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School of Medicine

Professor David Eisner M.A. D.Phil, FRCP (Hon), FMedSci

Photograph of David Eisner

BHF Professor of Cardiac Physiology

 

Research

Cardiovascular disease is the major cause of death in the developed world. David Eisner’s research group is trying to understand the mechanisms that regulate the contraction of the heart under both normal and diseased conditions. The heart is composed of billions of cells (myocytes) and, in order for it to pump blood these cells must contract synchronously. Contraction is initiated by an increase of the amount of calcium in the cell. Most of this calcium is released from an intracellular store. This group has defined the mechanisms that control the amount of calcium in the store and thence the amount that can be released to activate contraction. Current work is focused on changes in the store content of calcium in disease conditions.
 

Biography

David Eisner (B.A. Cambridge, Natural Sciences, 1976; D.Phil Oxford, Physiology, 1979).

He spent the period 1980- 1990 in the Department of Physiology at University College London. From 1990-1999 he was Professor of Veterinary Biology at Liverpool University before moving to Manchester as Professor of Cardiac Physiology in October 1999.

He has received the Pfizer Prize for Biology (1985), the Wellcome Prize in Physiology (1988) and given the QR Murphy lecture at the University of Wisconsin (1992), the Reimer Lecture of the International Society for Heart Research (2008), the Dorothy Wedgwood Lecture for Young People (2008) and the Peter Baker Memorial Lecture (2010). He has been elected a Fellow of the Academy of Medical Sciences and  to Honorary Fellowship of the Royal College of Physicians.  He serves on the editorial boards of Basic Research in Cardiology, Cell Calcium and Experimental Physiology.  He is a Senior Consulting Editor of Circulation Research. He is the Editor in Chief of  The Journal of  Molecular and Cellular Cardiology. Until July 2000, he was Chairman of the Editorial Board of The Journal of Physiology. He was previously International Secretary of the Physiological Society and Chair of the British Society for Cardiovascular Research.  He is  the past-Chair of the Working Group of Cardiac Cellular Electrophysiology of the European Society of Cardiology and the President-elect of the Federation of European Physiological Societies (FEPS).  He also chairs the International Scientific Programme Committe for the 2013 meeting of the International Union of Physiological Sciences (IUPS).  He has served on panels for the Research Assessment Exercise (RAE) in 2001 and 2008 and is currently a member of the Biological Sciences Panel for REF2014.

 

Publications

2011

  • Bode, E., Briston, S., Overend, C., O'Neill, S., Trafford, A. & Eisner, D (2011). Changes of SERCA activity have only modest effects on sarcoplasmic reticulum Ca2+ content in rat ventricular myocytes. J Physiol, 589(Pt 19), 4723-9. eScholarID:133003 | PMID:21825024 | DOI:10.1113/jphysiol.2011.211052
  • Briston, S., Caldwell, J., Horn, M., Clarke, J., Richards, M., Greensmith, D., Graham, H., Hall, M., Eisner, D., Dibb, K. & Trafford, A (2011). Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure. J Physiol, 589(Pt 6), 1367-82. eScholarID:123767 | PMID:21242250 | DOI:10.1113/jphysiol.2010.203984
  • Stokke, M., Briston, S., Jølle, G., Manzoor, I., Louch, W., Oyehaug, L., Christensen, G., Eisner, D., Trafford, A., Sejersted, O. & Sjaastad, I (2011). Ca2+ wave probability is determined by the balance between SERCA2-dependent Ca2+ reuptake and threshold SR Ca2+ content. Cardiovasc Res, 90(3), 503-12. eScholarID:123768 | PMID:21242164 | DOI:10.1093/cvr/cvr013

2010

  • Greensmith, D., Eisner, D. & Nirmalan, M (2010). The effects of hydrogen peroxide on intracellular calcium handling and contractility in the rat ventricular myocyte. Cell Calcium, 48(6), 341-51. eScholarID:99823 | PMID:21106236 | DOI:10.1016/j.ceca.2010.10.007
  • Kashimura, T., Briston, S., Trafford, A., Napolitano, C., Priori, S., Eisner, D. & Venetucci, L (2010). In the RyR2R4496C Mouse Model of CPVT, {beta}-Adrenergic Stimulation Induces Ca Waves by Increasing SR Ca Content and Not by Decreasing the Threshold for Ca Waves. Circ Res, 107(12), 1483-1489. eScholarID:99822 | PMID:20966392 | DOI:10.1161/CIRCRESAHA.110.227744
  • Stokke, M., Hougen, K., Sjaastad, I., Louch, W., Briston, S., Enger, U., Andersson, K., Christensen, G., Eisner, D., Sejersted, O. & Trafford, A (2010). Reduced SERCA2 abundance decreases the propensity for Ca2+ wave development in ventricular myocytes. Cardiovasc Res, 86(1), 63-71. eScholarID:83559 | PMID:20019150 | DOI:10.1093/cvr/cvp401

2009

  • Borisova, L., Wray, S., Eisner, D. & Burdyga, T (2009). How structure, Ca signals, and cellular communications underlie function in precapillary arterioles. Circ Res, 105(8), 803-10. eScholarID:56505 | PMID:19713534 | DOI:10.1161/CIRCRESAHA.109.202960
  • Dibb, K., Clarke, J., Horn, M., Richards, M., Graham, H., Eisner, D. & Trafford, A (2009). Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure. Circ Heart Fail, 2(5), 482-9. eScholarID:56502 | PMID:19808379 | DOI:10.1161/CIRCHEARTFAILURE.109.852228
  • Eisner DA, Cerbai E. (2009). Beating to time: calcium clocks, voltage clocks, and cardiac pacemaker activity. Am J Physiol Heart Circ Physiol, 296( 3), eScholarID:1d20242 | DOI:10.1152/ajpheart.00056.2009
  • Eisner DA, Kashimura T, O'Neill S, Venetucci LL, Trafford AW. (2009). What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? J Mol Cell Cardiol, 46( 4), eScholarID:1d20093 | DOI:10.1016/j.yjmcc.2008.12.005
  • Eisner, D. & Trafford, A (2009). What is the purpose of the large sarcolemmal calcium flux on each heartbeat? Am J Physiol Heart Circ Physiol, 297(2), H493-4. eScholarID:9116 | PMID:19525376 | DOI:10.1152/ajpheart.00423.2009
  • Eisner, D., Dibb, K. & Trafford, A (2009). The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate. Exp Physiol, 94(5), 520-8. eScholarID:9117 | PMID:19270038 | DOI:10.1113/expphysiol.2008.044008
  • Eisner, D., Kashimura, T., Venetucci, L. & Trafford, A (2009). From the ryanodine receptor to cardiac arrhythmias. Circ J, 73(9), 1561-7. eScholarID:9114 | PMID:19667488 | DOI:10.1253/circj.CJ-09-0478
  • Li, Y., Díaz, M., Eisner, D. & O'Neill, S (2009). The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes. J Physiol, 587(Pt 6), 1283-92. eScholarID:9120 | PMID:19153161 | DOI:10.1113/jphysiol.2008.164368
  • Murphy E, Eisner DA. (2009). Regulation of intracellular and mitochondrial sodium in health and disease. Circ Res, 104( 3), eScholarID:1d20241 | DOI:10.1161/CIRCRESAHA.108.189050

2008

  • Garcia-Dorado D, Piper H, Eisner DA. (2008). Sarcoplasmic reticulum and mitochondria in cardiac pathophysiology. Cardiovasc Res, 77( 2), 231-3. eScholarID:1d20243 | DOI:10.1093/cvr/cvm070
  • Lim G, Venetucci LL, Eisner DA, Casadei B. (2008). Does nitric oxide modulate cardiac ryanodine receptor function? Implications for excitation-contraction coupling. Cardiovasc Res, 77( 2), 256-64. eScholarID:1d18170 | DOI:10.1093/cvr/cvm012
  • Tao T, O'Neill SC, Diaz M, Li YY, Eisner DA, Zhang H. (2008). Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. Am J Physiol Heart Circ Physiol, 295( 2), H598-609. eScholarID:1d18172 | DOI:10.1152/ajpheart.01086.2007
  • Tao, T., O'Neill, S., Diaz, M., Li, Y., Eisner, D. & Zhang, H (2008). Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study. Am J Physiol Heart Circ Physiol, 295(2), H598-609. eScholarID:9121 | PMID:18515647 | DOI:10.1152/ajpheart.01086.2007
  • Venetucci LL, Eisner DA. (2008). Calsequestrin mutations and sudden death: a case of too little sarcoplasmic reticulum calcium buffering? Circ Res, 103( 3), 223-5. eScholarID:1d18142 | DOI:10.1161/CIRCRESAHA.108.181636
  • Venetucci LL, Trafford AW, O'Neill SC, Eisner DA. (2008). The sarcoplasmic reticulum and arrhythmogenic calcium release. Cardiovasc Res, 77( 2), 285-92. eScholarID:1d32516 | DOI:10.1093/cvr/cvm009

2007

  • Dibb K, Graham HK, Venetucci LL, Eisner DA, Trafford A. (2007). Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. Cell Calcium, 42( 4-5), eScholarID:1d31323
  • Dibb KKM, Eisner DA, Trafford AW. (2007). Regulation of systolic [Ca,<sup>2+</sup>]i and cellular Ca<sup>2+</sup> flux balance in rat ventricular myocytes by SR Ca<sup>2+</sup>, L-type Ca<sup>2+</sup> current and diastolic [Ca<sup>2+</sup>]i. Journal of Physiology, 585, 579-. eScholarID:1d27985
  • Dibb KKM, Graham HK, Venetucci LL, Eisner DA, Trafford AW. (2007). Analysis of cellular calcium fluxes in cardiac muscle to understand calcium homeostasis in the heart. Cell Calcium, 42(4-5), 503-12. eScholarID:1d27987
  • Dibb, K., Eisner, D. & Trafford, A (2007). Regulation of systolic [Ca2+]i and cellular Ca2+ flux balance in rat ventricular myocytes by SR Ca2+, L-type Ca2+ current and diastolic [Ca2+]i. J Physiol, 585(Pt 2), 579-92. eScholarID:9123 | PMID:17932152 | DOI:10.1113/jphysiol.2007.141473
  • Venetucci LA, Trafford AW, Eisner DA. (2007). Increasing ryanodine receptor open probability alone does not produce arrhythmogenic Ca waves: threshold SR Ca content is required. Circulation Research, 100, eScholarID:1d27320 | DOI:10.1161/01.RES.0000252828.17939.00
  • Venetucci LL, O'Neill SC, Eisner DA. (2007). Does the adenosine A2A receptor stimulate the ryanodine receptor? Cardiovasc Res, 73( 1), eScholarID:1d20244 | DOI:10.1016/j.cardiores.2006.10.023
  • Venetucci LL, Trafford AW, O'Neill SC, Eisner DA. (2007). Na/Ca exchange: regulator of intercellular calcium and source of arrhythmias in the heart. Annals of the New York Academy of Science, 1099, 315-25. eScholarID:1d27989

2006

  • Eisner DA, Li YY, O'neill S. (2006). Alternans of intracellular calcium: Mechanism and significance. Heart Rhythm, 3( 6), 743-5. eScholarID:1d31505
  • Kupittayanant P, Trafford AW, Díaz M, Eisner DA. (2006). A mechanism distinct from the L-type Ca current or Na-Ca exchange contributes to Ca entry in rat ventricular myocytes. Cell Calcium, 39( 5), 417-23. eScholarID:1d12887
  • Murphy E, Eisner DA. (2006). How does endothelin-1 cause a sustained increase in intracellular sodium and calcium which lead to hypertrophy? J Mol Cell Cardiol, 41( 5), eScholarID:1d20245 | DOI:10.1016/j.yjmcc.2006.08.003
  • Sipido, K., Varro, A. & Eisner, D (2006). Sodium calcium exchange as a target for antiarrhythmic therapy. Handb Exp Pharmacol, (171), 159-99. eScholarID:83612 | PMID:16610344
  • Venetucci L, Trafford AW, Díaz ME, O'Neill SC, Eisner DA. (2006). Reducing Ryanodine Receptor Open Probability As a Means to Abolish Spontaneous Ca2+ Release and Increase Ca2+ Transient Amplitude in Adult Ventricular Myocytes. Circ Res, 98, eScholarID:1d12938 | DOI:10.1161/01.RES.0000222000.35500.65

2005

  • Díaz M, Graham HK, O'neill S, Trafford AW, Eisner DA. (2005). The control of sarcoplasmic reticulum Ca content in cardiac muscle. Cell Calcium, 38( 3-4), 391-6. eScholarID:1d11619
  • Eisner DA, Diaz M, Li YY, O'Neill S, Trafford AW. (2005). Stability and instability of regulation of intracellular calcium. Exp Physiol, 90( 1), 3-12. eScholarID:1d11621

2004

  • Diaz ME, O'Neill SC, Eisner DA. (2004). Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans. Circulation Research, 94, 650-656. eScholarID:1d25957 | DOI:10.1161/01.RES.0000119923.64774.72
  • Dibb KKM, Rueckschloss U, Eisner DA, Isenberg G, Trafford AW. (2004). Mechanisms underlying enhanced cardiac excitation-contraction coupling observed in the senescent sheep myocardium. Journal of Molecular and Cellular Cardiology, 37, 1171-1181. eScholarID:1d26138 | DOI:10.1016/j.yjmcc.2004.09.005
  • Eisner DA, Diaz ME, O'Neill SC, Trafford AW. (2004). Physiological and pathological modulation of ryanodinereceptor function in cardiac muscle. Cell Calcium, 35( 6), 583-9. eScholarID:1d7974
  • Eisner DA, Sipido K. (2004). Sodium calcium exchange in the heart: necessity or luxury? Circ Res, 95( 6), 549-51. eScholarID:1d29687
  • O'Neill SC, Miller L, Hinch R, Eisner DA. (2004). Interplay between SERCA and sarcolemmal Ca2+ efflux pathways controls spontaneous release of Ca2+ from the sarcoplasmic reticulum in rat ventricular myocytes. Journal of Physiology, 559 (1), 121-128. eScholarID:1d25960 | DOI:10.1113/jphysiol.2003.058917
  • Wray S, Ravens U, Verkhratsky A, Eisner DA. (2004). Two centuries of excitation-contraction coupling. Cell Calcium, 35( 6), 485-9. eScholarID:1d28666

2003

  • Bers D M, Eisner DA, Valdivia H H. (2003). Sacroplasmic reticulum Ca2+ and heart failure roles of diastolic leak and Ca2+ transport. Circ Res, 93, 487-490. eScholarID:1d7195
  • Burdyga T, Shmygol A, Eisner DA, Wray S. (2003). A new technique for simultaneous and in situ measurements of Ca signals in arteriolar smooth muscle and endothelial cells. Cell Calcium, 34, 27-33. eScholarID:1d7194
  • O'Neill SC, Eisner DA. (2003). pH-dependent and -independent effects inhibit CA(2+)-induced CA2+ release during metabolic blockade in rat ventricular myocytes. Journal of Physiology, 550.2, 413-418. eScholarID:1d25098 | DOI:10.1113/jphysiol.2003.042846
  • Trafford AW, Eisner DA. (2003). No role for a voltage-sensitive release mechanism in cardiac muscle. Journal of Molecular and Cellular Cardiology, 35(2), 141-151. eScholarID:1d24983 | DOI:10.1016/S0022-2828(02)00288-2
  • Venetucci LL, Trafford AW, Eisner DA. (2003). Illuminating sarcoplasmic reticulum calcium. Circ Res, 93, 4-5. eScholarID:1d7214

2002

  • Diaz ME, Eisner DA, O'Neill SC. (2002). Depressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes. Circulation Research, 91, 585-593. eScholarID:1d2348 | DOI:10.1161/01.RES.0000035527.53514.C2
  • Eisner DA, Trafford AW. (2002). Heart failure and the ryanodine receptor: does Occam's razor rule? Circulation Research, 91, 978-981. eScholarID:1d24982
  • RD Smith, Eisner DA, S Wray. (2002). pH-induced changes in calcium: functional consequences and mechanisms of action in guinea-pig portal vein. 283, H2518-H2526. eScholarID:1d5176
  • Trafford AW, Diaz ME, O'Neill SC, Eisner DA. (2002). Integrative analysis of calcium signalling in cardiac muscle. Frontiers in Bioscience, 7, D843-D852. eScholarID:1d7212

2001

  • Diaz ME, Trafford AW, Eisner DA. (2001). The effects of exogenous Ca buffers on the systolic Ca transient in rat ventricular myocytes. Biophysical J, 80, 1915-1925. eScholarID:1d2367
  • Diaz ME, Trafford AW, Eisner DA. (2001). The role of intracellular Ca buffers in determining the shape of the systolic Ca transient in cardiac ventricular myocytes. Pflugers Archive, 442, 96-100. eScholarID:1d2350
  • Overend C.L, Eisner DA, O'Neill SC. (2001). Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition. Circulation Research, 88, 181-187. eScholarID:1d2508
  • Shmigol A V, Eisner DA, Wray S. (2001). Simultaneous measurements of changes in sarcoplasmic reticulum and cytosolic calcium, in rat uterine smooth muscle cells. J Physiol, 531, 707-713. eScholarID:1d7193
  • Trafford AW, Diaz ME, Eisner DA. (2001). Coordinated control of cell Ca loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca current. Circulation Research, 88, 195-201. eScholarID:1d2369
  • W Meme, O'Neill SC, Eisner DA. (2001). Low sodium inotropy is accompanied by diastolic Ca2+ gain and systolic loss in isolated guinea-pig ventricular myocytes. Journal of Physiology, 530, 487-495. eScholarID:1d25095 | DOI:10.1111/j.1469-7793.2001.0487k.x

2000

  • Choi H, Trafford AW, Eisner DA. (2000). Measurement of calcium entry and exit in quiescent rat ventricular myocytes. Pflugers Arch, 440( 4), 600-8. eScholarID:1d11825
  • Choi H. S, Trafford AW, Orchard C. H, Eisner DA. (2000). The effect of acidosis on systolic Ca2+ and sarcoplasmic reticulum calcium content in isolated rat ventricular myocytes. J Physiol, 529 Pt 3, 661-8. eScholarID:1d2389
  • Diaz ME, Trafford AW, O'Neill SC, Eisner DA. (2000). Can changes of ryanodine receptor expression affect cardiac contractility? Cardiovascular Research, 45, 1068-1071. eScholarID:1d25093
  • Eisner DA, Choi H.S, Diaz ME, O'Neill SC, Trafford AW. (2000). Integrative analysis of calcium cycling in cardiac muscle. Circulation Research, 87, 10857-1094. eScholarID:1d2344
  • Eisner DA, Diaz ME, O'Neill SC, Trafford AW. (2000). The ryanodine receptor: cause or consequence of diabetic heart failure? Journal of Molecular and Cellular Cardiology, 32, 1377-1379. eScholarID:1d25090
  • Eisner DA, Trafford AW. (2000). No Role for the Ryanodine Receptor in Regulating Cardiac Contraction? News Physiol Sci, 15, 275-279. eScholarID:1d11824
  • Trafford AW, Diaz ME, Gillian C. Sibbring, Eisner DA. (2000). Modulation of Ca-induced Ca release has not maintained effect on systolic Ca: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca fluxes in rat ventricular myocytes. Journal of Physiology, 522, 259-270. eScholarID:1d2371
  • Trafford AW, Sibbring G. C, Diaz ME, Eisner DA. (2000). The effects of low concentrations of caffeine on spontaneous Ca release in isolated rat ventricular myocytes. Cell Calcium, 28, 4, 269-76. eScholarID:1d2394

1999

  • Trafford AW, Diaz ME, Eisner DA. (1999). A novel, rapid and reversible method to measure Ca buffering and and timecourse of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytes. Pflugers Archive, 437, 501-503. eScholarID:1d23570

1998

  • A Shmigol, Eisner DA, S Wray. (1998). Carboxyeosin decreases the rate of decay of the [Ca2+]transient in uterine smooth muscle cells isolated from pregnant rats. European Journal of Physiology, 437, 158-160. eScholarID:1d33675
  • AE Trafford, ME Diaz, N Negretti, Eisner DA. (1998). Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of a Ca fluxes and sr Ca. Cardiovascular Research, 37, 710-717. eScholarID:1d33875
  • AV Shmigol, Eisner DA, S Wray. (1998). Propoerties of voltage-gated CA2+-transients in single smooth muscle cells isolated from pregnant rat uterus. Journal of Physiology-London, 511, 803-811. eScholarID:1d33755
  • AW Tafford, Eisner DA. (1998). Another trigger for the heartbeat. Journal of Physiology-London, 513, eScholarID:1d33641
  • AW Trafford, ME Diaz, Eisner DA. (1998). Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes. Pflugers Archive, 435, 743-745. eScholarID:1d33775
  • CL Overend, SC O'Neill, Eisner DA. (1998). The effect of tetracaine on stimulated contractions sr Ca2+ content and membrane current in isolated ventricular myocytes. Journal of Physiology-London, 507, 759-769. eScholarID:1d33526
  • Eisner DA, AW Trafford, ME Diaz, CL Overend, SC O'Neill. (1998). The control of CA release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. Cardiovascular Research, 38, 589-604. eScholarID:1d33926
  • Eisner DA, Trafford AW, Díaz M, Overend C, O'Neill S. (1998). The control of Ca release from the cardiac sarcoplasmic reticulum: regulation versus autoregulation. Cardiovasc Res, 38( 3), 589-604. eScholarID:1d11829
  • Trafford AW, Díaz M, Eisner DA. (1998). Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes. Pflugers Arch, 435( 5), 743-5. eScholarID:1d11831
  • Trafford AW, Díaz M, Eisner DA. (1998). Measurement of sarcoplasmic reticulum Ca content and sarcolemmal fluxes during the transient stimulation of the systolic Ca transient produced by caffeine. Ann N Y Acad Sci, 853, 368-71. eScholarID:1d11827
  • Trafford AW, Díaz M, Eisner DA. (1998). Stimulation of Ca-induced Ca release only transiently increases the systolic Ca transient: measurements of Ca fluxes and sarcoplasmic reticulum Ca. Cardiovasc Res, 37( 3), 710-7. eScholarID:1d11833
  • W Adams, Trafford AW, Eisner DA. (1998). 2,3-Butanedione monoxime (BDM)decreases sarcoplasmic reticulum Ca content bystimulating Ca release in isolated rat ventricular myocytes. Pflugers Archive, 436, 776-781. eScholarID:1d24389
  • Trafford AW, Eisner DA. (1998). Another trigger for the heartbeat. J Physiol, 513 ( Pt 1), 1. eScholarID:17d768
  • RD Smith, Eisner DA, SC Wray. The effects of changing intracellular pH on calcium and potassium currents in smooth muscle cells from the guinea pig ureter. Vol. 435. 1998. 518-552. eScholarID:19d250

1997

  • AE Trafford, ME Diaz, N Negretti, Eisner DA. (1997). Enhanced calcium current and decreased calcium efflux restore sarcoplasmic reticulum Ca content following depletion. Circulation Research, 81, 477-484. eScholarID:1d33925
  • CL Overend, Eisner DA, SC O'Neill. (1997). The effect of tetracaine on spontaneous Ca release and sarcoplasmic reticulum calcium content in rat ventricular myocytes. Journal of Physiology-London, 502, 471-479. eScholarID:1d33525
  • Díaz M, Trafford AW, O'Neill S, Eisner DA. (1997). A measurable reduction of s.r. Ca content follows spontaneous Ca release in rat ventricular myocytes. Pflugers Arch, 434( 6), 852-4. eScholarID:1d11835
  • Díaz M, Trafford AW, O'Neill S, Eisner DA. (1997). Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal Ca2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release. J Physiol, 501 ( Pt 1), 3-16. eScholarID:1d11839
  • Eisner DA, AC Elliott, GL Smith. (1997). The contribution of intracellular acidosis to the decline of developed pressure in ferret hearts exposed to cyanide. Journal of Physiology-London, 391, 99-108. eScholarID:1d33503
  • EK Naderali, N Buttel, Taggart MJ, AJ Bullock, Eisner DA, S Wray. (1997). The role of the sarcolemmal Ca2+-ATPase in the pH transients associated with contraction in rat smooth muscle. J. Physiol, 505, 329-336. eScholarID:1d33638
  • ME Diaz, AW Trafford, SC O'Neill, Eisner DA. (1997). A measurable reduction of sr Ca content follows spontaneous Ca release in rat ventricular myocytes. Pflugers Archive, 434, 852-854. eScholarID:1d33674
  • ME Diaz, AW Trafford, SC O'Neill, Eisner DA. (1997). Measurement of sarcoplasmic reticulum Ca2+ content and sarcolemmal CA2+ fluxes in isolated rat ventricular myocytes during spontaneous Ca2+ release. Journal of Physiology-London, 501, 3-16. eScholarID:1d33873
  • Trafford AW, Díaz M, Negretti N, Eisner DA. (1997). Enhanced Ca2+ current and decreased Ca2+ efflux restore sarcoplasmic reticulum Ca2+ content after depletion. Circ Res, 81( 4), 477-84. eScholarID:1d11837

1996

  • Austin CE, K Dilly, Eisner DA, S Wray. (1996). Simultaneous measurement of intracellular pH calcium and tension in rat mesenteric vessels: effects of extracellular pH. Biochem. Biophys. Res. Commun, 222, 537-540. eScholarID:1d33519
  • C Lamont, Eisner DA. (1996). The sarcolemmal mechanisms involved in the control of diastolic intracellular calcium in isolated rat cardiac trabeculae. Pflugers Archive, 432, 961-969. eScholarID:1d33872
  • Díaz M, Cook S, Chamunorwa J, Trafford AW, Lancaster M, O'Neill S, Eisner DA. (1996). Variability of spontaneous Ca2+ release between different rat ventricular myocytes is correlated with Na(+)-Ca2+ exchange and [Na+]i. Circ Res, 78( 5), 857-62. eScholarID:1d11841
  • ME Diaz, SJ Cook, JP Chamunorwa, AW Trafford, MK Lancaster, MK O'Neill, Eisner DA. (1996). Variability of spontaneous Ca release between different rat ventricular myocytes is correlated with NA-Ca exchange and intracellular Na concentration. Circulation Research, 78, 857-862. eScholarID:1d33774
  • Eisner DA, Trafford AW. (1996). A sideways look at sparks, quarks, puffs and blips. J Physiol, 497 ( Pt 1), 2. eScholarID:17d769

1995

  • AV Schmigol, RD Smith, Taggart MJ, S Wray, Eisner DA. (1995). Changes of pH affect calcium currents but not outward potassium currents in rat myometrial cells. Pflugers Archive, 431, 135-137. eScholarID:1d33637
  • AW Trafford, ME Diaz, SC O'Neill, Eisner DA. (1995). Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. Journal of Physiology-London, 488, 577-586. eScholarID:1d33754
  • AW Trafford, P Lipp, SC O'Neill, E Niggli, Eisner DA. (1995). Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. Journal of Physiology-London, 489, 319-326. eScholarID:1d33773
  • I Baro, Eisner DA. (1995). Factors controlling changes in intracellular CA2+ concentration produced by noradrenaline in rat mesenteric artery smooth muscle cells. Journal of Physiology-London, 482, 247-258. eScholarID:1d33518
  • N Negretti, A Varro, Eisner DA. (1995). Estimate of net calcium fluxes and sarcoplasmic reticulum content during systole in rat ventricular myocytes. Journal of Physiology-London, 486, 581-591. eScholarID:1d33672
  • Trafford AW, Díaz M, O'Neill S, Eisner DA. (1995). Comparison of subsarcolemmal and bulk calcium concentration during spontaneous calcium release in rat ventricular myocytes. J Physiol, 488 ( Pt 3), 577-86. eScholarID:1d11845
  • Trafford AW, Lipp P, O'Neill S, Niggli E, Eisner DA. (1995). Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. J Physiol, 489 ( Pt 2), 319-26. eScholarID:1d11843

1994

  • CH Orchard, Eisner DA, DG Allen. (1994). Sydney Ringer viewed in a new light. Cardiovascular Research, 28, 1765-1768. eScholarID:1d33640
  • Eisner DA, SC O'Neill, P Donoso. (1994). Properties of the fluorescent sodium indicator SBF1 in rant and rabbit cardic myocytes. Journal of Cardiovascular Electrophysiology, 5, eScholarID:1d33772
  • P Donoso, SC O'Neill, KW Dilly, N Negretti, Eisner DA. (1994). Comparison of the effects of caffeine and other methylxanthines on [Ca] in rat ventricular myocytes. British Journal of Pharmacology, 111, 455-458. eScholarID:1d33871

1993

  • A Varro, N Negretti, SB Hester, Eisner DA. (1993). An estimate of the calcium content of the sarcoplasmic reticulum in rat ventricular myocytes. European Journal of Physiology, 423, 158-160. eScholarID:1d33870
  • AW Trafford, SC O'Neill, Eisner DA. (1993). Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes. Pflugers Archive, 425, 181-183. eScholarID:1d33765
  • Eisner DA, GL Smith, SC O'Neill. (1993). The effects of lactic acid production on contraction and intracellular pH during hypoxia in cardiac muscle. Basic Research in Cardiology, 8, 421-429. eScholarID:1d33630
  • GL Smith, P Donoso, CJ Bauer, Eisner DA. (1993). Relationship between intracellular pH and metabolic concentrations during metabolic inhibition in isolated ferret heart. Journal of Physiology-London, 472, 11-22. eScholarID:1d33764
  • I Baro, SC O'Neill, Eisner DA. (1993). Changes of intracellular [Ca2+] during refilling of sarcoplasmic reticulum in rat ventricular and vascular smooth muscle. Journal of Physiology-London, 465, 21-41. eScholarID:1d33639
  • N Negretti, SC O'Neill, Eisner DA. (1993). The effects of inhibitors of sarcoplasmic reticulum function on the size and time course of the systolic Ca transient in rat ventricular myocytes. Journal of Physiology-London, 468, 35-52. eScholarID:1d33524
  • N Negretti, SC O'Neill, Eisner DA. (1993). The relative contributions of different intracellular and sarcolemmal systems to relaxation in rat ventricular myocytes. Cardiovascular Research, 27, 1826-1830. eScholarID:1d33763
  • RC Heaton, S Wray, Eisner DA. (1993). Effects of metabolic inhibition and changes of intracellular pH on potassium permebility and contraction of rat uterus. Journal of Physiology-London, 456, 43-56. eScholarID:1d33924
  • Trafford AW, O'Neill S, Eisner DA. (1993). Factors affecting the propagation of locally activated systolic Ca transients in rat ventricular myocytes. Pflugers Arch, 425( 1-2), 181-3. eScholarID:1d11847

1992

  • AC Elliott, GL Smith, Eisner DA, DG Allen. (1992). Metabolic changes during ischaemia and their role in contractile failure in isolated ferret hearts. Journal of Physiology-London, 454, 467-490. eScholarID:1d33517
  • E Toescu, SC O'Neill, OH Petersen, Eisner DA. (1992). Caffeine inhibits the agonist-evoked cystolic Ca2+ signal in mouse pancreatic acinar cells by blocking inositol triosphsphate production. J. Biol. Chem, 267, 23467-23470. eScholarID:1d33869
  • I Baro, Eisner DA. (1992). The effects of thapsigargin on [Ca2+] in isolated rat mesenteric artery vascular smooth muscle cells. European Journal of Physiology, 420, 115-117. eScholarID:1d33923
  • P Donoso, JG Mill, SC O'Neill, Eisner DA. Fluorescence measurements of cytoplasmic and mitochondrial sodium concentration in rat ventricular myocytes. Vol. 448. 1992. 493-509. eScholarID:19d249

1991

  • J Eiesland, I Baro, S Raimbach, Eisner DA, S Wray. (1991). Intracellular pH and buffering power measured inisolated single cells from pregnant rat uterus. Experimental Physiology, 76, 815-818. eScholarID:1d33922
  • SC O'Neill, S Valdeolmillos, C Lamont, P Donoso, Eisner DA. (1991). The contribution of Na-Ca exchange to relaxation in mammalian cardiac muscle. Annals of the New York Academy of Science, 639, 444-452. eScholarID:1d33516

1990

  • Eisner DA. (1990). Intracellular sodium in cardiac muscle: effects on contraction. Experimental Physiology, 75, 437-457. eScholarID:1d33921
  • MR Duchen, M Valdeolmillos, SC O'Neill, Eisner DA. (1990). Effects of metabolic blockade on the regulation of intracellular calcium in dissociated mouse sensory neurones. Journal of Physiology-London, 424, 411-426. eScholarID:1d33762
  • SC O'Neill, Eisner DA. (1990). A mechanism for the effects of caffeine on Ca release during diastole and systole in isolated rat ventricular myocytes. Journal of Physiology-London, 40, 519-536. eScholarID:1d33515
  • SC O'Neill, JG Mill, Eisner DA. (1990). Local activation of contraction in isolated rat ventricular myocytes. Am. J. Physiol, 258, C1165-C1168. eScholarID:1d33671
  • SC O'Neill, P Donoso, Eisner DA. (1990). Local activation of contraction in isolated rat ventricular myocytes: measurement of [Ca2+] and [caffeine]. Journal of Physiology-London, 425, 55-70. eScholarID:1d33506

1989

  • Eisner DA, CG Nichols, SC O'Neill, GL Smith, M Valdeolmillos. (1989). The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. Journal of Physiology-London, 411, 393-418. eScholarID:1d33505
  • M Valdeolmillos, SC O'Neill, GL Smith, Eisner DA. (1989). Calcium-induced calcium release activates contraction in intact cardiac cells. Pflugers Archive, 413, 676-678. eScholarID:1d33627
  • SC O'Neill, M Valdeolmillos, GL Smith, Eisner DA. (1989). The effects of metabolic inhibition on intracellular pH and Ca. Molecular and Cellular Biochemistry, 89, 199-203. eScholarID:1d33628
  • TJ Briscoe, MR Duchen, Eisner DA, SC O'Neill, M Valdeolmillos. (1989). Measurement of intracellular [Ca] in dissociated Type I cells of the rabbit carotid body. Journal of Physiology-London, 416, 421-434. eScholarID:1d33629

1988

  • Eisner DA, AC Elliott, GL Smith. (1988). Do changes of intracellular pH contribute to the fall of force in myocardial hypoxia? Biomedical Research, 9, 143-145. eScholarID:1d33861
  • Eisner DA, NA Kenning, SC O'Neill, G Pocock, CD Richards, M Valdeolmillos. (1988). A novel method for absolute measurement of intracellular pH applicable to any pH indicator. Pflugers Archive, 413, 553-558. eScholarID:1d33504
  • GL Smith, M Valdeolmillos, DG Allen, Eisner DA. (1988). The effects of rapid application of caffeine on intracellular calcium concentration in ferret papillary muscles. Journal of General Physiology, 92, 351-368. eScholarID:1d33868
  • SC O'Neill, M Valdeolmillos, DG Allen, Eisner DA. (1988). The effects of Ni on contraction and membrane current in isolated rat myocytes. Quarterly Journal of Experimental Physiology, 73, 1017-1020. eScholarID:1d33920

1987

  • RD Vaughan-Jones, Eisner DA, WJ Lederer. (1987). Effects of changes of intracellular pH on contraction in sheep cardiac Purkinje fibres. Journal of General Physiology, 89, 1015-1032. eScholarID:1d33753

1986

  • DG Allen, Eisner DA, PG Morris, JS Pirolo, GL Smith. (1986). Metabolic consequences on increasing intracellular calcium and force production in perfused ferret hearts. Journal of Physiology-London, 376, 121-141. eScholarID:1d33860
  • Eisner DA, M Valdeolmillos, SC Wray. (1986). The effects of membrane potential on active and passive sodium transport in xenopus oocytes. Journal of Physiology-London, 381, 193-203. eScholarID:1d33523
  • Eisner DA, M Valdeolmillos. (1986). A study of intracellular calcium oscillations in sheep cardiac Purkinje fires. Journal of Physiology-London, 372, 539-556. eScholarID:1d33919
  • Eisner DA, M Valdeolmillos. (1986). Measurement of intracellular calcium during the development and spontaneous relaxation of tonic tension in sheep cardiac Purkinje fibres. Journal of Physiology-London, 375, 269-281. eScholarID:1d33669
  • Eisner DA. (1986). The role of intracellular Ca ions in the therapeutic and toxic effects of cardiac glycosides adn catecholamines. Journal Of Cardiovascular Pharmacology, 8, S2-S9. eScholarID:1d33752
  • MB Cannell, Eisner DA, WJ Lederer, M Valdeolmillos. (1986). Effects of membrane potential on intracellular calcium concentration in sheep Purkinje fibres in sodium-free solutions. Journal of Physiology-London, 381, 193-203. eScholarID:1d33670

1985

  • CJ Nieman, Eisner DA. (1985). Effects of caffeine, tetracaine and ryanodine on calcium-dependent oscillations in sheep cardiac Purkinje fibres. Journal of General Physiology, 86, 877-889. eScholarID:1d33859
  • DG Allen, Eisner DA, JS Pirolo, GL Smith. (1985). The relationship between intracellular calcium and contraction in calcium overloaded ferret papillary muscles. Journal of Physiology-London, 364, 169-183. eScholarID:1d33858
  • DG Allen, Eisner DA, SC Wray. (1985). Birthday present for digitalis. Nature, 316, 674-675. eScholarID:1d33522
  • Eisner DA, M Valdeolmillos. (1985). The mechanism of the increase of tonic tension produced by caffeine in sheep cardiac Purkinje fibres. Journal of Physiology-London, 364, 313-326. eScholarID:1d33751
  • Eisner DA, WJ Lederer. (1985). Na-Ca exchange: stoichiometry and electrogenecity. Am. J. Physiol, 248, C189-C902. eScholarID:1d33761
  • J Requena, J Whitembury, T Tiffert, Eisner DA, LJ Mullins. (1985). The influence of chemical agents on the level of ionized [Ca++] in squid axons. Journal of General Physiology, 85, 789-804. eScholarID:1d33742
  • M Valdeolmilos, Eisner DA. (1985). The effects of fyanodine on calcium-overloaded sheep cardiac Purkinje fibres. Circulation Research, 56, 452-456. eScholarID:1d33857
  • SC Wray, Eisner DA, DG Allen. (1985). Two hundred years of the foxglove. Medical History, 5, 132-150. eScholarID:1d33668

1984

  • DG Allen, Eisner DA, CH Orchard. (1984). Characterization of oscillations of intracellular calcium concentration in ferret ventricular muscle. Journal of Physiology-London, 352, 113-128. eScholarID:1d33741
  • DG Allen, Eisner DA, CH Orchard. (1984). Factors influencing free intracellular calcium concentration in quiescent ferret ventricular muscle. Journal of Physiology-London, 350, 615-630. eScholarID:1d33740
  • Eisner DA, CH Orchard, DG Allen. (1984). Control of intracellular ionized calcium concentration by sarcolemmal and intracellular mechnisms. Journal of Molecular and Cellular Cardiology, 16, 137-146. eScholarID:1d33739
  • Eisner DA, SC Wray. (1984). Ion pumping in biological membranes. Contemporary Physics, 26, 3-21. eScholarID:1d33521
  • Eisner DA, WJ Lederer, RD Vaughan-Jones. (1984). The quantitative relationship between intracellular Na activity and tension in sheep cardiac Purkinje fibres. Journal of Physiology-London, 355, 251-266. eScholarID:1d33856
  • J Requena, J Whittembury, T Tiffert, Eisner DA, LJ Mullins. (1984). A comparison of measurements of intracellular Ca by Ca electrode and optical indicators. Biochim. Biophys. Acta, 805, 393-404. eScholarID:1d33667

1983

  • CH Orchard, Eisner DA, DG Allen. (1983). Oscillations of intracellular [Ca2] in mammalian cardiac muscle. Nature, 304, 735-738. eScholarID:1d33760
  • DG Allen, Eisner DA, MJ Lab, CH Orchard. (1983). The effects of low Na solutions on intracellular Ca concentration and tension in ferret ventricular muscle. Journal of Physiology-London, 345, 391-407. eScholarID:1d33666
  • Eisner DA, DE Richards. (1983). Stimulation and inhibition by ATP and orthophosphate of the potassium: potassium exchange in resealed red cell ghosts. Journal of Physiology-London, 335, 495-506. eScholarID:1d33738
  • Eisner DA, RD Vaughan-Jones, WJ Lederer. (1983). Comments on "active transport and inotropic state in guinea pig left atrium" which appeared in Circ Res 52 411-422, 1983. Circulation Research, 53, 834-835. eScholarID:1d33502
  • Eisner DA, RD Vaughan-Jones. (1983). Do calcium-activated potassium channels exist in the heart? Cell Calcium, 4, 371-386. eScholarID:1d33918
  • Eisner DA, WJ Lederer, RD Vaughan-Jones. (1983). The control of tonic tension by membrane potential and intracellular Na activity in the sheep cardiac Purkinje fibre. Journal of Physiology-London, 335, 723-743. eScholarID:1d33501
  • Eisner DA, WJ Lederer, S-S Sheu. (1983). The role of intracellular sodium activity in the antiarrhythmic action of local anaesthetics in sheep cardiac Purkinje fibres. Journal of Physiology-London, 340, 239-257. eScholarID:1d33514
  • RD Vaughan-Jones, WJ Lederer, Eisner DA. Calcium ions can influence intracellular pH in mammalian cardiac muscle. Vol. 301. 1983. 522-524. eScholarID:19d248

1982

  • Eisner DA, DE Richards. (1982). Inhibition of the sodium pump by inorganic phosphate in resealed red cell ghosts. Journal of Physiology-London, 326, 1-10. eScholarID:1d33664
  • L Arnold, J Page, D Attwell, MB Cannell, Eisner DA. (1982). The dependence on heart rate of the human ventricular action potential duration. Cardiovascular Research, 16, 547-551. eScholarID:1d33665
  • WJ Lederer, Eisner DA. (1982). The effects of sodium pump activity on the slow inward current in sheep cardiac Purkinje fibres. Proceedings of the Royal Society of London (Series B), 214, 249-262. eScholarID:1d33663

1981

  • D Attwell, I Cohen, Eisner DA. (1981). The effects of heart rate on the action potential of guinea-pig and human ventricular muscle. Journal of Physiology-London, 313, 439-461. eScholarID:1d33852
  • Eisner DA, DE Richards. (1981). The interaction of potassium ions and TP with the sodium pump of resealed red cell ghosts. Journal of Physiology-London, 319, 403-418. eScholarID:1d33855
  • Eisner DA, WJ Lederer, RD Vaughan-Jones. (1981). The dependence of sodium pumping and tension on intracellular sodium activity in voltage-clamped sheep cardiac Purkinje fibres. Journal of Physiology-London, 317, 163-187. eScholarID:1d33500
  • Eisner DA, WJ Lederer, RD Vaughan-Jones. (1981). The effects of rubidium ions and membrane potential on the intracellular sodium activity of sheep Purkinje fibres. Journal of Physiology-London, 317, 189-205. eScholarID:1d33853

1979

  • D Attwell, I Cohen, Eisner DA. (1979). Membrane potential and ion concentration stability conditions for a cell with a restricted extracellular space. Proceedings of The Royal Society, 206, 145-161. eScholarID:1d33851
  • D Atwell, Eisner DA, I Cohen. (1979). Voltage clamp and tracer flux data: effects of a restricted extracellular space. Quaterly Reviews of Biophysics, 12, 213-216. eScholarID:1d33626
  • D Atwell, I Cohen, Eisner DA, M Ohba, C Ojeda. (1979). The steady-state TTX-sensitive ("window") sodium current in cardiac Purkinje fibres. Pflugers Archive, 379, 137-142. eScholarID:1d33513
  • Eisner DA, WJ Lederer. (1979). Inotropic and arrhythmogenic effect of potassium depleted solutions on mammalian cardiac muscle. Journal of Physiology-London, 294, 255-277. eScholarID:1d33736
  • Eisner DA, WJ Lederer. (1979). The role of the sodium pump in the effects of potassium depleted solutions on mammalian cardiac muscle. Journal of Physiology-London, 294, 255-277. eScholarID:1d33490
  • WJ Lederer, AJ Spindler, Eisner DA. (1979). Thick slurry bevelling. A new technique for bevelling fine microelectrodes and micropipettes. Pflugers Archive, 381, 287-288. eScholarID:1d33737

1978

  • D Attwell, Eisner DA. (1978). Discrete membrane surface charge distributions, effects of fluctuations near individual channels. Biophysical J, 24, 869-875. eScholarID:1d33625
  • Eisner DA, WJ Lederer. (1978). Characterization of the electrogenic sodium pump in cardiac Purkinje fibres. Journal of Physiology-London, 441-447. eScholarID:1d33491
  • I Cohen, Eisner DA, D Noble. (1978). The action of adrenaline on pace-maker activity in cardiac Purkinje fibres. Journal of Physiology-London, 280, 155-168. eScholarID:1d33662

  • Case, R., Eisner, D., Gurney, A., Jones, O., Muallem, S. & Verkhratsky, A Evolution of calcium homeostasis: from birth of the first cell to an omnipresent signalling system. Cell Calcium, 42(4-5), 345-50. eScholarID:83611 | PMID:17574670 | DOI:10.1016/j.ceca.2007.05.001

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