Skip to main content Skip to navigation

[University home]

School of Medicine

Dr James Fildes PhD

Honorary Senior Lecturer in Translational Immunology

The Transplant Centre
University Hospital of South Manchester NHS Foundation Trust
Manchester
M23 9LT
UK

 

Role

Principal Research Scientist

 

Memberships of Committees and Professional Bodies

  • Member of the International Society for Heart and Lung Transplantation
  • Member of the European Society of Organ Transplantation
  • Member of the Transplantation Society
  • Member of the International Society of Natural Immunity
  • Member of the British Society of Immunology
  • Member of the British Transplantation Society

 

  • Article reviewer for American Journal of Transplantation
  • Article reviewer for Journal for Heart and Lung Transplantation
  • Article reviewer for Archivum Immunologiae et Therapiae Experimentalis
  • Article reviewer for Cellular Immunology
  • Article reviewer for Clinical Immunology
  • Article reviewer for Libertas Academica
  • Article reviewer Experimental and Molecular Pathology

 

  • Abstract reviewer for the International Society for Heart and Lung Transplantation Annual Meeting.
  • Abstract reviewer for the 1st Basic Science Symposium of the European Society for Organ Transplantation 2009
  • Programme committee for the 28th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation 2008

Research

The primary focus of my research is to further understand how the immune system recognises danger and damage. Our bodies remove as many as 20 billion damaged cells, many of which are cancerous, each day in an attempt to keep us healthy. I believe that this is the main priority of the immune system, rather than the search for foreign antigen. Using this principle, my research aims to delineate the natural history of the immune response to endogenous stress and to foreign antigen,in a variety of models including acute injury, asthma, cancer, infection, and long term injury associated with conditions such as heart failure or chronic rejection following transplantation. 

 

Teaching

If you are interested in undertaking a post-graduate degree (MRes, MPhil, MD, PhD), please see the university website (www.medicine.manchester.ac.uk/postgraduate/research/) for more information, or email james.fildes@manchester.ac.uk


We currently have projects available for funded students.

 

Qualifications

PhD

 

Publications

2012

  • Critchley WR, Fildes JE. (2012). Graft Rejection - Endogenous or Allogeneic? Immunology, epub, eScholarID:154857

2011

  • Ann Thorac Surg. (2011). Scrotal distension after endoscopic harvesting of the saphenous vein in patients with inguinal hernia. Ann Thorac Surg, 92(2), 733-735. eScholarID:154855
  • Khan UA, Davidson JA, Poulton KV, Wynn RF, Fildes JE. (2011). Activated NK cells have a potential therapeutic role in sustaining donor engraftment following paediatric haematopoietic stem cell transplantation for non-malignant disease. Br J Haematol, 154(4), 527-529. eScholarID:154854
  • Shaw SM, Critchley WR, Puchalka CM, Williams SG, Yonan N, Fildes JE. (2011). Brain natriuretic peptide induces CD8+ T cell death via a caspase 3 associated pathway - Implications following heart transplantation. Transpl Immunol, Epub, eScholarID:154856

2010

  • Archer LD, Langford K, Bigger B, Fildes JE. (2010). Immune activation or immunomodulation in the brains of MPS IIIB mice?. J Neurosci Res, eScholarID:56467
  • Glover AT, Shaw SM, Williams SG, Fildes JE. (2010). Can inflammation be an independent predictor of depression? Brain Behav Immun, 24(2), 173-175. eScholarID:154853

2009

  • Fildes JE, Shaw S, Yonan N, Williams S. (2009). The immune system and chronic heart failure: is the heart in control? J Am Coll Cardiol, 53( 12), 1013-20. eScholarID:1d18876 | DOI:10.1016/j.jacc.2008.11.046
  • Fildes JE, Shaw SM, Williams SG, Yonan NN A. (2009). Potential immunologic effects of statins in cancer following transplantation. Cancer Immunol Immunother, 58, 461-7. eScholarID:1d17633 | DOI:10.1007/s00262-008-0541-2
  • Fildes JE, Yonan N, Keevil B. (2009). Melatonin--a pleiotropic molecule involved in pathophysiological processes following organ transplantation. Immunology, 127( 4), 443-9. eScholarID:1d20183 | DOI:10.1111/j.1365-2567.2009.03113.x
  • Glover AT, Shaw SM, Williams SG, Fildes JE. (2009). Can inflammation be an independent predictor of depression? Brain Behav Immun, epub, eScholarID:75829
  • Keevil BG, Fildes JE, Baynes A, Yonan N. (2009). Liquid chromatography-mass spectrometry measurement of tacrolimus in finger-prick samples compared with venous whole blood samples. Ann Clin Biochem, eScholarID:1d18361 | DOI:10.1258/acb.2008.008147
  • Khan, U., Krishnamoorthy, B., Najam, O., Waterworth, P., Fildes, J. & Yonan, N (2009). A comparative analysis of saphenous vein conduit harvesting techniques for coronary artery bypass grafting - standard bridging versus the open technique. Interact Cardiovasc Thorac Surg, eScholarID:64375 | PMID:19696051 | DOI:10.1510/icvts.2009.209171
  • Khan, U., Williams, S., Fildes, J. & Shaw, S (2009). The pathophysiology of chronic graft failure in the cardiac transplant patient. Am J Transplant, 9(10), 2211-6. eScholarID:57494 | PMID:19764947 | DOI:10.1111/j.1600-6143.2009.02807.x
  • Krishnamoorthy, B., Najam, O., Khan, U., Waterworth, P., Fildes, J. & Yonan, N (2009). Randomized prospective study comparing conventional subcuticular skin closure with dermabond skin glue after saphenous vein harvesting. Ann Thorac Surg, 88(5), 1445-9. eScholarID:72331 | PMID:19853089 | DOI:10.1016/j.athoracsur.2009.06.047
  • Sarri S, Shaw SM, Gieschen-Krische MA, Archer L, Yonan N, Fildes JE. (2009). Myocardial heat shock protein 60 expression is upregulated following acute cardiac rejection. Transpl Immunol, eScholarID:1d19055 | DOI:10.1016/j.trim.2009.04.002
  • Shaw S, Chaggar P, Ritchie J, Shah M, Baynes A, O'Neill N, Fildes JE, Yonan N, Williams S. (2009). The efficacy and tolerability of ezetimibe in cardiac transplant recipients taking cyclosporin. Transplantation, 87( 5), 771-5. eScholarID:1d18860 | DOI:10.1097/TP.0b013e318198d7d0
  • Shaw S, Shah M, Williams S, Fildes JE. (2009). Immunological mechanisms of pentoxifylline in chronic heart failure. Eur J Heart Fail, 11( 2), 113-8. eScholarID:1d18365 | DOI:10.1093/eurjhf/hfn040
  • Shaw S, Yonan N, Williams S, Fildes JE. (2009). The interpretation of clinical trial data--wrongly ACCLAIM'ed? Am Heart J, 158( 2), 149-51. eScholarID:1d20318 | DOI:10.1016/j.ahj.2009.05.017
  • Shaw SM, Coppinger T, Waywell C, Dunne L, Archer LD, Critchley WR, Yonan N, Fildes JE, Williams SG. (2009). The effect of beta-blockers on the adaptive immune system in chronic heart failure. 27(3), 181-186. eScholarID:56377
  • Shaw SM, Fildes JE, Yonan NN A, Williams SG. (2009). Pleiotropic Effects and Cholesterol-Lowering Therapy. Cardiology, 112( 1), 4-12. eScholarID:1d17631
  • Shaw SM, Najam O, Khan U, Yonan N, Williams SG, Fildes JE. (2009). Ezetimibe and Atorvastatin both immunoregulate CD4+ T cells from cardiac transplant recipients in vitro. Transpl Immunol, eScholarID:1d18904 | DOI:10.1016/j.trim.2009.03.001
  • Shaw SM, Williams SG, Yonan N, Fildes JE. (2009). Decreased immune responses to influenza vaccination in patients with heart failure. J Card Fail, 15(6), 549-. eScholarID:56323

2008

  • Fildes JE, Shaw S, Mitsidou A, Rogacev K, Leonard C, Williams S, Yonan NN A. (2008). HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation. Transpl Immunol, 19( 2), 152-7. eScholarID:1d17634
  • Fildes JE, Shaw S, Walker A, McAlindon M, Williams S, Keevil B, Yonan N. (2008). Mannose-binding Lectin Deficiency Offers Protection From Acute Graft Rejection After Heart Transplantation. J Heart Lung Transplant, 27( 12), 1353-6. eScholarID:1d18190 | DOI:10.1016/j.healun.2008.08.011
  • Fildes JE, Shaw S, Yonan NN A, Williams S. (2008). Non-specific immunomodulation in chronic heart failure. Lancet, 371( 9630), eScholarID:1d17632
  • Fildes JE, Walker A, Williams S, Yonan NN A, Leonard C. (2008). CMV infection is associated with the depletion but lack of activation of peripheral blood natural killer cells in a lung transplant cohort. Transpl Immunol, 19( 3-4), 235-7. eScholarID:1d17630
  • Fildes JE, Yonan NN A, Leonard C. (2008). Natural killer cells and lung transplantation, roles in rejection, infection, and tolerance. Transpl Immunol, 19( 1), 1-11. eScholarID:1d17635
  • Fildes JE, Yonan NN A, Tunstall K, Walker A, Griffiths-Davies L, Bishop P, Leonard C. (2008). Natural killer cells in peripheral blood and lung tissue are associated with chronic rejection after lung transplantation. J Heart Lung Transplant, 27( 2), 203-7. eScholarID:1d17636
  • Shaw SM, Fildes JE, Puchalka CM, Basith M, Yonan N, Williams SG. (2008). BNP directly immunoregulates the innate immune system of cardiac transplant recipients in vitro. Transpl Immunol, eScholarID:1d18034 | DOI:10.1016/j.trim.2008.08.010

2007

  • Fildes JE, Williams S, Yonan NN A. (2007). Large population sizes are a prerequisite for genetic association studies. J Heart Lung Transplant, 26( 1), eScholarID:1d17638
  • Shaw S, Fildes JE, Yonan NN A, Williams S. (2007). Does brain natriuretic peptide interact with the immune system after cardiac transplantation? Transplantation, 84( 11), 1377-81. eScholarID:1d17637

2006

  • Barnard J, Richardson S, Sheldon S, Fildes JE, Pravica V, Hutchinson I, Leonard CT, Yonan NN A. (2006). The MDR1/ABCB1 gene, a high-impact risk factor for cardiac transplant rejection. Transplantation, 82( 12), 1677-82. eScholarID:1d16805

2005

  • Allen D, Fildes JE, Yonan NN A, Leonard CT. (2005). Changes in induced sputum in the presence of bronchiolitis obliterans syndrome and correlation with spirometry in single and bilateral lung transplant recipients. J Heart Lung Transplant, 24( 1), 88-91. eScholarID:1d29755
  • Bittar M, Carey J, Barnard J, Fildes JE, Pravica V, Yonan NN A, Hutchinson I. (2005). Interleukin 6 G-174C polymorphism influences outcome following coronary revascularization surgery. Heart Surg Forum, 8( 3), E140-5; discussion E145. eScholarID:1d29287
  • Fildes JE, Walker A, Densem C, Deiraniya A, Hutchinson I, Leonard CT, Yonan NN A. (2005). Angiotensin converting enzyme insertion/deletion polymorphism does not influence postcardiac transplantation hypertension onset or progression. J Heart Lung Transplant, 24( 4), 406-10. eScholarID:1d29616
  • Fildes JE, Walker A, Howlett R, Bittar M, Hutchinson I, Leonard CT, Yonan NN A. (2005). Donor CCR5 Delta32 polymorphism and outcome following cardiac transplantation. Transplant Proc, 37( 5), 2247-9. eScholarID:1d28898
  • Fildes JE, Walker A, Keevil B, Hutchinson I, Leonard CT, Yonan NN A. (2005). The effects of ACE inhibition on serum angiotensin II concentration following cardiac transplantation. Transplant Proc, 37( 10), 4525-7. eScholarID:1d16804
  • Polster K, Walker A, Fildes JE, Entwistle G, Yonan NN A, Hutchinson I, Leonard CT. (2005). CD4-veCD8-ve CD30+ve T cells are detectable in human lung transplant patients and their proportion of the lymphocyte population after in vitro stimulation with donor spleen cells correlates with preservation of lung physiology. Transplant Proc, 37( 5), 2257-60. eScholarID:1d11257

Top of page

| Skip to main content | Skip to navigation | Skip to Search |