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School of Medicine

Dr Guy Makin BA, BM, BCh, PhD, MRCP, FRCPCH

Photograph of Guy Makin

Clinical Senior Lecturer in Paediatric Oncology

Young Oncology Unit
Christie Hospital NHS Trust
Wilmslow Rd
Manchester
M20 4BX

 

Research

 

Teaching

PBL and clinical tutor for year 4 Families and Children module

Yr1 SSC supervisor

Yr3/4 SSC supervisor

Yr4 Project option supervisor

Families and Children OSCE examiner

UMAP quality control team leader

Academic Advisor

 

Collaborators and affiliated staff

Dr Jenny Adamski, Clinical Research Fellow University of Manchester

Shaun Villa, PhD Student University of Manchester

Dr Margaret Ashcroft, Imperial College, London

Prof Sue Burchill, CRUK Clinical Centre, Leeds

Dr Debbie Tweddle, University of Newcastle-upon-Tyne 

Professor Muhammad Zaman, Department of Biomedical Engineering, Boston University

Professor Chris Eiser & Dr Richard Rowe, Department of Psychology, University of Sheffield

Dr Tetanya Klymenko, Post doctoral research scientist Paterson Institute for Cancer Research

 

Publications

2011

  • Makin GWJ, Dive C. (2011). Targeting Bcl-2 family proteins in childhood leukaemia. In Saha V, Kearns P (Ed.), New agents for the treatment of childhood acute lymphoblastic leukaemia. (pp. 117-142). Springer. eScholarID:127015
  • Fallica, B., Makin, G. & Zaman, M (2011). Bioengineering approaches to study multidrug resistance in tumor cells. INTEGRATIVE BIOLOGY, 3(5), 529-539. eScholarID:127021 | DOI:10.1039/c0ib00142b
  • Harrison, L., Micha, D., Brandenburg, M., Simpson, K., Morrow, C., Denneny, O., Hodgkinson, C., Yunus, Z., Dempsey, C., Roberts, D., Blackhall, F., Makin, G. & Dive, C (2011). Hypoxic human cancer cells are sensitized to BH-3 mimetic-induced apoptosis via downregulation of the Bcl-2 protein Mcl-1. JOURNAL OF CLINICAL INVESTIGATION, 121(3), 1075-1087. eScholarID:127020 | DOI:10.1172/JCI43505
  • Holt, S., Brookes, K., Dive, C. & Makin, G (2011). Down-regulation of XIAP by AEG35156 in paediatric tumour cells induces apoptosis and sensitises cells to cytotoxic agents. Oncol Rep, 25(4), 1177-81. eScholarID:127025 | PMID:21286665 | DOI:10.3892/or.2011.1167
  • Klymenko T, Brandenburg M, Morrow C, Dive C, Makin G. (2011). The Novel Bcl-2 Inhibitor ABT-737 Is More Effective in Hypoxia and Is Able to Reverse Hypoxia-Induced Drug Resistance in Neuroblastoma Cells. Molecular Cancer Therapeutics, 10(12), 2373-2383. eScholarID:142568 | DOI:10.1158/1535-7163.MCT-11-0326

2010

  • Amoroso, L., Valteau-Couanet, D., Makin, G., Ladenstein, R., Conte, M., Luksch, R., Battaglia, F., Viscardi, E., Zanazzo, A., Asaftei, S., D'Angelo, P., Di Cataldo, A., Galleni, B., Nantron, M. & Garaventa, A (2010). PRELIMINARY RESULTS OF THE AAOCIATION TOPOTECAN-VINCRISTINE-DOXURUBICIN IN PATIENTS WITH METASTATIC NEUROBLASTOMA POORLY RESPONSIVE TO FIRST-LINE THERAPY (COJEC). eScholarID:127023

2009

  • Hussein, D, Holt, S, Brookes, K, Klymenko, T, Adamski, JJ, Hogg, A, Estlin, E, Ward, T, Dive, C, Makin, GWJ. (2009). Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours. Br J Cancer, eScholarID:1d32668 | DOI:10.1038/sj.bjc.6605100

2008

  • Adamski J, Estlin E, Makin GWJ. (2008). The cellular adaptations to hypoxia as novel therapeutic targets in childhood cancer. Cancer Treat Rev, 34( 3), eScholarID:1d32672 | DOI:10.1016/j.ctrv.2007.11.005
  • Adamski J, Steggall M, Yeoh K, Sutton R, Makin GWJ. (2008). Outcome of gram negative infection in immunocompromised children. Pediatr Blood Cancer, 51( 4), eScholarID:1d32669 | DOI:10.1002/pbc.21587

2006

  • Dean, E., Ranson, M., Blackhall, F., Makin, G., Ward, T., Houghten, R., Pinilla, C., Welsh, K., Reed, J. & Dive, C (2006). Preclinical development of xiapuradamib therapy for lung cancer. eScholarID:127022
  • Edge BJ, Holmes D, Makin GWJ. (2006). Sperm banking in adolescent cancer patients. Archives of Disease in Childhood, 91, 149-152. eScholarID:1d12575 | DOI:10.1136/adc.2005.075242
  • Hussein Deema, Estlin Edward, Dive C, Makin GWJ. (2006). Chronic hypoxia promotes HIF-1α-dependent resistance to etoposide and vincristine in neuroblastoma cells. Molecular Cancer Therapeutics, 5, 2241-2248. eScholarID:1d27522 | DOI:10.1158/1535-7163.MCT-06-0145

2005

  • Howell L, Mensah A, Brennan BMD, Makin GWJ. (2005). Detection of recurrence in childhood solid tumours. Cancer, 103, 1274-1279. eScholarID:1d11693 | DOI:10.1002/cncr.20896

2003

  • Makin GWJ, Dive C. (2003). Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy. Trends Mol Med, 9(6), 251-5. eScholarID:1d7331

2001

  • Makin GWJ, Bernard m Corfe, Griffiths GG.J, Thistlethwaite AA, Hickman JJ, Dive C. (2001). Damage-induced Bax N-terminal change, translocation to mitochondria and formation of Bax dimers/complexes occur regardless of cell fate. The EMBO Journal, 20, 6306-6315. eScholarID:1d1947 | DOI:10.1093/emboj/20.22.6306
  • Makin GWJ, Dive C. (2001). Apoptosis and cancer chemotherapy. Trends in Cell Biology, 11, S22-26. eScholarID:1d3877

1989

  • MAKIN, G., LOHNES, D., BYFORD, V., RAY, R. & JONES, G (1989). TARGET-CELL METABOLISM OF 1,25-DIHYDROXYVITAMIN-D3 TO CALCITROIC ACID - EVIDENCE FOR A PATHWAY IN KIDNEY AND BONE INVOLVING 24-OXIDATION. BIOCHEMICAL JOURNAL, 262(1), 173-180. eScholarID:127024

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