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School of Medicine

Dr Mark Harrison BSc MSc PhD

Photograph of Mark Harrison

Research Fellow

Health Economics (Health Methodology Group)

1.320 Jean McFarlane Building
The University of Manchester
Oxford Road
Manchester M13 9PT
 

 

Role

Mark is currently employed as a Research Fellow with the Health Economics Group and the National Institute of Health Research (NIHR) Research Design Service for the North West (http://www.rds-nw.nihr.ac.uk). In his role with the Research Design Service he provides methodological advice on research design and health economics to researchers in the region who are developing proposals for national, peer-reviewed funding competitions for applied health or social care research. Mark has over 10 years experience as an epidemiologist and academic health economist. Mark is an active researcher with multiple projects in collaboration with other research and clinical colleagues.

 

Memberships of Committees and Professional Bodies

International Health Economics Association

Health Economists Study Group

Editorial Board, BMC Health Services Research

Research

Ongoing and recent projects include:

Presentation of risk in discrete choice experiments: Discrete choice experiments (DCEs) have been adopted by researchers interested in valuing healthcare interventions. Risk is a ever-present part of healthcare and decisions made by patients and clinicians about commencing treatment are influenced by the potential benefits and risks. The aim of this project is to systematically identify published DCEs in healthcare that incorporated risk as an attribute and to appraise the methods underlying presentation, format and analysis of risk attributes. In collaboration with Katherine Payne, Dan Rigby from the Department of Environmental Economics, and Jordan Louviere and Terry Flynn at the University of Technology, Sydney.

Systemic Lupus Erythematosus (SLE): a systematic review of the literature to summarise the current evidence on the humanistic and economic burden of systemic lupus erythematosus (SLE) in terms of health-related quality of life (HRQoL) and costs, and the factors that drive this burden. This work is being conducted with Rachel Meacock.

Haemophilia: ITI Study - an economic analysis comparing low versus high dose immune tolerance induction (ITI) for children with severe haemophilia. The development of inhibitors is a serious complication in haemophilia treatment and prevents treatment with clotting factors from working. ITI aims to get rid of these inhibitors in order to allow factor VIII treatment to work effectively. However, ITI is an extremely intensive, lengthy and costly procedure, and its effectiveness is uncertain to date. The aim of the economic evaluation is therefore to model the relative clinical and cost-effectiveness of low versus high regimens of ITI using data collected during the RCT. This work is being conducted by Rachel Meacock under the supervision of Mark, and in collaboration with Alec Miners of the London School of Hygiene and Tropical Medicine, and Charles Hay, Consultant Haematologist, Manchester Royal Infirmary.

Colorectal cancer: development of a discrete-event simulation model to inform decision makers on how to plan the capacity required to deliver a flexible sigmoidoscopy colorectal cancer screening service including demands for other health care resources derived from the use of this screening programme. In collaboration with Matt Sutton, Ian Jacob, and Andrew Renehan and John Radford of the Christie Hospital within the Manchester Academic Health Sciences Centre.

Quality and Outcomes Framework: exploring the association between emergency admissions to secondary care and quality of primary care, and the impact of the introduction of the Quality and Outcomes Framework (QOF) on emergency hospital admissions by comparing admission rates for incentivised and non-incentivised ambulatory care sensitive conditions. In collaboration with Matt Sutton, Hugh Gravelle and Mark Dusheiko of the Centre for Health Economics, University of York, Martin Roland of the Institute of Public Health, University of Cambridge, and Tim Doran of the Primary Care Research Group.
 

 

Qualifications

PhD Epidemiology - The University of Manchester, 2008

MSc Epidemiology - University of Edinburgh, 2002

BSc(Hons) Business & Management Sciences - University of Bradford, 2000

 

Collaborators and affiliated staff

Professor Matt Sutton

Professor Katherine Payne

 

Primary Care Research Group - Dr David Reeves, Professor Anne Rogers, Dr Pete Bower, Dr Tim Doran

Arthritis Research UK Epidemiology Unit - Professor Deborah Symmons, Professor Ian Bruce, Professor David Felson

Centre for Health Evaluation and Outcomes Science, University of British Columbia, Canada - Nick Bansback

Maastricht University Medical Centre, the Netherlands - Dr Annelies Boonen 

 

Publications

2012

  • Harrison, M., Ahmad, Y., Haque, S., Dale, N., Teh, L., Snowden, N., Ho, P., Gorodkin, R. & Bruce, I (2012). Construct and Criterion Validity of the Short Form-6D Utility Measure in Patients with Systemic Lupus Erythematosus. J Rheumatol, eScholarID:155838 | PMID:22298908 | DOI:10.3899/jrheum.110648

2011

  • Camacho, E., Harrison, M., Farragher, T., Lunt, M., Bunn, D., Verstappen, S. & Symmons, D (2011). Parity, time since last live birth and long-term functional outcome: a study of women participating in the Norfolk Arthritis Register. Ann Rheum Dis, 70(4), 642-5. eScholarID:119684 | PMID:21372194 | DOI:10.1136/ard.2010.140301
  • Harrison MJ, Lee S, Deighton C, Symmons DPM. (2011). UK rheumatology consultant workforce provision 2007-9: results from the BSR/Arthritis Research UK Consultant Workforce Register. Clinical Medicine, 11(2), 119-124. eScholarID:122091
  • Harrison, M., Bansback, N., Marra, C., Drummond, M., Tugwell, P. & Boonen, A (2011). Valuing health for clinical and economic decisions: directions relevant for rheumatologists. J Rheumatol, 38(8), 1770-5. eScholarID:129108 | PMID:21807800 | DOI:10.3899/jrheum.110404
  • Harrison, M., Reeves, D., Harkness, E., Valderas, J., Kennedy, A., Rogers, A., Hann, M. & Bower, P (2011). A secondary analysis of the moderating effects of depression and multimorbidity on the effectiveness of a chronic disease self-management programme. Patient Educ Couns, eScholarID:127526 | PMID:21767927 | DOI:10.1016/j.pec.2011.06.007
  • Kirwan, J., Boonen, A., Harrison, M., Hewlett, S., Wells, G., Singh, J., Furst, D. & Dworkin, R (2011). OMERACT 10 Patient Perspective Virtual Campus: Valuing Health; Measuring Outcomes in Rheumatoid Arthritis Fatigue, RA Sleep, Arthroplasty, and Systemic Sclerosis; and Clinical Significance of Changes in Health. J Rheumatol, 38(8), 1728-34. eScholarID:129109 | PMID:21807793 | DOI:10.3899/jrheum.110393

2010

  • Barta, Z., Harrison, M., Wangrangsimakul, T., Shelmerdine, J., Teh, L., Pattrick, M., Edlin, H., Dale, N., Ahmad, Y. & Bruce, I (2010). Health-related quality of life, smoking and carotid atherosclerosis in white British women with systemic lupus erythematosus. Lupus, 19(3), 231-8. eScholarID:77823 | PMID:20007814 | DOI:10.1177/0961203309351032
  • Foster, H., Harrison, M., Pain, C., Symmons, D. & Baildam, E (2010). Delivery of paediatric rheumatology care in the UK-the projected shortfall. Clin Rheumatol, eScholarID:119682 | PMID:21181219 | DOI:10.1007/s10067-010-1656-3
  • Harrison, M., Fullwood, C., Bower, P., Kennedy, A., Rogers, A. & Reeves, D (2010). Exploring the mechanisms of change in the chronic disease self-management programme: Secondary analysis of data from a randomised controlled trial. Patient Educ Couns, eScholarID:119683 | PMID:21112719 | DOI:10.1016/j.pec.2010.10.026
  • Harrison, M., Lunt, M., Verstappen, S., Watson, K., Bansback, N. & Symmons, D (2010). Exploring the validity of estimating EQ-5D and SF-6D utility values from the health assessment questionnaire in patients with inflammatory arthritis. Health Qual Life Outcomes, 8, 21. eScholarID:77822 | PMID:20149253 | DOI:10.1186/1477-7525-8-21

2009

  • Boonen, A., Maetzel, A., Drummond, M., Suarez-Almazor, M., Harrison, M., Welch, V. & Tugwell, P (2009). The OMERACT Initiative. Towards a reference approach to derive QALY for economic evaluations in rheumatology. J Rheumatol, 36(9), 2045-9. eScholarID:77827 | PMID:19738211 | DOI:10.3899/jrheum.090355
  • Harrison MJ, Davies LM, Bansback NJ, McCoy MJ, Farragher TM, Verstappen SS, Hassell A, Symmons D. (2009). Why do patients with inflammatory arthritis often score states "Worse than Death" on the EQ-5D? An investigation of the EQ-5D classification system. Value Health, [Epub ahead of print], eScholarID:1d19320 | DOI:10.1111/j.1524-4733.2009.00565.x
  • Harrison MJ, Dixon WG, Watson KD, King YE, Groves R, Hyrich KL, Symmons D, BSRBR Control Centre Consortium. (2009). Rates of new-onset psoriasis in patients with rheumatoid arthritis receiving anti-TNF{alpha} therapy. Results from the British Society for Rheumatology Biologics Register. Ann Rheum Dis, 68(2), 209-215. eScholarID:1d17129 | DOI:10.1136/ard.2007.087288
  • Harrison, M., Boonen, A., Tugwell, P. & Symmons, D (2009). Same question, different answers: a comparison of global health assessments using visual analogue scales. Qual Life Res, 18(10), 1285-92. eScholarID:77824 | PMID:19856128 | DOI:10.1007/s11136-009-9546-3
  • Harrison, M., Davies, L., Bansback, N., McCoy, M., Verstappen, S., Watson, K., Symmons, D. & . (2009). The comparative responsiveness of the EQ-5D and SF-6D to change in patients with inflammatory arthritis. Qual Life Res, 18(9), 1195-205. eScholarID:77826 | PMID:19777373 | DOI:10.1007/s11136-009-9539-2
  • Harrison, M., Farragher, T., Clarke, A., Manning, S., Bunn, D. & Symmons, D (2009). Association of functional outcome with both personal- and area-level socioeconomic inequalities in patients with inflammatory polyarthritis. Arthritis Rheum, 61(10), 1297-304. eScholarID:77825 | PMID:19790115 | DOI:10.1002/art.24830

2008

  • Bansback N, Harrison MJ, Brazier J, Davies L, Kopec J, Marra C, Symmons D, Anis A. (2008). Health state utility values: a description of their development and application for rheumatic diseases. Arthritis Rheum, 59 (7), 1018-26. eScholarID:1d17752 | DOI:10.1002/art.23813
  • Harrison MJ, Davies LM, Bansback NJ, Ingram M, Anis AH, Symmons D. (2008). The validity and responsiveness of generic utility measures in rheumatoid arthritis: a review. J Rheumatol, 35 (4), 592-602. eScholarID:1d17133
  • Harrison MJ, Deighton C, Symmons D. (2008). An update on UK rheumatology consultant workforce provision: the BSR/ARC Workforce Register 2005-07: assessing the impact of recent changes in NHS provision. Rheumatology (Oxford), 47 (7), 1065-9. eScholarID:1d17751 | DOI:10.1093/rheumatology/ken099
  • Harrison MJ. (2008). An evaluation of a health status measure and two health utility measures in patients with inflammatory polyarthritis. The University of Manchester. eScholarID:77828

2007

  • Brennan A, Bansback N, Nixon R, Madan J, Harrison MJ, Watson KD, Symmons D. (2007). Modelling the cost effectiveness of TNF-alpha antagonists in the management of rheumatoid arthritis: results from the British Society for Rheumatology Biologics Registry. Rheumatology (Oxford), 46( 8), 1345-54. eScholarID:1d16569
  • Harrison MJ, Hassell A, Dawes P, Scott D, Knight S, Davis M, Mulherin D, Symmons D. (2007). The overall status in rheumatoid arthritis (OSRA) measure--further evidence to support its use in clinical practice. Rheumatology (Oxford), 46( 5), 849-55. eScholarID:1d15667

2006

  • Harrison MJ, Morley KD, Symmons D, Symmons DP. (2006). Developments in rheumatology consultant manpower provision: the BSR/arc Workforce Register 2003-05. Rheumatology (Oxford), 45(11), 1416-21. eScholarID:1d13388
  • Harrison MJ, O'Hare A, Campbell H, Adamson A, McNeillage J. (2006). Prevalence of autistic spectrum disorders in Lothian, Scotland: an estimate using the "capture-recapture" technique. Arch Dis Child, 91( 1), 16-9. eScholarID:1d13387
  • Symmons, D, Tricker, K, Harrison, MJ, Roberts, C, Davis, M, Dawes, P, Hassell, A, Knight, S, Mulherin, D, Scott, D. (2006). Patients with stable long-standing rheumatoid arthritis continue to deteriorate despite intensified treatment with traditional disease modifying anti-rheumatic drugs--results of the British Rheumatoid Outcome Study Group randomized controlled clinical trial. Rheumatology (Oxford), 45, 5, 558-565. eScholarID:1d11794 | DOI:10.1093/rheumatology/kei169

2005

  • Harrison, MJ, Tricker, K, Davies, LM, Hassell, A, Dawes, P, Scott, D, Knight, S, Davis, M, Mulherin, D, Symmons, D. (2005). The relationship between social deprivation, disease outcome measures, and response to treatment in patients with stable, long-standing rheumatoid arthritis. J Rheumatol, 32( 12), 2330-6. eScholarID:1d13152

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