Professor Judith Hoyland BSc, PhD

2011

• Gilbert, H., Hoyland, J., Freemont, A. & Millward-Sadler, S (2011). The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Arthritis Res Ther, 13(1), R8. eScholarID:135131 | PMID:21276216 | DOI:10.1186/ar3229
• Naidoo, K., Clay, V., Hoyland, J., Swindell, R., Linton, K., Illidge, T., Radford, J. & Byers, R (2011). YY1 expression predicts favourable outcome in follicular lymphoma. J Clin Pathol, 64(2), 125-9. eScholarID:135130 | PMID:21109702 | DOI:10.1136/jcp.2010.078188

2010

• Fraylich, M., Liu, R., Richardson, S., Baird, P., Hoyland, J., Freemont, A., Alexander, C., Shakesheff, K., Cellesi, F. & Saunders, B (2010). Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system. J Colloid Interface Sci, 344(1), 61-9. eScholarID:80104 | PMID:20070971 | DOI:10.1016/j.jcis.2009.12.030
• Gilbert, H., Hoyland, J. & Millward-Sadler, S (2010). The response of human anulus fibrosus cells to cyclic tensile strain is frequency-dependent and altered with disc degeneration. Arthritis Rheum, 62(11), 3385-94. eScholarID:108508 | PMID:20617521 | DOI:10.1002/art.27643
• Graham, H., Hodson, N., Hoyland, J., Millward-Sadler, S., Garrod, D., Scothern, A., Griffiths, C., Watson, R., Cox, T., Erler, J., Trafford, A. & Sherratt, M (2010). Tissue section AFM: In situ ultrastructural imaging of native biomolecules. Matrix Biol, 29(4), 254-260. eScholarID:80102 | PMID:20144712 | DOI:10.1016/j.matbio.2010.01.008
• McNicol, F., Hoyland, J., Cooper, R. & Carlson, G (2010). Skeletal muscle contractile properties and proinflammatory cytokine gene expression in human endotoxaemia. Br J Surg, 97(3), 434-42. eScholarID:80106 | PMID:20035532 | DOI:10.1002/bjs.6868
• Minogue, B., Richardson, S., Zeef, L., Freemont, A. & Hoyland, J (2010). Characterization of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum, 62(12), 3695-705. eScholarID:108517 | PMID:20722018 | DOI:10.1002/art.27710
• Minogue, B., Richardson, S., Zeef, L., Freemont, A. & Hoyland, J (2010). Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther, 12(1), R22. eScholarID:80101 | PMID:20149220 | DOI:10.1186/ar2929
• Richardson, S., Hoyland, J., Mobasheri, R., Csaki, C., Shakibaei, M. & Mobasheri, A (2010). Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering. J Cell Physiol, 222(1), 23-32. eScholarID:80107 | PMID:19725073 | DOI:10.1002/jcp.21915
• Strassburg, S., Richardson, S., Freemont, A. & Hoyland, J (2010). Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype. Regen Med, 5(5), 701-11. eScholarID:108521 | PMID:20868326 | DOI:10.2217/rme.10.59
• Tolofari, S., Richardson, S., Freemont, A. & Hoyland, J (2010). Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc. Arthritis Res Ther, 12(1), R1. eScholarID:80105 | PMID:20051117 | DOI:10.1186/ar2898

2009

• Evans, C., Liu, F., Glatt, V., Hoyland, J., Kirker-Head, C., Walsh, A., Betz, O., Wells, J., Betz, V., Porter, R., Saad, F., Gerstenfeld, L., Einhorn, T., Harris, M. & Vrahas, M (2009). Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage. Eur Cell Mater, 18, 96-111. eScholarID:80127 | PMID:20073015
• Fotheringham A, Freemont AJ, Hoyland JA. (2009). Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration. J Tissue Eng Regen Med, eScholarID:1d20131 | DOI:10.1002/term.180
• Kwong F, Hoyland JA, Evans C, Freemont AJ. (2009). Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop, 33( 1), 281-8. eScholarID:1d18430 | DOI:10.1007/s00264-008-0691-z
• Kwong, F., Hoyland, J., Freemont, A. & Evans, C (2009). Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion. J Orthop Res, 27(6), 752-7. eScholarID:80124 | PMID:19058174 | DOI:10.1002/jor.20794
• Le Maitre CL, Baird P, Freemont AJ, Hoyland JA. (2009). An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis Res Ther, 11( 1), eScholarID:1d18679 | DOI:10.1186/ar2611
• Le Maitre CL, Frain J, Millward-Sadler J, Fotheringham AP, Freemont AJ, Hoyland JA. (2009). Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs. Arthritis Rheum, 60( 2), 460-469. eScholarID:1d18427 | DOI:10.1002/art.24248
• Le Maitre, C., Freemont, A. & Hoyland, J (2009). Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. Arthritis Res Ther, 11(5), R137. eScholarID:21118 | PMID:19754961 | DOI:10.1186/ar2808
• Millward-Sadler SJ, Costello PPW, Freemont AJ, Hoyland JA. (2009). Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther, 11( 3), eScholarID:1d20133 | DOI:10.1186/ar2693
• Pockert, A., Richardson, S., Le Maitre, C., Lyon, M., Deakin, J., Buttle, D., Freemont, A. & Hoyland, J (2009). Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum, 60(2), 482-91. eScholarID:80123 | PMID:19180493 | DOI:10.1002/art.24291
• Richardson, S., Doyle, P., Minogue, B., Gnanalingham, K. & Hoyland, J (2009). Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc. Arthritis Res Ther, 11(4), R126. eScholarID:80122 | PMID:19695094 | DOI:10.1186/ar2793

2008

• Ali R, Le Maitre C, Richardson SM, Hoyland JA, Freemont AJ. (2008). Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration. Biotech Histochem, 83( 5), eScholarID:1d18177 | DOI:10.1080/10520290802539186
• Byers RJ, Sakhinia E, Joseph P, Glennie C, Hoyland JA, Menasce L, Radford JA, Illidge TM. (2008). Clinical quantitation of immune signature in follicular lymphoma by RT-PCR-based gene expression profiling. Blood, 111( 9), 4764-70. eScholarID:1d18684 | DOI:10.1182/blood-2007-10-115915
• Heathfield S, Le Maitre C, Hoyland JA. (2008). Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration. Arthritis Res Ther, 10( 4), eScholarID:1d18682 | DOI:10.1186/ar2468
• Hoyland JA, Le Maitre C, Freemont AJ. (2008). Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology, 47(6), 809-814. eScholarID:20720 | DOI:10.1093/rheumatology/ken056
• Kalson N, Richardson SM, Hoyland JA. (2008). Strategies for regeneration of the intervertebral disc. Regen Med, 3( 5), eScholarID:1d18179 | DOI:10.2217/17460751.3.5.717
• Le Maitre C, Frain J, Fotheringham A, Freemont AJ, Hoyland JA. (2008). Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Biorheology, 45( 5), 563-75. eScholarID:1d18428
• Mobasheri A, Bondy C, Moley K, Mendes A, Rosa S, Richardson SM, Hoyland JA, Barrett-Jolley R, Shakibaei M. (2008). Facilitative glucose transporters in articular chondrocytes. Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines. Adv Anat Embryol Cell Biol, 200, eScholarID:1d18178
• Purmessur D, Freemont AJ, Hoyland JA. (2008). Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. Arthritis Res Ther, 10( 4), eScholarID:1d18686 | DOI:10.1186/ar2487
• Richardson SM, Hoyland JA. (2008). Stem cell regeneration of degenerated intervertebral discs: current status. Curr Pain Headache Rep, 12(2), 83-88. eScholarID:1d18180 | DOI:10.1007/s11916-008-0016-3
• Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA. (2008). Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials, 29, eScholarID:1d16493
• Richardson SM, Knowles R, Marples D, Hoyland JA, Mobasheri A. (2008). Aquaporin expression in the human intervertebral disc. J Mol Histol, 39(3), 303-309. eScholarID:1d18181 | DOI:10.1007/s10735-008-9166-1
• Richardson SM, Knowles R, Tyler J, Mobasheri A, Hoyland JA. (2008). Expression of glucose transporters GLUT-1, GLUT-3, GLUT-9 and HIF-1alpha in normal and degenerate human intervertebral disc. Histochem Cell Biol, 129(4), 503-511. eScholarID:1d18182 | DOI:10.1007/s00418-007-0372-9
• Tholouli E, Sweeney E, Barrow E, Clay V, Hoyland JA, Byers RJ. (2008). Quantum dots light up pathology. J Pathol, 216( 3), 275-85. eScholarID:1d18681 | DOI:10.1002/path.2421

2007

• Freemont AJ, Hoyland JA. (2007). Morphology, mechanisms and pathology of musculoskeletal ageing. J Pathol, 211( 2), 252-9. eScholarID:1d16499
• Le Maitre CL, Freemont AJ, Hoyland JA. (2007). Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther, 9( 3), eScholarID:1d16127
• Le Maitre CL, Hoyland JA, Freemont AJ. (2007). Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1 beta and TNF alpha expression profile. Arthritis Res Ther, 9( 4), eScholarID:1d16125
• Le Maitre CL, Hoyland JA, Hoyland JA, Freemont AJ. (2007). Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ-zymographic and gene therapy study. Arthritis Res Ther, 9( 4), eScholarID:1d16150
• Le Maitre CL, Pockert A, Buttle D, Freemont AJ, Hoyland JA. (2007). Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans, 35( Pt 4), 652-5. eScholarID:1d16126
• Richardson SM, Mobasheri A, Freemont AJ, Hoyland JA. (2007). Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies. Histol Histopathol, 22(9), 1033-1041. eScholarID:1d16130
• Sakhinia E, Glennie C, Hoyland JA, Menasce L, Brady G, Miller CCJ, Radford JA, Byers RJ. (2007). Clinical quantitation of diagnostic and predictive gene expression levels in follicular and diffuse large B-cell lymphoma by RT-PCR gene expression profiling. Blood, 109( 9), 3922-8. eScholarID:1d16090

2006

• Freemont AJ, Hoyland JA. (2006). Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: its significance in cartilage repair and replacement. Eur J Radiol, 57( 1), eScholarID:1d20641 | DOI:10.1016/j.ejrad.2005.08.008
• Le Maitre CL, Freemont AJ, Hoyland JA. (2006). A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol, 87( 1), 17-28. eScholarID:1d12922 | DOI:10.1111/j.0959-9673.2006.00449.x
• Le Maitre CL, Freemont AJ, Hoyland JA. (2006). Human disc degeneration is associated with increased MMP 7 expression. Biotech Histochem, 81( 4-6), 125-31. eScholarID:1d16128
• Richardson SM, Richardson SM, Curran JM, Chen R, Vaughan-Thomas A, Hunt JA, Freemont AJ, Hoyland JA. (2006). The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-l-lactic acid (PLLA) scaffolds. Biomaterials, eScholarID:1d12921 | DOI:10.1016/j.biomaterials.2006.03.017
• Richardson SM, Richardson SM, Walker RV, Parker S, Rhodes NP, Hunt JA, Freemont AJ, Hoyland JA. (2006). Intervertebral Disc Cell Mediated Mesenchymal Stem Cell Differentiation. Stem Cells, 24(3), 707-716. eScholarID:1d12058 | DOI:10.1634/stemcells.2005-0205
• Sakhinia E, Byers R, Bashein A, Hoyland JA, Buckle AM, Brady G. (2006). Gene Expression analysis of myeloid and lymphoid lineage during mouse haematopoiesis. British Journal of Haematology, 135(1), 105-116. eScholarID:20735
• Sakhinia E, Farahangpour M, Tholouli E, Liu Yin J, Hoyland JA, Byers RJ, Byers RJ. (2006). Real-time PCR comparison of gene expression profiles in parallel bone marrow and peripheral blood samples in acute myeloid leukaemia. J Clin Pathol, eScholarID:1d13017
• Tholouli, E, Hoyland, JA, Di Vizio, D, O'connell, F, Macdermott, S, Twomey, D, Levenson, R, Yin, J, Golub, T, Loda, M, Byers, RJ. (2006). Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies. Biochem Biophys Res Commun, 348( 2), 628-36. eScholarID:1d13757

2005

• Freemont AJ, Hoyland JA, Denton J. (2005). The effects of lanthanum carbonate and calcium carbonate on bone abnormalities in patients with end-stage renal disease. Clin Nephrol, 64( 6), 428-37. eScholarID:1d12923
• Le Maitre CL, Freemont AJ, Hoyland JA. (2005). The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther, 7( 4), R732-45. eScholarID:1d10886 | DOI:10.1186/ar1732
• Le Maitre CL, Richardson SM, Baird P, Freemont AJ, Hoyland JA. (2005). Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J Pathol, 207(4), 445-452. eScholarID:1d12054 | DOI:10.1002/path.1862
• Mobasheri A, Richardson SM, Mobasheri R, Shakibaei M, Hoyland JA. (2005). Hypoxia inducible factor-1 and facilitative glucose transporters GLUT1 and GLUT3: putative molecular components of the oxygen and glucose sensing apparatus in articular chondrocytes. Histol Histopathol, 20(4), 1327-1338. eScholarID:1d12056
• Sakhinia E, Faranghpour M, Liu Yin J, Brady G, Hoyland JA, Byers RJ. (2005). Routine expression profiling of microarray gene signatures in acute leukaemia by real-time PCR of human bone marrow. Br J Haematol, 130( 2), 233-48. eScholarID:1d12041

2004

• Byers RJ, Roebuck J, Sakhinia E, Hoyland JA. (2004). PolyA PCR amplification of cDNA from RNA extracted from formalin-fixed paraffin-embedded tissue. Diagn Mol Pathol, 13( 3), 144-50. eScholarID:1d13157
• Le Maitre CL, Freemont AJ, Hoyland JA. (2004). Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol, 204( 1), 47-54. eScholarID:1d9610
• Le Maitre CL, Hoyland JA, Freemont AJ. (2004). Studies of human intervertebral disc cell function in a constrained in vitro tissue culture system. Spine, 29( 11), 1187-95. eScholarID:1d9611 | DOI:10.1097/00007632-200406010-00006

2003

• BatraG.S, HaineyL, Freemont AJ, AndrewG, SaundersP.T, Hoyland JA, Braidman IP. (2003). Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women. J Pathol, 200, 1, 65-73. eScholarID:1d25121
• Cheung J, Grant MME, Jones CJP, Hoyland JA, Freemont AJ, Hillarby M. (2003). Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. J Pathol, 201, 3(3), eScholarID:1d7411
• CP Brandwood, Hoyland JA, Hillarby M, Berry JL, Davies M, Selby PL, Mee AP. (2003). Apoptotic gene expression in Paget's disease: a possible role for BCL-2. Journal Of Pathology, 201, 504-512. eScholarID:1d25571
• Hoyland JA, Dixon J.A, Berry JL, Davies M, Selby PL, Mee AP. (2003). A comparison of in situ hybridisation, reverse transcriptase-polymerase chain reaction (RT-PCR) and in situ-RT-PCR for the detection of canine distemper virus RNA in Paget's disease. J.Virol.Methods, 109, 2, 253-259. eScholarID:1d6840
• MeeA.P, Hoyland JA. (2003). In situ hybridization and in situ reverse transcription polymerase chain reaction in human bone sections. Methods Mol.Med, 80, 201-223. eScholarID:1d5911

2002

• Bryden AAG, Hoyland JA, Freemont AJ, Clarke NW, George NJR. (2002). Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases. Br J Cancer, 86(3), 322-325. eScholarID:1d7256
• Bryden AAG, Hoyland JA, Freemont AJ, Clarke NW, Schembri Wismayer D, George NJR. (2002). E-cadherin and beta-catenin are down-regulated in prostatic bone metastases. BJU Int, 89( 4)(4), 400-403. eScholarID:1d7257
• Freemont AJ, Jeziorska M, Hoyland JA, Rooney P, Kumar S. (2002). Mast cells in the pathogenesis of chronic back pain: a hypothesis. J Pathol, 197( 3)(3), 281-285. eScholarID:1d10894
• Freemont AJ, Watkins A, Le Maitre CL, Baird P, Jeziorska M, Knight M.T, Ross E.R, O'Brien J.P, Hoyland JA. (2002). Nerve growth factor expression and innervation of the painful intervertebral disc. J.Pathol, 197, 3, 286-292. eScholarID:1d6826
• Freemont AJ, Watkins A, Le Maitre CL, Jeziorska M, Hoyland JA. (2002). Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J Pathol, 196( 4), 374-9. eScholarID:1d9615
• Freemont AJ, Watkins A, Le Maitre CL, Jeziorska M, Hoyland JA. (2002). Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J.Pathol, 196, 374-379. eScholarID:1d6827
• Hardy, R.G., Tselepis, C., Hoyland, JA, Wallis, Y., Pretlow, T.P., Talbot, I., Sanders, D.S., Matthews, G., Morton, D., Jankowski, J.A. (2002). Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut, 50, 4, 513-519. eScholarID:1d6838
• Sive J.I, Baird P, Jeziorska M, Watkins A, Hoyland JA, Freemont AJ. (2002). Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol.Pathol, 55, 2(2), 91-7. eScholarID:1d6835
• VermaS, RajaratnamJ.H, Denton J, Hoyland JA, Byers RJ. (2002). Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. Journal Of Clinical Pathology, 55, 9, 693-698. eScholarID:1d25123

2001

• Braidman I, Hainey L, Batra G, Selby P, Saunders P, Hoyland JA. (2001). Localization of estrogen receptor beta protein expression in adult human bone. J Bone Miner Res, 16( 2), 214-20. eScholarID:1d12050
• Braidman IP, Hainey L, Batra G, Selby PL, Saunders P.T, Hoyland JA. (2001). Localization of estrogen receptor beta protein expression in adult human bone. J.Bone Miner.Res, 16, 2, 214-220. eScholarID:1d7054
• Byers RJ, Hoyland JA, Braidman IP. (2001). Osteoporosis in men: a cellular endocrine perspective of an increasingly common clinical problem. J.Endocrinol, 168, 3, 353-362. eScholarID:1d7119
• Freemont AJ, LeMaitre C, Watkins A, Hoyland JA. (2001). Degeneration of intervertebral discs: current understanding of cellular and molecular events, and implications for novel therapies. Expert Rev Mol Med, 2001, 1-10. eScholarID:1d10888
• Janusz, M.J., Hookfin, E.B., Heitmeyer, S.A., Woessner, J.F., Freemont, AJ, Hoyland, JA, Brown, K.K., Hsieh, L.C., Almstead, N.G., De, B., Natchus, M.G., Pikul, S., Taiwo, Y.O. (2001). Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. Osteoarthritis.Cartilage, 9, 8, 751-760. eScholarID:1d6831
• JOP Cheung, Hillarby M, S Ayad, Hoyland JA, Jones CJP, Denton J, T Thomas, Wallis Gillian. (2001). A novel cell culture model of chondrocyte differentiation during mammalian endochondral ossification. J Bone Min Res, 16, 309-318. eScholarID:1d3169
• Le Maitre CL, Byers RJ, Liu YinJ.A, Hoyland JA, Freemont AJ. (2001). Dual colour FISH in paraffin wax embedded bone trephines for identification of numerical and structural chromosomal abnormalities in acute myeloid leukaemia and myelodysplasia. J.Clin.Pathol, 54, 9, 730-733. eScholarID:1d7146
• Braidman IP, Hoyland JA, Selby PL. (2001). Comment on "estrogen receptors alpha and beta are differentially expressed in developing bone". J.Clin.Endocrinol.Metab, 86, 11, eScholarID:17d239

2000

• Braidman IP, Baris C, Wood l, Selby PL, Adams JE, Freemont AJ, Hoyland JA. (2000). Preliminary evidence for impaired estrogen receptor-0 protein expression in osteoblasts & osteocytes from men with idiopathic osteoporosis. Bone, 26, 423-427. eScholarID:1d24150
• Byers R.J, Hoyland JA, Dixon J, Freemont AJ. (2000). Subtractive hybridization--genetic takeaways and the search for meaning. 81, 6, eScholarID:1d6837
• Iddon J, Hoyland JA, Downey SE, McMahon R, Baird P, Salter D, Bundred NJ. (2000). Expression of parathyroid hormone-related protein and its receptor in bones metastases from prostrate cancer. J Pathol, 191, 170-174. eScholarID:1d2719
• Núnêz, C., Bashein, A., Brunet, C., Hoyland, J., Freemont, A., Buckle, A., Murphy, C., Cross, M., Lucas, G., Bostock, V. & Brady, G (2000). Expression of the imprinted tumour-suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera. J Pathol, 190(1), 61-8. eScholarID:81625 | PMID:10640993 | DOI:10.1002/(SICI)1096-9896(200001)190:1<61::AID-PATH502>3.0.CO;2-#

1999

• Byers, R., Brown, J., Brandwood, C., Wood, P., Staley, W., Hainey, L., Freemont, A. & Hoyland, J (1999). Osteoblastic differentiation and mRNA analysis of STRO-1-positive human bone marrow stromal cells using primary in vitro culture and poly (A) PCR. J Pathol, 187(3), 374-81. eScholarID:81631 | PMID:10398094 | DOI:10.1002/(SICI)1096-9896(199902)187:3<374::AID-PATH257>3.0.CO;2-V
• Byers, R., Denton, J., Hoyland, J. & Freemont, A (1999). Differential patterns of altered bone formation in different bone compartments in established osteoporosis. J Clin Pathol, 52(1), 23-8. eScholarID:81632 | PMID:10343608
• Freemont, A., Byers, R., Taiwo, Y. & Hoyland, J (1999). In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage. Ann Rheum Dis, 58(6), 357-65. eScholarID:81633 | PMID:10340960
• Hoyland, J. & Picton, M (1999). Cellular mechanisms of renal osteodystrophy. Kidney Int Suppl, 73, S8-13. eScholarID:81626 | PMID:10633457
• Hoyland, J., Baris, C., Wood, L., Baird, P., Selby, P., Freemont, A. & Braidman, I (1999). Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone. J Pathol, 188(3), 294-303. eScholarID:81629 | PMID:10419599 | DOI:10.1002/(SICI)1096-9896(199907)188:3<294::AID-PATH361>3.0.CO;2-Y
• Kennedy, J., Baris, C., Hoyland, J., Selby, P., Freemont, A. & Braidman, I (1999). Immunofluorescent localization of estrogen receptor-alpha in growth plates of rabbits, but not in rats, at sexual maturity. Bone, 24(1), 9-16. eScholarID:81635 | PMID:9916778
• Lawton, D., Andrew, J., Marsh, D., Hoyland, J. & Freemont, A (1999). Expression of the gene encoding the matrix gla protein by mature osteoblasts in human fracture non-unions. Mol Pathol, 52(2), 92-6. eScholarID:81628 | PMID:10474688
• Mylona, P., Hoyland, J. & Sibley, C (1999). Sites of mRNA expression of the cystic fibrosis (CF) and multidrug resistance (MDR1) genes in the human placenta of early pregnancy: No evidence for complementary expression. Placenta, 20(5-6), 493-6. eScholarID:81630 | PMID:10419815 | DOI:10.1053/plac.1999.0400
• Sherwin, A., Carter, D., Poole, C., Hoyland, J. & Ayad, S (1999). The distribution of type VI collagen in the developing tissues of the bovine femoral head. Histochem J, 31(9), 623-32. eScholarID:81627 | PMID:10579632

1998

• Boot-Handford, R., Michaelidis, T., Hillarby, M., Zambelli, A., Denton, J., Hoyland, J., Freemont, A., Grant, M. & Wallis, G (1998). The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol, 79(5), 329-35. eScholarID:81634 | PMID:10193316
• Goddard, C., Smith, A., Hoyland, J., Baird, P., McMahon, R., Freemont, A., Shomaf, M., Haboubi, N. & Warnes, T (1998). Localisation and semiquantitative assessment of hepatic procollagen mRNA in primary biliary cirrhosis. Gut, 43(3), 433-40. eScholarID:81636 | PMID:98634924
• Mee, A., Dixon, J., Hoyland, J., Davies, M., Selby, P. & Mawer, E (1998). Detection of canine distemper virus in 100% of Paget's disease samples by in situ-reverse transcriptase-polymerase chain reaction. Bone, 23(2), 171-5. eScholarID:81637 | PMID:9701477

1997

• Byers, R., Denton, J., Hoyland, J. & Freemont, A (1997). Differential patterns of osteoblast dysfunction in trabecular bone in patients with established osteoporosis. J Clin Pathol, 50(9), 760-4. eScholarID:81638 | PMID:93899772
• Freemont, A., Hampson, V., Tilman, R., Goupille, P., Taiwo, Y. & Hoyland, J (1997). Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific. Ann Rheum Dis, 56(9), 542-9. eScholarID:81639 | PMID:9370879
• Freemont, A., Peacock, T., Goupille, P., Hoyland, J., O'Brien, J. & Jayson, M (1997). Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet, 350(9072), 178-81. eScholarID:81641 | PMID:9250186
• Hoyland, J., Mee, A., Baird, P., Braidman, I., Mawer, E. & Freemont, A (1997). Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction. Bone, 20(2), 87-92. eScholarID:81644 | PMID:9028531
• Lawton, D., Andrew, J., Marsh, D., Hoyland, J. & Freemont, A (1997). Mature osteoblasts in human non-union fractures express collagen type III. Mol Pathol, 50(4), 194-7. eScholarID:81640 | PMID:93503021
• Mee, A., Denton, J., Hoyland, J., Davies, M. & Mawer, E (1997). Quantification of vitamin D receptor mRNA in tissue sections demonstrates the relative limitations of in situ-reverse transcriptase-polymerase chain reaction. J Pathol, 182(1), 22-8. eScholarID:81642 | PMID:9227338 | DOI:10.1002/(SICI)1096-9896(199705)182:1<22::AID-PATH809>3.0.CO;2-I

1996

• A Salo, Hoyland JA, S Ayad, Kielty CM, Freemont AJ, T Kantomaa Pirttiniemi. (1996). The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage: response to mastication forces. Acta Odontologica Scandinavica, 54, eScholarID:1d24902
• Canfield, A., Sutton, A., Hoyland, J. & Schor, A (1996). Association of thrombospondin-1 with osteogenic differentiation of retinal pericytes in vitro. J Cell Sci, 109 ( Pt 2), 343-53. eScholarID:81649 | PMID:8838658
• Freemont, A. & Hoyland, J (1996). Cell adhesion molecules. Clin Mol Pathol, 49(6), M321-M330. eScholarID:81645 | PMID:16696098
• Mee, A., Davenport, L., Hoyland, J., Davies, M. & Mawer, E (1996). Novel and sensitive detection systems for the vitamin D receptor--in situ-reverse transcriptase-polymerase chain reaction and immunogold cytochemistry. J Mol Endocrinol, 16(2), 183-95. eScholarID:81647 | PMID:9156521
• Mee, A., Hoyland, J., Braidman, I., Freemont, A., Davies, M. & Mawer, E (1996). Demonstration of vitamin D receptor transcripts in actively resorbing osteoclasts in bone sections. Bone, 18(4), 295-9. eScholarID:81648 | PMID:8726384
• Tselepis, C., Hoyland, J., Barber, R., Thorp, B. & Kwan, A (1996). Expression and distribution of cartilage matrix macromolecules in avian tibial dyschondroplasia. Avian Pathol, 25(2), 305-24. eScholarID:81646 | PMID:18645860 | DOI:10.1080/03079459608419143

1995

• Andrew, J., Hoyland, J., Freemont, A. & Marsh, D (1995). Platelet-derived growth factor expression in normally healing human fractures. Bone, 16(4), 455-60. eScholarID:81651 | PMID:7605706
• Cooper, R., Freemont, A., Hoyland, J., Jenkins, J., West, C., Illingworth, K. & Jayson, M (1995). Herniated intervertebral disc-associated periradicular fibrosis and vascular abnormalities occur without inflammatory cell infiltration. Spine (Phila Pa 1976), 20(5), 591-8. eScholarID:81653 | PMID:7604329
• Mee, A., Hoyland, J., Baird, P., Bennett, D. & Sharpe, P (1995). Canine bone marrow cell cultures infected with canine distemper virus: an in vitro model of Paget's disease. Bone, 17(4 Suppl), 461S-466S. eScholarID:81650 | PMID:8579953
• Rehman, M., Hoyland, J., Denton, J. & Freemont, A (1995). Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis. J Clin Pathol, 48(3), 229-35. eScholarID:81652 | PMID:77304837
• Y Mylona, Kielty CM, Hoyland JA, JA Aplin. (1995). Expression of type VI collagen mRNAs in human endometrium during the menstrual cycle and first trimester of pregnancy. J. Reprod. Fertil, 103, eScholarID:1d24896

1994

• Hoyland, J., Freemont, A. & Sharpe, P (1994). Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res, 9(1), 75-80. eScholarID:81656 | PMID:8154312 | DOI:10.1002/jbmr.5650090111
• Rehman, M., Hoyland, J., Denton, J. & Freemont, A (1994). Age related histomorphometric changes in bone in normal British men and women. J Clin Pathol, 47(6), 529-34. eScholarID:81655 | PMID:80639354

1993

• Das-Gupta, E., Lyons, T., Hoyland, J., Lawton, D. & Freemont, A (1993). New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis. Int J Exp Pathol, 74(6), 627-34. eScholarID:81658 | PMID:8292560
• Dean, G., Hoyland, J., Denton, J., Donn, R. & Freemont, A (1993). Mast cells in the synovium and synovial fluid in osteoarthritis. Br J Rheumatol, 32(8), 671-5. eScholarID:81660 | PMID:8348268
• Hoyland, J., Newson, L., Jayson, M. & Freemont, A (1993). The vascular basement membrane in systemic sclerosis skin: heterogeneity of type IV collagen. Br J Dermatol, 129(4), 384-8. eScholarID:81659 | PMID:8217749
• Walsh, L., Freemont, A. & Hoyland, J (1993). The effect of tissue decalcification on mRNA retention within bone for in-situ hybridization studies. Int J Exp Pathol, 74(3), 237-41. eScholarID:81661 | PMID:8392858

1991

• Hoyland, J. & Freemont, A (1991). Investigation of a quantitative post-hybridization signal amplification system for mRNA-oligodeoxyribonucleotide in situ hybridization. J Pathol, 164(1), 51-8. eScholarID:81663 | PMID:2056388 | DOI:10.1002/path.1711640110
• Hoyland, J., Thomas, J., Donn, R., Marriott, A., Ayad, S., Boot-Handford, R., Grant, M. & Freemont, A (1991). Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage. Bone Miner, 15(2), 151-63. eScholarID:81662 | PMID:1764631
• Marles, P., Hoyland, J., Parkinson, R. & Freemont, A (1991). Demonstration of variation in chondrocyte activity in different zones of articular cartilage: an assessment of the value of in-situ hybridization. Int J Exp Pathol, 72(2), 171-82. eScholarID:81664 | PMID:2015200

1989

• Hoyland, J., Freemont, A. & Jayson, M (1989). Intervertebral foramen venous obstruction. A cause of periradicular fibrosis? Spine (Phila Pa 1976), 14(6), 558-68. eScholarID:81665 | PMID:2749370

1988

• Hoyland, J., Freemont, A., Denton, J., Thomas, A., McMillan, J. & Jayson, M (1988). Retained surgical swab debris in post-laminectomy arachnoiditis and peridural fibrosis. J Bone Joint Surg Br, 70(4), 659-62. eScholarID:81666 | PMID:3403620