prositron camera for longitudinal emission tomography. Br. J. Pharmac, 57, 1103-1117. eScholarID:1d23310

1983

  • JM Braganza, RM Case, Sharma HL, PRS Taskar. (1983). Copper absorption in the rat: effect of pH. eScholarID:2d682
  • M Birch, Sharma HL, WL Ford. (1983). Use of In-114m labelled lymphocytes for the selective irradiation of lymphoid tissue. eScholarID:2d780
  • M Birch, WL Ford, Sharma HL. (1983). Selective Irradiation of Lymphoid Tissue produced by injection of lymphocytes loaded with In-114m. eScholarID:2d512
  • S Cottrill, CA McAuliffe, RV Parish, Sharma HL. (1983). Radio-gold labelled pharmaceuticals. eScholarID:2d744
  • Sharma HL, Smith A, N Thatcher, D Crowther, S Owens, J Baer, A Zaki, CA McAuliffe, BW Fox. (1983). Blood clearance of radiolabelled CBDCA. eScholarID:2d708
  • BR Pullan, JA Chapman, AR Williams, Taylor CJ, DW Hukins, Sharma HL. (1983). Medical biophysics in Manchester. Eng Med, 12, 155-156. eScholarID:1d1305
  • E Hunter, JT Fell, Sharma HL, AM McNeilly, Smith A. (1983). The in vivo behaviour of hard gelatin capsules filled with thixotropic fluids (quantitative aspests)". Pharm. Ind, 45, 433-434. eScholarID:1d1299
  • E Hunter, JT Fell, Sharma HL. (1983). The gastric emptying of hard gelatin capsules. Int. J. Pharmaceutics, 17, 59-64. eScholarID:1d23308
  • Harrison, CA McAuliffe, A Zaki, J Baer, Sharma HL, AG Smith, H Jackson, B Fox. (1983). A comparative study of the distribution in the male rat of platinum labelled compounds. Cancer Chemotherapy and Pharmacology, 10, 90-95. eScholarID:1d23301
  • M Birch, WL Ford, Sharma HL. (1983). Selective irradiation of lymphoid tissue produced by injection of lymphocytes loaded with In-114m. British Journal of Radiology, 56, eScholarID:1d23303
  • MH Jamison, Sharma HL, JM Braganza, JM Case. (1983). The influence of pancreatic juice on 64Cu absorption in the rat. British Journal Of Nutrition And Nutrition Researc, eScholarID:1d23305
  • P Tasker, RM Case, Sharma HL, JM Braganza. (1983). Copper absorption in the rat:effect of pH. J. Physiol, 342, 80-81. eScholarID:1d23306
  • Sharma HL, N Thatcher, J Baer, A Zaki, Smith A, CA McAuliffe, D Crowther, S Owens, BW Fox. (1983). Blood clearance of radioactively labelled CBDCA in cancer patients. Cancer Chemotherapy and Pharmacology, 11, 5-7. eScholarID:1d23307
  • Sharma HL, Smith A, N Thatcher, D Crowther, S Owens, J Baer, A Zaki, CA McAuliffe, BW Fox. (1983). Blood clearance of radio-labelled Cis-diamine-1, 1-cyclobutane dicarboxylato platinum (11)(CBDCA). British Journal of Radiology, 56, eScholarID:1d23304
  • SM Cottrill, CA McAuliffe, RV Parish, Sharma HL. (1983). Radio-gold labelled Pharmaceuticals. British Journal of Radiology, 56, eScholarID:1d23302

1982

  • TJ Fell, CG Wilson, JG Hardy, E Hunter, Sharma HL, M Frier, SS Davis. (1982). Gastrointestinal transit of gamma-emitting radionuclide labelled preparations. London: eScholarID:4d50
  • E Hunter, JT Fell, Sharma HL, AM McNeilly, Smith A. (1982). The in vivo behaviour of hard gelatin capsules filled with thixotropic liquids. Pharm. Ind, 44, 90-91. eScholarID:1d1295
  • E Hunter, JT Fell, Sharma HL. (1982). The gastric emptying of pellets contained in high gelatin capsules. Drug Delivery and Industrial Pharmacy, 8, 751-757. eScholarID:1d23300
  • E Ward, R Seltz, Sharma HL. (1982). 181Ta(p,t) 179 Ta reaction: Evidence for a particle-cor-coupling. Physical Review Letters, C25, 2353-2360. eScholarID:1d23298
  • N Thatcher, D Crowther, Sharma HL, AG Smith, R Harrison, A Zaki, CA McAuliffe, B Fox. (1982). Blood clearance of three radioactively labelled platinum complexes, in patients with malignant disease. Cancer Chemotherapy and Pharmacology, 9, 9-16. eScholarID:1d23299

1981

  • JM Braganza, RM Case, MH Jamison, Sharma HL. (1981). Pancreatic secretions inhibit copper absorption in the rat. eScholarID:2d641
  • M Jamison, JM Braganza, RM Case, Sharma HL. (1981). Pancreatic secretions assist bile in limiting copper absorption in the rat. eScholarID:2d511
  • MH Jamison, Sharma HL, RM Case, P Tasker, M Bell, H Whitwell, JM Braganza. (1981). The influence of pancreatic secretions on copper metabolism. eScholarID:2d1328
  • E Hunter, JT Fell, Sharma HL. (1981). A comparison of the behaviour of tablet and capsule formations in vivo. J. Pharm. Pharmacol, 33, 617-618. eScholarID:1d23295
  • J Wagstaff, C Gibson, N Thatcher, WL Ford, Sharma HL, W Benson, D Crowther. (1981). A method for following human lymphocyte traffic using In-111 oxide labelling. Clin.Exp.immunol, 43, 435-442. eScholarID:1d1291
  • J Wagstaff, C Gibson, N Thatcher, WL Ford, Sharma HL, W Benson, D Crowther. (1981). Human lymphocyte trafic assessed by In-111 oxide labelling: clinical observation. Clin.Exp.Immunol, 43, 443-449. eScholarID:1d1290
  • JM Braganza, RM Case, MH Jamison, Sharma HL. (1981). Pancreatic secretions inhibit copper absorpton in the rat. J. Physiol, 316, eScholarID:1d23297
  • M Jamison, Sharma HL, RM Case, JM Braganza. (1981). Pancreatic secretions assist bile in limiting copper absorption in the rat. Gut, 22, eScholarID:1d23296
  • Sharma HL, AG Smith. (1981). The short-lived radioisotope production program in Manchester. J. Radioanalytical Chem, 64, 249-255. eScholarID:1d1288
  • SM Sparshot, Sharma HL, JD Kelly, WL Ford. (1981). Factors influencing the fate of In-111 labelled lymphoctytes after transfer syngeneic rats. J. Immuno. Methods, 41, 302-320. eScholarID:1d23294

1980

  • E Bradshaw, BJ Pleuvry, Sharma HL. (1980). Effect of droperidol on dopamine-induced increase in effecive renal plasma flow in gogs. British Journal of Anaesthesia, 52, 879-883. eScholarID:1d1286
  • E Hunter, JT Fell, RT Calvert, Sharma HL. (1980). In vivo disintegration of hard gelatin capsules in fasting and non-fasting subjects. Int. J. Pharmaceutics, 4, 175-183. eScholarID:1d23293
  • M Hyland, R Chapman, JL Durell, JN Mo, M McPhail, Sharma HL. (1980). The isotope shift of the P3/2 neutron orbit radius for N=29. J. Phys. G: Nuclear Physics, 6, 261-270. eScholarID:1d1285

1979

  • DJ Hay, Sharma HL, BR Pullan, MH Irving. (1979). How far does colifoam spread?. eScholarID:2d509
  • E Hunter, JT Fell, RT Calvert, Sharma HL. (1979). In vivo assessment of solid dosage forms. eScholarID:2d707
  • E Lupton, R Lawson, RA Shields, HJ Testa, Sharma HL, KLJ Herman. (1979). Diuresis renography and paranchymal retention function in the assessment of upper urinary tract. eScholarID:2d510
  • D Hay, Sharma HL, M Irving. (1979). Retrograde spread of intrarectal hydrocortisone containing foam. British Medical Journal, 2, 1365-1366. eScholarID:1d23291
  • DJ Hay, Sharma HL, MH Irving. (1979). Spread of steroid-containing foam after intrarectal administration. British Medical Journal, 1, 1751-1753. eScholarID:1d23290
  • E Bradshaw, B Pleuvry, Sharma HL. (1979). The effects of dopamine on the EPRF in dogs:interaction with droperidol anaesthesia. British journal of anaesthesia, 51, 566-567. eScholarID:1d1281
  • E Hunter, JT Fell, Calvert RT, Sharma HL. (1979). In vivo assessment of solid dosage forms. Journal of Pharmacy and Pharmacology (suppl), eScholarID:1d23292
  • R Chapman, H Hyland, JL Durell, JN Mo, M McPhail, Sharma HL, NH Merrill. (1979). Neutron orbit sizes of the isotopes of tin. Nuclear Physics, A316, 40-60. eScholarID:1d1279
  • Sharma HL, AG Smith. (1979). Labelling metrizamide (Amipaque) with iodine-125. Acta Radiologica (including Supplements), 20, 289-291. eScholarID:1d23289

1978

  • G Berrier-Ronsin, M Vergnes, G Rotbard, J Vernotte, J Kalifa, R Seltz, Sharma HL. (1978). Nuclear levels in 191,193,195,197PT excited via neutron pick up. Physical Review Letters, C17, 529-543. eScholarID:17d118

1976

  • M Vergnes, G Rotbard, J Kalifa, J Vernotte, G Berrier, R Seltz, Sharma HL, NM Hintz. (1976). Study of 190,192,194Pt using the (p,t) reaction. Bull. American phys. Society, 21, eScholarID:1d1278
  • M Vergnes, G Rotbard, J Kalifa, J Vernotte, R Seltz, Sharma HL. (1976). Levels of 191pt observed in the 192pt (p,d) 191pt reaction. Bull. American phys. society, 21, eScholarID:1d1277
  • Sharma HL, NM Hintz. (1976). A study of the Osmium isotopes with the (p,t) reaction. Physical Review Letters, C13, 558. eScholarID:17d43

1975

  • H Taketani, Sharma HL, NM Hintz. (1975). Shape transitional aspects of odd-A Eu isotopes studies by the (p,t) reaction. Physical Review Letters, C13, 108-114. eScholarID:17d557

1973

  • Sharma HL, NM Hintz. (1973). A search for excited 0+states in 188,190os. Bull. American phys. society, 18, eScholarID:1d1276
  • Sharma HL, NM Hintz. (1973). New K=0 bands and two-phonon gamma vibrations in 188os and190os. Physical Review Letters, 31, 1517-1521. eScholarID:17d42
  • Sharma HL, R Seltz, NM Hints. (1973). Search for an excited rotational band in Mo-98 with the (p,t) reaction. Physical Review Letters, 2567-2571. eScholarID:17d556

  • M Ashford, JT Fell, D Atwood, Sharma HL, PJ Woodhead. In vitro and in vivo evaluation of pectin for colonic drug delivery. eScholarID:2d751
  • Stops F, Fell JT, Collett JH, Martini L.G, Sharma HL, Anne-Marie Smith. Floating Dosage forms to prolong gastro retention - An in vivo study in the fasted state. eScholarID:2d1208

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