Professor David Thompson
Professor of Gastroenterology
- Email: david.thompson@manchester.ac.uk
- Telephone: +44 (0)161 206 4363
Role
Professor David Thompson, FRCP, fMedSci, is an academic gastroenterologist with 25 years experience in clinical gastroenterology and gastrointestinal research.
His research interested as gastrointestinal physiology in health and disease (see Pubmed: David.George.Thompson)
He is academic leader of the University of Manchester GI Science Group and academic lead for the North West Region’s Integrated Academic Training Programmes.
Collaborators and affiliated staff
Collaborators
- Professor Graham Dockray
Department of Physiology, University of Liverpool - Professor Hans Gregerson
Centre for Sensorimotor Interaction, Aalborg University, Denmark - Professor Stephen Williams
Imaging Research Group, Institute of Psychiatry, London - Professor Francis Creed
Community Psychiatry, University of Manchester
Publications
2012
- Bower P, Kennedy A, Reeves D, Rogers A, Blakeman T, Chew-Graham C, Bowen R, Eden M, Gardner C, Hann M, Lee V, Morris R, Protheroe J, Richardson G, Sanders C, Swallow A and Thompson DG. (2012). A cluster randomised controlled trial of the clinical and cost-effectiveness of a 'whole systems' model of self-management support for the managment of long-term conditions in primary care: trial protocol. Implementation Science, eScholarID:138915
2010
- Burdyga G, Varro A, Dimaline R, Thompson DG, Dockray GJ. (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol, 299(1), G63-69. eScholarID:106089 | DOI:10.1152/ajpgi.00059.2010
- Burdyga, G., Varro, A., Dimaline, R., Thompson, D. & Dockray, G (2010). Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 299(1), G63-G69. eScholarID:126481 | DOI:10.1152/ajpgi.00059.2010
- Halder, S., Macfarlane, G., Thompson, D., O'Brien, S., Musleh, M. & McBeth, J (2010). Predictors of persistent gastrointestinal symptoms among new presenters to primary care. Eur J Gastroenterol Hepatol, 22(3), 296-305. eScholarID:77757 | PMID:20169655 | DOI:10.1097/MEG.0b013e32832bab61
- Jayasekeran, V., Singh, S., Tyrrell, P., Michou, E., Jefferson, S., Mistry, S., Gamble, E., Rothwell, J., Thompson, D. & Hamdy, S (2010). Adjunctive Functional Pharyngeal Electrical Stimulation Reverses Swallowing Disability following Brain Lesions. Gastroenterology, eScholarID:77756 | PMID:20138037 | DOI:10.1053/j.gastro.2010.01.052
- Lassman DJ, McKie S, Greogry LJ, Lal S, D'Amato M, Steele I, Varro A, Dockray GJ, Williams SC, Thompson DG. (2010). Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology, 138(4), 1514-1524. eScholarID:106093 | DOI:10.1053/j.gastro.2009.12.060
- Lassman, D., Mckie, S., Gregory, L., Lal, S., D'Amato, M., Steele, I., Varro, A., Dockray, G., Williams, S. & Thompson, D (2010). Defining the Role of Cholecystokinin in the Lipid-Induced Human Brain Activation Matrix. GASTROENTEROLOGY, 138(4), 1514-1524. eScholarID:126479 | DOI:10.1053/j.gastro.2009.12.060
- Little TJ, Gopinath A, Patel E, McGlone A, Lassman DJ, D'Amato M, McLaughlin JT, Thompson DG. (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor. Neuorgastroenterology and Motility, 22(11), 1183-1190. eScholarID:106087 | DOI:10.1111/j.1365-2982.2010.01552.x
- Little, T., Gopinath, A., Patel, E., McGlone, A., Lassman, D., D'Amato, M., McLaughlin, J. & Thompson, D (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor. NEUROGASTROENTEROLOGY AND MOTILITY, 22(11), 1183. eScholarID:126482 | DOI:10.1111/j.1365-2982.2010.01552.x
2009
- Little TJ, Gupta N, Case RM, Thompson DG, McLaughlin JT. (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. Am J Physiol Regul Integr Comp Physiol, 297(3), R632-R639. eScholarID:1d19922 | DOI:10.1152/ajpregu.00090.2009
- Little, T., Gupta, N., Case, R., Thompson, D. & McLaughlin, J (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 297(3), R632-R639. eScholarID:126485 | DOI:10.1152/ajpregu.00090.2009
- Paine PP, Worthen SF, Gregory LJ, Thompson DG, Aziz Q. (2009). Personality differences affect brainstem autonomic responses to visceral pain. Neurogastroenterol Motil, eScholarID:1d19921 | DOI:10.1111/j.1365-2982.2009.01348.x
- Paine, P., Worthen, S., Gregory, L., Thompson, D. & Aziz, Q (2009). Personality differences affect brainstem autonomic responses to visceral pain. NEUROGASTROENTEROLOGY AND MOTILITY, 21(11), 1155. eScholarID:126483 | DOI:10.1111/j.1365-2982.2009.01348.x
- Power ML, Hamdy S, Goulermas John, Tyrrell PJ, Turnbull Ian, Thompson DG. (2009). Predicting aspiration after hemispheric stroke using discriminant analysis. Dysphagia, eScholarID:1d27391
- Power ML, Hamdy S, Goulermas JY, Tyrrell PJ, Turnbull II W, Thompson DG. (2009). Predicting aspiration after hemispheric stroke from timing measures of oropharyngeal bolus flow and laryngeal closure. Dysphagia, eScholarID:1d28303
- Power, M., Hamdy, S., Goulermas, J., Tyrrell, P., Turnbull, I. & Thompson, D (2009). Predicting Aspiration After Hemispheric Stroke from Timing Measures of Oropharyngeal Bolus Flow and Laryngeal Closure. DYSPHAGIA, 24(3), 257-264. eScholarID:126484 | DOI:10.1007/s00455-008-9198-4
- Thompson DG, Evans T. (2009). Coordinating academic training for physicians. Clin Med, 9( 1), eScholarID:1d19923
2008
- Burdyga G, de Lartigue G, Raybould H, Morris R, Dimaline R, Varro A, Thompson DG, Dockray G. (2008). Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach. J Neurosci, 28( 45), eScholarID:1d32124 | DOI:10.1523/JNEUROSCI.2493-08.2008
- Burdyga, G., de Lartigue, G., Raybould, H., Morris, R., Dimaline, R., Varro, A., Thompson, D. & Dockray, G (2008). Cholecystokinin Regulates Expression of Y2 Receptors in Vagal Afferent Neurons Serving the Stomach. JOURNAL OF NEUROSCIENCE, 28(45), 11583-11592. eScholarID:126480 | DOI:10.1523/JNEUROSCI.2493-08.2008
- Creed FH, B Tomeson, Guthrie EA, J Ratcliffe, L Fernandes, N Read, S Palmer, Thompson DG. (2008). The relationship between somatisation and outcome in patients with severe irritable bowel syndrome. Journal Of Psychosomatic Research, 64(6), eScholarID:1d28280 | DOI:10.1016/j.jpsychores.2008.02.016
- Creed, F., Tomenson, B., Guthrie, E., Ratcliffe, J., Fernandes, L., Read, N., Palmer, S. & Thompson, D (2008). The relationship between somatisation and outcome in patients with severe irritable bowel syndrome. JOURNAL OF PSYCHOSOMATIC RESEARCH, 64(6), 613-620. eScholarID:126486 | DOI:10.1016/j.jpsychores.2008.02.016
- Harris M, Singh S, John Rothwell, Thompson DG, Hamdy S. (2008). Rapid rate magnetic stimulation of human sacral nerve roots alters excitability within the cortico-anal pathway. Neurogastroenterology & Motility, 20(10), eScholarID:1d28275
- Nicholl BI, Halder SL, G Macfarlane, Thompson DG, O'Brien SJ, M Musleh, McBeth J. (2008). Psychosocial risk markers for new onset irritable bowel syndrome -results of a large prospective population-based study. Pain, 137(1), eScholarID:1d28278
2007
- Mistry, S., Verin, E., Singh, S., Jefferson, S., Rothwell, J., Thompson, D. & Hamdy, S (2007). Unilateral suppression of pharyngeal motor cortex to repetitive transcranial magnetic stimulation reveals functional asymmetry in the hemispheric projections to human swallowing. J Physiol, 585(Pt 2), 525-38. eScholarID:77789 | PMID:17932140 | DOI:10.1113/jphysiol.2007.144592
- Power ML, Hamdy S, Singh S, Tyrrell PJ, Turnbull IIW, Thompson DG. (2007). Deglutitive laryngeal closure in stroke patients. J Neurol Neurosurg Psychiatry, 78( 2), eScholarID:1d16884
- Thompson DG. (2007). Severe chronic abdominal pain in the absence of adhesions. Best Pract Res Clin Gastroenterol, 21( 3), eScholarID:1d32206 | DOI:10.1016/j.bpg.2007.01.010
2006
- G Burdyga, A Varro, R Dimaline, Thompson DG, G J Dockray. (2006). Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones. Neuroscience, 137, 1405-1415. eScholarID:1d26912
- Galina Burdyga, Andrea Varro, Rod Dimaline, Thompson DG, Graham J Dockray. (2006). Ghrelin receptors in rat and human nodose ganglia: putative role in regulating cannabinoid (CV-1) and melanin concentrating hormone (MCH-1) receptor abundance. American Journal of Physiology (Gastrointestinal Liver Physiology), 290, 1289-1297. eScholarID:1d26904
- Harris M, Akkermans, Hamdy S, Hobson AR, Thompson DG, Aziz Q. (2006). Neurophysiological evaluation of healthy human anorectal sensation. American Journal of Phsyiology, 5, eScholarID:1d27389
- Jacqueline R McDermott, Leslie F, Massimo D'Amato, Thompson DG, Grencis RR.K, McLaughlin JT. (2006). Immune control of food intake: enteroendocrine cells are regulated by CD4+ T- lymphocytes during small intestinal inflammation. Gut, 55, eScholarID:1d26664 | DOI:10.1136/gut.2005.081752
- Mistry S, John Rothwell, Thompson DG, Hamdy S. (2006). Modulation of human cortical swallowing motor pathways following pleasant and aversive taste stimuli. American Journal of Physiology, 291, eScholarID:1d27011 | DOI:10.1152/ajpgi.00573.2005
- Paine P, Aziz Q, E Gardener, Hobson AR, Mistry S, Thompson DG, Hamdy S. (2006). Assessing the temporal reproducibility of human oesophageal motor evoked potentials to TMS. Journal of Clinical Neurophysiology, 23, eScholarID:1d27010
- Power, ML, Fraser, CH, Hobson, AR, Singh, S, Rothwell, John C, Nicholson, D, Tyrrell, PJ, Turnbull, II W, Thompson, DG, Hamdy, S. (2006). Evaluating oral stimulation as a treatment for dysphagia after stroke. Dysphagia, 21( 1), eScholarID:1d16886
- Robinson JA, Lee V, Kennedy AP, Liz Middleton, Rogers AE, Thompson DG, Reeves D. (2006). A randomised controlled trial of self-help interventions in patients with a primary care diagnosis of IBS. Gut, 55, eScholarID:1d26100 | DOI:10.1136/gut.2004.062901
- Sanchoy Sarkar, Clifford J Woolf, Hobson AR, Thompson DG, Aziz Q. (2006). Perceptual wind-up in the human oesophagus is enhanced by central sensitization. Gut, 55, eScholarID:1d26909
- Thompson DG. (2006). Neurogastroenterology: imaging of the sensory and motor control of the GI tract. Journal Of Psychosomatic Research, 61, eScholarID:1d27404
- Visanji JM, Thompson DG, Padfield PJ. (2006). Induction of G2/M phase cell cycle arrest by carnosol and carnosic acid is associated with alteration of cyclin A and cyclin B1 levels. Cancer Letters, 237, eScholarID:1d26492
- Willert RP, Delaney CM, Hobson AR, Thompson DG, Clifford Woolf, Aziz Q. (2006). Constitutive cyclo-oxygenase-2 does not contribute to the development of human visceral pain hypersensitivity. European Journal of Pain, 10, eScholarID:1d11260
2005
- Creed FH, Ratcliffe J, Lakshmi Fernandes, Stephen Palmer, Christine Rigby, Tomenson BM, Guthrie EA, Nicholas Read, Thompson DG. (2005). Outcome in severe irritable bowel syndrome with and without accompanying depressive, panic and neurasthenic disorders. British Journal Of Psychiatry, 186, 507-515. eScholarID:1d26489 | DOI:10.1192/bjp.186.6.507
- Thompson DG. (2005). IBS - The irritation of inflammation. Gastroenterology, 129, eScholarID:1d26496
- Lassman DJ, Madhu Potluri, Thompson DG. (2005). A novel method of measuring gut responses to nutrients in man. Neurogastroenterology & Motility, 17, eScholarID:17d855
- Singh S, Mistry S, John Rothwell, Thompson DG, Hamdy S. (2005). Enhancement of human pharyngeal cortical excitability in response to interventional paired associatve stimulation. Gastroenterology, 128, eScholarID:17d212
2004
- G Burdyga, Lal S, A Varro, R Dimaline, Thompson DG, G.J. Dockray. (2004). Expression of cannabinoid CB-1 receptors by vagal afferent neurons is inhibited by cholecystokinin. Journal of Neuroscience, 24, 2708-2715. eScholarID:1d25852 | DOI:10.1523/JNEUROSCI.0713-04.2004
- Lal S, McLaughlin JT, Barlow JD, Massimo D'Amato, G Giacovelli, A Varro, G.J. Dockray, Thompson DG. (2004). Cholecystokinin pathways modulate sensations induced by gastric distension in man. American Journal of Physiology, 287, G72-G79. eScholarID:1d25857 | DOI:10.1152/ajpgi.00351.2003
- Parker C, Power ML, Hamdy S, Bowen A, Tyrrell PJ, Thompson DG. (2004). Awareness of dysphagia by patients following stroke, Predicts Swallowing Performance and Clinical Outcome. Dysphagia, 19, eScholarID:1d25654
- Tohru Hira, Elliott AC, Thompson DG, Case RR.M, McLaughlin JT. (2004). Multiple fatty acid sensing mechanisms operate in enteroendocrine cells: novel evidence for direct mobilization of stored calcium by cytosolic fatty acid. Journal of Biological Chemistry, 279, 26082-26089. eScholarID:1d7866 | DOI:10.1074/jbc.M400098200
- Willert RP, Woolf CJ, Hobson AR, Delaney CM, Thompson DG, Aziz Q. (2004). The Development and Maintenence of Human Visceral Pain Hypersensitivity is Dependent on the N-Methyl-D-Aspartate Receptor. Gastroenterology, 126, 683-692. eScholarID:1d7003 | DOI:10.1053/j.gastro.2003.11.047
- Leslie F, J McDermott, Thompson DG, Grencis RR.K, McLaughlin JT. (2004). Small intestinal inflammation reduces food intake via a CD4 T-lymphocyte/IL4 receptor dependent pathway in mice. Gut, 53 (Suppl VI), A21. eScholarID:17d467
2003
- Burdyga G, Lal, S, Jiang W, Thompson, DG, Attwood, S, Saeed, SS, Grundy David, Varro A, Dimaline R, Dockray GJ. (2003). Localisation of orexin-1 receptors to vagal afferent neurons in the rat and man. Gastroenterology, 124, 129-139. eScholarID:1d6593
- Leslie F, McLaughlin JT, Andrea Varro, Graham J Dockray, Thompson DG, B K Mandal. (2003). Plasma cholecystokinin concentrations are elevated in acute upper gastrointestinal infections. Quarterly Journal Of Medicine, 96, 870-871. eScholarID:1d26630
- T Hira, Case RR.M, Thompson DG, McLaughlin JT. (2003). Fatty acids act directly on intracellular calcium stores to mobilize calcium in the EEC cell line STC1. Journal of Physiology, eScholarID:1d34029
- Leslie F, J McDermott, Kazmi S, Grencis RR.K, Thompson DG. (2003). Small intestinal inflammation is associated with increased EEC numbers and hypophagia. Gut, 52(S1), A15. eScholarID:17d309
- tohru hira, Case RR.M, Thompson DG, McLaughlin JT. (2003). Fatty acids act directly on intracellular calcium stores in the EEC cell line STC1. Gut, 52(S1), A54. eScholarID:17d939
2002
- Benson RSP, Sidhu SS, Jones MM.N, Case RR.M, Thompson DG. (2002). Fatty acid signalling in a mouse enteroendocrine cell line involves fatty acid aggregates rather than free fatty acids. J. Physiol, 538 (Pt 1), 121-31. eScholarID:1d2641
- Burdyga G, Spiller D, Morris R, Lal S, Thompson DG, Saeed SR, Dimaline R, Varro A, Dockray GJ. (2002). Expression of the leptin receptor in rat and human nodose ganglion neurones. Neuroscience, 339-347. eScholarID:1d6591
- Hamdy S, Rothwell JC, Fraser CH, Power ML, Gow DP, Thompson DG. (2002). Patterns of excitability in human esophageal sensorimotor cortex to painful and non-painful visceral stimulation. Am. J. Physiol, 282(2), eScholarID:1d2060
2001
- Hamdy S, Aziz Q, Thompson DG, Rothwell JC. (2001). Physiology and pathophysiology of the swallowing area of human motor cortex. Neural Plasticity, 8(1-2), eScholarID:1d2590
1999
- McLaughlin J, Grazia LucĂ M, Jones MN, D'Amato M, Dockray GJ, Thompson DG. (1999). Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology, 116, 46-53. eScholarID:1d2071