Skip to main content Skip to navigation

[University home]

School of Medicine

Professor David Denning FRCP FRCPath DCH FMedSci

Photograph of David Denning

Professor of Medicine and Medical Mycology

Education and Research Centre
University Hospital of South Manchester
Southmoor Road
Manchester
M23 9LT

 

Role

Director, National Aspergillosis Centre, based at University Hospital of South Manchester.

 

Research

Aspergillus causes 100,000s of life-threatening infections worldwide and millions of allergic and chronic infections, with much morbidity. Over the past few decades, the incidence of invasive aspergillosis has risen steadily. It is now the most common invasive mould infection worldwide. Mortality is almost 100% if the disease is left untreated and high (40 to 90%)  with therapy. Invasive aspergillosis occurs in 5 to 25% of all leukemia patients and is the leading infectious cause of death in many transplant centres. Aspergillus fumigatus is the most common responsible species, causing approximately 90% of human Aspergillus infections.

As well as the clinical aspects of medical mycology including diagnostics and the role of filamentous fungi in various forms of severe allergy, research carried out in the Manchester Fungal Disease Group group ranges from genomics through to diagnostics and studies of new antifungal drugs. Current collaboration with the JC Venter [genomics] Institute involve the sequencing and comparative analysis of multiple isolates of A. fumigatus.

Projects in the laboratory include studies of the frequency and mechanisms of nazole drug resistance, human genetic variants underlying the different aspergillus diseases, the role of Aspergillus and Candida pathogenicity factors in infection using knockout mutants, and identification of novel drug targets. A substantial effort goes into evaluation of new antifungal drugs and diagnostics clinically and in the clinical laborarory.  The Aspergillus Website has been developed to enable the dissemination of medical and scientific information about Aspergillus and aspergillosis

Work is or has been supported by the Wellcome Trust, National Institute of Allergy and Infectious Diseases (USA), the EU, the Moulton Trust, the Medical Research Council, the Fungal Research Trust and the Chronic Granulomatous Disease Research Trust.

 

Teaching

Most teaching involves project options students and postgaduate research students.

Externally, expertise on chronic and allergic aspergillosis and the treatment of fungal disease is shared with doctors all over the world.

 

Biography

  • Practising physician at one of Manchester's University Hospitals with expertise in fungal infections, particularly aspergillosis, antifungal resistance, the treatment of fungal infection and infection in the immunocompromised patient
  • Graduate of Guys Hospital London in 1980, with training in medicine, paediatrics, gastroenteroloy, haematology, infectious diseases and clinical microbiology, including a 3 year fellowship at Stanford University with Professor David Stevens (1987-1990)
  • Author of >400 research papers and chapters, mostly on fungal disease, resistance in fungi and treatment of fungal infection.
  • Co-author of ‘Medicine' with Professor Paul O'Neil and Dr Tim Dornan, an undergraduate textbook of medicine now in its third edition (2008).
  • Author of 24 citation classics (>100 citations)
  • Personal citation index of >17,500 (Sept 2011)
  • Research grant income to Manchester University >£18M since 1990
  • Director of National Aspergillosis Centre,  based at University Hospital of South Manchester, Wythenshawe Hospital.
  • Co-ordinator of the International Genome Sequencing project for Aspergillus fumigatus (funded by NIH, Wellcome Trust and Spanish government) 1997-2005
  • Founder and Editor of Aspergillus website (1998-)
  • Consultant (current or past) to multiple pharmaceutical companies with regard to antifungal drug discovery including Merck, Pfizer, Schering Plough, Oxford Glycosciences and Astellas.
  • Founder and Chair, Scientific Advisory Board of F2G Ltd, an antifungal drug discovery company spun out from Manchester University (1998-).
  • Founder and Chief Medical Officer of Myconostica (now a Lab21 company), developing and commercialising molecular diagnostics for fungal disease (2006-2011).
  • Listed in Who's Who in the World since 1996/7 Listed in Who's Who in Healthcare since 1997 Listed in Who's Who in Science and Technology since 2005
  • Chairman of several international conferences (Trends in Invasive Fungal Infection (x3 1993, 1997 and 1999; Advances against Aspergillosis x4 2004, 2006, 2008, 2010 and 2012: Aspergillus Genetics and Genomes Focus Meeting 2004, and other smaller meetings) and sessions at major congresses.
 

Qualifications

MB BS FRCP FRCPath DCH FIDSA FMedSci

 

Collaborators and affiliated staff

Principal investigators in the Manchester Fungal Diseases Group include:
 

 

Publications

2011

  • Adamama-Moraitou, K., Pardali, D., Day, M., Denning, D., Papazoglou, L., Papastefanou, A. & Rallis, T (2011). Aspergillus fumigatus Bronchopneumonia in a Hellenic Shepherd Dog. Journal of the American Animal Hospital Association, 47(2), E13-E18. eScholarID:128319 | DOI:10.5326/JAAHA-MS-5497
  • Albarrag AM, Anderson MJ, Howard SJ, Robson GD, Warn PA, Sanglard D, Denning DW. (2011). Interrogation of related clinical pan-azole resistant Aspergillus fumigatus strains – G138C, Y431C and G434C SNPs in cyp51A, Upregulation of cyp51A and integration and activation of transposon Atf1 into cyp51A promoter. J Clin Microbiol, 55, 5113-5121. eScholarID:140897
  • Baxter, C., Bishop, P., Low, S., Baiden-Amissah, K. & Denning, D (2011). Pulmonary aspergillosis: an alternative diagnosis to lung cancer after positive [(18)F]FDG positron emission tomography. Thorax, 66(7), 638-640. eScholarID:128323 | DOI:10.1136/thx.2010.155515
  • Baxter, C., Jones, A., Webb, K. & Denning, D (2011). Homogenisation of cystic fibrosis sputum by sonication - An essential step for Aspergillus PCR. Journal of Microbiological Methods, 85(1), 75-81. eScholarID:128317 | DOI:10.1016/j.mimet.2011.01.024
  • Denning DW, Pleuvry A, Cole DC. (2011). Global burden of chronic pulmonary aspergillosis as a sequel to tuberculosis. Bulletin WHO, 89, 864-872. eScholarID:140896
  • Denning, D., Park, S., Lass-Florl, C., Fraczek, M., Kirwan, M., Gore, R., Smith, J., Bueid, A., Moore, C., Bowyer, P. & Perlin, D (2011). High-frequency Triazole Resistance Found In Nonculturable Aspergillus fumigatus from Lungs of Patients with Chronic Fungal Disease. Clinical Infectious Diseases, 52(9), 1123-1129. eScholarID:128318 | DOI:10.1093/cid/cir179
  • Hauser, P., Bille, J., Lass-Florl, C., Geltner, C., Feldmesser, M., Levi, M., Patel, H., Muggia, V., Alexander, B., Hughes, M., Follett, S., Cui, X., Leung, F., Morgan, G., Moody, A., Perlin, D. & Denning, D (2011). Multicenter, Prospective Clinical Evaluation of Respiratory Samples from Subjects at Risk for Pneumocystis jirovecii Infection by Use of a Commercial Real-Time PCR Assay. Journal of Clinical Microbiology, 49(5), 1872-1878. eScholarID:128321 | DOI:10.1128/JCM.02390-10
  • Purcell, J., McKenna, J., Critten, P., Denning, D. & Hassan, I (2011). Mixed mould species in laboratory cultures of respiratory specimens: how should they be reported, and what are the indications for susceptibility testing? Journal of Clinical Pathology, 64(6), 543-545. eScholarID:128320 | DOI:10.1136/jcp.2010.084517
  • Slater, J., Gregson, L., Denning, D. & Warn, P (2011). Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice. Medical Mycology, 49, S107-S113. eScholarID:128322 | DOI:10.3109/13693786.2010.523852
  • Smith, N. & Denning, D (2011). Underlying conditions in chronic pulmonary aspergillosis including simple aspergilloma. European Respiratory Journal, 37(4), 865-872. eScholarID:128324 | DOI:10.1183/09031936.00054810

2010

  • Ann Chai, L., Denning, D. & Warn, P (2010). Candida tropicalis in human disease. Crit Rev Microbiol, 36(4), 282-98. eScholarID:101410 | PMID:20883082 | DOI:10.3109/1040841X.2010.489506
  • Dannaoui, E., Schwarz, P., Slany, M., Loeffler, J., Jorde, A., Cuenca-Estrella, M., Hauser, P., Shrief, R., Huerre, M., Freiberger, T., Gaustad, P., Rodriguez-Tudela, J., Bille, J., Denning, D., Bretagne, S. & Lortholary, O (2010). Molecular detection and identification of zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study Group (EFISG) evaluation. J Clin Microbiol, 48(6), 2043-6. eScholarID:101413 | PMID:20375233 | DOI:10.1128/JCM.02319-09
  • Denning DW Hope WW. (2010). Therapy for fungal diseases: opportunities and priorities. Trends Microbiol, eScholarID:77601
  • Felton TW, Baxter C, Roberts S, Hope WW, Denning DW. (2010). Efficacy and safety of posaconazole for chronic pulmonary aspergillosis. Clin Infect Dis, 51, 1383-1391. eScholarID:113649 | DOI:10.1086/657306
  • Harrison, E., Stalhberger, T., Whelan, R., Sugrue, M., Wingard, J., Alexander, B., Follett, S., Bowyer, P., Denning, D. & . (2010). Aspergillus DNA contamination in blood collection tubes. Diagn Microbiol Infect Dis, 67(4), 392-4. eScholarID:101408 | PMID:20638611 | DOI:10.1016/j.diagmicrobio.2010.02.028
  • Hiemenz, J., Raad, I., Maertens, J., Hachem, R., Saah, A., Sable, C., Chodakewitz, J., Severino, M., Saddier, P., Berman, R., Ryan, D., Dinubile, M., Patterson, T., Denning, D. & Walsh, T (2010). Efficacy of caspofungin as salvage therapy for invasive aspergillosis compared to standard therapy in a historical cohort. Eur J Clin Microbiol Infect Dis, 29(11), 1387-94. eScholarID:101414 | PMID:20703506 | DOI:10.1007/s10096-010-1013-0
  • Lestner J, Denning DW. (2010). Tremor: a newly described adverse event with long-term itraconazole therapy. J Neurol, Neurosurg Psych, 81, 327-329. eScholarID:79307 | DOI:10.1136/jnnp.2009.174706
  • Slater, J., Gregson, L., Denning, D. & Warn, P (2010). Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice. Med Mycol, eScholarID:101416 | PMID:20950221 | DOI:10.3109/13693786.2010.523852
  • Smith, N. & Denning, D (2010). Underlying conditions in chronic pulmonary aspergillosis, including simple aspergilloma. Eur Respir J, eScholarID:101415 | PMID:20595150 | DOI:10.1183/09031936.00054810
  • Tuckwell, D., Denning, D. & Bowyer, P (2010). A public resource for metabolic pathway mapping of Aspergillus fumigatus Af293. Med Mycol, eScholarID:101407 | PMID:20507264 | DOI:10.3109/13693786.2010.490243
  • Warn PA, Sharp A, Morrissey G, Lowther J, Denning DW. (2010). Activity of Aminocandin (IP960; HMR3270) compared to Amphotericin B, Itraconazole and Caspofungin and Micafungin in Neutropenic Murine Models of Disseminated Infection Caused by Itraconazole Susceptible and Resistant Strains of Aspergillus fumigatus. Int J Antimicrob Ag, 35, 146-151. eScholarID:79310 | DOI:10.1016/j.ijantimicag.2009.09.029

2009

  • Chakrabarti, A, Denning, DW, Ferguson, B, Ponikau, J, Buzina, W, Kita, H, Marple, B, Panda, N, Vlaminck, S, Kauffmann-Lacroix, C, Das, A, Singh, P, Taj-Aldeen, S, Kantarcioglu, A, Handa, K, Gupta, A, Thungabathra, M, Shivaprakash, M, Bal, A, Fothergill, A, Radotra, B. (2009). Fungal rhinosinusitis: a categorization and definitional schema addressing current controversies. Laryngoscope, 119, 1809-1818. eScholarID:1d19800 | DOI:10.1002/lary.20520
  • Denning DW, O'Driscoll B, Powell GGL, Chew FFH, Atherton GT, Vyas AA, Miles J, Morris JJA, Niven RR M. (2009). Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. Am J Respir Crit Care Med, 179, 11-18. eScholarID:1d19809 | DOI:10.1164/rccm.200805-737OC
  • Fedorova N, Harris S, Chen D, Denning DW, Yu J, Cotty P, Nierman W. (2009). Using aCGH to study intraspecific genetic variability in two pathogenic molds, Aspergillus fumigatus and Aspergillus flavus. Med Mycol, 47 Suppl 1, S34-S41. eScholarID:1d19803 | DOI:10.1080/13693780802354029
  • Hong M, Ryan RR, Arkwright PD, Gennery AR, Costigan C, Dominguez M, Denning DW, McConnell V, Cant AJ, Abinun M, Spickett GP, Swan DC, Gillespie C, Young DA, Lilic D. (2009). Pattern Recognition Receptor Expression is Not Impaired in Patients with Chronic Mucocutaneous Candidiasis with or without Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED). Clin Exp Immunol, 156, 40-51. eScholarID:79304 | DOI:10.1111/j.1365-2249.2009.03873.x
  • Howard, S, Cerar, D, Anderson, M, Albarrag, A, Fisher, M, Pasqualotto, A, Laverdiere, M, Arendrup, M, Perlin, D, Denning, DW. (2009). Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. Emerg Infect Dis, 15( 7), eScholarID:1d21206 | DOI:10.3201/eid1507.090043
  • Klich MA, Tang S, Denning DW. (2009). Aflatoxin and Ochratoxin Production by Aspergillus Species Under Ex Vivo Conditions. Mycopathologia, 168, 185-191. eScholarID:1d19801 | DOI:10.1007/s11046-009-9215-7
  • Kontoyiannis, D, Ratanatharathorn, V, Young, J, Raymond, J, Laverdière, M, Denning, DW, Patterson, T, Facklam, D, Kovanda, L, Arnold, L, Lau, W, Buell, D, Marr, K. (2009). Micafungin alone or in combination with other systemic antifungal therapies in hematopoietic stem cell transplant recipients with invasive aspergillosis. Transpl Infect Dis, 11( 1), eScholarID:1d19807 | DOI:10.1111/j.1399-3062.2008.00349.x
  • Lestner JM, Roberts SA, Moore CB, Howard SJ, Denning DW, Hope WW. (2009). Toxicodynamics of itraconazole: implications for therapeutic drug monitoring. Clin Infect Dis, 49, 928-930. eScholarID:79309 | DOI:10.1086/605499
  • Mabey Gilsenan JE, Atherton GT, Bartholomew J, Giles PF, Attwood T, Denning DW, Bowyer P. (2009). Aspergillus genomes and the Aspergillus cloud. Nucleic Acids Research, 37, D509-D514. eScholarID:1d18442 | DOI:10.1093/nar/gkn876
  • Majithiya JB, Sharp AD, Parmar AA, Denning DW, Warn PA. (2009). Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. J Antimicrob Chemother, 63( 1), eScholarID:1d19806 | DOI:10.1093/jac/dkn431
  • O'Driscoll BR, Powell G, Chew F, Niven R, Miles J, Vyas AA, Denning DW. (2009). Comparison of skin prick tests with specific serum IgE (RAST test) in the diagnosis of fungal sensitisation in patients with severe asthma. Clin Exp Allergy, 39, 1677. eScholarID:79306 | DOI:10.1111/j.1365-2222.2009.03339.x
  • Verweij PE, Howard SJ, Melchers WJ, Denning DW. (2009). Azole-resistance in Aspergillus: proposed nomenclature and breakpoints. Drug Resistance Updates, 12(6), 141-147. eScholarID:77602 | DOI:10.1016/j.drup.2009.09.002
  • Verweij PE, Howard, SJ, Melchers WJG, Denning DW. (2009). Azole-resistance in Aspergillus: Proposed nomenclature and breakpoints. Drug Resistance Updates, 12(6), 141-147. eScholarID:128352 | DOI:10.1016/j.drup.2009.09.002
  • Warn PA, Sharp AD, Parmar AA, Majithiya JB, Denning DW, Hope WW. (2009). Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, the importance of tissue concentrations and the impact of immune status on the antifungal effect. Antimicrob Agents Chemother, 53, 3453. eScholarID:1d19802 | DOI:10.1128/AAC.01601-08

2008

  • De Pauw, B, Walsh, T, Donnelly, J, Stevens, D, Edwards, J, Calandra, T, Pappas, P, Maertens, J, Lortholary, O, Kauffman, C, Denning, DW, Patterson, T, Maschmeyer, G, Bille, J, Dismukes, W, Herbrecht, R, Hope, WW, Kibbler, C, Kullberg, B, Marr, K, Muñoz, P, Odds, F, Perfect, J, Restrepo, A, Ruhnke, M, Segal, B, Sobel, J, Sorrell, T, Viscoli, C, Wingard, J, Zaoutis, T, Bennett, J, NULL, NULL. (2008). Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis, 46( 12), 181-21. eScholarID:1d17529
  • Fedorova, N, Khaldi, N, Joardar, V, Maiti, R, Amedeo, P, Anderson, M, Crabtree, J, Silva, J, Badger, J, Albarraq, A, Angiuoli, S, Bussey, H, Bowyer, P, Cotty, P, Dyer, P, Egan, A, Galens, K, Fraser-Liggett, C, Haas, B, Inman, J, Kent, R, Lemieux, S, Malavazi, I, Orvis, J, Roemer, T, Ronning, C, Sundaram, J, Sutton, G, Turner, G, Venter, J, White, O, Whitty, B, Youngman, P, Wolfe, K, Goldman, G, Wortman, J, Jiang, B, Denning, DW, Nierman, W. (2008). Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genet, 4( 4), e1000046-. eScholarID:1d17526 | DOI:10.1371/journal.pgen.1000046
  • Hope WW, Billaud E, Lestner J, Denning DW. (2008). Therapeutic drug monitoring for triazoles. Curr Opin Infect Dis, 21( 6), 580-586. eScholarID:1d19808 | DOI:10.1097/QCO.0b013e3283184611
  • Pasqualotto AC, Denning DW. (2008). New and emerging treatments for fungal infection. Journal of Antimicrobial Chemotherapy, 61, i19-i30. eScholarID:17460 | DOI:10.1093/jac/dkm428
  • Pasqualotto AC, Shah M, Wynn R, Denning DW. (2008). Voriconazole plasma monitoring. archives of diseases in childhood, 93, 578-581. eScholarID:17583 | DOI:10.1136/adc.2007.118844
  • Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis D, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik J-A, Wingard JR, Patterson TF. (2008). Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America (IDSA). Clinical Infectious Diseases -Chicago-, 46, 327-360. eScholarID:17474 | DOI:10.1086/525258

2007

  • Bowyer P, Denning DW. (2007). Genomic analysis of allergen genes in Aspergillus spp: the relevance of genomics to everyday research. Med Mycol, 45, 17-26. eScholarID:1d17528
  • Hedayati M, Pasqualotto A, Warn P, Bowyer P, Denning DW. (2007). Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology, 153(6), 1677-1692. eScholarID:1d17527
  • Hope WW, Drusano GL, Moore CB, Sharp A, Louie A, Walsh TJ, Denning DW, Warn PA. (2007). The effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis. Antimicrob Agents Chemother, 51(1), 285-295. eScholarID:1d14404 | DOI:10.1128/AAC.00601-06
  • Hope WW, Warn PA, Sharp A, Reed P, Keevil B, Louie A, Walsh T, Denning DW, Drusano G. (2007). Optimization of the dosage of flucytosine in combination with amphotericin B for disseminated candidiasis: a pharmacodynamic rationale for reduced dosing. Antimicrob Agents Chemother, 51(10), 3760-3762. eScholarID:1d17530
  • Pasqualotto A, Howard SJ, Moore C, Denning DW. (2007). Flucytosine therapeutic monitoring: 15 years experience from the UK. J Antimicrob Chemother, 59(4), 791-793. eScholarID:1d32605
  • Pasqualotto AC, Denning DW, Anderson MJ. (2007). A cautionary tale: the lack of consistency in allele sizes between two laboratories for a published Multi-Locus Microsatellite Typing (MLMT) system. J Clin Microbiol, 45, 522-528. eScholarID:1d14618
  • Rodriguez-Tudela, J, Donnelly, J, Pfaller, M, Chryssantou, E, Warn, P, Warn, PA, Denning, DW, Espinel-Ingroff, A, Barchiesi, F, Cuenca-Estrella, M. (2007). Statistical analyses of correlation for fluconazole minimal inhibitory concentrations and Candida spp. for standard methodologies of EUCAST (E.Dis. 7.1) and CLSI (M27 A2). J Clin Microbiol, 45, 109-111. eScholarID:1d14403

2006

  • Anaissie, et al. (2006). Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis, 43( 8), eScholarID:1d30864
  • Bowyer P, Blightman O, Denning DW. (2006). Relative reactivity of Aspergillus allergens used in serological tests. Med Mycol, 44 Suppl, 24-28. eScholarID:1d14621
  • Bowyer P, Fraczek M, Denning DW. (2006). Comparative genomics of fungal allergens and epitopes shows widespread distribution of closely related allergen and epitope orthologues. BMC Genomics, 7, 251-. eScholarID:1d14391
  • Cavling Arendrup M, Ronan O'driscoll B, Petersen E, Denning DW. (2006). Acute pulmonary aspergillosis in immunocompetent subjects after exposure to bark chippings. Scand J Infect Dis, 38(10), 945-949. eScholarID:1d14625
  • Charlier C, Hart E, Lefort A, Ribaud P, Dromer F, Denning DW, Lortholary O. (2006). Fluconazole for the management of invasive candidiasis: where do we stand after 15 years? J Antimicrob Chemother, 57(3), 384-410. eScholarID:1d14410
  • Denning DW, O'Driscoll BR, Hogaboam C, Bowyer P, Niven RR M. (2006). The link between fungi and severe asthma; a summary of the evidence. Eur Resp J, 27, 615-626. eScholarID:1d32786
  • Denning, DW, Marr, K, Lau, W, Facklam, D, Ratanatharathorn, V, Becker, C, Ullmann, A, Seibel, N, Flynn, P, van Burik, J, Buell, D, Patterson, T. (2006). Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis. J Infect, 53(5), 337-349. eScholarID:1d14408
  • Hamer E, Moore C, Denning DW. (2006). Comparison of two fluorescent whiteners, Calcofluor and Blankophor, for the detection of fungal elements in clinical specimens in the diagnostic laboratory. Clin Microbiol Infect, 12(2), 181-184. eScholarID:1d14411
  • Hassan I, Critten P, Isalska B, Denning DW. (2006). Audit of laboratory mycology services for the management of patients with fungal infections in the northwest of England. J Clin Pathol, 59(7), 759-763. eScholarID:1d14406
  • Hope WW, Warn PA, Sharp A, Howard SJ, Kasai M, Louie A, Walsh T, Drusano G, Denning DW. (2006). Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect. Antimicrob Agents Chemother, 50(11), 3680-3688. eScholarID:1d14630 | DOI:10.1128/AAC.00369-06
  • Howard SJ, Walker S, Andrew S, Borman A, Johnson E, Denning DW. (2006). Sub-cutaneous phaeohyphomycosis caused by Cladophialophora devriesii in a United Kingdom resident. Med Mycol, 44(6), 553-556. eScholarID:1d14628
  • Howard SJ, Webster I, Moore C, Gardiner R, Park S, Perlin D, Denning DW. (2006). Multi-azole resistance in Aspergillus fumigatus. Int J Antimicrob Agents, 28(5), 450-453. eScholarID:1d14624
  • Jain L, Denning DW. (2006). The efficacy and tolerability of voriconazole in the treatment of chronic cavitary pulmonary aspergillosis. J Infect, 52(5), e133-e137. eScholarID:1d14412
  • Lass-Florl C, Cuenca-Estrella M, Denning DW, Rodriguez-Tudela J. (2006). Antifungal susceptibility testing in Aspergillus spp. according to EUCAST methodology. Med Mycol, 44 Suppl, 319-325. eScholarID:1d14620
  • Pasqualotto A, Denning DW. (2006). Post-operative aspergillosis. Clin Microbiol Infect, 12(11), 1060-1076. eScholarID:1d14626
  • Sambatakou H, Dupont B, Lode H, Denning DW. (2006). Voriconazole treatment for subacute invasive and chronic pulmonary aspergillosis. Am J Med, 119, e17-e24. eScholarID:1d14407
  • Sambatakou H, Pravica V, Hutchinson I, Denning DW. (2006). Cytokine profiling of pulmonary aspergillosis. Int J Immunogenet, 33(4), 297-302. eScholarID:1d14405
  • Warn PA, Sharp A, Denning DW. (2006). In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp. J Antimicrob Chemother, 57(1), 1198-1207. eScholarID:1d14416
  • Warn PA, Sharp A, Mosquera J, Spickermann J, Schmitt-Hoffmann A, Heep M, Denning DW. (2006). Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus. J Antimicrob Chemother, 58( 6), 1198-1207. eScholarID:1d14619 | DOI:10.1093/jac/dkl396
  • Woodcock AA, Steel N, Moore C, Howard SJ, Custovic A, Denning DW. (2006). Fungal contamination of bedding. Allergy, 61(1), 140-142. eScholarID:1d13029
  • Wortman, J, Fedorova, N, Crabtree, J, Joardar, V, Maiti, R, Haas, B, Amedeo, P, Lee, E, Angiuoli, S, Jiang, B, Anderson, M, Denning, DW, White, O, Nierman, W. (2006). Whole genome comparison of the A. fumigatus family. Med Mycol, 44 Suppl, 3-7. eScholarID:1d14622
  • Denning DW. Aspergillus and aspergillosis-Progress on many fronts., Med Mycol. Vol. 44 Suppl. 2006. 1369-3786. 1. eScholarID:19d148

2005

  • Dodgson A, Pujol C, Pfaller M, Denning DW, Soll D. (2005). Evidence for recombination in Candida glabrata. Fungal Genet Biol, 42( 3), 233-43. eScholarID:1d11225
  • Galagan, et al. (2005). Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature, 438( 7071), 1105-15. eScholarID:1d14415 | DOI:10.1038/nature04341
  • Hope WW, Walsh T, Denning DW. (2005). Laboratory diagnosis of invasive aspergillosis. Lancet Infect Dis, 5(10), 609-622. eScholarID:1d11217
  • Hope WW, Walsh T, Denning DW. (2005). The invasive and saprophytic syndromes due to Aspergillus spp. Med Mycol, 43 Suppl 1, S207-S238. eScholarID:1d11220
  • Machida, et al. (2005). Genome sequencing and analysis of Aspergillus oryzae. Nature, 438, 1157-1161. eScholarID:1d14413 | DOI:10.1038/nature04300
  • Nierman et al. (2005). Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature, 438, 1151-1156. eScholarID:1d12399
  • Nierman W, May G, Kim H, Anderson MJ, Chen D, Denning DW. (2005). What the Aspergillus genomes have told us. Med Mycol, 43 Suppl 1, S3-5. eScholarID:1d11216
  • Nierman, et al. (2005). Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature, 438( 7071), 1151-6. eScholarID:1d14414 | DOI:10.1038/nature04332
  • O'Driscoll B, Hopkinson L, Denning DW. (2005). Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med, 5(1), 4-. eScholarID:1d11224
  • Paisley D, Robson G, Denning DW. (2005). Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus. Med Mycol, 43, 397-402. eScholarID:1d11218
  • Paoletti M, Rydholm C, Schwier E, Anderson M, Szakacs G, Lutzoni F, Debeaupuis J, Latgé J, Denning DW, Dyer P. (2005). Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol, 15(13), 1242-1248. eScholarID:1d11223
  • Paoletti M, Rydholm C, Schwier EU, Anderson MJ, Szakacs G, Lutzoni F, Debeaupuis J-P, Latgé J-P, Denning DW, Dyer PS. (2005). Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. Curr Biol, 15, 1242-1248. eScholarID:1d11793
  • Patterson, T, Boucher, H, Herbrecht, R, Denning, DW, Lortholary, O, Ribaud, P, Rubin, R, Wingard, J, DePauw, B, Schlamm, H, Troke, P, Bennett, J, NULL, NULL. (2005). Strategy of following voriconazole versus amphotericin B therapy with other licensed antifungal therapy for primary treatment of invasive aspergillosis: impact of other therapies on outcome. Clin Infect Dis, 41( 10), 1448-52. eScholarID:1d14417
  • Ronning, C, Fedorova, N, Bowyer, P, Coulson, R, Goldman, G, Kim, H, Turner, G, Wortman, J, Yu, J, Anderson, M, Denning, DW, Nierman, W. (2005). Genomics of Aspergillus fumigatus. Rev Iberoam Micol, 22( 4), 223-8. eScholarID:1d14409
  • Sambatakou H, Denning DW. (2005). Invasive pulmonary aspergillosis transformed into fatal mucous impaction by immune reconstitution in an AIDS patient. Eur J Clin Microbiol Infect Dis, 24, 628-633. eScholarID:1d11219
  • Warn PA, Sharp A, Morrissey G, Denning DW. (2005). Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis. J Antimicrob Chemother, 56(3), 590-593. eScholarID:1d11221 | DOI:10.1093/jac/dki268

2004

  • Boyd A, Modi S, Howard SJ, Moore C, Keevil B, Denning DW. (2004). Adverse reactions to voriconazole. Clin Infect Dis, 39( 8), 1241-4. eScholarID:1d9551
  • Hope WW, Padwell A, Guiver M, Denning DW. (2004). Invasive pulmonary aspergillosis with spontaneous resolution and the diagnostic utility of PCR from tissue specimens. J Infect, 49( 2), 136-40. eScholarID:1d9561
  • Hope WW, Tabernero L, Denning DW, Anderson MJ. (2004). Molecular mechanisms of primary resistance to flucytosine in Candida albicans. Antimicrob Agents Chemother, 48( 11), 4377-86. eScholarID:1d9554 | DOI:10.1128/AAC.48.11.4377-4386.2004
  • Keevil B, Newman S, Lockhart S, Howard SJ, Moore C, Denning DW. (2004). Validation of an assay for voriconazole in serum samples using liquid chromatography-tandem mass spectrometry. Ther Drug Monit, 26( 6), 650-7. eScholarID:1d9549
  • Mabey, JE, Anderson, MJ, Giles, PF, Miller, C, Attwood, T, Paton, NW, Bronberg-Bauer, E, Robson, GD, Oliver, SG, Denning, DW. (2004). CADRE: the Central Aspergillus Data REpository. Nucleic Acids Research, 32, D4101-D405. eScholarID:1d18444 | DOI:10.1093/nar/gkh009
  • Maertens, J, Raad, I, Petrikkos, G, Boogaerts, M, Selleslag, D, Petersen, F, Sable, C, Kartsonis, N, Ngai, A, Taylor, A, Patterson, T, Denning, DW, Walsh, T, NULL. (2004). Efficacy and safety of caspofungin for treatment of invasive aspergillosis in patients refractory to or intolerant of conventional antifungal therapy. Clin Infect Dis, 39( 11), 1563-71. eScholarID:1d11226
  • Sari-Kouzel H, Chadwick P, Muir L, Herrick A, Denning DW. (2004). Mycobacterium chelonae finger infection associated with Raynaud's phenomenon. Ann Rheum Dis, 63( 9), 1178-9. eScholarID:1d11228
  • Zaspel U, Denning DW, Lemke A, Greene R, Schürmann D, Maschmeyer G, Ruhnke M, Herbrecht R, Ribaud P, Lortholary O, Zonderland H, Rabe K, Röttgen R, Bittner R, Neumann K, Oestmann J. (2004). Diagnosis of IPA in HIV: the role of the chest X-ray and radiologist. Eur Radiol, 14(11), 2030-2037. eScholarID:1d11227
  • H Sari-Houzel, Herrick AL, P R Chadwick, LTS Muir, Denning DW. (2004). Mycobacterium chelonae finger infection associated with Raynaud's phenomenon. Annals of Rheumatic Diseases, 6, 1178-1179. eScholarID:17d198

2003

  • Anderson MJ, Brookman JL, Denning DW. (2003). Aspergillus. Genomics of Plants and Fungi Mycology Series Vol 18. ( 18, pp. pp 1-39). eScholarID:3d1047
  • Denning DW, Kibbler C, Barnes R. (2003). British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections. Lancet Infect Dis, 3( 4), 230-40. eScholarID:1d6731
  • Denning DW, Riniotis K, Dobrashian R, Sambatakou H. (2003). Chronic cavitary and fibrosing pulmonary and pleural aspergillosis: case series, proposed nomenclature change, and review. Clin Infect Dis, 37 Suppl 3, S265-80. eScholarID:1d6730
  • Denning DW. (2003). Echinocandin antifungal drugs. Lancet, 362( 9390), 1142-51. eScholarID:1d6729
  • Warn PA, Morrissey G, Morrissey J, Denning DW. (2003). Activity of Micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistence to amphotericin B. Journal of Antimicrobial Chemotherapy, 51, 913-919. eScholarID:1d15580 | DOI:10.1093/jac/dkg185

2002

  • Denning DW, Ribaud P, Milpied N, Caillot D, Herbrecht R, Thiel E, Haas A, Ruhnke M, Lode H. (2002). Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis. Clin Infect Dis, 34( 5), 563-71. eScholarID:1d6733
  • Herbrecht R, Denning DW, Troke PF, Patterson TF, Bennett JE, Greene RE, Oestmann JW, Kern W, Marr KA. (2002). Randomised comparison of voriconazole and amphotericin B in primary therapy of invasive aspergillosis. 347, 408-415. eScholarID:1d4450
  • Herbrecht, R, Denning, DW, Patterson, T, Bennett, J, Greene, R, Oestmann, J, Kern, W, Marr, K, Ribaud, P, Lortholary, O, Sylvester, R, Rubin, R, Wingard, J, Stark, P, Durand, C, Caillot, D, Thiel, E, Chandrasekar, P, Hodges, M, Schlamm, H, Troke, P, de Pauw, B. (2002). Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med, 347( 6), 408-15. eScholarID:1d6732 | DOI:10.1056/NEJMoa02019100284793,15334406

2001

  • Caillott D, Couaillier J-F, Bernard A, Casasnovas O, Denning, DW, Mannone L, Lopez J, Couillault G, Piard F, Vagner O, Guy H. (2001). Increasing volume and changing characteristics of IPA on sequential thoracic CT scans in neutropenic patients. 19, 253-259. eScholarID:1d4448
  • Crosdale D, Poulton K, Ollier W, Thomson W, Denning DW. (2001). Mannose-binding lectin gene polymorphisms as a susceptibility factor for chronic necrotizing pulmonary aspergillosis. J Infect Dis, 184( 5), 653-6. eScholarID:1d6734
  • Crosdale D, Poulton K, Ollier WER, Thomson W, Denning DW. (2001). Mannose binding lectin gene polymorphisms as a susceptibility factor for chronic necrotisng pulmonary aspergillosis. J Infect Dis, 184, 5, 653-656. eScholarID:1d4449
  • Denning DW, Griffiths CEM. (2001). Muco-cutaneous retinoid-effects and photosensitivity related to the novel triazole antifungal agent voriconazole. Clinical & Experimental Dermatology, 145, 648-653. eScholarID:1d6957

2000

  • Brookman J, Denning DW. (2000). Molecular genetics in Aspergillus fumigatus. 3, 468-474. eScholarID:1d4446

1996

  • Carlson GL, Mughal M, Birch M, Denning DW. (1996). Aspergillus wound infection following laparostomy. Journal Of Infection, 33, 119-121. eScholarID:1d27096

Top of page

| Skip to main content | Skip to navigation | Skip to Search |