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School of Medicine

Professor Adnan Custovic MSc DM MD PhD FRCP

Photograph of Adnan Custovic

Professor of Allergy / Head, Respiratory Research Group

The University of Manchester
University Hospital of South Manchester NHS Foundation Trust
Second Floor
Education and Research Centre
Manchester
M23 9LT
UK
 

 

Memberships of Committees and Professional Bodies

Election to Senior Positions in Learned Societies

July 2009-July 2012: Secretary, British Society for Allergy and Clinical Immunology (BSACI)

June 2009-June 2013: President, Asthma Section of the European Academy of Allergy and Clinical Immunology (EAACI)

September 2002-September 2004: International Representative to the Environmental and Occupational Disorders Interest Section of the American Academy of Allergy, Asthma and Immunology

August 2000-August 2003: Secretary, British Society for Allergy and Clinical Immunology

July 2000-July 2001: Chairman, European Society of Paediatric Allergy and Clinical Immunology Committee on Environmental Allergens

July 1997-July 2000: Member of the Council, British Society for Allergy and Clinical Immunology


Membership of International and National Committees

2006-2009: Specialist Advisory Committee for Immunology and Allergy, The Joint Royal Colleges of Physicians Training Board (JRCPTB)

Sep 2007-Sep 2010: Asthma UK Research Committee

Jan 2008 – Dec 2009: World Allergy Organisation (WAO) Education Council

Jan 2008 – Dec 2009: World Allergy Organisation (WAO) Allergy Diagnosis Special Committee

Jan 2008 – Dec 2009: World Allergy Organisation (WAO) Asthma Special Committee

Jan 2008 – Dec 2009: World Allergy Organisation (WAO) Impact of Climate Change on Allergy Special Committee,

2002-current: British asthma guidelines steering group, British Thoracic Society/Scottish Intercollegiate Guidelines Network. Member of non-pharmacological management group

2006-2008: ERS (European Respiratory Society) Taskforce on Management of wheezing disorders in Children

2005-2007: GARD (Global Alliance Against Chronic Respiratory Diseases)

2005-2010: ARIA (Allergic Rhinitis and its Impact on Asthma) Guidelines Committee

Oct 2005 - Jul 2006: National Allergy Advisory Group, Department of Health. Member

2003-2004: The National Asthma Campaign Early Life Task Force (ELTF)

2002-2003: The National Asthma Campaign Consultation on clinical asthma research strategy (CARS)

2001-2002: The National Asthma Campaign Consultation on basic asthma research strategy (BARS)

2000-2002: Member of the European Multidisciplinary Scientific Network on Indoor Environment and Health – EUROEXPO Group

2000-2001: GINA (Global Initiative for Asthma) NHLBI/WHO Workshop – Consultant Contributor

2000-2001: IAACI/WHO Program for Primary Prevention of Allergy and Asthma – Consultant Contributor

1995: World Health Organisation/ International Academy of Allergy and Clinical Immunology International Committee on Indoor Allergens and Asthma
 

Membership of Learned Societies

Elected Fellow: American Academy of Allergy, Asthma and Immunology

Elected Member: Association of Physicians of Great Britain and Ireland

Elected Member: Collegium Internationale Allergologicum

Member: British Society of Allergy and Clinical Immunology

Member: European Academy of Allergology and Clinical Immunology

Honorary Member: The Allergy Society of South Africa

Research

My academic work focused principally on the relationship between allergic disease and the environment and primary prevention of asthma and allergic diseases. The current focus of the research programme of my group is in the area of gene-environment interactions in the development of asthma and allergic diseases. We are investigating the hypothesis that the relationship between genotype and phenotype in complex diseases such as asthma and allergies may not be linear or unidirectional, but modulated by a number of environmental factors. For example, in mouse models, the effects of G*E interactions on complex traits are greater than the main genetic effects. Thus, in human studies, true associations between genetic variants and phenotype may be lost when study participants are exposed to a wide range of unmeasured environmental factors. Our birth cohort (Manchester Asthma and Allergy Study) has the optimum study design to investigate complex chronic disorders which start in early life (population-based, with careful longitudinal phenotyping and contemporaneous measurement of environmental exposures). Using this population we have shown that high endotoxin exposure is protective against the development of allergies, but only in children with a specific genotype (C allele homozygotes of CD14/-159) (Am J Respir Crit Care Med 2006;174:386-92), explaining the disparities in association studies of this SNP in different settings around the world (replicated in two further studies). We pan to use the results from our basic medical research programme (following appropriate replication) to define a series of environmental interventions targeted at individuals with specific “risk” genotypes. These interventions will be tested in proof of concept studies aiming at the primary prevention of asthma and allergies. Furthermore, we will utilise the MAAS dataset to develop and validate novel diagnostic tests to help physicians and patients to differentiate symptomatic from asymptomatic allergic sensitisation.

Our basic biomedical research capability has recently been enhanced by the appointment of Prof Fernando Martinez (University of Arizona) as a Visiting Professor and the recruitment of a Lecturer in Functional genomics (Dr J Curtin, UCSF) to explore the functionality of the identified SNP variants. 

Keywords:

• Allergy
• Asthma
• Environment
• Allergens
• Gene-environment interactions

 

Methodological Knowledge

• Birth cohort studies

• Case-control studies
 

 

Biography

Adnan Custovic is a Professor of Allergy and a Head of Respiratory Research Group at the School of Translational Medicine. His professional training consisted of a specialist training in Paediatrics (University Children’s Hospital Sarajevo, 1987-91) and successive appointments at the University Hospital of South Manchester as a Clinical Research Fellow (1992-1994) and Specialist Registrar in Allergy (1994-1998). This period saw him awarded M.Sc. (1991), M.D. with Gold Medal (1996) and Ph.D. (2000).

He is currently BSACI Secretary and has served one previous term as a BSACI Secretary (2000-3); Represented allergy on the Specialist Advisory Committee for Immunology and Allergy, JRCPTB (2006-9); Member of British asthma guidelines working group (BTS/SIGN); President of Asthma section of EAACI; Member of EAACI PractAll working group which established and published guidelines on the new approach to classification of asthma endotypes within the asthma syndrome; Member of EAACI Peaditric PractAll Guidelines working group; Member of EAACI Paediatric rhinitis taskforce; Member of ARIA (Allergic Rhinitis and its Impact on Asthma) Committee and co-author of ARIA guidelines; Member of the World Allergy Organisation (WAO) Education Council, WAO Allergy Diagnosis Special Committee, WAO Asthma Special Committee and WAO Impact of Climate Change on Allergy Special Committee; Co-authored World Health Organization (WHO) Guidelines on Prevention of Allergy and Allergic Asthma; Through CREATE project contributed to the development of certified reference materials for allergenic products and validation of methods for their quantification; Member ERS Working Group Report on definition, assessment and treatment of wheezing disorders in preschool children.

Professor Custovic is Associate Editor of Thorax and a member of the Editorial board of PLoS Medicine, Annals of Respiratory Medicine, Treatment Strategies-Respiratory and Primary Care Respiratory Journal.  He was the Editorial board member of Allergy, Pediatric Allergy and Immunology and Annals of Allergy and Immunology.

 

Contributions to standards of care in allergy

Professor Custovic has developed and grown a large tertiary allergy service (adult and paediatric) at University Hospital of South Manchester (5-fold increase in the capacity and number of patients seen between December 2009 and December 2010). He is currently Clinical Lead in Allergy. He provided leadership in preparing plans for the North-West Regional Allergy Service, and is an active member of the of the North West Allergy and Immunology Regional Network. His work improved access to allergy services across the region by securing sustainable funding, training doctors and health care professionals at all levels & developing standards of care across the region.

Contribution through training: Professor Custovic is a Training Programme Director for Allergy in the North Western Deanery.  He developed North West deanery Training programme for SpR in allergy.

Influence on public policy: He presented evidence to the House of Lords on the situation of allergy in the UK.  Quoted in resultant House of Lords Science and Technology Committee sixth report on Allergy (July 2007).

Prof Custovic leads an exceptionally active clinical research group, and is a world leading authority on the primary prevention of allergic diseases; 180 publications, >300 abstracts, book “Managing Allergy”, 22 book chapters; Main work focused principally on the relationship between allergic disease and the environment and primary prevention of asthma and allergic diseases

 

Collaborators and affiliated staff

Examples of academic bioscience partnerships

Local: We have strong and long established research partnerships within University of Manchester with: genetics (Ollier) and informatics and biostatistics (Buchan); strong links with new NIHR networks (e.g. Medicines for Children).

National: MRC-funded STELAR consortium (all UK asthma birth cohorts: Southampton, Imperial, Aberdeen, Bristol); Holgate (genetics, Southampton); Johnston (rhinovirus, Imperial College); Stocks (lung function in childhood, ICH London); Britton (allergy in Ethiopia, Nottingham),

International (selected examples): Holt (T-cell immunology, Perth); Tannock (probiotics, Dunedin); collaborations for G*E replication (Bisgaard, Copenhagen; Aberle and Grle, Croatia; Mogulkoc, Turkey; Addo-Yobo, Ghana); collaborating centre EU GA2LEN network
Industry: GSK (ICS intervention in infant wheeze), Nestle (RCT on probiotics for eczema), Phadia (diagnostic tests)

 

Publications

2012

  • Gore, C., Custovic, A., Tannock, G., Munro, K., Kerry, G., Johnson, K., Peterson, C., Morris, J., Chaloner, C., Murray, C. & Woodcock, A (2012). Treatment and secondary prevention effects of the probiotics Lactobacillus paracasei or Bifidobacterium lactis on early infant eczema: randomized controlled trial with follow-up until age 3 years. Clin Exp Allergy, 42(1), 112-22. eScholarID:145791 | PMID:22092692 | DOI:10.1111/j.1365-2222.2011.03885.x
  • Paternoster, et al (2012). Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet, 44(2), 187-192. eScholarID:154904 | PMID:22197932 | DOI:10.1038/ng.1017

2011

  • Custovic A, Nicolaou N. (2011). Peanut allergy: Overestimated in epidemiology or underdiagnosed in primary care? J Allergy Clin Immunol, 127(3), 631-632. eScholarID:119711 | DOI:10.1016/j.jaci.2011.01.026
  • Custovic A, Simpson A. (2011). Gene–environment interactions in asthma: Lessons for the development of new drugs for asthma. Inhalation, 5(6), 18-23. eScholarID:142163
  • Custovic, A., Rothers, J., Stern, D., Simpson, A., Woodcock, A., Wright, A., Nicolaou, N., Hankinson, J., Halonen, M. & Martinez, F (2011). Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies. J Allergy Clin Immunol, 127(2), 390-397.e1-9. eScholarID:146156 | PMID:21281869 | DOI:10.1016/j.jaci.2010.10.050
  • Custovic, A., Soderstrom, L., Ahlstedt, S., Sly, P., Simpson, A. & Holt, P (2011). Allergen-specific IgG antibody levels modify the relationship between allergen-specific IgE and wheezing in childhood. J Allergy Clin Immunol, 127(6), 1480-5. eScholarID:146157 | PMID:21492924 | DOI:10.1016/j.jaci.2011.03.014
  • Lötvall, J., Akdis, C., Bacharier, L., Bjermer, L., Casale, T., Custovic, A., Lemanske, R., Wardlaw, A., Wenzel, S. & Greenberger, P (2011). Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol, 127(2), 355-60. eScholarID:146153 | PMID:21281866 | DOI:10.1016/j.jaci.2010.11.037
  • Marinho S, Simpson A, Marsden P, Smith JA, Custovic A. (2011). Quantification of atopy, lung function and airway hypersensitivity in adults. Clinical and Translational Allergy, 1, 16. eScholarID:148486 | DOI:10.1186/2045-7022-1-16
  • Murray, C., Canoy, D., Buchan, I., Woodcock, A., Simpson, A. & Custovic, A (2011). Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clin Exp Allergy, 41(1), 78-85. eScholarID:146155 | PMID:20718779 | DOI:10.1111/j.1365-2222.2010.03598.x
  • Nicolaou, N. & Custovic, A (2011). Molecular diagnosis of peanut and legume allergy. Curr Opin Allergy Clin Immunol, 11(3), 222-8. eScholarID:146163 | PMID:21464707 | DOI:10.1097/ACI.0b013e32834656c2
  • Nicolaou, N., Murray, C., Belgrave, D., Poorafshar, M., Simpson, A. & Custovic, A (2011). Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol, 127(3), 684-685. eScholarID:119120 | PMID:21272928 | DOI:10.1016/j.jaci.2010.12.012
  • Semic-Jusufagic A, Simpson A, Hankinson J, Custovic A. (2011). A Polymorphism in Gasdermin B (GSDMB) gene is associated with severe asthma exacerbations in childhood: A population-based birth cohort study. Acta Medica Academica, 40(2), 110-121. eScholarID:142157 | DOI:10.5644/ama2006-124.14
  • Stevens, W., Addo-Yobo, E., Roper, J., Woodcock, A., James, H., Platts-Mills, T. & Custovic, A (2011). Differences in both prevalence and titre of specific immunoglobulin E among children with asthma in affluent and poor communities within a large town in Ghana. Clin Exp Allergy, 41(11), 1587-94. eScholarID:146152 | PMID:21810123 | DOI:10.1111/j.1365-2222.2011.03832.x
  • Valovirta, E., Berstad, A., de Blic, J., Bufe, A., Eng, P., Halken, S., Ojeda, P., Roberts, G., Tommerup, L., Varga, E., Winnergard, I. & . (2011). Design and recruitment for the GAP trial, investigating the preventive effect on asthma development of an SQ-standardized grass allergy immunotherapy tablet in children with grass pollen-induced allergic rhinoconjunctivitis. Clin Ther, 33(10), 1537-46. eScholarID:146154 | PMID:21999887 | DOI:10.1016/j.clinthera.2011.09.013

2010

  • Al Ali W, Custovic A, Simpson A, Khoury A, Woodcock A. (2010). Household characteristics and allergen and endotoxin levels in Syria. East Mediterr Health J, 16(7), 717-724. eScholarID:92765
  • Bousquet, et al (2010). Development and implementation of guidelines in allergic rhinitis – an ARIA-GA2LEN paper. Allergy, 65(10), 1212-21. eScholarID:100925 | PMID:20887423 | DOI:10.1111/j.1398-9995.2010.02480.x
  • Brozek, J., Bousquet, J., Baena-Cagnani, C., Bonini, S., Canonica, G., Casale, T., van Wijk, R., Ohta, K., Zuberbier, T. & Schünemann, H (2010). Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol, 126(3), 466-76. eScholarID:119721 | PMID:20816182 | DOI:10.1016/j.jaci.2010.06.047
  • Custovic, A., Simpson, A., Bardin, P. & Le Souëf, P (2010). Allergy is an important factor in asthma exacerbation: a pro/con debate. Respirology, 15(7), 1021-7. eScholarID:100919 | PMID:20796248 | DOI:10.1111/j.1440-1843.2010.01826.x
  • Kirkby, J., Stanojevic, S., Welsh, L., Lum, S., Badier, M., Beardsmore, C., Custovic, A., Nielsen, K., Paton, J., Tomalak, W. & Stocks, J (2010). Reference equations for specific airway resistance in children: the Asthma UK initiative. Eur Respir J, 36(3), 622-9. eScholarID:100922 | PMID:20150205 | DOI:10.1183/09031936.00135909
  • Murray, C., Custovic, A., Lowe, L., Aldington, S., Williams, M., Beasley, R. & Woodcock, A (2010). Effect of addition of salmeterol versus doubling the dose of fluticasone propionate on specific airway resistance in children with asthma. Allergy Asthma Proc, 31(5), 415-21. eScholarID:100924 | PMID:20929609 | DOI:10.2500/aap.2010.31.3362
  • Nicolaou, N., Poorafshar, M., Murray, C., Simpson, A., Winell, H., Kerry, G., Harlin, A., Woodcock, A., Ahlstedt, S. & Custovic, A (2010). Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol, 125(1), 191-7.e1-13. eScholarID:80257 | PMID:20109746 | DOI:10.1016/j.jaci.2009.10.008
  • Quanjer, P., Stanojevic, S., Stocks, J., Hall, G., Prasad, K., Cole, T., Rosenthal, M., Perez-Padilla, R., Hankinson, J., Falaschetti, E., Golshan, M., Brunekreef, B., Al-Rawas, O., Kühr, J., Trabelsi, Y. & Ip, M (2010). Changes in the FEV₁/FVC ratio during childhood and adolescence: an intercontinental study. Eur Respir J, 36(6), 1391-9. eScholarID:100918 | PMID:20351026 | DOI:10.1183/09031936.00164109
  • Quanjer, P., Stanojevic, S., Stocks, J., Hall, G., Prasad, K., Cole, T., Rosenthal, M., Perez-Padilla, R., Hankinson, J., Falaschetti, E., Golshan, M., Brunekreef, B., Al-Rawas, O., Kühr, J., Trabelsi, Y., Ip, M. & . (2010). Changes in the FEV₁/FVC ratio during childhood and adolescence: an intercontinental study. Eur Respir J, 36(6), 1391-9. eScholarID:146158 | PMID:20351026 | DOI:10.1183/09031936.00164109
  • Semic-Jusufagic A, Simpson A, Murray C, Marinho S, Custovic A. (2010). Breastfeeding and the Development of Asthma and Atopy during Childhood: a Birth Cohort Study. Acta Medica Academica, 39(2), 132-143. eScholarID:102612
  • Semic-Jusufagic, A., Gevaert, P., Bachert, C., Murray, C., Simpson, A. & Custovic, A (2010). Increased serum-soluble interleukin-5 receptor alpha level precedes the development of eczema in children. Pediatr Allergy Immunol, 21(7), 1052-8. eScholarID:100921 | PMID:20735756 | DOI:10.1111/j.1399-3038.2010.01077.x
  • Simpson, A., Tan, V., Winn, J., Svensen, M., Bishop, C., Heckerman, D., Buchan, I. & Custovic, A (2010). Beyond Atopy: Multiple Patterns of Sensitization in Relation to Asthma in a Birth Cohort Study. Am J Respir Crit Care Med, 181(11), 1200-1206. eScholarID:80255 | PMID:20167852 | DOI:10.1164/rccm.200907-1101OC

2009

  • Fowler SJ, Langley SJ, Truman NJ, Woodcock A, Simpson A, Custovic A. (2009). Long term effects of allergen sensitisation and exposure in adult asthma: A prospective study. World Allergy Organization Journal, 2(5), 83-90. eScholarID:80267 | DOI:10.1097/WOX.0b013e3181a45f96
  • Patel, S., Murray, C., Woodcock, A., Simpson, A. & Custovic, A (2009). Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy, 64(12), 1766-72. eScholarID:80258 | PMID:19796219 | DOI:10.1111/j.1398-9995.2009.02099.x
  • Simpson, A. & Custovic, A (2009). Prevention of allergic sensitization by environmental control. Curr Allergy Asthma Rep, 9(5), 363-9. eScholarID:80259 | PMID:19671379 | DOI:10.1007/s11882-009-0053-y
  • Stanojevic, S, Wade, A, Cole, T, Lum, S, Custovic, A, Silverman, M, Hall, G, Welsh, L, Kirkby, J, Nystad, W, Badier, M, Davis, S, Turner, S, Piccioni, P, Vilozni, D, Eigen, H, Vlachos-Mayer, H, Zheng, J, Tomalak, W, Jones, M, Hankinson, J, Stocks, J. (2009). Spirometry Centile Charts for Young Caucasian Children: The Asthma UK Collaborative Initiative. Am J Respir Crit Care Med, 180(6), 547-552. eScholarID:1d20515 | DOI:10.1164/rccm.200903-0323OC
  • Custovic A, Managing Allergy. Edited by Adnan Custovic and Thomas Platts-Mills. Atlas Medical Publishin, 1st edition 2009 ISBN-13: 978 1 84692 025 7, ISBN-ebook 978 1 84692 593 1 ISBN-10: 1846920256 282 pages. eScholarID:19m1

2008

  • Bisgaard H, Simpson A, Palmer CNA, Bønnelykke K, Mclean I, Mukhopadhyay S, Pipper CB, Halkjaer LB, Lipworth B, Hankinson J, Woodcock A, Custovic A. (2008). Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med, 5(6), e131-. eScholarID:1d17519 | DOI:10.1371/journal.pmed.0050131
  • Bousquet, et al. (2008). Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy, 63 (Suppl 86), 8-160. eScholarID:1d19681 | DOI:10.1111/j.1398-9995.2007.01620.x
  • Bousquet, et al. (2008). Important research questions in allergy and related diseases: nonallergic rhinitis: a GA2LEN paper. Allergy, 63(7), 842-853. eScholarID:1d19680 | DOI:10.1111/j.1398-9995.2008.01715.x
  • Brand, P, Baraldi, E, Bisgaard, H, Boner, A, Castro-Rodriguez, J, Custovic, A, de Blic, J, de Jongste, J, Eber, E, Everard, M, Frey, U, Gappa, M, Garcia-Marcos, L, Grigg, J, Lenney, W, Le Souëf, P, McKenzie, S, Merkus, P, Midulla, F, Paton, J, Piacentini, G, Pohunek, P, Rossi, G, Seddon, P, Silverman, M, Sly, P, Stick, S, Valiulis, A, van Aalderen, W, Wildhaber, J, Wennergren, G, Wilson, N, Zivkovic, Z, Bush, A. (2008). Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur Respir J, 32(4), 1096-1110. eScholarID:1d19677 | DOI:10.1183/09031936.00002108
  • Custovic A. (2008). Primary prevention by avoidance and elimination. Drugs Today (Barc), 44 (Suppl B), 11-15. eScholarID:1d19676
  • Gore C, Munro K, Lay C, Bibiloni R, Morris J, Woodcock AA, Custovic A, Tannock G. (2008). Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. J Allergy Clin Immunol, 121(1), 135-140. eScholarID:1d17525 | DOI:10.1016/j.jaci.2007.07.061
  • Nicolaou NN, Simpson A, Lowe L, Murray CS, Woodcock AA, Custovic A. (2008). Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study. J Allergy Clin Immunol, 122(3), 500-506. eScholarID:1d19289 | DOI:10.1016/j.jaci.2008.06.033
  • Sly, P, Boner, A, Björksten, B, Bush, A, Custovic, A, Eigenmann, P, Gern, J, Gerritsen, J, Hamelmann, E, Helms, P, Lemanske, R, Martinez, FD, Pedersen, S, Renz, H, Sampson, H, von Mutius, E, Wahn, U, Holt, P. (2008). Early identification of atopy in the prediction of persistent asthma in children. Lancet, 372, 1100-1106. eScholarID:1d19679 | DOI:10.1016/S0140-6736(08)61451-8
  • Smith, JA, Smith, JA, Drake, R, Simpson, Angela, Simpson, A, Woodcock, AA, Woodcock, A, Pickles, A, Custovic, A, Custovic, A. (2008). Dimensions of Respiratory Symptoms in Pre-school Children: Population-based Birth Cohort Study. Am J Respir Crit Care Med, 177(12), 1358-1363. eScholarID:1d17153 | DOI:10.1164/rccm.200709-1419OC
  • van et al. (2008). The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy, 63(3), 310-326. eScholarID:1d19682 | DOI:10.1111/j.1398-9995.2007.01612.x

2007

  • Addo-Yobo E, Woodcock A, Allotey A, Baffoe-Bonnie B, Strachan D, Custovic A. (2007). Exercise-induced bronchospasm and atopy in Ghana: two surveys ten years apart. PLoS Med, 4( 2), eScholarID:1d20517 | DOI:10.1371/journal.pmed.0040070
  • Custovic A, Bush R. (2007). Two blind mice: new insights into mouse allergy. J Allergy Clin Immunol, 120( 4), 758-9. eScholarID:1d20518 | DOI:10.1016/j.jaci.2007.08.018
  • Custovic A. (2007). Probability of hospital admission with acute asthma exacerbation increases with specific IgE antibody levels. Allergy Clin Immunol Int: J World Allergy Org, Suppl 2, 270-273. eScholarID:1d33197
  • Marinho S, Simpson A, Lowe L, Kissen P, Murray CS, Custovic A. (2007). Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study. Allergy, 62(4), 385-393 . eScholarID:1d17522
  • Marinho S, Simpson A, Söderström L, Woodcock A, Ahlstedt S, Custovic A. (2007). Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. Allergy, 62( 12), eScholarID:1d17521
  • Semic-Jusufagic A, Bachert C, Gevaert P, Holtappels G, Lowe L, Woodcock A, Simpson A, Custovic A. (2007). Staphylococcus aureus sensitization and allergic disease in early childhood: population-based birth cohort study. J Allergy Clin Immunol, 119(4), 930-936 . eScholarID:1d17523
  • Semic-Jusufagic A, Custovic A. (2007). Active smoking among asthmatic youth--how concerned we need to be. Int J Chron Obstruct Pulmon Dis, 2( 1), 3-4. eScholarID:1d19683

2006

  • Bousquet, et al. (2006). Pharmacologic and anti-IgE treatment of allergic rhinitis ARIA update (in collaboration with GA2LEN). Allergy, 61( 9), 1086-96. eScholarID:1d20933 | DOI:10.1111/j.1398-9995.2006.01144.x
  • Custovic A, Simpson A. (2006). What are we learning from genetic cohort studies? Paediatr Respir Rev, 7 Suppl 1, S90-2. eScholarID:1d14399
  • Gore RB, Curbishley L, Truman N, Hadley E, Woodcock AA, Langley S, Custovic A. (2006). Intranasal air sampling in homes: relationships among reservoir allergen concentrations and asthma severity. J Allergy Clin Immunol, 117( 3), 649-55. eScholarID:1d13022 | DOI:10.1016/j.jaci.2005.12.1351
  • Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. (2006). High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy, 61( 1), 119-23. eScholarID:1d13030 | DOI:10.1111/j.1398-9995.2005.00946.x
  • Gore RB, Durrell b, Bishop S, Curbishley L, Woodcock AA, Custovic A. (2006). High-efficiency vacuum cleaners increase personal mite allergen exposure, but only slightly. Allergy, 61, 221-228. eScholarID:1d12352
  • Keil T, Kulig M, Simpson A, Custovic A, Wickman M, Kull I, Lødrup C, Carlsen K, Smit H, Wijga A, Schmid S, Berg A, Bollrath C, Eller E, Bindslev-Jensen C, Halken S, Høst A, Heinrich J, Porta D, Forastiere F, Brunekreef B, Krämer U, Willich S, Wahn U, Lau S. (2006). European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs -- a GALEN initiative. Allergy, 61(2), 221-228. eScholarID:1d13026
  • Keil, T, Kulig, M, Simpson, A, Custovic, A, Wickman, M, Kull, I, Lødrup Carlsen, K, Carlsen, K, Smit, H, Wijga, A, Schmid, S, Von Berg, A, Bollrath, C, Eller, E, Bindslev-Jensen, C, Halken, S, Høst, A, Heinrich, J, Fantini, M, Brunekreef, B, Krämer, U, Willich, S, Wahn, U, Lau, S. (2006). European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures--a GA2LEN initiative. Allergy, 61( 9), 1104-11. eScholarID:1d17524
  • Marinho S, Simpson A, Custovic A. (2006). Allergen avoidance in the secondary and tertiary prevention of allergic diseases: does it work? Prim Care Respir J, 15( 3), 152-8. eScholarID:1d14400
  • Murray CS, Poletti G, Kebadze T, Morris J, Woodcock AA, Johnston S, Custovic A. (2006). Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax, 61( 5), 376-382. eScholarID:1d13027
  • Murray CS, Simpson B, Kerry G, Woodcock AA, Custovic A. (2006). Dietary intake in sensitized children with recurrent wheeze and healthy controls: a nested case-control study. Allergy, 61( 4), 438-42. eScholarID:1d13023
  • Murray CS, Woodcock AA, Langley S, Morris J, Custovic A. (2006). Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet, 368( 9537), 754-62. eScholarID:1d14398 | DOI:10.1016/S0140-6736(06)69285-4
  • Nicolaou N, Lowe L, Murray CS, Woodcock AA, Simpson A, Custovic A. (2006). Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. Am J Respir Crit Care Med, 174( 3), 254-259. eScholarID:1d14402
  • Nicolaou N, Yiallouros P, Pipis S, Ioannou P, Simpson A, Custovic A. (2006). Domestic allergen and endotoxin exposure and allergic sensitization in Cyprus. Pediatr Allergy Immunol, 17( 1), 17-21. eScholarID:1d13025
  • Semic-Jusufagic A, Simpson A, Custovic A. (2006). Environmental exposures, genetic predisposition and allergic diseases: one size never fits all. Allergy, 61( 4), 397-9. eScholarID:1d13024
  • Simpson A, John S, Jury F, Niven R, Niven RR M, Woodcock AA, Ollier WER, Custovic A. (2006). Endotoxin Exposure, CD14 and Allergic Disease: An Interaction between Genes and the Environment. Am J Respir Crit Care Med, 174(4), 386-392. eScholarID:1d13021 | DOI:10.1164/rccm.200509-1380OC
  • Thomas M, Custovic A, Woodcock A, Morris J, Simpson A, Murray CS. (2006). Atopic wheezing and early life antibiotic exposure: a nested case-control study. Pediatr Allergy Immunol, 17( 3), 184-188. eScholarID:1d14666
  • Woodcock AA, Steel N, Moore CB, Howard SJ, Custovic A, Denning DW. (2006). Fungal contamination of bedding. Allergy, 61(1), 140-142. eScholarID:41808

2005

  • Calam R, Gregg L, Simpson A, Simpson B, Woodcock AA, Custovic A. (2005). Behavior Problems Antecede the Development of Wheeze in Childhood: a Birth Cohort Study. Am J Respir Crit Care Med, 171(4), 323-7. eScholarID:1d9084 | DOI:10.1164/rccm.200406-791OC
  • Custovic A, Murray CS, Simpson A. (2005). Allergy and infection: understanding their relationship. Allergy, 60 Suppl 79, eScholarID:1d10458
  • Custovic A, Wijk R. (2005). The effectiveness of measures to change the indoor environment in the treatment of allergic rhinitis and asthma: ARIA update (in collaboration with GA(2)LEN). Allergy, 60( 9), 1112-5. eScholarID:1d11198
  • Gore C, Johnson R, Caress A, Woodcock AA, Custovic A. (2005). The information needs and preferred roles in treatment decision-making of parents caring for infants with atopic dermatitis: a qualitative study. Allergy, 60 (7), eScholarID:1d26092 | DOI:10.1111/j.1398-9995.2005.00776.x
  • Hadley E.A, Smillie F.I, Turner MMA, Custovic A, Woodcock AA, Arkwright PD. (2005). Effect of Mycobacterium vaccae on cytokine responses in children with atopic dermatitis. Clinical and Experminetal Immunology, 140, 101-108. eScholarID:1d26611
  • Lack G, Custovic A, Beyer K, Eigenmann P. (2005). Lessons regarding the IgE system. Allerg Immunol (Paris), 37( 2), 72-4. eScholarID:1d11202
  • Langley S, Goldthorpe S, Craven M, Woodcock AA, Custovic A. (2005). Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects. Thorax, 60( 1), 17-21. eScholarID:1d9081
  • Lowe L, Simpson A, Woodcock AA, Morris J, Murray CS, Custovic A. (2005). Wheeze Phenotypes and Lung Function in Pre-School Children. Am J Respir Crit Care Med, 171(3), eScholarID:1d9085 | DOI:10.1164/rccm.200406-695OC
  • Murray CS, Tannock G, Simon M, Harmsen H, Welling G, Custovic A, Woodcock AA. (2005). Fecal microbiota in sensitized wheezy and non-sensitized non-wheezy children: a nested case-control study. Clin Exp Allergy, 35( 6), eScholarID:1d11199
  • Nicolaou N, Siddique N, Custovic A. (2005). Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy, 60( 11), 1357-60. eScholarID:1d13031
  • Sehgal N, Custovic A, Woodcock AA. (2005). Potential roles in rhinitis for protease and other enzymatic activities of allergens. Curr Allergy Asthma Rep, 5( 3), 221-6. eScholarID:1d10456
  • Simpson A, Custovic A. (2005). Pets and the development of allergic sensitization. Curr Allergy Asthma Rep, 5( 3), 212-20. eScholarID:1d10457
  • Simpson A, Custovic A. (2005). The role of allergen avoidance in the secondary prevention of atopic disorders. Curr Opin Allergy Clin Immunol, 5( 3), 223-7. eScholarID:1d11201
  • Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. (2005). IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol, 116( 4), 744-9. eScholarID:1d12138 | DOI:10.1016/j.jaci.2005.06.032
  • Simpson, A, Maniatis, N, Jury, F, Cakebread, J, Lowe, L, Holgate, S, Woodcock, AA, Ollier, WER, Collins, A, Custovic, A, Holloway, J, John, S. (2005). Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33)predict impaired early-life lung function. Am J Respir Crit Care Med, 172(1), 55-60. eScholarID:1d10460 | DOI:10.1164/rccm.200412-1708OC

2004

  • Al-Mousawi M, Lovel HJ, Behbehani N, Arifhodzic N, Woodcock AA, Custovic A. (2004). Asthma and sensitization in a community with low indoor allergen levels and low pet-keeping frequency. J Allergy Clin Immunol, 114( 6), 1389-94. eScholarID:1d9083
  • Asher, I, Baena-Cagnani, C, Boner, A, Canonica, G, Chuchalin, A, Custovic, A, Dagli, E, Haahtela, T, Haus, M, Lemmo-Hoten, M, Holgate, S, Holloway, J, Holt, P, Host, A, Iikura, Y, Johansson, S, Kaplan, A, Kowalski, M, Lockey, R, Naspitz, C, Odhiambo, J, Ring, J, Sastre, J, Venables, K, Vichyanond, P, Volovitz, B, Wahn, U, Warner, J, Weiss, K, Zhong, N, NULL. (2004). World Allergy Organization guidelines for prevention of allergy and allergic asthma. Int Arch Allergy Immunol, 135( 1), 83-92. eScholarID:1d9089
  • Bornehag C, Sundell J, Bonini S, Custovic A, Malmberg P, Skerfving S, Sigsgaard T, Verhoeff A. (2004). Dampness in buildings as a risk factor for health effects, EUROEXPO: a multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. Indoor Air, 14( 4), 243-57. eScholarID:1d9090
  • Custovic A, Simpson A, Woodcock AA. (2004). Manchester cohort. Pediatr Pulmonol Suppl, 26, 12-3. eScholarID:1d9099
  • Custovic A, Simpson A. (2004). Environmental allergen exposure, sensitisation and asthma: from whole populations to individuals at risk. Thorax, 59( 10), 825-7. eScholarID:1d9088
  • Gore C, Custovic A. (2004). Can we prevent allergy? Allergy, 59( 2), 151-61. eScholarID:1d9101
  • Gore C, Custovic A. (2004). Protective parasites and medicinal microbes? The case for the hygiene hypothesis. Prim Care Respir J, 13( 2), 68-75; discussion 83. eScholarID:1d20926 | DOI:10.1016/j.pcrj.2004.02.005
  • Lowe L, Custovic A, Woodcock AA. (2004). Childhood asthma. Curr Allergy Asthma Rep, 4( 2), 159-65. eScholarID:1d9100
  • Lowe L, Woodcock AA, Murray CS, Murray CS, Morris J, Simpson A, Custovic A. (2004). Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med, 158( 10), eScholarID:1d9087
  • Lowe, L, Murray, CS, Martin, L, Deas, J, Cashin, E, Poletti, G, Simpson, A, Woodcock, AA, Custovic, A. (2004). Reported versus confirmed wheeze and lung function in early life. Arch Dis Child, 89( 6), eScholarID:1d9092
  • Murray CS, Murray CS, Woodcock AA, Smillie F, Cain G, Kissen P, Custovic A. (2004). Tobacco smoke exposure, wheeze, and atopy. Pediatr Pulmonol, 37( 6), eScholarID:1d9096
  • Murray CS, Simpson A, Custovic A. (2004). Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc, 1( 2), eScholarID:1d11197
  • Simpson A, Custovic A. (2004). Allergen avoidance in the primary prevention of asthma. Curr Opin Allergy Clin Immunol, 4( 1), 45-51. eScholarID:1d9097
  • Simpson A, Custovic A. (2004). The role of allergen avoidance in primary and secondary prevention. Pediatr Pulmonol Suppl, 26, 225-8. eScholarID:1d9098
  • Stipić-Marković A, Pevec B, Radulović Pevec M, Custovic A, Predović J. (2004). Allergic diseases in relationship with environmental factors in a population of school children in Zagreb, Croatia. Arh Hig Rada Toksikol, 55( 2-3), 221-8. eScholarID:1d28722
  • Woodcock AA, Lowe L, Murray CS, Simpson B, Pipis S, Kissen P, Simpson A, Custovic A, NAC Manchester Asthma and Allergy Study Group. (2004). Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med, 170( 4), eScholarID:1d9094 | DOI:10.1164/rccm.200401-083OC

2003

  • Calam R, Gregg L, Simpson B M, Morris J, Woodcock A, Custovic A. (2003). Childhood asthma, behaviour problems and family functioning. Journal Of Allergy And Clinical Immunology, 122, eScholarID:1d25592 | DOI:10.1016/S0091-6749(03)01606-3
  • Calam R, Gregg L, Simpson B, Morris J, Woodcock AA, Custovic A. (2003). Childhood asthma, behavior problems, and family functioning. J Allergy Clin Immunol, 112( 3), 499-504. eScholarID:1d9103
  • Custovic A, Simpson B, Simpson A, Hallam C, Marolia H, Walsh D, Campbell J, Woodcock AA. (2003). Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults. J Allergy Clin Immunol, 111( 2), 402-7. eScholarID:1d6780
  • Francis H, Fletcher G, Anthony C, Pickering C, Oldham L, Hadley E, Custovic A, Niven RR M. (2003). Clinical effects of air filters in homes of asthmatic adults sensitized and exposed to pet allergens. Clin Exp Allergy, 33( 1), 101-5. eScholarID:1d9439
  • Gore C, Custovic A. (2003). Primary and secondary prevention of allergic airway disease. Paediatr Respir Rev, 4( 3), 213-24. eScholarID:1d10288
  • Gore C, Peterson C, Kissen P, Simpson B, Lowe L, Woodcock AA, Custovic A. (2003). Urinary eosinophilic protein X, atopy, and symptoms suggestive of allergic disease at 3 years of age. J Allergy Clin Immunol, 112( 4), 702-8. eScholarID:1d9102
  • Gore RB, Bishop S, Durrell B, Curbishley L, Woodcock A, Custovic A. (2003). Air filtration units in homes with cats: can they reduce personal exposure to cat allergen? Clin Exp Allergy, 33( 6), 765-9. eScholarID:1d6785 | DOI:10.1046/j.1365-2222.2003.01678.x
  • Gore RB, Durrell B, Bishop S, Curbishley L, Woodcock A, Custovic A. (2003). High-efficiency particulate arrest-filter vacuum cleaners increase personal cat allergen exposure in homes with cats. J Allergy Clin Immunol, 111( 4), 784-7. eScholarID:1d6786 | DOI:10.1067/mai.2003.1378
  • Langley S, Goldthorpe S, Craven M, Morris J, Woodcock AA, Custovic A. (2003). Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol, 112( 2), 362-8. eScholarID:1d9104
  • Langley S, Goldthorpe S, Custovic A, Woodcock AA. (2003). Relationship among pulmonary function, bronchial reactivity, and exhaled nitric oxide in a large group of asthmatic patients. Ann Allergy Asthma Immunol, 91( 4), 398-404. eScholarID:1d9105
  • Lowe L, Custovic A, Woodcock A. (2003). Childhood asthma. Curr Allergy Asthma Rep, 3( 2), 109-14. eScholarID:1d10291
  • Simpson A, Custovic A. (2003). Early pet exposure: friend or foe? Curr Opin Allergy Clin Immunol, 3( 1), 7-14. eScholarID:1d10290
  • Simpson A, Green R, Custovic A, Woodcock A, Arruda L, Chapman M. (2003). Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK. Allergy, 58( 1), 53-6. eScholarID:1d6781
  • Simpson A, Simpson B, Custovic A, Craven M, Woodcock AA. (2003). Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and dog allergen. Clin Exp Allergy, 33( 9), 1183-9. eScholarID:1d6779
  • Stipić-Marković A, Pevec B, Pevec M, Custovic A. (2003). [Prevalence of symptoms of asthma, allergic rhinitis, conjunctivitis and atopic eczema: ISAAC (International Study of Asthma and Allergies in Childhood) in a population of schoolchildren in Zagreb]. Acta Med Croatica, 57( 4), 281-5. eScholarID:1d29377
  • Woodcock, AA, Forster, L, Matthews, E, Martin, J, Letley, L, Vickers, M, Britton, J, Strachan, D, Howarth, P, Altmann, D, Frost, C, Custovic, A. (2003). Control of exposure to mite allergen and allergen-impermeable bed covers for adults with asthma. N Engl J Med, 349( 3), 225-36. eScholarID:1d6772 | DOI:10.1056/NEJMoa023175

2002

  • Addo-Yobo E, Custovic A, Taggart S, Asafo-Agyei A, Woodcock A. (2002). Seasonal variability in exercise test responses in Ghana. Pediatr Allergy Immunol, 13( 4), 303-6. eScholarID:1d10292
  • Brutsche M, Joos L, Carlen Brutsche I, Bissinger R, Tamm M, Custovic A, Woodcock AA. (2002). Array-based diagnostic gene-expression score for atopy and asthma. J Allergy Clin Immunol, 109( 2), 271-3. eScholarID:1d9440
  • Custovic A, Murray CS, Gore RB, Woodcock A. (2002). Controlling indoor allergens. Ann Allergy Asthma Immunol, 88( 5), eScholarID:1d10295
  • Custovic A, Murray CS. (2002). The effect of allergen exposure in early childhood on the development of atopy. Curr Allergy Asthma Rep, 2( 5), 417-23. eScholarID:1d10294
  • Custovic A, Simpson B, Murray CS, Lowe L, Woodcock A. (2002). The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol, 13 Suppl 15, 32-7. eScholarID:1d10289
  • Gore C, Custovic A. (2002). Preventive measures and their effects. Results from cohort studies. Paediatr Respir Rev, 3( 3), 205-18. eScholarID:1d10293
  • Gore RB, Custovic A. (2002). Is allergen avoidance effective? Clin Exp Allergy, 32( 5), 662-6. eScholarID:1d10296
  • Gore RB, Hadi E, Craven M, Smillie F, O'Meara T, Tovey E, Woodcock A, Custovic A. (2002). Personal exposure to house dust mite allergen in bed: nasal air sampling and reservoir allergen levels. Clin Exp Allergy, 32( 6), 856-9. eScholarID:1d6789
  • Green R, Custovic A, Sanderson G, Hunter J, Johnston S, Woodcock AA. (2002). Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ, 324( 7340), eScholarID:1d6777 | DOI:10.1136/bmj.324.7340.763
  • Green RM, Custovic A, Hunter J, Johnson SL, Woodcock AA. (2002). Risk factors for hospital admission with acute Asthma:synergism between sensitisation and exposure to allergens and viral respiratory infections. British Medical Journal, 324, 763-766. eScholarID:1d4367
  • Lowe L, Murray CS, Custovic A, Simpson B, Kissen P, Woodcock AA. (2002). Specific airway resistance in 3-year-old children: a prospective cohort study. Lancet, 359( 9321), eScholarID:1d6774 | DOI:10.1016/S0140-6736(02)08781-0
  • Lowe L, Murray CS, Custovic A, Simpson BM, Kissen PM, Woodcock AA. (2002). Specific airway resistance in three year-old children. Lancet, 359, 1904-1908. eScholarID:1d4366
  • Murray CS, Pipis S, McArdle E, Lowe L, Custovic A, Woodcock AA. (2002). Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population. Thorax, 57( 5), 388-92. eScholarID:1d6776
  • Murray CS, Pipis SD, McArdle EC, Lowe L, Custovic A, Woodcock AA. (2002). Lung function at one month as a risk factor for infant wheezing in a high risk population. Thorax, 57, 388-392. eScholarID:1d4357
  • Simpson A, Simpson B, Custovic A, Cain G, Craven M, Woodcock A. (2002). Household characteristics and mite allergen levels in Manchester,UK. Clin Exp Allergy, 32( 10), 1413-9. eScholarID:1d6782
  • Woodcock A, Moradi M, Smillie F, Murray CS, Murray CS, Burnie JP, Custovic A. (2002). Clostridium difficile, atopy and wheeze during the first year of life. Pediatr Allergy Immunol, 13( 5), 357-60. eScholarID:1d6788
  • WoodcockA, MoradiM, SmillieF.I, Murray CS, Burnie JP, Custovic A. (2002). Clostridium difficile, atopy and wheeze during the first year of life. Pediatr.Allergy Immunol, 13, 5, eScholarID:1d7127

2001

  • Addo-Yobo E, Custovic A, Taggart S, Craven M, Bonnie B, Woodcock AA. (2001). Risk factors for asthma in urban Ghana. J Allergy Clin Immunol, 108( 3), 363-8. eScholarID:1d6778
  • al Mousawi M, Behbehani N, Arifhodzic N, Lovel H, Woodcock A, Custovic A. (2001). Environmental allergens in Kuwait. Allergy, 56 (12), eScholarID:1d10300
  • Brutsche M, Brutsche I, Wood P, Mogulkoc N, Custovic A, Egan J, Woodcock A. (2001). B-cell isotype control in atopy and asthma assessed with cDNA array technology. Am J Physiol Lung Cell Mol Physiol, 280( 4), L627-37. eScholarID:1d10307
  • Brutsche, M, Brutsche, I, Wood, P, Brass, A, Morrison, N, Rattay, M, Mogulkoc, N, Simler, N, Craven, M, Custovic, A, Egan, J, Woodcock, A. (2001). Apoptosis signals in atopy and asthma measured with cDNA arrays. Clin Exp Immunol, 123( 2), 181-7. eScholarID:1d10309
  • Custovic A, Hallam C, Simpson B, Craven M, Simpson A, Woodcock A. (2001). Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol, 108( 4), 537-9. eScholarID:1d6783
  • Custovic A, Hallam Cl, Simpson BM, Craven m, Simpson Angela, Woodcock AA. (2001). Decreased prevalance of sensitization to cats with high exposure to cat allergen. Allergy Clin Immunol, 108, 537-539. eScholarID:1d4364
  • Custovic A, Simpson B, Simpson A, Kissen P, Woodcock A. (2001). Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial. Lancet, 358( 9277), 188-93. eScholarID:1d6791 | DOI:10.1016/S0140-6736(01)05406-X
  • Custovic A, Simpson BM, Simpson Angela, Kissen PM, Woodcock AA. (2001). Effect of enviromental manipulation in pregnancy and early life on respiratory symptoms and atopy during the first year of life: a randomised trial. Lancet, 358, eScholarID:1d4358
  • Custovic A, Woodcock A. (2001). Environmental allergen exposure and asthma: prospects for primary prevention. Mediators Inflamm, 10( 6), 295-8. eScholarID:1d10299
  • Custovic A, Woodcock A. (2001). Exposure and sensitization in infants and children. Curr Opin Allergy Clin Immunol, 1( 2), 133-8. eScholarID:1d10298
  • Custovic A, Woodcock A. (2001). On allergens and asthma (again): does exposure to allergens in homes exacerbate asthma? Clin Exp Allergy, 31( 5), 670-3. eScholarID:1d10305
  • Liccardi G, Custovic A, Cazzola M, Russo M, D'Amato M, D'Amato G. (2001). Avoidance of allergens and air pollutants in respiratory allergy. Allergy, 56( 8), 705-22. eScholarID:1d10303
  • M Al Mousawi, N Behbehani, N Afrihodzic, Lovel HJ, Woodcock AA, Custovic A. (2001). Environmental allergens in Kuwait. Allergy, 56(12), eScholarID:1d23714
  • Murray CS, Woodcock A, Custovic A. (2001). The role of indoor allergen exposure in the development of sensitization and asthma. Curr Opin Allergy Clin Immunol, 1( 5), 407-12. eScholarID:1d10297
  • Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali, S, McElroy P, Custovic, A, Woodcock, AA, Prichard D, Venn A, Britton J. (2001). Independant effects of intestinal parasite infection and domestic allergen exposure on the risk of wheeze in Ethiopia. Lancet, 358, eScholarID:1d4362
  • Scrivener, S, Yemaneberhan, H, Zebenigus, M, Tilahun, D, Girma, S, Ali, S, McElroy, P, Custovic, A, Woodcock, A, Pritchard, D, Venn, A, Britton, J. (2001). Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study. Lancet, 358( 9292), 1493-9. eScholarID:1d10301
  • Simpson A, Woodcock A, Custovic A. (2001). Housing characteristics and mite allergen levels: to humidity and beyond. Clin Exp Allergy, 31( 6), 803-5. eScholarID:1d10304
  • Simpson B, Custovic A, Simpson A, Hallam C, Walsh D, Marolia H, Campbell J, Woodcock A. (2001). NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults. Clin Exp Allergy, 31( 3), 391-9. eScholarID:1d6784
  • Smillie F, Elderfield A, Patel F, Cain G, Tavenier G, Brutsche M, Craven M, Custovic A, Woodcock A. (2001). Lymphoproliferative responses in cord blood and at one year: no evidence for the effect of in utero exposure to dust mite allergens. Clin Exp Allergy, 31( 8), 1194-204. eScholarID:1d10302
  • Woodcock A, Addo-Yobo E, Taggart S, Craven M, Custovic A. (2001). Pet allergen levels in homes in Ghana and the United Kingdom. J Allergy Clin Immunol, 108( 3), 463-5. eScholarID:1d6790
  • Woodcock AA, Addo-Yobp EOD, Taggart SCO, Craven M, Custovic A. (2001). Pet allergen levels in homes in Ghana and the UK. Allergy Clin Immunol, 108, eScholarID:1d4360

2000

  • Asher, I, Boner, A, Chuchalin, A, Custovic, A, Dagli, E, Haus, M, Hemmo-Lotem, M, Holgate, S, Holt, P, Høst, A, Iikura, I, Johansson, S, Kowalski, M, Naspitz, C, Odhiambo, J, Vichyanond, P, Volovitz, B, Wahn, U, Warner, J, Weiss, K, Zhong, N. (2000). Prevention of allergy and asthma: interim report. Allergy, 55( 11), 1069-88. eScholarID:1d10311
  • Brutsche M, Brutsche I, Munawar M, Langley S, Masterson C, Daley-Yates P, Brown R, Custovic A, Woodcock A. (2000). Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Lancet, 356( 9229), 556-61. eScholarID:1d10313
  • Custovic A, Hallam C, Woodcock H, Simpson B, Houghton N, Simpson A, Woodcock A. (2000). Synthetic pillows contain higher levels of cat and dog allergen than feather pillows. Pediatr Allergy Immunol, 11( 2), 71-3. eScholarID:1d10314
  • Custovic A, Simpson B, Simpson A, Hallam C, Craven M, Brutsche M, Woodcock A. (2000). Manchester Asthma and Allergy Study: low-allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol, 105( 2 Pt 1), 252-8. eScholarID:1d10320
  • Custovic A, Woodcock A. (2000). Clinical effects of allergen avoidance. Clin Rev Allergy Immunol, 18( 3), 397-419. eScholarID:1d10312
  • Fryer, A, Spiteri, M, Bianco, A, Hepple, M, Jones, P, Strange, R, Makki, R, Tavernier, G, Smilie, F, Custovic, A, Woodcock, A, Ollier, W, Hajeer, A. (2000). The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun, 1( 8), 509-14. eScholarID:1d10308
  • Fryer,A.A., Spiteri,M.A., Bianco,A., Hepple,M., Jones,P.W., Strange,R.C., Makki,R., Tavernier,G., Smilie,F.I., Custovic, A, Woodcock,A.A., Ollier,W.E., Hajeer,A.H. (2000). The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. 1, 8, eScholarID:1d21948
  • Woodcock A, Custovic A. (2000). Allergen avoidance. Schweiz Med Wochenschr, 130( 49), 1903-8. eScholarID:1d10310
  • Woodcock A, Custovic A. (2000). Allergen avoidance: does it work? Br Med Bull, 56( 4), 1071-86. eScholarID:1d10306

1999

  • Custovic A, Simpson B, Simpson A, Hallam C, Craven M, Woodcock A. (1999). Relationship between mite, cat, and dog allergens in reservoir dust and ambient air. Allergy, 54( 6), 612-6. eScholarID:1d10318
  • Custovic A, Woodcock A. (1999). Feather or synthetic? That is the question. Clin Exp Allergy, 29( 2), 144-7. eScholarID:1d10330
  • Custovic A, Woodcock A. (1999). Indoor environment and asthma. Monaldi Arch Chest Dis, 54( 6), 465-9. eScholarID:1d10316
  • Custovic A, Woodcock A. (1999). Reducing allergen exposure in asthma patients. Practitioner, 243( 1596), 232-5. eScholarID:1d10317
  • Custovic A, Woodcock H, Craven M, Hassall R, Hadley E, Simpson A, Woodcock A. (1999). Dust mite allergens are carried on not only large particles. Pediatr Allergy Immunol, 10( 4), 258-60. eScholarID:1d10315
  • Green R, Simpson A, Custovic A, Faragher B, Chapman M, Woodcock A. (1999). The effect of air filtration on airborne dog allergen. Allergy, 54( 5), 484-8. eScholarID:1d10319
  • Green R, Simpson A, Custovic A, Woodcock A. (1999). Vacuum cleaners and airborne dog allergen. Allergy, 54( 4), 403-5. eScholarID:1d10323
  • Hallam C, Custovic A, Simpson B, Houghton N, Simpson A, Woodcock A. (1999). Mite allergens in feather and synthetic pillows. Allergy, 54( 4), 407-8. eScholarID:1d10322
  • Hodson T, Custovic A, Simpson A, Chapman M, Woodcock A, Green R. (1999). Washing the dog reduces dog allergen levels, but the dog needs to be washed twice a week. J Allergy Clin Immunol, 103( 4), 581-5. eScholarID:1d10326
  • Niven R, Fletcher A, Pickering A, Custovic A, Sivour J, Preece A, Oldham L, Francis H. (1999). Attempting to control mite allergens with mechanical ventilation and dehumidification in British houses. J Allergy Clin Immunol, 103( 5 Pt 1), 756-62. eScholarID:1d10324
  • Niven RR M, Pickering CC A, Fletcher Am, Custovic A, Kennaugh J, Sivious JB, Preece AR, Oldham LA, Fransis HC. (1999). Attempting to control mitrs and mite allergen with mechanical vntilation and dehumidification in british homes. 103(5), eScholarID:1d4465
  • Simpson A, Custovic A, Pipis S, Adisesh A, Faragher B, Woodcock A. (1999). Exhaled nitric oxide, sensitization, and exposure to allergens in patients with asthma who are not taking inhaled steroids. Am J Respir Crit Care Med, 160( 1), 45-9. eScholarID:1d10321
  • Tunnicliffe W, Fletcher T, Hammond K, Roberts K, Custovic A, Simpson A, Woodcock A, Ayres J. (1999). Sensitivity and exposure to indoor allergens in adults with differing asthma severity. Eur Respir J, 13( 3), 654-9. eScholarID:1d10325

1998

  • Cain G, Elderfield A, Green R, Smillie F, Chapman M, Custovic A, Woodcock A. (1998). The effect of dry heat on mite, cat, and dog allergens. Allergy, 53( 12), 1213-5. eScholarID:1d10331
  • Custovic A, Chapman M. (1998). Risk levels for mite allergens. Are they meaningful? Allergy, 53( 48 Suppl), 71-6. eScholarID:1d10329
  • Custovic A, Fletcher A, Pickering C, Francis H, Green R, Smith A, Chapman M, Woodcock A. (1998). Domestic allergens in public places III: house dust mite, cat, dog and cockroach allergens in British hospitals. Clin Exp Allergy, 28( 1), 53-9. eScholarID:1d10337
  • Custovic A, Simpson A, Chapman M, Woodcock A. (1998). Allergen avoidance in the treatment of asthma and atopic disorders. Thorax, 53( 1), 63-72. eScholarID:1d10334
  • Custovic A, Simpson A, Pahdi H, Green R, Chapman M, Woodcock A. (1998). Distribution, aerodynamic characteristics, and removal of the major cat allergen Fel d 1 in British homes. Thorax, 53( 1), 33-8. eScholarID:1d10335
  • Custovic A, Simpson A, Woodcock A. (1998). Importance of indoor allergens in the induction of allergy and elicitation of allergic disease. Allergy, 53( 48 Suppl), 115-20. eScholarID:1d10328
  • Custovic A, Woodcock A. (1998). Indoor environmental factors and respiratory illness. Clin Exp Allergy, 28( 10), 1178-81. eScholarID:1d10332
  • Simpson A, Hassall R, Custovic A, Woodcock A. (1998). Variability of house-dust-mite allergen levels within carpets. Allergy, 53( 6), 602-7. eScholarID:1d10333
  • Woodcock A, Custovic A. (1998). ABC of allergies. Avoiding exposure to indoor allergens. BMJ, 316( 7137), 1075-8. eScholarID:1d10336
  • Woodcock A, Custovic A. (1998). Role of the indoor environment in determining the severity of asthma. Thorax, 53 Suppl 2, S47-51. eScholarID:1d10327

1997

  • Addo Yobo E, Custovic A, Taggart S, Asafo-Agyei A, Woodcock A. (1997). Exercise induced bronchospasm in Ghana: differences in prevalence between urban and rural schoolchildren. Thorax, 52( 2), 161-5. eScholarID:1d10338
  • Custovic A, Green R, Fletcher A, Smith A, Pickering C, Chapman M, Woodcock A. (1997). Aerodynamic properties of the major dog allergen Can f 1: distribution in homes, concentration, and particle size of allergen in the air. Am J Respir Crit Care Med, 155( 1), 94-8. eScholarID:1d10339

1996

  • Custovic A, Green R, Smith A, Chapman M, Woodcock A. (1996). New mattresses: how fast do they become a significant source of exposure to house dust mite allergens? Clin Exp Allergy, 26( 11), 1243-5. eScholarID:1d10341
  • Custovic A, Green R, Taggart S, Smith A, Pickering C, Chapman M, Woodcock A. (1996). Domestic allergens in public places. II: Dog (Can f1) and cockroach (Bla g 2) allergens in dust and mite, cat, dog and cockroach allergens in the air in public buildings. Clin Exp Allergy, 26( 11), 1246-52. eScholarID:1d10340
  • Custovic A, Taggart S, Francis H, Chapman M, Woodcock A. (1996). Exposure to house dust mite allergens and the clinical activity of asthma. J Allergy Clin Immunol, 98( 1), 64-72. eScholarID:1d10344
  • Custovic A, Woodcock A. (1996). Allergen avoidance. Br J Hosp Med, 56( 8), 409-12. eScholarID:1d10342
  • Fletcher A, Pickering C, Custovic A, Simpson J, Kennaugh J, Woodcock A. (1996). Reduction in humidity as a method of controlling mites and mite allergens: the use of mechanical ventilation in British domestic dwellings. Clin Exp Allergy, 26( 9), 1051-6. eScholarID:1d10343
  • Taggart S, Custovic A, Francis H, Faragher E, Yates C, Higgins B, Woodcock A. (1996). Asthmatic bronchial hyperresponsiveness varies with ambient levels of summertime air pollution. Eur Respir J, 9( 6), 1146-54. eScholarID:1d10345

1995

  • Custovic A, Taggart S, Kennaugh J, Woodcock A. (1995). Portable dehumidifiers in the control of house dust mites and mite allergens. Clin Exp Allergy, 25( 4), 312-6. eScholarID:1d10348
  • Custovic A, Taggart S, Niven RR M, Woodcock A. (1995). Evaluating exposure to mite allergens. J Allergy Clin Immunol, 96( 1), 134-5. eScholarID:1d10346
  • Taggart S, Custovic A, Richards D, Woodcock A. (1995). GR106642X: a new, non-ozone depleting propellant for inhalers. BMJ, 310( 6995), 1639-40. eScholarID:1d10347

1994

  • Custovic A, Arifhodzic N, Robinson A, Woodcock A. (1994). Exercise testing revisited. The response to exercise in normal and atopic children. Chest, 105(4), 1127-1132. eScholarID:1d10350
  • Custovic A, Arifhodzic N, Taggart SCO, Woodcock A. (1994). Assessing exercise-induced bronchospasm. Chest, 105(5), 1624-25. eScholarID:1d29625
  • Custovic A, Taggart S, Woodcock A. (1994). House dust mite and cat allergen in different indoor environments. Clin Exp Allergy, 24( 12), 1164-8. eScholarID:1d10349

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