Professor John Aplin MA, PhD

2012

• Holder BS, Tower CL, Jones CJ, Aplin JD, Abrahams VM. (2012). Heightened Pro-Inflammatory Effect of Preeclamptic Placental Microvesicles on Peripheral Blood Immune Cells in Humans. Biology of Reproduction, eScholarID:143812 | DOI:10.1095/biolreprod.111.097014

2011

• Aplin JD, Jones, CJ. (2011). Fucose, placental evolution and the glycocode. eScholarID:135680
• Diao H, Aplin JD, Xiao S, Chun J, Li Z, Chen S, Ye X. (2011). Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biology of Reproduction, 84(2), 255-265. eScholarID:135684 | DOI:10.1095/biolreprod.110.086942
• Harris LK, Crocker IP, Baker PN, Aplin JD, Westwood M. (2011). IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance receptor. Biology of Reproduction, 84(3), 440-446. eScholarID:135683 | DOI:10.1095/biolreprod.110.088195
• Jasper MJ, Care AS, Sullivan B, Ingman WV, Aplin JD, Robertson SA. (2011). Macrophage-derived LIF and IL1B regulate alpha(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy. Biology of Reproduction, 84(1), 179-188. eScholarID:135681 | DOI:10.1095/biolreprod.110.085399
• McKay TR, Camarasa MV, Iskender B, Ye J, Bates N, Miller D, Fitzsimmons JC, Foxler D, Mee M, Sharp TV, Aplin J, Brison DR, Kimber SJ. (2011). Human feeder cell line for derivation and culture of hESc/hiPSc. Stem Cell Research, 7(2), 154-162. eScholarID:152274 | DOI:10.1016/j.scr.2011.04.005
• Nakamura H, Jasper MJ, Hull ML, Aplin JD, Robertson SA. (2011). Macrophages regulate expression of α1,2 fucosyltransferase genes in human endometrial epithelial cells. eScholarID:135682
• Salker MS, Christian M, Steel JH, Nautiyal J, Lavery S, Trew G, Webster Z, Al-Sabbagh M, Puchchakayala G, Föller M, Landles C, Sharkey AM, Quenby S, Aplin JD, Regan L, Lang F, Brosens JJ. (2011). Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nature Medicine, eScholarID:135679 | DOI:10.1038/nm.2498
• Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman MS, Evans WH, Newson R, Case CP. (2011). Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nature Nanotechnology, 6, 824-833. eScholarID:143825 | DOI:10.1038/nnano.2011.188
• Tilbrook, H., Cox, H., Hewitt, C., Kang'ombe, A., Chuang, L., Jayakody, S., Aplin, J., Semlyen, A., Trewhela, A., Watt, I. & Torgerson, D (2011). Yoga for chronic low back pain: a randomized trial. Ann Intern Med, 155(9), 569-78. eScholarID:136773 | PMID:22041945

2010

• Aplin JD. (2010). Developmental cell biology of human villous trophoblast: current research problems. Int J Dev Biol, 54(2-3), 323-9. eScholarID:83005 | DOI:10.1387/ijdb.082759ja
• Blankley RT, Robinson NJ, Aplin JD, Crocker IP, Gaskell SJ, Whetton AD, Baker PN, Myers JE. (2010). A gel-free quantitative proteomics analysis of factors released from hypoxic-conditioned placentae. Reprod Sci, 17(3), 247-57. eScholarID:83003 | DOI:10.1177/1933719109351320
• Blankley RT, Robinson NJ, Aplin JD, Crocker IP, Gaskell SJ, Whetton AD, Baker PN, Myers JE. (2010). A gel-free quantitative proteomics analysis of factors released from hypoxic-conditioned placentae. Reprod Sci, 17(3), 247-57. eScholarID:84874 | DOI:10.1177/1933719109351320
• Forbes K, Souquet B, Garside R, Aplin JD, Westwood M. (2010). Transforming growth factor-{beta} (TGF{beta}) receptors I/II differentially regulate TGF{beta}1 and IGF-binding protein-3 mitogenic effects in the human placenta. Endocrinology, 151(4), 1723-31. eScholarID:83008 | DOI:10.1210/en.2009-0896
• Harris LK, Smith SD, Keogh RJ, Jones RL, Baker PN, Knöfler M, Cartwright JE, Whitley GS, Aplin JD. (2010). Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling. Am J Pathol, 177(4), 2103-15.. eScholarID:93436 | DOI:10.2353/ajpath.2010.100182
• Ingman K, Cookson VJ, Jones CJ, Aplin JD. (2010). Characterisation of Hofbauer cells in first and second trimester placenta: incidence, phenotype, survival in vitro and motility. Placenta, 31(6), 535-44.. eScholarID:83000 | DOI:10.1016/j.placenta.2010.03.003
• JD Aplin. (2010). Redefining endometrial receptivity. Indian J Physiol Pharmacol, 54, 1-6. eScholarID:102733
• Jones CJ, Aplin JD, Burton GJ. (2010). First Trimester Histiotrophe Shows Altered Sialylation Compared with Secretory Phase Glycoconjugates in Human Endometrium. Placenta, eScholarID:84845
• Miller DL, Jones CJ, Aplin JD, Nardo LG. (2010). Altered glycosylation in peri-implantation phase endometrium in women with stages III and IV endometriosis. Hum Reprod. 2010, 25(2), 406-11. eScholarID:83001
• Sanches JC, Jones CJ, Aplin JD, Iozzo RV, Zorn TM, Oliveira SF. (2010). Collagen fibril organization in the pregnant endometrium of decorin-deficient mice. J Anat, 216(1), 144-55. eScholarID:83004 | DOI:10.1111/j.1469-7580.2009.01170.x
• Singh H, Nardo L, Kimber SJ, Aplin JD. (2010). Early stages of implantation as revealed by an in vitro model. Reproduction, 139(5), 905-14.. eScholarID:82999 | DOI:10.1530/REP-09-0271
• Tower CL, Lui S, Charlesworth NR, Smith SD, Aplin JD, Jones RL. (2010). Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development. Reproduction, 140(6), 931-42. eScholarID:102727 | DOI:10.1530/REP-10-0307

2009

• Anjum N, Baker PN, Robinson N, Aplin JD. (2009). Maternal celiac disease autoantibodies bind directly to syncytiotrophoblast and inhibit placental tissue transglutaminase activity. Reprod Biol Endocrinol, 7, eScholarID:1d20180 | DOI:10.1186/1477-7827-7-16
• Bai X, Williams JL, Greenwood SL, Baker PN, Aplin JD, Crocker IP. (2009). A placental protective role for trophoblast-derived TNF-related apoptosis-inducing ligand (TRAIL). Placenta, 30(10), 655-60. eScholarID:83007
• Ball, M, Carmody, M, Wynne, F, Dockery, P, Aigner, A, Cameron, I, Higgins, J, Smith, S, Aplin, JD, Moore, T. (2009). Expression of pleiotrophin and its receptors in human placenta suggests roles in trophoblast life cycle and angiogenesis. Placenta, 30( 7), 649-53. eScholarID:1d20174 | DOI:10.1016/j.placenta.2009.05.001
• Ben-Nagi J, Walker A, Jurkovic D, Yazbek J, Aplin JD. (2009). Effect of cesarean delivery on the endometrium. Int J Gynaecol Obstet, 106( 1), 30-4. eScholarID:1d20176 | DOI:10.1016/j.ijgo.2009.02.019
• Chen, C, Liu, S, Huang, J, Aplin, JD, Wu, Y, Chen, P, Hu, C, Ko, C, Lee, M, Chen, C. (2009). Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats. Hum Reprod, 24( 1), 154-65. eScholarID:1d20181 | DOI:10.1093/humrep/den356
• Forbes K, Desforges M, Garside R, Aplin JD, Westwood M. (2009). Methods for siRNA-mediated Reduction of mRNA and Protein Expression in Human Placental Explants, Isolated Primary Cells and Cell Lines. Placenta, 30(2), 124-129. eScholarID:1d18240 | DOI:10.1016/j.placenta.2008.10.003
• Forbes K, West G, Garside R, Aplin JD, Westwood M. (2009). THE PROTEIN-TYROSINE PHOSPHATASE, SHP-2, IS A CRUCIAL MEDIATOR OF EXOGENOUS IGF SIGNALLING TO HUMAN TROPHOBLAST. Endocrinology, 150(10), 4744-4754. eScholarID:1d20171 | DOI:10.1210/en.2009-0166
• Lee MY, Huang JP, Chen YY, Aplin JD, Wu YH, Chen CY, Chen PC, Chen CP. (2009). Angiogenesis in differentiated placental multipotent mesenchymal stromal cells is dependent on integrin alpha5beta1. PLoS One, 4(10), e6913. eScholarID:83006
• Salgado RR, Capelo L, Favaro R, Glazier JD, Aplin JD, Zorn T. (2009). Hormone-regulated expression and distribution of versican in mouse uterine tissues. Reprod Biol Endocrinol, 7, eScholarID:1d20173 | DOI:10.1186/1477-7827-7-60
• Singh H, Aplin JD. (2009). Adhesion molecules in endometrial epithelium: tissue integrity and embryo implantation. J Anat, 215( 1), 3-13. eScholarID:1d20175 | DOI:10.1111/j.1469-7580.2008.01034.x
• Smith S, Dunk C, Aplin JD, Harris LK, Jones RLee. (2009). Evidence for immune cell involvement in decidual spiral arteriole remodeling in early human pregnancy. Am J Pathol, 174(5), 1959-1971. eScholarID:1d20178 | DOI:10.2353/ajpath.2009.080995
• Chen CP, Liu SH, Huang JP, Aplin JD, Wu YH, Chen PC, Hu CS, Ko CC, Lee MY, Chen CY. "Engraftment potential of human placenta-derived mesenchymal stem cells after in utero transplantation in rats" Hum Reprod. 2009 Jan;24(1):154-65. eScholarID:19m26
• Forbes K, Desforges M, Garside R, Aplin JD, Westwood M. "Methods for siRNA-ediated reduction of mRNA and protein expression in human placental explants, isolated primary cells and cell lines" Placenta. 2009; Feb;30(2):124-9. eScholarID:19m24

2008

• Aplin JD, Singh H. (2008). Bioinformatics and transcriptomics studies of early implantation. Annals of the New York Academy of Science, 1127, 116-120. eScholarID:1d28192 | DOI:10.1196/annals.1434.005
• Chen, C, Lee, M, Huang, J, Aplin, JD, Wu, Y, Hu, C, Chen, P, Li, H, Hwang, S, Liu, S, Yang, Y. (2008). Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins. Stem Cells, 26( 2), 550-61. eScholarID:1d32263 | DOI:10.1634/stemcells.2007-0406
• Forbes K, Westwood M, Baker PN, Aplin JD. (2008). Insulin-like growth factor-I and -II regulate the life cycle of trophoblast in the developing human placenta. American Journal of Physiology - Cell Physiology, In Press 2008, eScholarID:1d28174 | DOI:10.1152/ajpcell.00035.2008
• Forbes K, Westwood M, Baker PN, Aplin JD. (2008). Insulin-like growth factor-I and -II regulate the life cycle of trophoblast in the developing human placenta. American Journal of Physiology: Cell Physiology, 294(6), C1313-C1322. eScholarID:1d17243 | DOI:10.1152/ajpcell.00035.2008
• Harris LK, Baker PN, Brenchley PEC, Aplin JD. (2008). Trophoblast-derived heparanase is not required for invasion. Placenta, 29, eScholarID:1d17118 | DOI:10.1016/j.placenta.2008.01.012
• Jones CJP, Harris LK, Whittingham J, Aplin JD, Mayhew T. M. (2008). A re-appraisal of the morphophenotype and basal lamina coverage of cytotrophoblasts in human term placenta. Placenta, 29, 215-219. eScholarID:1d28141 | DOI:10.1016/j.placenta.2007.11.004
• Robinson N, Wareing MM, Hudson NK, Blankley R, Baker PN, Aplin JD, Crocker IP. (2008). Oxygen and the liberation of placental factors responsible for vascular compromise. Laboratory Investigation, 88( 3), 293-305. eScholarID:1d28176

2007

• Harris LK, Aplin JD. (2007). Vascular remodeling and extracellular matrix breakdown in the uterine spiral arteries during pregnancy. Reprod. Sci, 14 (8 supp), 28-34. eScholarID:1d28113
• Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Whitley GJ, Aplin JD. (2007). BeWo cells induce vascular remodelling via Fas ligand-and matrix metalloproteinase-dependent mechanisms. Human Reproduction, 22(11), 2834-2841. eScholarID:1d16609
• Jones CJP, Carter A, Aplin JD, Enders A.C. (2007). Glycosylation at the fetomaternal interface in haemomonochorial placentae from five widely separated species of mammal: is there evidence for convergent evolution? Cells, Tissues, Organs, 185, 269-284. eScholarID:1d27602
• Robinson N, Baker PN, Jones CJP, Aplin JD. (2007). A role for tissue transglutaminase in stabilisation of membrane-cytoskeletal particles shed from the human placenta. Biology of Reproduction, Jul 11 2007, eScholarID:1d27797

2006

• Aplin JD. (2006). Embryo implantation: the molecular mechanism remains elusive. Reprod Biomed Online, 13(6), 833-839. eScholarID:1d14488
• Aplin JD. (2006). In vitro analysis of trophoblast invasion. Methods Mol Med, 122, 45-57. eScholarID:1d30836
• Ayling LJ, Whitley GS, Aplin JD, Cartwright JE. (2006). Dimethylarginine dimethylaminohydrolase (DDAH) regulates trophoblast invasion and motility through effects on nitric oxide. Hum Reprod, 21( 10), 2530-2537. eScholarID:1d30001
• Harris LK, Keogh RJ, Wareing MM, Baker PN, Cartwright J, Aplin JD. (2006). Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism. American Journal Of Pathology, 169 (5), 1863-1874. eScholarID:1d27411 | DOI:10.2353/ajpath.2006.060265

2005

• Chen C, Yang Y, Su T, Chen C, Aplin JD. (2005). Hypoxia and transforming growth factor-beta 1 act independently to increase extracellular matrix production by placental fibroblasts. J Clin Endocrinol Metab, 90( 2), 1083-90. eScholarID:1d10728
• Crocker IP, Wareing MM, Ferris G, Jones CJP, Cartwright JE, Baker PN, Aplin JD. (2005). The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro. Journal Of Pathology, 206 (4), 476-485. eScholarID:1d26572 | DOI:10.1002/path.1801
• Miller A, Aplin JD, Westwood M. (2005). Adenovirally mediated expression of insulin-like growth factors enhances the function of first trimester placental fibroblasts. J Clin Endocrinol Metab, 90( 1), 379-85. eScholarID:1d29390

2004

• Aplin JD, Kimber SS.J. (2004). Trophoblast-uterine interactions at implantation. Reprod Biol Endocrinol, 5 (2), eScholarID:1d14580
• Bauer S, Pollheimer J, Hartmann J, Husslein P, Aplin JD, Knöfler M. (2004). Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures. J Clin Endocrinol Metab, 89(2), 812-822. eScholarID:1d10730 | DOI:10.1210/jc.2003-031351
• Bauer S, Pollheimer J, Hatmann J, Husslein P, Aplin J, Knoefler M. (2004). TNFa inhibits trophoblast migration through elevation of PAL-1: a potential mechanism in the pathogenesis of preeclampsia. J Clin Endocrinol Metab, 89, 812-822. eScholarID:1d8151
• Coppock H, White A, Aplin JD, Westwood M. (2004). Matrix metalloprotease-3 and -9 proteolyze insulin-like growth factor-binding protein-1. Biol Reprod, 71( 2), 438-43. eScholarID:1d10798 | DOI:10.1095/biolreprod.103.023101

2003

• Chen C.P, Aplin JD. (2003). Placental extracellular matrix: gene expression, deposition by placental fibroblasts and the effect of oxygen. Placenta, 24 (4), 316-325. eScholarID:1d6516
• San-Martin SH, Soto-Suazo M, De Oliveira FS, Aplin JD, Abrahamsohn P, Zorn TMT. (2003). Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in the mouse. Reproduction, 125, 585-595. eScholarID:1d6515

2002

• Cartwright JE, Kenny L, Dash PR, Crocker IP, Aplin JD, Baker PN, Whitley GS. (2002). Trophoblast invasion of spiral arteries: a novel in vitro model. Placenta, 23(2-3), 232-5. eScholarID:1d25380
• Lacey HA, T Haigh, Jones CJP, Westwood M, Aplin JD. (2002). Mesenchymally derived IGF-I provides a paracrine stimulus for trophoblast migration BMC Developmental Biology. BMC Developmental Biology, 2 (1), eScholarID:1d3731

2001

• Meseguer M, Aplin JD, Caballero-Campo P, Martin JC, Remohi J, Simon C. (2001). Hormonal and embryonic regulation of human endometrial MUC1. Biology of Reproduction, 64, 181-192. eScholarID:1d2018
• Meseguer M, Aplin JD, Caballero-Campo P, O'Connor JE, Martin JC, Remohi J, Pellicer A, Simon C. (2001). Human endometrial mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod, 64(2), 590-601. eScholarID:1d11597 | DOI:10.1095/biolreprod64.2.590
• Westwood M, Aplin JD, IA Collinge, Gill A, White A, Gibson JM. (2001). Alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis. Journal of Biological Chemistry, 276 (45), 41668-41674. eScholarID:1d2387 | DOI:10.1074/jbc.M102793200