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School of Medicine

Professor Charles McCollum 

Photograph of Charles McCollum

Professor of Surgery

  • Email: cnmcc@manchester.ac.uk
  • Telephone: +44 (0)161 291 5853
  • Alternative Telephone: +44 (0) 161 291 5853 (Secretary)
  • Fax: +44 (0) 161 291 5854

Education and Research Centre
University Hospital of South Manchester
Wythenshawe
Manchester
M23 9LT

 

Role

  • Head of the Academic Surgery Unit

Principle investigator in the following studies:

  • The role of cerebral emboli in the causation of Alzheimer’s and vascular dementia funded by the Welcome Trust
  • The detection of venous to arterial circulations shunts (v-sCs): An evaluation of available techniques funded by British Heart Foundation
  • Development of engineered compression stockings for DVT prophylaxis funded by ATM and the Clothworkers’ Foundation
  • The role of venous to arterial circulation shunts, cerebral emboli and endothelial dysfunction in migraine funded by British Heart Foundation, Migraine Trust and Migraine Action
  • An evaluation of potential therapies to inhibit cerebral emboli in dementia funded by the Alzheimer’s Society

Founding chairman of the Vascular Governance North West Programme

Chairman of the Steering Committee for a North West College of Academic Surgeons

 

Memberships of Committees and Professional Bodies

  • Association of Surgeons of Great Britain & Ireland
  • British Medical Association
  • European Society for Vascular and Endovascular Surgery
  • International College of Angiology
  • International Society of Cardiovascular Surgery
  • International Society of Thrombosis and Haemostasis
  • Surgical Infection Society (Charter Member)
  • Surgical Research Society of Great Britain & Ireland
  • Vascular Surgical Society of Great Britain & Ireland
  • Member of UK National Screening Committee, Abdominal Aortic Aneurysms
  • Member, vCJD Committee on Blood Transfusion
  • Member, Working Party on alternatives to blood transfusion for the National Blood Service
     

Research

Professor McCollum’s research is in arterial and venous disease. He leads a research team of fellows, scientists and technicians, and his collaborations are with various disciplines including particularly epidemiology, neuro-imaging, mental health and stroke medicine. Research teams are assembled to investigate the role of cerebral emboli in dementia, migraine and dialysis-related brain injury.
Special research interests include:

Arterial Disease

  • Carotid surgery, angioplasty and stenting
  • Extra-cranial and upper limb arterial disease
  • Thoraco-abdominal and peri-renal aortic aneurysm
  • Endovascular aneurysm repair (EVAR)
  • Screening for abdominal aortic aneurysm
  • Paradoxical embolism
  • Cerebral embolism

Venous disease

  • Deep vein thrombosis
  • Venous thromboembolism
  • Chronic venous insufficiency
  • Varicose veins (VVs)
  • Microfoam sclerotherapy for VVs
  • Leg ulcers or venous ulcers
  • Novel treatments for VVs
  • Compression therapy

Other

  • Clinical trials in vascular disease and dementia
  • Stroke in young adults
  • Migraine and migraine with aura
  • Cerebral injury in haemodialysis
  • Autologous blood transfusion
  • Blood transfusion strategies in surgery
  • A novel blood transfusion trigger

Keywords

  • Vascular disease
  • Arterial thrombosis
  • Venous thrombosis
  • Deep vein thrombosis (DVT)
  • Pulmonary embolism (PE)
  • Cerebral perfusion
  • Paradoxical embolism
  • Carotid artery disease
  • Ischaemia - reperfusion injury
  • Cerebral emboli
  • Migraine
  • Migraine with aura
  • Venous disease
  • Leg ulceration
  • Autologous blood transfusion
  • Vascular dementia
  • Alzheimer's disease
  • Inflammatory responses
 

Methodological Knowledge

  • Complex vascular surgery
  • Multi-centre clinical trials
  • Population studies (cardiovascular epidemiology)
  • Autologous blood transfusion strategies
  • Investigation of cerebral perfusion
 

Teaching

I have been involved in both undergraduate and postgraduate education, having been trained in presentation skills, delivering lectures, and on interactive video link teaching including remote television teaching, my role is now that of a trainer. 

My commitment to undergraduate teaching remains a priority and includes one-to-one teaching in the outpatients, team teaching on the wards and formal lectures to undergraduates and postgraduates. We strive to ensure that our trainees become fully involved in all aspects of our clinical practice, audit and research. In vascular surgery we have regular clinical meetings and a postgraduate x-ray meeting with the vascular radiologists and trainees in both surgery and radiology. The academic surgeons of the future need careful support in their approach to surgical training. They need to be identified and introduced to research method at an early stage and to this end, I supervise higher degree research for surgeons, cardiologists and scientists:

I am now founding the North West College of Academic Surgery to offer the opportunity of a career in academic surgery to high flying undergraduates and to rejuvenate academic surgery in the North West. I am joined in this venture by all the remaining surgical academics in Manchester and by approaching a dozen NHS colleagues who have demonstrated excellence in research or surgical education. Members of this working party can boast a research grant income of £11.4 million since 2000.

 

Biography

Professor McCollum was appointed Professor of Surgery and Head of the Department of Surgery in the University of Manchester in 1989 and is an Honorary Consultant Surgeon at South Manchester University Hospital. The Academic Surgery Unit includes the Breast Unit which was developed to achieve an International reputation for research in surgical oncology now directed by Professor Nigel Bundred. Professor McCollum was previously trained in Birmingham and Leeds before being appointed Lecturer to Sir Geoffrey Slaney in Birmingham in 1978. He moved to London in 1983 as Senior Lecturer and subsequently Reader in Surgery in the University of London and Honorary Consultant Surgeon to Charing Cross Hospital. He is a Vascular Surgeon with a tertiary referral practice in carotid artery disease, cerebral perfusion, complex aneurysm surgery, including thoraco-abdominal aneurysm and in complex venous disease.
His initial research was on the role of intravascular emboli on the causation of pulmonary damage (shock lung) in surgical shock. He gained an international reputation for developing an Indium-labelled platelet technique for measuring thrombus growth in arterial disease and vascular prostheses leading to research contracts evaluating novel platelet inhibitory drugs. This early research led to the Moynihan Prize at the Association of Surgeons (UK), two Patey Prizes at the Surgical Research Society of Great Britain and the Hunterian Professorship at the Royal College of Surgeons of in 1985. His recent focus was to establish a cardiovascular epidemiology group in close collaboration with the Department of Public Health and Epidemiology in Manchester. It was research on paradoxical embolism as a cause of stroke in young adults that led to the hypothesis that multiple asymptomatic paradoxical micro-emboli over many years may be the cause of dementia. This led to a collaboration with Old Age Psychiatry leading to substantial funding from the Wellcome Trust and Alzheimer’s Society for research on cerebral emboli as a cause of dementia. Teams are now been assembled to explore the role of cerebral emboli in migraine and dialysis related cerebral injury.

Professor McCollum and his team continue to investigate which patients are at risk of venous insufficiency and venous ulceration. This includes a retrospective cohort study comparing the frequency of venous insufficiency in patients undergoing hip and arm surgery and a study to investigate the frequency of DVT following sprain and conservatively managed ankle fracture. He is also looking at a novel technique using ultrasound contrast to measure calf vein blood flow and measure the effects of standard compression stockings. Professor McCollum is working to further develop a novel technology for the automated manufacture of bespoke compression hosiery.

Professor McCollum has published over 380 papers including 264 on original research. Recent grant income includes project grant funding from the MRC, British Heart Foundation, Wellcome Trust, Alzheimer’s Society and Cancer Research Campaign in addition to grants from the manufactures of vascular grafts or devices, and the pharmaceutical industry. (Total £3.85 million since 2000).

 

Qualifications

  • MB, ChB (Birmingham) 1972
  • FRCS (London) 1976
  • FRCS (Edinburgh) 1976
  • MD (Birmingham) 1981
  • Certificate of Higher Surgical Training 1981
 

Collaborators and affiliated staff

  • Professor.Anthony Heagerty, Professor of Medicine and Head of Cardiovascular Sciences Research Group, University of Manchester
  • Dr.Simon Ray, Consultant Cardiologist and Clinical Director, Cardiology Department, Wythenshawe Hospital, Manchester
  • Dr.Brendan Davies, Consultant Neurologist, North Staffordshire Neurosciences Centre, Stoke on Trent
  • Dr.Charles Sherrington, Consultant Neurologist, Greater Manchester Neurosciences Centre, Hope Hospital, Manchester
  • Professor. Gary Macfarlane, Professor of Epidemiology, University of Aberdeen, Aberdeen
  • Dr.William Newman, Senior Lecturer and Consultant Clinical Genetist, University of Manchester
  • Mrs.Julie Morris, Head of Medical Statistics, Wythenshawe Hospital, Manchester
  • Dr.Paul Rolan, Professor of Pharmacology and Honorary Consultant Physician Headache Clinic, University of Adelaide, Australia
  • Prof Alistair Burns (Professor of Psychiatry)
  • Dr Sandip Mitra (Nephrologist Manchester Royal Infirmary)
  • Dr Nitin Purandare (Department of Psychiatry)
  • Prof Alan Jackson (Neuroradiology)
  • Dr Ismail Mohammed (Nephrology)
  • Dr Caroline Schiach, Consultant Haematologist
  • Dr Andrew Mortimer, Consultant Anaesthetist
  • Dr Oliver Hill, Consultant Anaesthestist
  • Mr Kay, Wrightington Hospital
  • Mr Kurdy, Department of Orthopaedics
  • Mr Walter, Emergency Medicine
  • Dr Dias and his team in the School of Materials
 

Publications

2011

  • Grant SW, Grayson AD, Purkayastha D, Wilson S, McCollum CN. (2011). A logistic risk model for mortality following elective abdominal aortic aneurysm repair. The British Journal of Surgery, 98(5), 652-658. eScholarID:127963 | DOI:10.1002/bjs.7463
  • Kirwan CC, McDowell G, McCollum CN, Byrne JG. (2011). Incidence of Venous Thromboembolism during Chemotherapy for Breast Cancer: Impact. Anti Cancer Research, 31(6), 3-8. eScholarID:127962
  • Markus HS, McCollum C, Imray C, Goulder MA, Gilbert J, King A. (2011). The von Willebrand Inhibitor ARC1779 reduces cerebral embolisation after carotid endarterectomy: A randomised trial. Stroke 2011 June 23 doi:10.1161/STROKEAHA.111.616649, eScholarID:127961 | DOI:10.1161/​STROKEAHA.111.616649

2010

  • International Carotid Stenting Study (ICSS) investigators. (2010). Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of randomised controlled trial. The Lancet, 375(9719), 985-997. eScholarID:127969 | DOI:10.1016/S0140-6736(10)60239-5

2009

  • Sastry S, MacNab A, Daly K, Ray SG, McCollum CN. (2009). Transcranial Doppler detection of venous-to-arterial circulation shunt: Patent Foramen Ovale criteria. Journal of Clinical Ultrasound, 37, 276-280. eScholarID:127965 | DOI:10.1002/jcu.20564

2008

  • Daly KJ, Hutchinson S, McCollum CN. (2008). Can a peripheral artery be used to detect venous to arterial circulation shunts? Cerebrovasculaer Disease, 25, 111-114. eScholarID:127964 | DOI:10.1159/000112320
  • Perry E, Sekar V, Wren J, Purandare N, Burns A ans McCollum C. (2008). Cerebral emboli predict cognitive decline in the common dementias. British Journal of Surgery, 95(2), 265-268. eScholarID:127960
  • Purandare N, Oude Voshaar RR, McCollum CN, Jackson A-, Burns AS. (2008). Paradoxical embolisation and cerebral white matter lesions in dementia. Br J Radiol, 81( 961), eScholarID:1d17060

2007

  • McCollum CN. (2007). Surgery for venous leg ulcers. BMJ, 335( 7610), 55-6. eScholarID:1d17255
  • Oude Voshaar RR, Purandare N, Hardicre J, McCollum CN, Burns AS. (2007). Asymptomatic spontaneous cerebral emboli and mood in a cohort of older people: a prospective study. Am J Geriatr Psychiatry, 15( 12), 1057-60. eScholarID:1d17268
  • Patiar S, Kirwan C, McDowell G, Bundred NJ, McCollum CN, Byrne GJ. (2007). Prevention of venous thromboembolism in surgical patients with breast cancer. Br J Surg, 94( 4), 412-20. eScholarID:1d17263
  • Purandare N, Voshaar R, Morris J, Byrne J, Wren J, Heller R, McCollum CN, Burns AS. (2007). Asymptomatic spontaneous cerebral emboli predict cognitive and functional decline in dementia. Biol Psychiatry, 62( 4), 339-44. eScholarID:1d17265
  • Sastry S, Daly K, Chengodu T, McCollum CN. (2007). Is transcranial Doppler for the detection of venous-to-arterial circulation shunts reproducible? Cerebrovasc Dis, 23( 5-6), 424-9. eScholarID:1d17271
  • Voshaar R, Purandare N, Hardicre J, McCollum CN, Burns AS. (2007). Asymptomatic spontaneous cerebral emboli and cognitive decline in a cohort of older people: a prospective study. Int J Geriatr Psychiatry, 22( 8), 794-800. eScholarID:1d17273

2006

  • Bennett J, Haynes S, Torella F, Grainger H, McCollum CN. (2006). Acute normovolemic hemodilution in moderate blood loss surgery: a randomized controlled trial. Transfusion, 46( 7), 1097-103. eScholarID:1d15347 | DOI:10.1111/j.1537-2995.2006.00857.x
  • Daly K, Ross E, Norris H, McCollum CN. (2006). Vascular complications of prosthetic inter-vertebral discs. Eur Spine J, 15 Suppl 5, 644-9. eScholarID:1d17258
  • Davies LM, Tamara Brown, Haynes S, Katherine Payne, Elliott RA, McCollum CN. (2006). Cost effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion. Health Technology Assessment. Health Technology Assessment, 10 (44), 1-228. eScholarID:1d13154
  • Henao E, Hodge M, Felkai D, McCollum CN, Noon G, Lin P, Lumsden A, Bush R. (2006). Contrast-enhanced Duplex surveillance after endovascular abdominal aortic aneurysm repair: improved efficacy using a continuous infusion technique. J Vasc Surg, 43( 2), 259-64; discussion 2. eScholarID:1d17276
  • Kirwan C, McCollum CN, Bundred NJ, Byrne GJ. (2006). Current UK practice of thromboprophylaxis for breast surgery. Br J Surg, 93( 10), 1224-5. eScholarID:1d17260
  • Malde D, Abidia A, McCollum CN, Welch M. (2006). The success of routine MRSA screening in vascular surgery: a nine year review. Int Angiol, 25( 2), 204-8. eScholarID:1d17277
  • Patankar T, E Widjaja, H Chant, McCollum CN, Baldwin RC, Jeffries S, Sutcliffe CL, Burns AS, Jackson A-. (2006). Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis. European Journal of Neurology, 13, 10-16. eScholarID:1d12651
  • Purandare N, Burns AS, Daly K, Hardicre J, Morris J, Macfarlane G, McCollum CN. (2006). Cerebral emboli as a potential cause of Alzheimer's disease and vascular dementia: case-control study. BMJ, 332( 7550), 1119-24. eScholarID:1d14454 | DOI:10.1136/bmj.38814.696493.AE
  • Purandare N, Oude Voshaar R, Burns AS, Velupandian UM, McCollum CN. (2006). Paradoxical embolization: a potential cause of cerebral damage in Alzheimer's disease? Neurol Res, 28( 6), 679-84. eScholarID:1d14452
  • Purandare N, Oude Voshaar RC, Davidson YS, Gibbons LC, Hardicre J, McCollum CN, Burns AS, Jackson A-, Mann DMA. (2006). Genetic variations and white matter hyperintensities in dementia. J Amer Geriatr Soc, 54, 1395-1400. eScholarID:1d14096
  • Purandare N, Voshaar R, Hardicre J, Byrne J, McCollum CN, Burns AS. (2006). Cerebral emboli and depressive symptoms in dementia. Br J Psychiatry, 189, 260-3. eScholarID:1d17275
  • Purandare, N, Oude Voshaar, R, Davidson, YS, Gibbons, LC, Hardicre, J, Byrne, J, McCollum, CN, Jackson, A-, Burns, AS, Mann, DMA. (2006). Deletion/insertion polymorphism in the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: a pilot study. Journal of the American Geriatric Society, 54, 1395-1400. eScholarID:1d13625
  • Sastry S, Riding G, Morris J, Taberner D, Cherry N, Heagerty AM, McCollum CN. (2006). Young Adult Myocardial Infarction and Ischemic Stroke: the role of paradoxical embolism and thrombophilia (The YAMIS Study). J Am Coll Cardiol, 48( 4), 686-91. eScholarID:1d15346 | DOI:10.1016/j.jacc.2006.02.074
  • Seriki D, Ashleigh R, Butterfield J, England A, McCollum CN, Akhtar N, Welch M, Welch C. (2006). Midterm follow-up of a single-center experience of endovascular repair of abdominal aortic aneurysms with use of the Talent stent-graft. J Vasc Interv Radiol, 17( 6), 973-7. eScholarID:1d17261

2005

  • Abd-El-Aleem S, Morgan C, Ferguson M, McCollum CN, Ireland G. (2005). Spatial distribution of mast cells in chronic venous leg ulcers. Eur J Histochem, 49( 3), 265-72. eScholarID:1d17256
  • Dix F, Picton A, McCollum CN. (2005). Effect of superficial venous surgery on venous function in chronic venous insufficiency. Ann Vasc Surg, 19( 5), 678-85. eScholarID:1d11244
  • Dix FP, Boyle S, McCollum CN. (2005). Mild and moderate varicose vein reflux does not deteriorate over time. PHLEBOLOGY, 20, 1, eScholarID:1d17279
  • Dix FP, Reilly B, David MC, Simon D, Dowding E, Ivers L, Bhowmick A, McCollum CN. (2005). Effect of leg elevation on healing, venous velocity and ambulatory venous pressure in venous ulceration. PHLEBOLOGY, 20, 2, eScholarID:1d17278
  • Haynes S, Bennett J, Torella F, McCollum CN. (2005). Does washing swabs increase the efficiency of red cell recovery by cell salvage in aortic surgery? Vox Sang, 88( 4), 244-8. eScholarID:1d29284
  • McDowell G, Temple I, Li C, Kirwan C, Bundred N, McCollum CN, Burton I, Kumar S, Byrne GJ. (2005). Alteration in platelet function in patients with early breast cancer. Anticancer Res, 25( 6B), 3963-6. eScholarID:1d12398
  • Purandare N, Welsh S, Hutchinson S, Riding G, Burns AS, McCollum CN. (2005). Cerebral emboli and paradoxical embolisation in dementia: a pilot study. Int J Geriatr Psychiatry, 20( 1), 12-6. eScholarID:1d9299

2004

  • Devine C, McCollum CN. (2004). Heparin-bonded Dacron or polytetrafluorethylene for femoropopliteal bypass: five-year results of a prospective randomized multicenter clinical trial. J Vasc Surg, 40( 5), 924-31. eScholarID:1d15348 | DOI:10.1016/j.jvs.2004.08.033
  • Simon D, Dix F, McCollum CN. (2004). Management of venous leg ulcers. BMJ, 328( 7452), 1358-62. eScholarID:1d28813
  • Welsh S, Mead G, Chant H, Picton A, O'Neill PA, McCollum CN. (2004). Early carotid surgery in acute stroke: a multicentre randomised pilot study. Cerebrovasc Dis, 18( 3), 200-5. eScholarID:1d9573 | DOI:10.1159/000079942

2003

  • Kirwan C, Nath E, Byrne GJ, McCollum CN. (2003). Prophylaxis for venous thromboembolism during treatment for cancer: questionnaire survey. BMJ, 327( 7415), 597-8. eScholarID:1d29059

2002

  • McCollum CN, Antithrombotic Trialists' Collaboration. (2002). Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. British Medical Journal, 324, 71-86. eScholarID:1d25008
  • Haynes S, Torrela F, Wong JC, Dalrymple K, James M, McCollum CN. Economic evaluation of a randomized clinincal trail of haemodilution with cell salvage in aortic surgery.. Vol. 89 (6). 2002. 731-6. eScholarID:19d220
  • Torrela F, Haynes S, Kirwin CC, Bhatt AN, McCollum CN. Acute normovolemic hemodilution and intraperative cell salvation in aortic surgery. Vol. 36(1). 2002. 31-4. eScholarID:19d221
  • Wong JC, Torrela F, Haynes S, Dalrymple K, Mortimer AJ, McCollum CN. Autologous versus Allogenic Transfusion in Aortic Surgery:A multi-centre randomized clinical trial.. Vol. 235(1). 2002. 145-51. eScholarID:19d219

2001

  • SA Abd-El-Aleem, Ferguson MW.J, Appleton II, A Bhowmick, McCollum CN, Ireland GW. (2001). Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. Journal Of Pathology, 195, 616-623. eScholarID:1d24991
  • Haynes S, Wong JC, Torrela F, Dalrymple K, Pilsworth L, McCollum CN. The influence of homologous blood transfusion on immunity and clinical outcome in aortic surgery.. Vol. 22 (3). 2001. 244-250. eScholarID:19d218

2000

  • F Torella, Haynes S, A Lardi, O'Dwyer ST, McCollum CN. (2000). Unchanging attitudes to autologous transfusion in the UK. Transfusion Medicine, 11, eScholarID:1d24997

1997

  • ISD Roberts, Farrington CC, DJA Goldsmith, HS Neild, McCollum CN, Heagerty AM, Canfield AE. (1997). The expression of osteopontin and thrombospondin-1 in calcified and non-calcified arterial lesions. Journal Of Pathology, 181, A31. eScholarID:17d99

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