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School of Medicine

Dr Janine Lamb 

Photograph of Janine Lamb

Lecturer in Complex Human Genetics/Genomics - CIGMR

Centre for Integrated Genomic Medical Research (CIGMR)
Stopford Building
Oxford Road
Manchester, M13 9PT

 

Role

Janine Lamb is a Lecturer in Complex Human Genetics/Genomics, within the Centre for Integrated Genomic Medical Research (CIGMR), School of Cancer and Enabling Sciences. Janine moved to Manchester from the University of Oxford, Wellcome Trust Centre for Human Genetics in 2006, from where she gained her DPhil in molecular genetics.

Her work has centred on understanding genetic susceptibility to autism spectrum disorders as part of the International Molecular Genetic Study of Autism Consortium; a collaboration of scientists and clinicians from Europe and the United States. This research has included publication of the first whole genome screen for autism susceptibility loci and screening of more than fifty positional and functional candidate genes. Recent research has focused on association studies using high density single nucleotide polymorphism genotyping. This work has been presented at many national and international conferences, and has been widely published in peer-reviewed scientific journals. The IMGSAC is also a major participant in the Autism Genome Project (AGP) Consortium, identifying for the first time the likely role of genome-wide copy number variants in autism susceptibility.
 

 

Memberships of Committees and Professional Bodies


Biography

University of Manchester: Lecturer in Complex Human Genetics/Genomics, August 2006 - present
Wellcome Trust Centre for Human Genetics, University of Oxford:
Postdoctoral Research Fellow. 2001 – 2006.
University of Oxford: DPhil. in molecular genetics, 1997-2001
Wellcome Trust Centre for Human Genetics, University of Oxford: Research Assistant, 1995- 1997
University of Manchester: Bsc Hons in Pharmacology (sandwich), 1989-1993
 

 

Qualifications


 

Publications

2012

  • Casey, et al (2012). A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet, 131(4), 565-79. eScholarID:158924 | PMID:21996756 | DOI:10.1007/s00439-011-1094-6

2011

  • Lamb, J.A. (2011). Whole Genome Linkage and Association Analyses. In Amaral, D., Dawson, G., Geschwind, D (Ed.), Autism Spectrum Disorders. Oxford, UK: Oxford University Press. eScholarID:108153
  • Anney, et al (2011). Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders. Eur J Hum Genet, Epub ahead of print, eScholarID:125811 | PMID:21522181 | DOI:10.1038/ejhg.2011.75
  • Chinoy, H., Lamb, J., Ollier, W. & Cooper, R (2011). Recent advances in the immunogenetics of idiopathic inflammatory myopathy. Arthritis Res Ther, 13(3), 216 (Epub ahead of print). eScholarID:125810 | PMID:21658295 | DOI:10.1186/ar3327
  • Chinoy, H., Lamb, J.A., Ollier, W.E.R., Cooper, R.G. (In-press). The Genetics of Myositis. Arthritis Research and Therapy, eScholarID:108151

2010

  • Autism et al. (2010). A genomewide scan for common alleles affecting risk for autism. Human Molecular Genetics, 19(20), 4072-4082. eScholarID:108121 | DOI:10.1093/hmg/ddq307
  • Pinto, et al (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466(7304), 368-372. eScholarID:82891 | PMID:20531469 | DOI:10.1038/nature09146

2009

  • Asher J, Lamb J, Brocklebank D, Cazier J, Maestrini E, Addis L, Sen M, Baron-Cohen S, Monaco A. (2009). A whole-genome scan and fine-mapping linkage study of auditory-visual synesthesia reveals evidence of linkage to chromosomes 2q24, 5q33, 6p12, and 12p12. Am J Hum Genet, 84(2), 279-285. eScholarID:1d18818 | DOI:10.1016/j.ajhg.2009.01.012
  • Chinoy, H., Lamb, J., Ollier, W. & Cooper, R (2009). An update on the immunogenetics of idiopathic inflammatory myopathies: major histocompatibility complex and beyond. Curr Opin Rheumatol, 21(6), 588-593. eScholarID:68198 | PMID:19730377 | DOI:10.1097/BOR.0b013e3283315a22
  • Lamb, J.A. (2009). Molecular Genetics of Autism. Encyclopedia of Life Sciences (ELS), EPub, eScholarID:54252 | DOI:10.1002/9780470015902.a0021455
  • Maestrini, E, Pagnamenta, A, Lamb, J, Bacchelli, E, Sykes, N, Sousa, I, Toma, C, Barnby, G, Butler, H, Winchester, L, Scerri, T, Minopoli, F, Reichert, J, Cai, G, Buxbaum, J, Korvatska, O, Schellenberg, G, Dawson, G, Bildt, A, Minderaa, R, Mulder, E, Morris, A, Bailey, A, Monaco, A. (2009). High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Mol Psychiatry, Epub ahead of print, eScholarID:1d20694 | DOI:10.1038/mp.2009.34
  • Newbury, D, Warburton, P, Wilson, N, Bacchelli, E, Carone, S, Lamb, J, Maestrini, E, Volpi, E, Mohammed, S, Baird, G, Monaco, A. (2009). Mapping of partially overlapping de novo deletions across an autism susceptibility region (AUTS5) in two unrelated individuals affected by developmental delays with communication impairment. Am J Med Genet A, 149(4), 588-597. eScholarID:1d18817 | DOI:10.1002/ajmg.a.32704
  • Pagnamenta, A, Wing, K, Akha, E, Knight, S, Bölte, S, Schmötzer, G, Duketis, E, Poustka, F, Klauck, S, Poustka, A, Ragoussis, J, Bailey, A, Monaco, A, Lamb, J, International Molecular Genetic Study of Autism Consortium (IMGSAC). (2009). A 15q13.3 microdeletion segregating with autism. Eur J Hum Genet, 17(5), 687-692. eScholarID:1d20696 | DOI:10.1038/ejhg.2008.228
  • Sykes, N., Toma, C., Wilson, N., Volpi, E., Sousa, I., Pagnamenta, A., Tancredi, R., Battaglia, A., Maestrini, E., Bailey, A., Monaco, A. & IMGSAC, I (2009). Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection. Eur J Hum Genet, 17(10), 1347-53. eScholarID:54366 | PMID:19384346 | DOI:10.1038/ejhg.2009.47
  • Weiss, L., Arking, D., , T., Daly, M. & Chakravarti, A (2009). A genome-wide linkage and association scan reveals novel loci for autism. Nature, 461(7265), 802-8. eScholarID:83363 | PMID:19812673 | DOI:10.1038/nature08490

2008

  • Autism Genome Project Consortium, Liu X, Paterson A, Szatmari P, Lamb J. (2008). Genome-wide linkage analyses of quantitative and categorical autism subphenotypes. Biol Psychiatry, 64(7), 561-570. eScholarID:1d18848 | DOI:10.1016/j.biopsych.2008.05.023
  • BrownJ.J, Ollier WER, ArscottG, Ke X, Lamb J, Day PJR, BayatA. (2008). Genetic susceptibility to Keloid scarring: SMAD gene SNP frequencies in Afro-Caribbeans. Exp. Dermatol, 17(7), 610-613. eScholarID:1d17650 | DOI:10.1111/j.1600-0625.2007.00654.x
  • Chinoy, H, Platt, H, Lamb, J, Betteridge, Z, Gunawardena, H, Fertig, N, Varsani, H, Davidson, J, Oddis, C, McHugh, N, Wedderburn, L, Ollier, WER, Cooper, RG, NULL. (2008). The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients. Arthritis Rheum, 58(10), 3247-3254. eScholarID:1d17861 | DOI:10.1002/art.23900
  • Gong, X., Bacchelli, E., Blasi, F., Toma, C., Betancur, C., Chaste, P., Delorme, R., Durand, C., Fauchereau, F., Botros, H., Leboyer, M., Mouren-Simeoni, M., Nygren, G., Anckarsäter, H., Rastam, M., Gillberg, I., Gillberg, C., Moreno-De-Luca, D., Carone, S., Nummela, I., Rossi, M., Battaglia, A., IMGSAC, I., Jarvela, I., Maestrini, E. & Bourgeron, T (2008). Analysis of X chromosome inactivation in autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet, 147B(6), 830-5. eScholarID:54338 | PMID:18361425 | DOI:10.1002/ajmg.b.30688
  • Sousa, I, Clark, T, Toma, C, Kobayashi, K, Choma, M, Holt, R, Sykes, N, Lamb, J, Bailey, A, Battaglia, A, Maestrini, E, Monaco, A. (2008). MET and autism susceptibility: family and case-control studies. Eur J Hum Genet, 17(6), 749-758. eScholarID:1d18819 | DOI:10.1038/ejhg.2008.215

2007

  • Sykes, N.H and Lamb, J.A. (2007). Autism: the quest for the genes. Expert Rev Mol Med, 9(24), 1-15. eScholarID:58301 | DOI:10.1017/S1462399407000452
  • Toma, C., Rossi, M., Sousa, I., Blasi, F., Bacchelli, E., Alen, R., Vanhala, R., Monaco, A.P., Jarvela, I., Maestrini, E., International Molecular Genetic Study of Autism Consortium (IMGSAC). (2007). Is ASMT a susceptibility gene for Autism Spectrum Disorders? A replication study in European populations. Molecular Psychiatry, 12(11), 977-979. eScholarID:58369 | DOI:10.1038/sj.mp.4002069

2006

  • Bonora, E., Lamb, J.A., Barnby, G. Bailey, A.J., and Monaco, A.P. (2006). Genetic Basis of Autism. In Moldin, S.O. and Rubenstein, J.L.R (Ed.), Understanding Autism: From Basic Neuroscience to Treatment. (pp. 49-74). CRC Press. eScholarID:58151
  • Blasi, F., Bacchelli, E., Carone, S., Toma, C., Monaco, A., Bailey, A., Maestrini, E. & IMGSAC, I (2006). SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. Eur J Hum Genet, 14(1), 123-6. eScholarID:54340 | PMID:16205742 | DOI:10.1038/sj.ejhg.5201444
  • Blasi, F., Bacchelli, E., Pesaresi, G., Carone, S., Bailey, A., Maestrini, E. & IMGSAC, I (2006). Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. Am J Med Genet B Neuropsychiatr Genet, 141B(3), 220-1. eScholarID:54339 | PMID:16508939 | DOI:10.1002/ajmg.b.30287
  • Parr, J.R., Lamb, J.A., Bailey, A.J., Monaco, A.P. and The International Molecular Genetic Study of Autism Consortium (IMGSAC). (2006). Response to paper by Molloy et al: Linkage on 21q and 7q in autism subset with regression. Molecular Psychiatry, 11(7), 617-619. eScholarID:85075

2005

  • BarnbyG, AbbottA, SykesN, MorrisA, WeeksD.E, MottR, Lamb J, BaileyA.J, MonacoA.P. (2005). Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am. J. Hum. Genet, 76(6), 950-966. eScholarID:1d17681
  • Bonora,E., Lamb, J, Barnby,G., Sykes,N., Moberly,T., Beyer,K.S., Klauck,S.M., Poustka,F., Bacchelli,E., Blasi,F., Maestrini,E., Battaglia,A., Haracopos,D., Pedersen,L., Isager,T., Eriksen,G., Viskum,B., Sorensen,E.U., Brondum-Nielsen,K., Cotterill,R., Engeland,H., Jonge,M., Kemner,C., Steggehuis,K., Scherpenisse,M., Rutter,M., Bolton,P.F., Parr,J.R., Poustka,A., Bailey,A.J., Monaco,A.P. (2005). Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. Eur. J. Hum. Genet, 13, 2, 198-207. eScholarID:1d17682
  • Lamb, J, Barnby,G., Bonora,E., Sykes,N., Bacchelli,E., Blasi,F., Maestrini,E., Broxholme,J., Tzenova,J., Weeks,D., Bailey,A.J., Monaco,A.P. (2005). Analysis of IMGSAC autism susceptibility loci: evidence for sex limited and parent of origin specific effects. J. Med. Genet, 42(2), 132-137. eScholarID:1d17683

2004

  • D'Adamo P, Bacchelli E, Blasi F, Lipp H, Toniolo D, Maestrini E, International Molecular Genetic Study of Autism Consortium (IMGSAC), Lamb J. (2004). DNA variants in the human RAB3A gene are not associated with autism. Genes Brain Behav, 3(2), 123-124. eScholarID:1d20702

2003

  • Bacchelli,E., Blasi,F., Biondolillo,M., Lamb, J, Bonora,E., Barnby,G., Parr,J., Beyer,K.S., Klauck,S.M., Poustka,A., Bailey,A.J., Monaco,A.P., Maestrini,E. (2003). Screening of nine candidate genes for autism on chromosome 2q reveals rare nonsynonymous variants in the cAMP-GEFII gene. Mol. Psychiatry, 8(11), 916-924. eScholarID:1d17679
  • Bonora,E., Beyer,K.S., Lamb, J, Parr,J.R., Klauck,S.M., Benner,A., Paolucci,M., Abbott,A., Ragoussis,I., Poustka,A., Bailey,A.J., Monaco,A.P. (2003). Analysis of reelin as a candidate gene for autism. Mol. Psychiatry, 8(10), 885-892. eScholarID:1d17680

2002

  • Beyer, K., Blasi, F., Bacchelli, E., Klauck, S., Maestrini, E., Poustka, A. & IMGSAC, I (2002). Mutation analysis of the coding sequence of the MECP2 gene in infantile autism. Hum Genet, 111(4-5), 305-309. eScholarID:54341 | PMID:12384770 | DOI:10.1007/s00439-002-0786-3
  • Bonora, E., Bacchelli, E., Levy, E., Blasi, F., Marlow, A., Monaco, A., Maestrini, E. & IMGSAC, I (2002). Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region. Mol Psychiatry, 7(3), 289-301. eScholarID:54343 | PMID:11920156 | DOI:10.1038/sj.mp.4001004
  • Lamb, J., Parr, J., Bailey, A. & Monaco, A (2002). Autism: in search of susceptibility genes. Neuromolecular Med, 2(1), 11-28. eScholarID:54367 | PMID:12230302 | DOI:10.1385/NMM:2:1:11
  • Newbury,D.F., Bonora,E., Lamb, J, Fisher,S.E., Lai,C.S., Baird,G., Jannoun,L., Slonims,V., Stott,C.M., Merricks,M.J., Bolton,P.F., Bailey,A.J., Monaco,A.P. (2002). FOXP2 is not a major susceptibility gene for autism or specific language impairment. Am. J. Hum. Genet, 70(5), 1318-1327. eScholarID:1d17678

2001

  • International Molecular Genetic Study of Autism Consortium. (2001). A genomewide screen for autism: strong evidence for linkage to chromosomes 2q, 7q, and 16p. Am J Hum Genet, 69(3), 570-581. eScholarID:56481 | PMID:11481586 | DOI:10.1086/323264
  • International Molecular Genetic Study of Autism Consortium. (2001). Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q. Hum Mol Genet, 10(9), 973-982. eScholarID:56482 | PMID:11392322

2000

  • Lamb J, MooreJ, BaileyA, MonacoA.P. (2000). Autism: recent molecular genetic advances. Hum. Mol. Genet, 9(6), 861-868. eScholarID:1d17677
  • Ogilvie, C., Moore, J., Daker, M., Palferman, S., Docherty, Z. and IMGSAC. (2000). Chromosome 22q11 deletions are not found in autistic patients identified using strict diagnostic criteria. American Journal of Medical Genetics. Part a, 96, 15-17. eScholarID:56544 | DOI:10.1002/(SICI)1096-8628(20000207)96:1<15::AID-AJMG5>3.0.CO;2-M

1999

  • FisherS.E, MarlowA.J, Lamb J, MaestriniE, WilliamsD.F, RichardsonA.J, WeeksD.E, SteinJ.F, MonacoA.P. (1999). A quantitative-trait locus on chromosome 6p influences different aspects of developmental dyslexia. Am. J. Hum. Genet, 64(1), 146-156. eScholarID:1d17676
  • Maestrini, E., Lai, C., Marlow, A., Matthews, N., Wallace, S., Bailey, A., Cook, E. H., Weeks, D. E., Monaco, A. P. and IMGSAC. (1999). Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit beta3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. American Journal of Medical Genetics, 88, 492-496. eScholarID:53935

1998

  • International Molecular Genetic Study of Autism Consortium. (1998). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Human Molecular Genetics, 7, 571-578. eScholarID:53872

1994

  • Turner, N., Dolan, J., Grimsditch, D., Lamb, J., Worby, A., Murray, K., Coates, W. & Warrington, B (1994). Pulmonary effects of type V cyclic GMP specific phosphodiesterase inhibition in the anaesthetized guinea-pig. Br J Pharmacol, 111(4), 1047-1052. eScholarID:54304 | PMID:8032606
  • Turner, N., Lamb, J., Worby, A. & Murray, K (1994). Relaxation of guinea-pig trachea by cyclic AMP phosphodiesterase inhibitors and their enhancement by sodium nitroprusside. Br J Pharmacol, 111(4), 1198-1204. eScholarID:54306 | PMID:8032589

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