Professor Paul Bishop PhD, FRCOphth
Professor of Ophthalmology and Matrix Biology
- Email: paul.bishop@manchester.ac.uk
- Telephone: +44 (0)161 275 5755
- Alternative Telephone: +44 (0)161 276 5619 (Manchester Royal Eye Hospital)
Role
Co-Director of Centre for Advanced Discovery and Experimental Therapeutics (CADET)
Consultant Ophthalmologist, Manchester Royal Eye Hospital, CMMCUH NHS Trust
Research
Research Interests:
- Mechanisms underpinning age-related diseases
- Age-related macular degeneration
- Complications of diabetes (especially retinopathy)
- Hereditary retinal degenerations
- Extracellular matrix and its role in disease
- Angiogenesis
Links:
Manchester NIHR Biomedical Research Centre (www.manchesterbrc.org)
Investigative Ophthalmology and Vision Sciences MSc course
Biography
Paul is an ophthalmologist and clinician scientist. Soon after graduating in Medicine at Nottingham University he moved to Manchester. This is where he undertook his postgraduate medical training and he was appointed as a Consultant Ophthalmologist at Manchester Royal Eye Hospital in 1998. He specialises in the management of medical retinal conditions.
Whilst training as an ophthalmologist he completed a PhD in biochemistry (1993). From 1991-2006 he held successive Wellcome Trust Clinical Fellowships including a Vision Research Training Fellowship, a Clinician Scientist Fellowship and a Senior Clinical Fellowship; he was appointed to a personal Chair in 2006.
He is currently Co-Director of CADET. This Centre aims to discover and develop new medicines for common age-related diseases. It primarily uses proteomics and metabolomics as discovery platforms, and is taking new drugs through to clinical trials.
The focus of his ophthalmic research is medical retinal disease and he has research projects spanning from laboratory-based research into new treatments for age-related macular degeneration and diabetic retinopathy through to leading major interventional clinical trials.
Qualifications
B Med Sci Hons (University of Nottingham)
BM BS (University of Nottingham)
FRCS (London); FRCOphth
PhD (Biochemistry, University of Manchester)
CCT in Ophthalmology (Specialist Training Authority of the UK)
Publications
2011
- Cehajic-Kapetanovic J, Le Goff MM, Allen A, Lucas RJ, Bishop PN. (2011). Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2. Mol. Vision, 17, 1171-1183. eScholarID:133469
2010
- (2010) Screening assays for binding antagonists of the AMD-associated variant of factor H (H384). eScholarID:109694
2009
- Kalyanasundaram T, Black GCM, O'Sullivan J, Bishop PN. (2009). A novel peripherin/RDS mutation resulting in a retinal dystrophy with phenotypic variation. Eye, 23( 1), 237-239. eScholarID:1d20124 | DOI:10.1038/eye.2008.33
2003
- Scott P G, Dodd C M, Grossman J G, Sheehan J K, Bishop PN. (2003). Light and x-ray scattering show decorin to be a dimer in solution. J Biol Chem, 278, eScholarID:1d7191
2001
- Bos KJ, Holmes DF, Kadler KE, McLeod D-, Morris NP, Bishop PN. (2001). Axial structure of the heterotypic collagen fibrils of vitreous humour and cartilage. Journal of Molecular Biology, 306, eScholarID:1d23734
1999
- Beatty S, Au Eong KG, McLeod D-, Bishop PN. (1999). Photocoagulation of subfoveal choroidal neovascular membranes in age-related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and Republic of Ireland. British Journal Of Ophthalmology, 83, 1103-1104. eScholarID:1d23926
- Bishop PN, McLeod D-, Reardon A. (1999). The effects of hyaluronan lyase, hyaluronidase and chondroitin ABC lyase on mammalian vitreous gel. Invest. Ophthalmol. Vis. Sci, 40, 2173-2178. eScholarID:1d2920
- S Beatty, KG Au Eong, McLeod D-, Bishop PN. (1999). Photocoagulation of subfoveal choroidal neovascular membrane in age-related macular degeneration: the impact of the macular photocoagulation study in the United Kingdom and the Republic of Ireland (commentary). British Journal Of Ophthalmology, 83, 1103-1104. eScholarID:1d24361
1998
- A Reardon, D Heinegard, McLeod D-, JK Sheehan, Bishop PN. (1998). The large chondroitin sulphate proteoglycan versican in mammalian vitreous. Matrix Biology, 17, 325-333. eScholarID:1d24359
- Bishop PN, Tullo AB. (1998). Pyoderma gangrenosum and peripheral ulcerative keratitis. Cornea, 17, 346-7. eScholarID:1d24364
1996
- Bishop PN, S Ayad, S Rearden, McLeod D-, J Sheehan, Kielty CM. (1996). Type VI collagen is present in human and bovine vitreous. Graefe's Archive of Clinical and Experimental Ophthalmology, 234, 710-713. eScholarID:1d24341
- Bishop PN. (1996). The biochemical structure of mammalian vitreous. Eye, 10, 664-670. eScholarID:1d24365
- DJ Brown, Bishop PN, H Hamdi, MC Kenney. (1996). Fragmentation of structural components of mammalian vitreous by an endogenous matrix metalloproteinase. Current Eye Research, 15, 439-445. eScholarID:1d24366
1994
- Bishop PN, Crossman M, McLeod D, Ayad S. (1994). Extraction and characterization of the tissue forms of collagen types II and IX from bovine vitreous. Biochem J, 299 ( Pt 2), 497-505. eScholarID:1d30837
1993
- Bishop PN, Boulton M, McLeod D, Stoddart R. (1993). Glycan localization within the human interphotoreceptor matrix and photoreceptor inner and outer segments. Glycobiology, 3( 4), 403-12. eScholarID:1d30396
1992
- Bishop PN, McLeod D, Ayad S. (1992). Extraction and characterisation of the intact form of bovine vitreous type IX collagen. Biochem Biophys Res Commun, 185( 1), 392-7. eScholarID:1d30838
1991
- Bishop PN, Bonshek RR, Jones C, Ridgway A, Stoddart R. (1991). Lectin binding sites in normal, scarred, and lattice dystrophy corneas. Br J Ophthalmol, 75( 1), 22-7. eScholarID:1d30011
- Bishop PN, McLeod D, Ayad S. (1991). Extraction of the intact form of type IX collagen from mammalian vitreous. Biochem Soc Trans, 19( 4), eScholarID:1d30305
- Bishop PN, Tullo A, Killough R, Richmond S. (1991). An immune dot-blot test for the diagnosis of ocular infection with Chlamydia trachomatis. Eye, 5 ( Pt 3), 305-8. eScholarID:1d30003