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School of Medicine

Professor John McLaughlin BSc (Hons) MB ChB(Hons) PhD FRCP

Photograph of John McLaughlin

Professor of Gastroenterology and Nutrition

Inflammation Sciences

School of Translational Medicine

Clinical Sciences Building

Salford Royal NHS Trust

Salford M6 8HD

UK

OR

Room 1.704

Stopford Building

University of Manchester

Oxford Rd

Manchester

M13 9PL

UK

 

Role

  • I am a clinical academic and my roles are split between 3 domains:
  • Teaching and Training: 30%

    • Programme Lead for North West Academic Clinical Fellowship Programme
    • Programme Director for  MRes in Medical Sciences
    • Strategic lead for intercalation, Manchester Medical School
    • Developing new MB PhD programme
    • Academic Foundation Tutor, Salford
    • Clinical teaching, examining  and supervision
  • Research: 20%
    • Current funding from MRC and BBSRC, with 6 current and 5 previous PhD students
      • Lead for Comprehensive Local Research Network for Gastroenterology in Greater Manchester
      • National Research Committees:
      • British Society of Gastroenterology Research Committee (Chair elect) and BAPEN (Chair)
      • NIHR Panel of Experts
      • Salford Hospital Clinical Trial Facility Steering Committee
  • Consultant Gastroenterologist, Salford Royal Hospitals: 50%
    • Regional GI Physiology service
 

Memberships of Committees and Professional Bodies

Section Committee, Neurogastroenterology and Motility, British Society of Gastroenterology.

Research Committee, British Society of Gastroenterology

Chair of Research and Science Committee, BAPEN

Editorial Board: 'Therapeutic Advances in Gastroenterology' and 'Frontiers in Gastrointestinal Pharmacology'

Specialist Training Committee for Gastroenterology, North West Deanery

Physiological Society

Bayliss and Starling Society

Royal College of Physicians

Research

Current research interests are all linked around central topics of the gastrointestinal response to food, gastrointestinal inflammation, appetite regulation, and the gut-brain axis.

Drawing on the strong Gastroenterology research history in Manchester, these activities have found broader relevance in an era of rapidly increasing obesity.

There is also a growing realisation that both diet and the microenvironment of the gut are pertinent to many other key areas of biomedical research, and particularly close links with the Faculty of Life Sciences and the food industry have consequently been forged. This is embodied in the cross-faculty 'Diet, Digestion and Health' group which I lead together with Dr Craig Smith in Life Sciences.

I also sit on the newly formed Salford Royal Hospitals Clinical Trial Facility Steering Committee.

  • Gastrointestinal physiology: clinical and basic
  • Nutrient sensing mechanisms in the gut
  • Inflammatory Bowel Disease: models and genes
  • Appetite regulation in health and disease
  • Enteroendocrine cells in health and disease
  • Diabetic gastroenteropathy
  • The epithelial barrier

 Research is currently funded by MRC, BBSRC, CORE and Diabetes UK.

 

Teaching

Teaching and training have been major components of my work, largely undertaken within Manchester Medical School:

Programme Lead for Academic Clinical Fellowships (North West Intergrated Academic Training)

Strategic lead for Intercalation, Manchester Medical School.

Programme Director MRes Medical Sciences (Intercalated Medical Students) 2007-2010

I have also developed a pilot MB PhD programme linked to the MRes

Programme Director, MRes for Academic Clinical Fellows

Current supervisor for 6 PhD students (including students in FLS) and academic advisor to 11 PhD/MD students

OSCE Examinder: lead role 2005-2009 Salford Site

Academic Foundation Programme Board

Academic Foundation Tutor, Salford.

Clinical teaching and lectures

Year 4 project option and SSC tutor

Academic Advisor

Medical School Admissions Panels

Curriculum Development Group

 

Biography

John McLaughlin is Professor of Gastroenterology in the School of Translational Medicine, Faculty of Medical and Human Sciences, University of Manchester. His BSc Physiology (1st Class Hons) MB ChB (Hons) and PhD degrees were all awarded by Manchester. His research interests are gastrointestinal physiology in health and disease particularly the interactions between nutrients and the gut epithelium, gut inflammation, and gut-to-brain signalling. 

He trained in Gastroenterology and General Medicine in the North West Region also, with a period as an MRC Travelling Fellow at Harvard University. Spending 50% of his time as a Consultant Gastroenterologist he manages the clinical GI physiology service at Salford Royal University (Hope) Hospital, and leads the Comprehensive Local Research Network for Gastroenterology in Greater Manchester. He is Chair elect of the British Society of Gastroenterology Research Committee. Close clinical and academic links are also in place with the developing obesity services in Salford.

The last 5 years have been dominated by developing new clinical researchers, by close engagement with intercalating medical students undertaking a Masters in Research and by delivering training and mentorship to academic clinical fellows in integrated training.

He was awarded the British Society of Gastroenterology's Francis Avery Jones Research Award in 2007, and the European Rising Star in Gastroenterology Award in 2008.

 

Qualifications

BSc (1st Class Hons) University of Manchester 1987

MB ChB (Hons) University of Manchester 1990

PhD University of Manchester 1998

MRCP(UK) 1993

CCST Gastoenterology and General Medicine 2002

FRCP (London) 2007

 

Collaborators and affiliated staff

Collaborators

  • Professor Maynard Case,  Faculty of Life Sciences, Manchester University
  • Professor Richard Grencis
    Faculty of Life Sciences, Manchester University
  • Dr Craig Smith
    Faculty of Life Sciences, Manchester University
  • Dr Jason Bruce, Faculty of Life Sciences, Manchester University
  • Dr Sheena Cruickshank Faculty of Life Sciences, Manchester University
     
  • Dr Anil Day, Faculty of Life Sciences, Manchester University
  • Dr Bill Newman, FMHS, Manchester University
  • Prof Rayaz Malik, FMHS, Manchester University
  • Dr Shane McKie, FMHS, Manchester University
  • Prof Graham Dockray, Prof Andrea Varro, Prof Rod Dimaline
    Liverpool University
  • Prof Steve Collins and Dr W Khan
    McMaster University
  • Prof Christoph Beglinger
    Basel University
  • Prof TC Wang
    Colombia University

 

 

 

 

Publications

2012

  • Jones RB, McKie S, Astbury N, Little TJ, Tivey S, Lassman DJ, McLaughlin J, Luckman S, Williams SR, Dockray GJ, Thompson DG. (2012). FUNCTIONAL NEUROIMAGING DEMONSTRATES THAT GHRELIN INHIBITS THE CENTRAL NERVOUS SYSTEM RESPONSE TO INGESTED LIPID. Gut, In press, eScholarID:150926
  • Moran, G, Pennock, J, McLaughlin, J. (2012). Enteroendocrine cells in terminal ileal Crohn's disease. Journal of Crohn's and Colitis, in press, eScholarID:152375

2011

  • Asker E Jeukendrup and John McLaughlin. (2011). Carbohydrate ingestion during exercise: effects on performance, training adaptations and trainability of the gut. Nestlé Nutrition Workshop Series. (pp. ). eScholarID:109116

2010

  • Cotterill L, Payne, D, Levison S, McLaughlin J, Wesley E, Feeney M, Durbin, H, Lal, S, Makin A, Campbell S, Roberts SA, O'Neill C, Edwards C, Newman WG. (2010). Replication and meta-analysis of 13,000 cases defines the risk for IL23R and ATG16L1 variants in Crohn's disease. Canadian Journal of Gastroenterology, in press, eScholarID:65515
  • Jackson, A, Case, RM, Bruce, J, Mclaughlin, J. (2010). Fatty acids do not stimulate enteroendocrine cells via particle sensing mechanisms. Int Dairy Journal, 20, 243-247. eScholarID:78903 | DOI:10.1016/j.idairyj.2009.11.007
  • Jackson, A., Case, R., Bruce, J. & McLaughlin, J (2010). Fatty acids do not stimulate enteroendocrine cells via particle sensing mechanisms. INTERNATIONAL DAIRY JOURNAL, 20(4), 243-247. eScholarID:127787 | DOI:10.1016/j.idairyj.2009.11.007
  • Levison, S., McLaughlin, J., Zeef, L., Fisher, P., Grencis, R. & Pennock, J (2010). Colonic Transcriptional Profiling in Resistance and Susceptibility to Trichuriasis: Phenotyping a Chronic Colitis and Lessons for latrogenic Helminthosis. INFLAMMATORY BOWEL DISEASES, 16(12), 2065-2079. eScholarID:127785 | DOI:10.1002/ibd.21326
  • Levison, SE, Pennock, J, McLaughlin, J, Grencis, RK. (2010). Colonic Transcriptional Profiling in Resistance and Susceptibility to Trichuriasis: Phenotyping a Chronic Colitis and Lessons for Iatrogenic Helminthosis. Inflammatory Bowel Diseases, 16, 2065-2079. eScholarID:78904 | DOI:10.1002/ibd.21326
  • Little, T., Gopinath, A., Patel, E., McGlone, A., Lassman, D., D'Amato, M., McLaughlin, J. & Thompson, D (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor. NEUROGASTROENTEROLOGY AND MOTILITY, 22(11), 1183. eScholarID:127786 | DOI:10.1111/j.1365-2982.2010.01552.x
  • Little, TJ, Gopinath, A, Lassman, D, Patel, E, McGlone, A, McLaughlin, J, Thompson DG. (2010). Gastric emptying of hexose sugars: role of osmolality, molecular structure and the CCK1 receptor. Neurogastroenterology and Motility, 22, 1183-1190. eScholarID:85664 | DOI:10.1111/j.1365-2982.2010.01552.x
  • Moran, G, McLaughlin, J. (2010). The immune/enteroendocrine link in the regulation of food intake in intestinal disease. Agro Food, 21(10), eScholarID:94082
  • Moran, GW, McLaughlin, JT. (In-press). Plasma chromogranin A in patients with inflammatory bowel disease. Inflammatory Bowel Diseases, 16, 914-915. eScholarID:65338 | DOI:10.1002/ibd.21096

2009

  • Anthony D. Jackson, John McLaughlin. (2009). Digestion and absorption. Surgery, 27(6), 231-236. eScholarID:66066 | DOI:10.1016/j.mpsur.2009.03.003
  • John McLaughlin. (2009). Gastrointestinal physiology. Surgery, 27(6), 225-230. eScholarID:66063 | DOI:10.1016/j.mpsur.2009.04.009
  • Little TJ, Gupta N, Case RM, Thompson DG, McLaughlin JT. (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. Am J Physiol Regul Integr Comp Physiol, 297(3), R632-R639. eScholarID:1d19922 | DOI:10.1152/ajpregu.00090.2009
  • Little, T., Gupta, N., Case, R., Thompson, D. & McLaughlin, J (2009). Sweetness and bitterness taste of meals per se does not mediate gastric emptying in humans. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 297(3), R632-R639. eScholarID:127782 | DOI:10.1152/ajpregu.00090.2009
  • McLaughlin JT, Lambert DS, Padfield PJ, Julian PH Burt, O'Neill CA. (2009). The mycotoxin Patulin, modulates tight junctions in Caco-2 cells. Toxicology in vitro, 23, 83-88. eScholarID:1d28295 | DOI:10.1016/j.tiv.2008.10.009
  • McLaughlin, J., Lambert, D., Padfield, P., Burt, J. & O'Neill, C (2009). The mycotoxin patulin, modulates tight junctions in caco-2 cells. TOXICOLOGY IN VITRO, 23(1), 83-89. eScholarID:127788 | DOI:10.1016/j.tiv.2008.10.009
  • K. Farrer, M. Wale, J. L. Shaffer and J. Mclaughlin. (2009). Malnutrition universal screening tool: a risk factor for Clostridium difficile infection in hospital?. Proceedings of the Nutrition Society, 68, E46--. eScholarID:67348
  • McLaughlin J. (2009). How should we classify and treat patients with functional GI disorders?. Therapeutic advances in gastroenterology, 1, 153-156. eScholarID:65445

2008

  • Moran GW, Leslie FC, Levison SC, Mclaughlin, JT. (2008). Enteroendocrine cells - Neglected players in GI disorders? . Therapeutic advances in Gastroenterology, 1, 51-60. eScholarID:65434 | DOI:10.1177/1756283X08093943
  • Motomura Y, Ghia J, Wang H, Akiho H, El-Sharkawy R, Collins M, Wan Y, McLaughlin JT, Khan W. (2008). Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments. Gut, 57(4), 475-481. eScholarID:1d32468 | DOI:10.1136/gut.2007.129296
  • Motomura, Y., Ghia, J. & Wang, H (2008). Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments (vol 57, pg 475, 2008). GUT, 57(9), 1340-1340. eScholarID:127784
  • E. Barthorpe, J. McLaughlin, B. Kuczynska and K. Farrer. (2008). Uptake of the MUST screening tool for inpatients in a Teaching Hospital: an audit of progress to date. Proceedings of the Nutrition Society, 67, 127. eScholarID:67341

2007

  • Lambert DS, Padfield PJ, McLaughlin JT, Cannell S, O'Neill CA. (2007). Ochratoxin A displaces claudins from detergent resistant membrane microdomains. Biochem. Biophys. Res. Commun, 358(2), 632-636. eScholarID:1d27725 | DOI:10.1016/j.bbrc.2007.04.180
  • McLaughlin J. (2007). Long chain fatty acid sensing in the gastrointestinal tract. 35(4), 1199-1202. eScholarID:65536
  • Wang H, Steeds J, Motomura Y, Deng Y, Verma-Gandhu M, El-Sharkawy R, McLaughlin JT, Grencis RR.K, Khan W. (2007). CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection. Gut, 567, 949-957. eScholarID:1d32469 | DOI:10.1136/gut.2006.103226

2006

  • Gavin Stewart, Tohru Hira, Andrew Higgins, Smith CP, McLaughlin JT. (2006). Mouse GPR40 receptor heterologously expressed in Xenopus oocytes is activated by short, medium and long chain fatty acids. American Journal of Physiology: Cell Physiology, 290, C785-92. eScholarID:1d26819 | DOI:10.1152/ajpcell.00462.2005
  • Jackson, AD, McLaughlin, J. (2006). Digestion and absorption. Surgery, 24(7), 250-254. eScholarID:66061
  • Jacqueline R McDermott, Leslie F, Massimo D'Amato, Thompson DG, Grencis RR.K, McLaughlin JT. (2006). Immune control of food intake: enteroendocrine cells are regulated by CD4+ T- lymphocytes during small intestinal inflammation. Gut, 55, 492-497. eScholarID:1d26665 | DOI:10.1136/gut.2005.081752
  • JK Limdi, O'Neill CA, McLaughlin JT. (2006). Do probiotics have a therapeutic role in gastroenterology. World J. Gastroenterology, 14(12), eScholarID:1d18367
  • McLaughlin JT, Houghton LA. (2006). The rationale, efficacy and safety evidence for tegaserod in the treatment of irritable bowel syndrome. Expert Opinion on Drug Safety, 5, 313-327. eScholarID:1d12913

2004

  • Best LC, McLaughlin JT. (2004). Nutrients as regulators of endocrine and neuroendocrine research. Topics in Current Genetics. ( 7, pp. 100-110). eScholarID:3d238
  • Best LC, McLaughlin JT. (2004). Nutrients as regulators of endocrine and neuroendocrine secretion. Topics in Current Genetics. ( 7, ). Springer Verlag. eScholarID:3d531
  • Lal S, McLaughlin JT, Barlow JD, Massimo D'Amato, G Giacovelli, A Varro, G.J. Dockray, Thompson DG. (2004). Cholecystokinin pathways modulate sensations induced by gastric distension in man. American Journal of Physiology, 287, 72-79. eScholarID:1d25856 | DOI:10.1152/ajpgi.00351.2003
  • McLaughlin JT, Ai W, Sinclair NF, Colucci R, Raychowdhury R, Koh TJ, Wang T. (2004). PACAP and gastric regulate the histidine decarboxylase promoter via distinct mechanisms. Am J Physiol Gastrointest Liver Physiol, 286, 51-59. eScholarID:1d6640
  • McLaughlin JT, Padfield PJ, JP Burt, O'Neill CA. (2004). Ochratoxin A increases permeability through tight junction removal of specific claudin isoforms. Amer. J. Physiol-cell physiol, 287(5), 1412-1417. eScholarID:1d25860 | DOI:10.1152/ajpcell.00007.2004
  • N F Sinclair, W Ai, R Raychowdhury, M Bi, TJ Koh, TC Wang, McLaughlin JT. (2004). Gastrin activates the human HB-EGF promoter via the MAP kinase signalling pathway through a GC rich gastric response element. American Journal of Physiology (Gastrointestinal Liver Physiology), 286(6), 992-999. eScholarID:1d26629
  • Sinclair NF, Wandong A, Raychowdhury R, Bi M, Wang TC, Koh TJ, McLaughlin JT. (2004). Gastrin Regulates the Heparin Binding Epidermal-like Growth Factor Promoter Via a PKC/EGFR dependent mechanism. American Journal of Physiology, 286, 992-999. eScholarID:1d7605 | DOI:10.1152/ajpgi.00206.2002
  • Tohru Hira, Elliott AC, Thompson DG, Case RR.M, McLaughlin JT. (2004). Multiple fatty acid sensing mechanisms operate in enteroendocrine cells: novel evidence for direct mobilization of stored calcium by cytosolic fatty acid. Journal of Biological Chemistry, 279, 26082-26089. eScholarID:1d7867 | DOI:10.1074/jbc.M400098200
  • Leslie F, J McDermott, Thompson DG, Grencis RR.K, McLaughlin JT. (2004). Small intestinal inflammation reduces food intake via a CD4 T-lymphocyte/IL4 receptor dependent pathway in mice. Gut, 53 (Suppl VI), A21. eScholarID:17d467
  • Y Motomura, M Verma-Gandhu, RT Sharkaley, McLaughlin JT, Grencis RR.K, W I Khan. (2004). Colonic 5-HT and muscle responses to the same infective agent differ in Th1 and Th2 dominant environments. Gastroenterology, 126(S2), A216. eScholarID:17d652

2003

  • Leslie F, McLaughlin JT, Andrea Varro, Graham J Dockray, Thompson DG, B K Mandal. (2003). Plasma cholecystokinin concentrations are elevated in acute upper gastrointestinal infections. Quarterly Journal Of Medicine, 96, 870-871. eScholarID:1d26630
  • McLaughlin JT. (2003). Irritable Bowel Syndrome. Medicine, 31, eScholarID:1d7452
  • T Hira, Case RR.M, Thompson DG, McLaughlin JT. (2003). Fatty acids act directly on intracellular calcium stores to mobilize calcium in the EEC cell line STC1. Journal of Physiology, eScholarID:1d34029
  • tohru hira, Case RR.M, Thompson DG, McLaughlin JT. (2003). Fatty acids act directly on intracellular calcium stores in the EEC cell line STC1. Gut, 52(S1), A54. eScholarID:17d939

2002

  • (2002). Gastrointestinal Physiology. Surgery, 20(7), ii-vii. eScholarID:66059
  • Raychowdhury R, Fleming J, McLaughlin JT, Bulitta C, Wang T. (2002). Identification and characterization of a third gastrin response element (GAS-RE3) in the human histidine decarboxylase gene promoter. Biochem. Biophys. Res. Commun, 297(5), eScholarID:1d2908

2001

  • McLaughlin JT. (2001). Endocrine cells as sensory transducers. Digestion, 63, eScholarID:17d385

2000

  • McLaughlin JT. (2000). The brain-gut axis in health and disease. Journal of the Royal College of Physicians (London), 34, eScholarID:1d26631

1999

  • McLaughlin J, Grazia Lucà M, Jones MN, D'Amato M, Dockray GJ, Thompson DG. (1999). Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology, 116, 46-53. eScholarID:1d2071
  • McLaughlin, JT, Thompson, DG. (1999). Fatty acids and proximal gastric tone. Motility. Motility, 45, 8-10. eScholarID:65587

1998

  • McLaughlin JT, Lomax RB. Hall L. Dockray GJ. Thompson DG. Warhurst G. (1998). Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1. J Physiol, 513(1), 11-18. eScholarID:65424
  • McLaughlin, JT, Troncon, LEA, Barlow, J, Heggie, LJ, Thompson, DG. (1998). Evidence for a lipid specific effect in nutrient induced human proximal gastric relaxation. Gut, 43, 248-251. eScholarID:65416

1996

  • McLaughlin, JT, Thompson , DG. (1996). The role of intragastric distribution of food in functional dyspepsia. Motility, (32), 10-13. eScholarID:65583

1994

  • (1994). Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains. Clin Exper Pharmacol Physiol, 21, 109-115. eScholarID:65403

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