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School of Medicine

Professor Karl Herholz MD, FRCP

Photograph of Karl Herholz

Professor of Clinical Neuroscience

The University of Manchester
Wolfson Molecular Imaging Centre
27 Palatine Road
Manchester
England
M20 3LJ

 

Role

 

Memberships of Committees and Professional Bodies

  • Royal College of Physicians, fellow
  • Royal Society of Medicine, fellow
  • Association of British Neurologists
  • British Neuro-Oncology Society
  • Deutsche Gesellschaft für Neurologie
  • Society of Cerebral Blood Flow and Metabolism
  • Manchester Medical Society
  • British Medical Association
  • Society of Nuclear Medicine
    • Brain Imaging Council, President (2010/2011)

Research

  • Neuroimaging studies (PET and MRI) of
    • dementia (early diagnosis of dementia in patients with mild cognitive deficits, multicentre studies, impairment of specific transmitter systems and their relevance for cognitive symptoms and distinction of dementing disorders, monitoring of progression, clinical trials in collaboration with pharmaceutical companies)
    • brain tumors (grading of metabolic activity, detection of progression to higher grade of malignancy, interference with and plasticity of normal brain function, monitoring of therapy, 3D visualization for planning of neurosurgical intervention)
  • Coordination of International Multicentre Studies
    • Early Diagnosis of Neurodegenerative Diseases within the EU-funded Networks on Diagnostic Molecular Imaging (www.dimi.eu) and Imaging of Neuroinflammation in Neurodegenerative Diseases (INMiND)
    • Chief investigator of the EU-funded "Network for Efficiency and Standardisation of Dementia Diagnosis" (NEST-DD) with a comprehensive clinical and neuroimaging digital database of more than 1000 subjects
    • Collaboration with the NIH-funded Alzheimer’s Disease Neuroimaging Initiative (ADNI)
 

Methodological Knowledge

  • Functional neuroimaging, especially using positron emission tomography (PET)
  • Accredited expert in radiation protection (ARSAC)
 

Biography

  • Graduation as medical doctor at the University of Erlangen, Germany, in 1980
  • After basic general clinical training, clinical research fellow at the Max-Planck-Institute for Neurological Research in Cologne, Germany, since 1982
  • Clinical specialist training in neurology at municipal and university hospitals, Cologne, Germany, from 1982 to 1990
  • Since 1994 professor of neurology at the University of Cologne
  • Since 2005, after moving to the University of Manchester, UK, professor in clinical neuroscience and head of the neuroscience imaging programme at the Wolfson Molecular Imaging Centre (WMIC)
  • WMIC director from April 2006 to July 2010
 

Qualifications

  • Doctor of medicine (Dr.med.), University of Erlangen, Germany
  • Specialist board examination in neurology, Duesseldorf, Germany
  • Habilitation and Venia legendi in neurology, University of Cologne, Germany
 

Publications

2012

  • Bohnen, N., Djang, D., Herholz, K., Anzai, Y. & Minoshima, S (2012). Effectiveness and Safety of 18F-FDG PET in the Evaluation of Dementia: A Review of the Recent Literature. J Nucl Med, 53(1), 59-71. eScholarID:153916 | DOI:jnumed.111.096578 [pii] 10.2967/jnumed.111.096578
  • Djang, D., Janssen, M., Bohnen, N., Booij, J., Henderson, T., Herholz, K., Minoshima, S., Rowe, C., Sabri, O., Seibyl, J., Van Berckel, B. & Wanner, M (2012). SNM Practice Guideline for Dopamine Transporter Imaging with 123I-Ioflupane SPECT 1.0. J Nucl Med, 53(1), 154-63. eScholarID:153913 | DOI:jnumed.111.100784 [pii] 10.2967/jnumed.111.100784

2011

  • Carter, S., Caine, D., Burns, A., Herholz, K. & Lambon Ralph, M (2011). Staging of the cognitive decline in Alzheimer's disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer's disease. Int J Geriatr Psychiatry, eScholarID:153912 | DOI:10.1002/gps.2738
  • Cawthorne, C., Prenant, C., Smigova, A., Julyan, P., Maroy, R., Herholz, K., Rothwell, N. & Boutin, H (2011). Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [(1)F]-IL1RA and PET imaging in rats. Br J Pharmacol, 162(3), 659-72. eScholarID:153915 | DOI:10.1111/j.1476-5381.2010.01068.x
  • Drake, C., Boutin, H., Jones, M., Denes, A., McColl, B., Selvarajah, J., Hulme, S., Georgiou, R., Hinz, R., Gerhard, A., Vail, A., Prenant, C., Julyan, P., Maroy, R., Brown, G., Smigova, A., Herholz, K., Kassiou, M., Crossman, D., Francis, S., Proctor, S., Russell, J., Hopkins, S., Tyrrell, P., Rothwell, N. & Allan, S (2011). Brain inflammation is induced by co-morbidities and risk factors for stroke. Brain Behav Immun, 25(6), 1113-22. eScholarID:128095 | DOI:S0889-1591(11)00058-4 [pii] 10.1016/j.bbi.2011.02.008
  • Herholz, K (2011). Amyloid PET: Its diagnostic potential compared to FDG. Medicine Nucleaire, 35, 322-326. eScholarID:128096 | DOI:10.1016/j.mednuc.2011.02.007
  • Herholz, K (2011). Molecular imaging in Alzheimer's Disease. European Neurological Review, 6(1), 16-20. eScholarID:128098 | DOI:10.1016/j.jalz.2010.05.515
  • Herholz, K (2011). Perfusion SPECT and FDG-PET. Int Psychogeriatr, 1-7. eScholarID:153911 | DOI:S1041610211000937 [pii] 10.1017/S1041610211000937
  • Herholz, K. & Ebmeier, K (2011). Clinical amyloid imaging in Alzheimer’s disease. Lancet Neurology, 10, 667-670. eScholarID:128097 | DOI:10.1016/S1474-4422(11)70123-5
  • Herholz, K., Westwood, S., Haense, C. & Dunn, G (2011). Evaluation of a calibrated (18)F-FDG PET score as a biomarker for progression in Alzheimer disease and mild cognitive impairment. J Nucl Med, 52(8), 1218-26. eScholarID:134134 | PMID:21764801 | DOI:10.2967/jnumed.111.090902
  • Kalbe, E., Onur, O., Minnerop, M., Reimann, J., Althaus, A., Ahmadzadehfar, H., Dodel, R., Strach, K., Clemen, C., Herholz, K., Haense, C., Fink, G. & Schroder, R (2011). Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study. J Neurol, 258(3), 515-8. eScholarID:153914 | DOI:10.1007/s00415-010-5774-2
  • Markiewicz, P., Matthews, J., Declerck, J. & Herholz, K (2011). Robustness of correlations between PCA of FDG-PET scans and biological variables in healthy and demented subjects. Neuroimage, 56(2), 782-7. eScholarID:128100 | DOI:S1053-8119(10)00800-1 [pii] 10.1016/j.neuroimage.2010.05.066
  • Markiewicz, P., Matthews, J., Declerck, J. & Herholz, K (2011). Verification of predicted robustness and accuracy of multivariate analysis. Neuroimage, 56(3), 1382-5. eScholarID:128099 | DOI:S1053-8119(11)00192-3 [pii] 10.1016/j.neuroimage.2011.02.036
  • Merhof, D., Markiewicz, P., Platsch, G., Declerck, J., Weih, M., Kornhuber, J., Kuwert, T., Matthews, J. & Herholz, K (2011). Optimized data preprocessing for multivariate analysis applied to (99m)Tc-ECD SPECT data sets of Alzheimer's patients and asymptomatic controls. J Cereb Blood Flow Metab, 31(1), 371-83. eScholarID:107300 | DOI:10.1038/jcbfm.2010.112

2010

  • Galldiks N, Kracht LW, Berthold F, Miletic H, Klein JC, Herholz KG, Jacobs AH, Heiss WD. (2010). [11C]-L-Methionine Positron Emission Tomography in the Management of Children and Young Adults with Brain Tumours. Journal of Neuro-Oncology, 96(2), 231-239. eScholarID:1d19616 | DOI:10.1007/s11060-009-9953-x
  • Haense, C., Kalbe, E., Herholz, K., Hohmann, C., Neumaier, B., Krais, R. & Heiss, W (2010). Cholinergic system function and cognition in mild cognitive impairment. Neurobiol Aging, eScholarID:107297 | DOI:10.1016/j.neurobiolaging.2010.08.015
  • Hampel, H., R. Frank, K. Broich, S. Teipel, R. G. Katz, J. Hardy, K. Herholz, A. L. Bokde, F. Jessen, Y. G. Hoessler, W. R. Sanhai, H. Zetterberg, J. Woodcock and K. Blennow. (2010). Biomarkers for Alzheimer’s disease: academic, industry and regulatory perspectives. Nature Reviews Drug Discovery, 9, 560-574. eScholarID:84161 | DOI:10.1038/nrd3115
  • Herholz, K (2010). Cerebral glucose metabolism in preclinical and prodromal Alzheimer's disease. Expert Rev Neurother, 10(11), 1667-73. eScholarID:107296 | DOI:10.1586/ern.10.136
  • Kalbe, E., Onur, O., Minnerop, M., Reimann, J., Althaus, A., Ahmadzadehfar, H., Dodel, R., Strach, K., Clemen, C., Herholz, K., Haense, C., Fink, G. & Schroder, R (2010). Early signs of VCP-related frontotemporal dementia: a neuropsychological, FDG-PET and fMRI study. J Neurol, eScholarID:107298 | DOI:10.1007/s00415-010-5774-2
  • Terriere, E., Dempsey, M., Herrmann, L., Tierney, K., Lonie, J., O'Carroll, R., Pimlott, S., Wyper, D., Herholz, K. & Ebmeier, K (2010). 5-(123)I-A-85380 binding to the alpha4beta2-nicotinic receptor in mild cognitive impairment. Neurobiol Aging, 31(11), 1885-93. eScholarID:107295 | DOI:S0197-4580(08)00365-5 [pii] 10.1016/j.neurobiolaging.2008.10.008
  • Tolboom, N., van der Flier, W., Boverhoff, J., Yaqub, M., Wattjes, M., Raijmakers, P., Barkhof, F., Scheltens, P., Herholz, K., Lammertsma, A. & van Berckel, B (2010). Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images. J Neurol Neurosurg Psychiatry, 81(8), 882-4. eScholarID:107299 | DOI:jnnp.2009.194779 [pii] 10.1136/jnnp.2009.194779

2009

  • Herholz, K. (2009). Functional imaging with FDG-PET in mild cognitive impairment. Imaging the Aging Brain. In Jagust, W., D'Esposito, M (Ed.), Imaging the Aging Brain. (pp. 183-190). Oxford: Oxford University Press. eScholarID:84157
  • Haense, C., K. Herholz, W. J. Jagust and W. D. Heiss. (2009). Performance of FDG PET for Detection of Alzheimer’s Disease in Two Independent Multicenter Samples (NEST-DD and ADNI). Dementia and Geriatric Cognitive Disorders, 28, 259-266. eScholarID:84158 | DOI:10.1159/000241879
  • Markiewicz, P. J., J. C. Matthews, J. Declerck and K. Herholz. (2009). Robustness of multivariate image analysis assessed by resampling techniques and applied to FDG-PET scans of patients with Alzheimer's disease. Neuroimage, 46(2), 472-485. eScholarID:84166 | DOI:10.1016/j.neuroimage.2009.01.020
  • Salmon, E, Kerrouche, N, Perani, D, Lekeu, F, Holthoff, V, Beuthien-Baumann, B, Sorbi, S, Lemaire, C, Collette, F, Herholz, KG. (2009). On the multivariate nature of brain metabolic impairment in Alzheimer's disease. Neurobiol Aging, 30(2), 186-197. eScholarID:1d17584 | DOI:10.1016/j.neurobiolaging.2007.06.010
  • Ullrich, R. T., L. Kracht, A. Brunn, K. Herholz, P. Frommolt, H. Miletic, M. Deckert, W. D. Heiss and A. H. Jacobs. (2009). Methyl-L-11C-methionine PET as a diagnostic marker for malignant progression in patients with glioma. Journal of Nuclear Medicine, 50(12), 1962-1968. eScholarID:84172 | DOI:10.2967/jnumed.109.065904

2008

  • Garibotto, V, Borroni, B, Kalbe, E, Herholz, KG, Salmon, E, Holtoff, V, Sorbi, S, Cappa, S, Padovani, A, Fazio, F, Perani, D. (2008). Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence. Neurology, 71( 17), eScholarID:1d19520 | DOI:10.1212/01.wnl.0000327670.62378.c0
  • Haense CC, Buerger K, Kalbe E, Drzezga A, Teipel S, Markiewicz P, Herholz KG, Heiss W, Hampel H. (2008). CSF total and phosphorylated tau protein, regional glucose metabolism and dementia severity in Alzheimer's disease. Eur J Neurol, 15( 11), eScholarID:1d19521 | DOI:10.1111/j.1468-1331.2008.02274.x
  • Herholz KG, Weisenbach S, Kalbe E. (2008). Deficits of the cholinergic system in early AD. Neuropsychologia, 46( 6), 1642-7. eScholarID:1d17580
  • Herholz KG. (2008). Acetylcholine esterase activity in mild cognitive impairment and Alzheimer's disease. Eur J Nucl Med Mol Imaging, 35 Suppl 1, S25-9. eScholarID:1d17581
  • Klein J, Herholz KG, Wienhard K, Heiss W. (2008). Cortical flattening applied to high-resolution 18F-FDG PET. J Nucl Med, 49( 1), 44-9. eScholarID:1d17582
  • Mosconi, L, Tsui, W, Herholz, KG, Pupi, A, Drzezga, A, Lucignani, G, Reiman, E, Holthoff, V, Kalbe, E, Sorbi, S, Diehl-Schmid, J, Perneczky, R, Clerici, F, Caselli, R, Beuthien-Baumann, B, Kurz, A, Minoshima, S, de Leon, M. (2008). Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementias. J Nucl Med, 49( 3), 390-8. eScholarID:1d17579 | DOI:10.2967/jnumed.107.045385
  • Salmon E, Perani D, Collette F, Feyers D, Kalbe E, Holthoff V, Sorbi S, Herholz KG. (2008). A comparison of unawareness in frontotemporal dementia and Alzheimer's disease. J Neurol Neurosurg Psychiatry, 79( 2), 176-9. eScholarID:1d17583
  • Terrière, E, Dempsey, M, Herrmann, L, Tierney, K, Lonie, J, O'Carroll, R, Pimlott, S, Wyper, D, Herholz, KG, Ebmeier, K. (2008). 5-(123)I-A-85380 binding to the alpha4beta2-nicotinic receptor in mild cognitive impairment. Neurobiol Aging, eScholarID:1d19523 | DOI:10.1016/j.neurobiolaging.2008.10.008

2007

  • Coope DJ, Herholz KG, Price PM. (2007). Brain tumours: planning and monitoring therapy with PET. In: Cancer Imaging, Hayat M (ed). Elsevier Science. eScholarID:3d1091
  • Vollmar S, Hampl JA, Kracht L, Herholz KG. (2007). Integration of Functional Data (PET) into Brain Surgery Planning and Neuronavigation. Advances in Medical Engineering. Springer. eScholarID:3d951
  • Coope DJ, Cizek J, Eggers C, Vollmar S, Heiss W, Herholz KG. (2007). Evaluation of Primary Brain Tumors Using <sup>11</sup>C-Methionine PET with Reference to a Normal Methionine Uptake Map. Journal of Nuclear Medicine, 48(12), 1971-80. eScholarID:1d16835
  • Eggers C, Szelies B, Bauer B, Wienhard K, Schröder H, Herholz KG, Heiss W. (2007). Imaging of acetylcholine esterase activity in brainstem nuclei involved in regulation of sleep and wakefulness. Eur J Neurol, 14( 6), 690-3. eScholarID:1d17585
  • Herholz KG, Carter S, Jones M. (2007). Positron emission tomography imaging in dementia. Br J Radiol, 80 Spec No 2, S160-7. eScholarID:1d17578
  • Herholz KG, Coope DJ, Jackson A. (2007). Metabolic and molecular imaging in neuro-oncology. Lancet Neurology, 6(8), 711-24. eScholarID:1d16060
  • Herting, B, Beuthien-Baumann, B, Pöttrich, K, Donix, M, Triemer, A, Lampe, J, von Kummer, R, Herholz, KG, Reichmann, H, Holthoff, V. (2007). Prefrontal cortex dysfunction and depression in atypical parkinsonian syndromes. Mov Disord, 22( 4), 490-7. eScholarID:1d17587
  • Rueger, M, Kracht, L, Hilker, R, Thiel, A, Sobesky, J, Winkeler, A, Thomas, A, Heneka, M, Graf, R, Herholz, KG, Heiss, W, Jacobs, A. (2007). Role of in vivo imaging of the central nervous system for developing novel drugs. Q J Nucl Med Mol Imaging, 51( 2), 164-81. eScholarID:1d17586

2006

  • Herholz KG, Morris CM, Perani D. (2006). The dementias: early diagnosis and evaluation. Taylor & Francis. eScholarID:4d156
  • Herholz KG. (2006). Positron emission tomography (PET) ligands and metabolic brain imaging. Neurodegenerative Diseases. Henry Stewart Talks. eScholarID:3d963
  • Coope DJ, Vollmar S, Eggers C, Herholz KG, Heiss WD. (2006). Development of a normal <sup>11</sup>C-methionine PET uptake map: a novel approach to the evaluation of brain tumors using PET [Abstracts for the Seventh Congress of the European Association for Neuro-Oncology (EANO)]. eScholarID:2d2046
  • Eggers C, Herholz KG, Kalbe E, Heiss W. (2006). Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease. Neurosci Lett, 408( 1), 46-50. eScholarID:1d14191
  • Galldiks N, Kracht L, Burghaus L, Thomas A, Jacobs A, Heiss W, Herholz KG. (2006). Use of 11C-methionine PET to monitor the effects of temozolomide chemotherapy in malignant gliomas. Eur J Nucl Med Mol Imaging, 33( 5), 516-24. eScholarID:1d14192
  • Heiss W, Herholz KG. (2006). Brain receptor imaging. J Nucl Med, 47( 2), 302-12. eScholarID:1d14193
  • Herholz KG. (2006). Cognitive dysfunction and emotional-behavioural changes in MS: the potential of positron emission tomography. J Neurol Sci, 245( 1-2), 9-13. eScholarID:1d14194
  • Kerrouche N, Herholz KG, Mielke R, Holthoff V, Baron J. (2006). 18FDG PET in vascular dementia: differentiation from Alzheimer's disease using voxel-based multivariate analysis. J Cereb Blood Flow Metab, 26( 9), 1213-21. eScholarID:1d14195
  • Kracht LW, Herholz KG, Vollmar S, Jacobs AH. (2006). Brain Tumors: Astrocytoma, Oligodendroglioma, and Glioblastoma Images with PET and SPECT. Molecular Anatomic Imaging: PET-CT and SPECT-CT Integrated Modality Imaging Lippincott, eScholarID:1d33052
  • Masdeu, J, Irimia, P, Asenbaum, S, Bogousslavsky, J, Brainin, M, Chabriat, H, Herholz, KG, Markus, H, Martínez-Vila, E, Niederkorn, K, Schellinger, P, Seitz, R, NULL. (2006). EFNS guideline on neuroimaging in acute stroke. Report of an EFNS task force. Eur J Neurol, 13( 12), eScholarID:1d21256 | DOI:10.1111/j.1468-1331.2006.01507.x
  • Peters, F, Perani, D, Herholz, KG, Holthoff, V, Beuthien-Baumann, B, Sorbi, S, Pupi, A, Degueldre, C, Lemaire, C, Collette, F, Salmon, E. (2006). Orbitofrontal dysfunction related to both apathy and disinhibition in frontotemporal dementia. Dement Geriatr Cogn Disord, 21( 5-6), 373-9. eScholarID:1d14196
  • Salmon, E, Kerrouche, N, Herholz, KG, Perani, D, Holthoff, V, Beuthien-Baumann, B, Degueldre, C, Lemaire, C, Luxen, A, Baron, J, Collette, F, Garraux, G. (2006). Decomposition of metabolic brain clusters in the frontal variant of frontotemporal dementia. Neuroimage, 30( 3), 871-8. eScholarID:1d14197
  • Salmon, E, Perani, D, Herholz, KG, Marique, P, Kalbe, E, Holthoff, V, Delbeuck, X, Beuthien-Baumann, B, Pelati, O, Lespagnard, S, Collette, F, Garraux, G. (2006). Neural correlates of anosognosia for cognitive impairment in Alzheimer's disease. Hum Brain Mapp, 27( 7), 588-97. eScholarID:1d14198
  • Thiel A, Habedank B, Herholz KG, Kessler J, Winhuisen L, Haupt W, Heiss W. (2006). From the left to the right: How the brain compensates progressive loss of language function. Brain Lang, 98( 1), 57-65. eScholarID:1d14199

2005

  • Anchisi, D, Borroni, B, Franceschi, M, Kerrouche, N, Kalbe, E, Beuthien-Beumann, B, Cappa, S, Lenz, O, Ludecke, S, Marcone, A, Mielke, R, Ortelli, P, Padovani, A, Pelati, O, Pupi, A, Scarpini, E, Weisenbach, S, Herholz, KG, Salmon, E, Holthoff, V, Sorbi, S, Fazio, F, Perani, D. (2005). Heterogeneity of brain glucose metabolism in mild cognitive impairment and clinical progression to Alzheimer disease. Arch Neurol, 62( 11), 1728-33. eScholarID:1d14184
  • Cizek J, Herholz KG, Schrader R. (2005). Robust non-linear registration of 3D medical images with one-to-one deformations. Neuroimage, eScholarID:1d10969
  • Herholz KG, Habedank B, Wallesch C W, Forstl. (2005). Funktionelle bildgebende Diagnostik. Demenzen, 134-139. eScholarID:1d10974
  • Herholz KG, Weisenbach S, Kalbe E, Diederich N, Heiss W. (2005). Cerebral acetylcholine esterase activity in mild cognitive impairment. Neuroreport, 16( 13), 1431-4. eScholarID:1d14185
  • Herholz KG. (2005). Action of cholinesterase inhibitors in patients' brains. Journal of Neurology, Neurosurgery and Psychiatry, 76 (3), eScholarID:1d10870
  • Hilker F, Schweitzer K, Coburger S, Ghaemi M, Weisenbach S, Jacobs AH, Rudolf J, Herholz KG, Heiss WD. (2005). Nonlinear Progression of Parkinson Disease as Determined by Serial Positron Emission Tomographic Imaging of Striatal Fluorodopa F 18 Activity. Archives of Neurology, 62 (3), 378-382. eScholarID:1d10905
  • Hilker R, Portman A T, Voges J, Staal M J, Burghaus L, van Laar T, Koulousakis A, Maguire R P, Pruim J, Herholz, KG, Sturm V, Heiss W D, Leenders K L. (2005). Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. Journal of Neurology, Neurosurgery and Psychiatry, eScholarID:1d10911
  • Hilker R, Thomas A, Klein J, Weisenbach S, Kalbe E, Burghaus L, Jacobs A, Herholz KG, Heiss W. (2005). Dementia in Parkinson disease: functional imaging of cholinergic and dopaminergic pathways. Neurology, 65( 11), 1716-22. eScholarID:1d14189
  • Holthoff VA, Beuthien-Baumann B, Kalbe E, Ludecke S, Lenz O, Zundorf G, Spirling S, Schierz K, Winiecki P, Sorbi S, Herholz, KG. (2005). Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression. Biol Psychiatry, 57 (4), 412-421. eScholarID:1d10907
  • Jacobs A H, Kracht L W, Grossman A, Roger M A, Thomas A V, Thiel A, Herholz KG. (2005). Imaging in Neurooncology. NeuroRx, 2, 333-347. eScholarID:1d10972
  • Jacobs, A, Thomas, A, Kracht, L, Li, H, Dittmar, C, Garlip, G, Galldiks, N, Klein, J, Sobesky, J, Hilker, R, Vollmar, S, Herholz, KG, Wienhard, K, Heiss, W. (2005). 18F-fluoro-L-thymidine and 11C-methylmethionine as markers of increased transport and proliferation in brain tumors. J Nucl Med, 46( 12), 1948-58. eScholarID:1d14190
  • Kalbe E, Salmon E, Perani D, Holthoff V, Sorbi S, Elsner A, Weisenbach S, Brand M, Lenz O, Kessler J, Luedecke S, Ortelli P, Herholz, KG. (2005). Anosognosia in very mild Alzheimer's disease but not in mild cognitive impairment. Dementia & Geriatric Cognitive Disorders, 19, 349-356. eScholarID:1d10912
  • Lange C, Kracht L, Herholz KG, Sachsse U, Irle E. (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research (Neuroimaging Section) Epub, eScholarID:1d10975
  • Mosconi L, Pupi A, Herholz KG, Prohovnik I, Nacmias B, De Cristofaro M T R, Fayyaz M, Bracco L, Sorbi S. (2005). Metabolic interaction between ApoE genotype and onset age in Alzheimer's disease: implications for brain reserve. Journal of Neurology, Neurosurgery and Psychiatry, 76 (1), 15-23. eScholarID:1d10910
  • Salmon E, Lespagnard S, Marique P, Peeters F, Herholz, KG, Perani D, Holthoff V, Kalbe E, Anchisi D, Adam S, Collette F, Garraux G. (2005). Cerebral metabolic correlates of four dementia scales in Alzheimer's disease. Journal of Neurology Epub, eScholarID:1d10913
  • Sobesky J, Thiel A, Ghaemi M, Hilker R, Jacobs A, Rudolf J, Herholz KG, Heiss W D. (2005). Crossed cerebellar diaschisis in acute human stroke: A PET study of serial changes and response to supratentorial reperfusion. Journal of Cerebral Blood Flow and Metabolism Epub, eScholarID:1d10968
  • Thiel A, Habedank B, Winhuisen L, Herholz KG, Kessler J, Haupt W F, Heiss W D. (2005). Essential language function of the right hemisphere in brain tumor patients. Annals of Neurology, 57(1), 128-131. eScholarID:1d10908 | DOI:10.1002/ana.20342
  • Thiel A, Haupt W F, Habedank B, Winhuisen L, Herholz KG, Kessler J. (2005). Neuroimaging guided rTMS of left inferior frontal gyrus interferes with repetition priming. Neuroimage, 25 (3), 815-823. eScholarID:1d10909

2004

  • Herholz KG, Herscovitch P, Heiss W D. (2004). NeuroPET. Berlin/Heidelberg/NY: Springer. eScholarID:4d134
  • Vollmar S, Cizek J, Sue M, Klein J, Herholz KG, Jacobs A, Kremer K, Macho V. (2004). VINCI -"Volume imaging in Neurological Research, Co-Registration and ROIs included". Forschung and wissenschaftliches Rechnen 2003. eScholarID:3d839
  • Cizek J, Herholz KG, Vollmar S, Schrader R, Klein J, Heiss W D. (2004). Fast and robust registraion of PET and MR images of human brain. Neuroimage, 22(1), 434-442. eScholarID:1d10979
  • Galldiks N, Burghaus L, Vollmar S, Cizek J, Impekoven P, Thomas A, Jacobs A H, Herholz KG. (2004). Novel Neuroimaging Findings in a Patient with Cerebral Whipple's Disease: A magnetic Resonance Imaging and Positron Emission Tomography Study. Journal of Neuroimaging, 14(4), 372-376. eScholarID:1d10978
  • Hartmann P, Herholz KG, Salzberger B, Petereit H F. (2004). Unusual and severe symptomatic impairment of neutrophil function after one cycle of temozolomide in patients with malignant glioma. Ann. Hematol, 83(4), eScholarID:1d10982
  • Heiss WD, Habedank B, Klein J C, Herholz KG, Wienhard K, Lenox M, Nutt R. (2004). Metabolic Rates in Small Brain Nuclei Determined by High-Resolution PET. Journal of Nuclear Medicine, 45(11), 1811-1815. eScholarID:1d10965
  • Herholz KG, Heiss W D. (2004). PET in clinical neurology. Molecular Imaging & Biology, 6(4), eScholarID:1d10984
  • Herholz KG, Weisenbach S, Zundorf G, Lenz O, Schrader H, Bauer B, Kalbe E, Heiss W D. (2004). In-vivo Study of Acetylcholine Esterase in Basal Forebrain, Amygdala, and Cortex in Mild to Moderate Alzheimer disease. Neuroimage, 21(1), 136-143. eScholarID:1d10988 | DOI:10.1016/j.neuroimage.2003.09.042
  • Herholz, KG, Zundorf G, Bauer B, Weisenbach S, Heiss W D, Silman I, Soreq H, Anglister L, Michaelson D M, Fisher A. (2004). Measuring cerebral acetylcholine esterase activity in Alzheimer dementia by PET functional parametric imaging. Cholinergic Mechanisms, eScholarID:1d10981
  • Holthoff V A, Beuthien-Baumann B, Zundorf G, Triemer A, Lundecke S, Winiecki P, Koch R, Fuchtner F, Herholz KG. (2004). Changes in Brain Metabolism Associated with Remission in Unipolar Major Deprssion. Acta Psychiatr.Scand, 110(3), 184-194. eScholarID:1d10980
  • Kracht L W, Miletic H, Busch S, Jacobs A H, Voges J, Hoevels M, Klein J C, Herholz KG, Heiss W D. (2004). Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathology. Clinical Cancer Research, 10, 7163-7170. eScholarID:1d26691
  • Kracht L W, Miletic H, Busch S, Jacobs A H, Voges J, Hoevels M, Lucht H, Herholz KG, Heiss W D. (2004). Brain Tumor Extent with [11C]-L-methionine Positron Emission Tomography: Local Comparison with Stereotactic Histopatholoy. Clinical Cancer Research, 10, 7163-7170. eScholarID:1d10967
  • Mosconi L, Nacmias B, Sorbi S, De Cristofaro M T, Fayazz M, Tedde A, Bracco L, Herholz KG, Pupi A. (2004). Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 75(3), eScholarID:1d10977
  • Mosconi L, Perani D, Sorbi S, Herholz, KG, Nacmias B, Holthoff V, Salmon E, Baron J C, De Cristofaro M T, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A. (2004). MCI conversion to dementia and the APOE genotype: A prediction study with FDG-PET. Neurology, 63(12), 2332-2340. eScholarID:1d10966
  • Mosconi L, Pupi A, De Cristofaro M T, Fayyaz M, Sorbi S, Herholz KG. (2004). Functional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease. The journal of Nuclear Medicine, 45(3), 382-392. eScholarID:1d10976
  • Mosconi L, Sorbi S, Nacmias B, De Cristofaro M T, Fayyaz M, Bracco L, Herholz KG, Pupi A. (2004). Age and ApoE genotype interaction in Alzheimer's disease: an FDG-PET study. Psychiatry Research: Neuroimaging, 130(2), eScholarID:1d10983
  • Hilker R, Voges J, Weisenbach S, Kalbe E, Burghaus L, Ghaemi M, Lehrke R, Koulousakis A, Herholz, KG, Sturm V, Heiss W D. (2004). Subthalamic nucleus stimulation restores glucose metabolism in associative and limbic cortices and in cerebellum: evidence from a FDG-PET study in advanced Parkinson's disease. Journal of Cerebral Blood Flow & Metabolism, 24, 7. eScholarID:17d214

2003

  • Ebmeier K P, Darcourt J, Dougall N J, Glasbus M F, Herholz, KG, Koulibaly P M, Migneco O, Nobili F, Pupi A, Robert P, Rodriguez G, Scheidhauer K, Ebmeier K P. (2003). Voxel-based approaches in clinical imaging. SPECT in dementia. Basel. eScholarID:3d840
  • Scheidhauer K, Herholz KG, Ebmeier K P. (2003). Comparing HMPAO-SPECT and FDG-PET in Alzheimer's Disease. SPECT in dementia. Basel. eScholarID:3d466
  • Fesl G, Moriggl B, Schmid U D, Naidich T P, Herholz KG, Yousry T A. (2003). Inferior central sulcus: variations of anatomy and function on the example of the motor tongue area. Neuroimage, 20(1), eScholarID:1d10992
  • Heiss W D, Thiel A, Kessler J, Herholz KG. (2003). Disturbance and recovery of language function: correlates in PET activation studies. Neuroimage, 20(1), eScholarID:1d10990
  • Heiss W D, Thiel A, Winhuisen L, Muhlberger B, Kessler J, Herholz KG. (2003). Functional imaging in the assessment of capability for recovery after stroke. Journal of Rehabilitation Medicine, 35(Suppl), 27-33. eScholarID:1d10997
  • Herholz KG, Kracht L, Heiss W D. (2003). Monitoring of the Effect of Chemotherapy in a Mixed Glioma by C-11-methionine PET. Journal of Neuroimaging, 13(3), eScholarID:1d11002
  • Herholz KG. (2003). PET studies in dementia. Annals of Nuclear Medicine, 17(2), 79-89. eScholarID:1d10999
  • Hilker R, Voges J, Ghaemia M, Lehrke R, Rudolf J, Koulousakis A, Herholz, KG, Wienhard K, Sturm V, Heiss W D. (2003). Deep brain stimulation of the subthalamic nucleus does not increase the striatal dopamine concentration in parkinsonian humans. Mov Disord, 18(1), eScholarID:1d11001
  • Jacobs A H, Li H, Winkeler A, Hilker R, Knoess C, Ruger A, Galldiks N, Schaller B, Sobesky J, Kracht L, Monfared P, Klein M, Vollmar S, Bauer B, Wagner R, Graf R, Wienhard K, Herholz, KG, Heiss W D. (2003). PET-based molecular imaging in neuroscience. Eur J Nucl Med Mol.Imaging, 30, eScholarID:1d10998
  • Jacobs A H, Voges J, Kracht L W, Dittmar C, Winkeler A, Thomas A, Wienhard K, Herholz KG, Heiss W D. (2003). Imaging in gene therapy of patients with glioma. J. Neurooncol, 65(3), eScholarID:1d10985
  • Kracht L W, Friese M, Herholz KG, Schroeder R, Bauer B, Jacobs A, Heiss W D. (2003). Methyl-[(11)C]- l-methionine uptake as measured by positron emission tomography correlates in microvessel density in patients with glioma. Eur.J Nucl Med Mol.Imaging, 30(6), eScholarID:1d11000
  • Mosconi L, Sorbi S, Nacmias B, De Cristofaro M RT R, Fayyaz M, Cellini E, Bagnoli S, Bracco L, Herholz, KG, Pupi A. (2003). Brain metabolic differences between sporadic and familial Alzheimer's disease. Neurology, 61(8), eScholarID:1d10991
  • Salmon E, Garraux G, Delbeuck X, Collette F, Kalbe E, Zuendorf G, Perani D, Fazio F, Herholz KG. (2003). Predominant ventromedial frontopolar metabolic impairment in frontoemporal dementia. Neuroimage, 20(1), eScholarID:1d10993
  • Sturm V, Lenartz D, Koulousakis A, Treuer H, Herholz KG, Klein J C, Klosterkitter J. (2003). The Nucleus Accumbens: A Target for Deep Brain Stimulation in Obsessive-Compulsive-and Anxiety-Disorders. Journal of Chemical Neuroanatomy, 26(4), eScholarID:1d10996
  • Thiel A, Hilker R, Kessler J, Habedank B, Herholz KG, Heiss W D. (2003). Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study. J. Neural Transm, 110(11), eScholarID:1d10989
  • Zundorf G, Kerrouche N, Herholz KG, Baron J C. (2003). An efficient principal component analysis for multivariate 3D voxel-based mapping of brain functional imaging data sets as applied to FDG-PET and normal aging. Hum.Brain Mapp, 18(1), eScholarID:1d11003

2002

  • Herholz KG, Kessler J, Ehlen P, Kalbe E, Strotmann T, Markowitsch H J, Senda M, Kimura Y, Herscovitch P. (2002). Brain regions involved in learning face-name associations and the effects of age, performance, and learning phase. Brain imaging using SPECT. San Diego, CA: Academic Press. eScholarID:3d467
  • Zundorf G, Herholz, KG, Lercher M, Wienhard K, Bauer B, Weisenbach S, Heiss W D, Senda M, Kimura Y, Herscovitch P. (2002). PET functional parametric images of acetylcholine esterase activity without blood sampling. Brain imaging using PET. San Diego, CA: Academic Press. eScholarID:3d611
  • Heiss W D, Thiel A, Kessler J, Herholz KG. (2002). Sprachaktivierung im PET bei isch,mischen Insulten und Hirntumoren. Zentralblatt fur Neurochirurgie, 63(4), eScholarID:1d32753
  • Herholz KG, Schopphoff H, Schmidt M, Mielke R, Eschner W, Scheidhauer K, Schicha H, Heiss W D, Ebmeier K P. (2002). Direct comparison of spatially normalized PET and SPECT scans in Alzheimer disease. Journal of Nuclear Medicine, 43(1), eScholarID:1d11024
  • Herholz, KG, Salmon E, Perani D, Baron J C, Holthoff V, Frolich L, Ito K, Mielke R, Kalbe E, Zundorf G, Delbeuck X, Pelati O, Anchisi D, Fazio F, Kerrouche N, Calautti C, Beuthien-Baumann B, Menzel C, Schroder J, Kato T, Arahata Y, Henze M, Heiss W D. (2002). Discrimination between Alzheimer Dementia and Controls by Automated Analysis of Multicenter FDG PET. Neuroimage, 17, 302-316. eScholarID:1d11023 | DOI:10.1006/nimg.2002.1208
  • Hilker R, Klein C, Hedrich K, Ozelius L J, Vieregge P, Herholz KG, Pramstaller P P, Heiss W D. (2002). The striatal dopaminergic deficit is dependent on the number of mutant alleles in a family with mutations in the parkin gene: evidence for enzymatic parkin function in humans. Neurosi.Lett, 323(1), eScholarID:1d32785
  • Hilker R, Voges J, Thiel A, Ghaemi M, Herholz KG, Sturm V, Heiss W D. (2002). Deep brain stimulation of the subthalamic nucleus versus levodopa challenge in Parkinson's disease: measuring the on-and off-conditions with FDG-PET. Journal of Neural transmission, 10, eScholarID:1d11021
  • Huber M, Herholz KG, Habedank B, Thiel A, Muller-Kuppers M, Ebel H, Subic-Wrana C, Kohle K, Heiss W D. (2002). Differente Muster regionaler Hirnaktivitat nach emotionaler Stimulation bei alexithymen Patienten im Vergleich zu Normalpersonen. Eine Positronen-Emissions-Tomographische (PET) Studie mit 150-H2O und emotionaler Stimulierung durch autobiographische Erinnerung. Psychother. Psychosom. Med Psychol, 51(11), eScholarID:1d11020
  • Jacobs A , Winkler A, Dittmar C, Gossman A, Deckert M, Kracht L, Thiel A, Garlip G, Hilker R, Sobesky J, Vollmar S, Kummer C, Graf R, Voges J, Wienhard K, Herholz, KG, Heiss W D. (2002). Molecular and functional imaging technology for the development of efficient treatment strategies for gliomas. Technol. Cancer Res Treat, 1(3), eScholarID:1d11008
  • Szelies B, Sobesky J, Pawlik G, Mielke R, Bauer B, Herholz KG, Heiss W D. (2002). Impaired benzodiazepine receptor binding in peri-lesional cortex of patients with symptomatic epilepsies studied by [11C]-flumazenil PET. Eur.J Neurol, 9(2), eScholarID:1d11022

2001

  • Ghaemi M, Rudolf J, Hilker R, Herholz KG. (2001). Increased pineal Fdopa uptake is related to severity of Parkinson's disease - a PET study. J. Pineal Res, 30 (4), eScholarID:1d11095
  • Herholz KG, Ehlen P, Kessler J, Strotmann T, Kalbe E, Markowitsch H J. (2001). Learning face-name associations and the effect of age and performance:a PET activation study. Neuropsychologia, 39, eScholarID:1d11098
  • Herholz KG, Lercher M, Wienhard K, Bauer B, Lenz O, Heiss W D. (2001). PET measurement of cerebral acetylcholine esterase activity without blood sampling. European Journal of Nuclear Medicine, 28, eScholarID:1d11097
  • Herholz KG, Perani D, Fazekas F, Markus H, Baumgartner R W, Baron J C. (2001). A survey of neuroimaging research in European neurological departments. Eur.J Neurol, 8(2), eScholarID:1d11025
  • Hilker R, Klein C, Ghaemi M, Kis B, Strotmann T, Ozelius L J, Lenz O, Vieregge P, Herholz, KG, Heiss W D, Pramstaller P P. (2001). Positron emission tomographic analysis of the nigrostriatal dopaminergic system in familial parkinsonism associated with mutations in the parkin gene. Annals of Neurology, 49, 367-76. eScholarID:1d11096
  • Huber M, Siol T, Herholz KG, Lenz O, Kohle K, Heiss W D. (2001). Activation of Thalamo-Cortical Systems in Post-Traumatic Flashbacks: A Positron Emission Tomography Study. Traumatology, 7(4), eScholarID:1d11026
  • Jauss M, Herholz KG, Kracht L, Pantel J, Hartmann T, Jensen M, Essig M, Schroder. (2001). Frontotemporal dementia: Clinical, neuroimaging and molecular biological findings in 6 patients. European Archives of Psychiatry & Clinical Neuroscience, 251, eScholarID:1d11027
  • Thiel A, Herholz KG, Koyuncu A, Ghaemi M, Kracht L W, Habedank B, Heiss W D. (2001). Plasticity of language networks in patients with brain tumors. A positron emission tomography activation study. Annals of Neurology, 50, eScholarID:1d11028

2000

  • Bartenstein P, Grunwald F, Kuwert T, Tatsch K, Sabri O, Benkert O, Fahlbusch R, Grunder G, Herholz, KG, Weiller C. (2000). Clinical applications of single photon emission tomography in neuromedicine. 1. Neuro-oncology, epilepsy, movement disorders, cerebrovascular disease. Nuklearmedizin, 39(7), 180-95. eScholarID:1d14183
  • Bartenstein, P, Grünwald, F, Kuwert, T, Tatsch, K, Sabri, O, Benkert, O, Fahlbusch, R, Gründer, G, Herholz, KG, Weiller, C. (2000). Clinical applications of single photon emission tomography in neurology. 2. Dementia, psychoses, inflammation, skull and brain injuries. Nuklearmedizin, 39( 8), 218-32. eScholarID:1d14182
  • Herholz KG, Bauer B, Wienhard K, Kracht L, Mielke R, Lenz O, Strotmann T, Heiss W D. (2000). In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism. J Neural Transm, 12, eScholarID:1d11174
  • Herholz KG, Heiss W D. (2000). Functional imaging correlates of recovery after stroke in humans. Journal of Cerebral Blood Flow & Metabolism, 20, eScholarID:1d11100
  • Kessler J, Mielke R, Grond M, Herholz KG, Heiss W D. (2000). Frontal lobe tasks do not reflect frontal lobe function in patients with probable Alzheimer's disease. Journal of Neuroscience, 1, eScholarID:1d11101
  • Muzik O, Da Silva E A, Juhasz C, Chugani D C, Shah J, Nagy F, Canady A, von Stockhausen H M, Herholz, KG, Gates J, Frost M, Ritter F, Watson C, Chugani H T. (2000). Intracranial EEG vs. flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology, 54, eScholarID:1d11175
  • Thiel A, Pietrzyk U, Sturm V, Herholz KG, Hovels M, Schroder R. (2000). Enhanced accuracy in differential diagnosis of radiation necrosis by positron emission tomography-magnetic resonance imaging coregistration: technical case report. Neurosurgery, 46 (1), eScholarID:1d11099

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