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School of Medicine

Dr Mark Wareing 

Photograph of Mark Wareing

Senior Scientist

  Maternal and Fetal Health Research Centre,

  5th Floor (Research), St. Mary's Hospital, Oxford Road,

  Manchester, M13 9WL, U.K.

 

Publications

2012

  • Wareing, M. (2012). Effects of oxygenation and luminal flow on human placenta chorionic plate blood vessel function. Journal of Obstetrics and Gynaecology Research, 38(1), 185-191. eScholarID:144640 | DOI:10.1111/j.1447-0756.2011.01666.x

2011

  • Abad C, Antczak DF, Carvalho J, Chamley LW, Chen Q, Daher S, Damiano AE, Dantzer V, Díaz P, Dunk CE, Daly E, Escudero C, Falcón B, Guillomot M, Han YW, Harris LK, Huidobro-Toro JP, Illsley N, Jammes H, Jansson T, Johnson GA, Kfoury JR Jr, Marín R, Murthi P, Novakovic B, Myatt L, Petroff MG, Pereira FT, Pfarrer C, Redman CW, Rice G, Saffery R, Tolosa JM, Vaillancourt C, Wareing M, Yuen R, Lash GE. (2011). IFPA Meeting 2010 Workshop Report I: Immunology; Ion transport; Epigenetics; Vascular reactivity; Epitheliochorial placentation; Proteomics. Presented at International Federation of Placental Associations. Santiago, Chile: Elsevier. eScholarID:126056
  • Dilworth MR, Kusinski LC, Baker BC, Renshall LJ, Greenwood SL, Sibley CP, Wareing M. (2011). Defining fetal growth restriction in mice: A standardized and clinically relevant approach. Placenta, 32(11), 914-916. eScholarID:144641 | DOI:10.1016/j.placenta.2011.08.007
  • Higgins, L. Greenwood, S.L., Wareing, M., Sibley, C.P. & Mills, T.A. (2011). Obesity and the placenta: A consideration of nutrient exchange mechanisms in relation to aberrant fetal growth. Placenta, 32(1), 1-7. eScholarID:126054 | DOI:10.1016/j.placenta.2010.09.019
  • Kusinski LC, Dilworth MR, Baker PN, Sibley CP, Wareing M, Glazier JD. (2011). System A activity and vascular function in the placental-specific Igf2 knockout mouse. Placenta, 32(11), 871-876. eScholarID:144637 | DOI:10.1016/j.placenta.2011.07.086
  • Rossoni, L.V., Wareing, M., Wenceslau, C., Al-Abri, M., Cobb, C. & Austin, C.E. (2011). Acute simvastatin increases endothelial nitric oxide synthase phosphorylation via AMP-activated protein kinase and reduces contractility of isolated rat mesenteric resistance arteries. Clin Sci (Lond). [Epub ahead of print], eScholarID:126457 | DOI:10.1042/CS20110259
  • Samangaya, R.A., Wareing, M., Skillern, L. & Baker, P.N. (2011). The effect of clinical intervention with the phosphodiesterase type 5 (PDE5) inhibitor, sildenafil citrate (Viagra) on small arteries from women with pre-eclampsia. Hypertension in Pregnancy, 30(2), 144-152. eScholarID:111909 | DOI:10.3109/10641955.2010.484083
  • von Dadelszen P, Dwinnell S, Magee L, Carleton B, Gruslin A, Lee B, Lim K, Liston R, Miller S, Rurak D, Sherlock R, Skoll M, Wareing M, Baker P; for the Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group. (2011). Sildenafil citrate therapy for severe early-onset intrauterine growth restriction. British Journal of Obstetrics & Gynaecology (BJOG), 118(5), 624-628. eScholarID:126455 | DOI:10.1111/j.1471-0528.2010.02879.x
  • Wareing, M. & Greenwood, S.L. (2011). Review: Potassium channels in the human fetoplacental vasculature. Placenta, 32, S203-S206. eScholarID:126055 | DOI:10.1016/j.placenta.2010.12.022

2010

  • Chirayath, H.H., Wareing, M., Taggart, M.J. & Baker, P.N. (2010). Endothelial dysfunction in myometrial arteries of women with gestational diabetes. Diabetes Research and Clinical Practice, 89(2), 7. eScholarID:82011 | DOI:10.1016/j.diabres.2010.03.022
  • M.F. Kiernan, A. Barrie, J. Szkolar, T.A. Mills & M. Wareing. (2010). Functional Evidence for Oxygen-Sensitive Voltage-Gated Potassium Channels. Placenta, 31(6), 3. eScholarID:82010 | DOI:10.1016/j.placenta.2010.03.009

2009

  • Kusinski LC, Baker PN, Sibley CP, Wareing M. (2009). In Vitro Assessment of Mouse Uterine and Fetoplacental Vascular Function. Reprod Sci, 16(8), 740-748. eScholarID:1d19592 | DOI:10.1177/1933719109336613
  • Mills TA, Wareing M, Shennan A, Poston L, Baker PN, Greenwood SL. (2009). Acute and chronic modulation of placental chorionic plate artery reactivity by reactive oxygen species. Free Radic Biol Med, 47( 2), eScholarID:1d20125 | DOI:10.1016/j.freeradbiomed.2009.04.019

2008

  • Corcoran J, Lacey HA, Baker PN, Wareing M. (2008). Altered potassium channel expression in the human placental vasculature of pregnancies complicated by fetal growth restriction. Hypertension in Pregnancy, 27(1), 75-86. eScholarID:1d28139 | DOI:10.1080/10641950701826158
  • Robinson N, Wareing M, Hudson NK, Blankley R, Baker PN, Aplin JD, Crocker IP. (2008). Oxygen and the liberation of placental factors responsible for vascular compromise. Laboratory Investigation, 88( 3), eScholarID:1d28175
  • Sweeney M, Wareing M, Mills TA, Baker PN, Taggart M. (2008). Characterisation of tone oscillations in placental and myometrial arteries from normal pregnancies and those complicated by pre-eclampsia and growth restriction. Placenta, 29(4), 356-365. eScholarID:1d20126 | DOI:10.1016/j.placenta.2008.01.007

2007

  • Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright JE, Whitley GJ, Aplin JD. (2007). BeWo cells induce vascular remodelling via Fas ligand-and matrix metalloproteinase-dependent mechanisms. Human Reproduction, 22(11), 2834-2841. eScholarID:1d16609
  • Hudson NK, O'Hara M, Lacey HA, Corcoran J, Hemmings D.G, Wareing M, Baker PN, Taggart MJ. (2007). Modulation of human arterial tone during pregnancy: The effect of the bioactive metabolite Sphingosine-1-Phosphate. Biology of Reproduction, 77(1), 45-52. eScholarID:1d27789
  • Jewsbury S, Baker PN, Wareing M. (2007). Relaxation of human placental arteries and venins by ATP-sensitive potassium channel openers. European Journal of Clinical Investigation, 37(1), 65-72. eScholarID:1d15372
  • Mills TA, Baker PN, Wareing M. (2007). The effect of mode of delivery onplacental chorionic plate vascular reactivity. Hypertension in Pregnancy, 26, 201-210. eScholarID:1d16607
  • Mills TA, Taggart MJ, Greenwood SL, Baker PN, Wareing M. (2007). Histamine-induced contraction and relaxation of placental chorionic plate arteries. Placenta, 28(11), 1158-1164. eScholarID:1d20129 | DOI:10.1016/j.placenta.2007.05.008

2006

  • Chirayath H, Wareing M, Taggart MJ, Baker PN. (2006). Acute hyperglycemia in uterine arteries from pregnant, but not non-pregnant mice, enhances endothelium-dependent relaxation. Vascular Pharmacol, 46(2), 147-153. eScholarID:1d15083
  • Cooper E.J, Wareing M, Greenwood SL, Baker PN. (2006). Oxygen tension and normalisation pressure modulate nifedipine-sensitive relaxation of human placental chorionic plate arteries. Placenta, 27, 402-410. eScholarID:1d13040
  • Harris LK, Keogh RJ, Wareing M, Baker PN, Cartwright J, Aplin JD. (2006). Invasive trophoblasts stimulate vascular smooth muscle cell apoptosis by a fas ligand-dependent mechanism. American Journal Of Pathology, 169(5), 1863-1874. eScholarID:1d27410 | DOI:10.2353/ajpath.2006.060265
  • Myers JE, Hall C, Wareing M, Gillham JC, Baker PN. (2006). The effect of maternal characteristics on endothelial-dependent relaxation of myometrial arteries. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 124, 158-163. eScholarID:1d26648 | DOI:10.1016/j.ejogrb.2005.05.017
  • Wareing M, Bai X, Seghier F, Turner CM, Greenwood SL, Baker PN, Taggart MJ, Fyfe GK. (2006). Expression and function of potassium channels in the human placental vasculature. Am J Physiol Regul Integr Comp Physiol, 291(2), R437-R446. eScholarID:1d13043
  • Wareing M, Greenwood SL, Baker PN. (2006). Reactivity of human placental chorionic plate vessels is modified by level of oxygenation: differences between arteries and veins. Placenta, 27(1), 42-48. eScholarID:1d12570
  • Wareing M, Greenwood SL, Fyfe GK, Baker PN, Taggart MJ. (2006). Glibenclamide Inhibits Agonist-induced Vasoconstriction of Placental Chorionic Plate Arteries. Placenta, 27(6-7), 660-668. eScholarID:1d26644
  • Wareing M, Greenwood SL, Fyfe GK, Baker PN. (2006). Reactivity of human placental chorionic plate vessels from pregnancies complicated by Intrauterine Growth Restriction (IUGR). Biology of Reproduction, 75, 518-523. eScholarID:1d14581
  • Wareing M, Greenwood SL, Fyfe GK, Baker PN. (2006). Reactivity of human placental chorionic plate vessels from pregnancies complicated by intrauterine growth restriction (IUGR). Biology of Reproduction, 75, 518-523. eScholarID:1d15149
  • Wareing M, Myers JE, O'Hara M, Kenny L, Taggart MJ, Skillem L, Machin L, Baker PN. (2006). Phosphodiesterase-5 inhibitors and omental and placental small artery function in normal pregnancy and pre-eclampsia. Eur J Obstet Gynecol Reprod Biol, 127(1), 41-49. eScholarID:1d15086

2005

  • Ashton SV, Whitley GSt.J, Dash PR, Wareing M, Crocker IP, Baker PN, Cartwright JE. (2005). Uterine spiral artery remodelling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. Arteriosclerosis, Thrombosis and Vascular Biology, 25(1), 102-108. eScholarID:1d10152
  • Cooper E, Wareing M, Greenwood SL, Baker PN. (2005). Effects of oxygen tension and normalization pressure on endothelin-induced constriction of human placental chorionic plate arteries. J Soc Gynecol Investig, 12(7), 488-494. eScholarID:1d15098
  • Crocker IP, Wareing M, Ferris G, Jones CJP, Cartwright JE, Baker PN, Aplin JD. (2005). The effect of vascular origin, oxygen, and tumour necrosis factor alpha on trophoblast invasion of maternal arteries in vitro. Journal Of Pathology, 206 (4), eScholarID:1d26571 | DOI:10.1002/path.1801
  • Mills TA, Wareing M, Bugg G, Greenwood SL, Baker PN. (2005). Chorionic plate artery function and Doppler indices in normal pregnancy and intrauterine growth restriction. Eur J Clin Invest, 35(12), 758-764. eScholarID:1d15095
  • Wareing M, Akef H, Greenwood SL, Bugg G, Baker PN. (2005). Umbilical artery Doppler waveform indices from normal pregnant women are related to vasodilatation of placental chorionic plate small arteries. J.Obstet. Gynecol, 25(3), 248-252. eScholarID:1d15151
  • Wareing M, Myers JE, O'Hara M, Baker PN. (2005). Sildenafil citrate (Viagra) enhances vasodilatation in fetal growth restriction. Journal of clinical endocrinology and metabolism, 90(5), eScholarID:1d26650 | DOI:10.1210/jc.2004-1831
  • Wareing M, O’Hara M, Seghier F, Baker PN, Taggart MJ. (2005). The involvement of Rho-associated kinases in agonist-dependent contractions of human maternal and placental arteries at term gestation. American Journal of Obstetrics & Gynecology, 193(3), 815-824. eScholarID:1d13054

2004

  • Wareing M, Baker PN. (2004). Vasoconstriction of small arteries isolated from the human placental chorionic plate in normal and compromised pregnancy. Hypertens Pregnancy, 23(3), 237-246. eScholarID:1d10733
  • Wareing M, Myers JE, O'Hara M, Kenny L, Warren AY, Taggart MJ, Skillern L, Machin I, Baker PN. (2004). Effects of a phosphodiesterase-5(PDE5) inhibitor on endothelium-dependent relaxation of myometrial small arteries. American Journal Of Obstetrics And Gynecology, 190(5), 1283-1290. eScholarID:1d25907

2003

  • Ferguson, C.J, Wareing, M., Delannoy, M, Fenton, R.A, McLarnon, S.J, Ashton, N, Cox, A.J, McMahon, R.F.T, Garrick, L.M, Green, R., , Smith, C.P, Riccardi, D. (2003). Iron handling and gene expression of divalent metal transporter DMT1 in the kidneys of the anemic Belgrade rat. Kidney International, 64, 1755-1764. eScholarID:1d11862
  • Wareing M, Fergusson CJ, Delonnoy M, Cox A, McMahon RFT, Green RR, Riccardi DD, Smith CP. (2003). Altered dietary iron intake is a strong modulator of renal DMT1 expression. American Journal of Physiology (Renal Physiol.), 285, F1050-F1059. eScholarID:1d6553
  • Wareing M, Greenwood SL, Taggart MJ, Baker PN. (2003). Vasoactive responses of veins isolated from the human placental chorionic plate. Placenta, 24.(7), 790-796. eScholarID:1d6550
  • Wareing M, H Bhatti, O'Hara M, Kenny L, AY Warren, Taggart MJ, Baker PN. (2003). Vasoactive effects of neurokinin B on human blood vessels. American Journal Of Obstetrics And Gynecology, 188(1), 196-202. eScholarID:1d5217

2002

  • Wareing M, Crocker IP, A Warren, Taggart MJ, Baker PN. (2002). Characterization of small arteries isolated from the human placental chorionic plate. Placenta, 23(5), 400-409. eScholarID:1d23499

2001

  • Ferguson CJ, Wareing M, Ward DT, Green RR, Smith CP, Riccardi DD. (2001). Cellular localization of divalent metal transporter DMT-1 in rat kidney. American Journal of Physiology, 280(5), F803-F814. eScholarID:1d6554

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