Skip to main content Skip to navigation

[University home]

School of Medicine

Professor Peter Clayton BSc, MD(Manchester), MRCP, FRCPCH

Photograph of Peter Clayton

Professor of Child Health & Paediatric Endocrinology

University:
Paediatric Endocrinology
5th Floor (Research)
Royal Manchester Children's Hospital
Oxford Road
Manchester
M13 9WL

Hospital:
Endocrinology Dept
Royal Manchester Children's Hospital
Oxford Road
Manchester
M13 9WL

 

Role

Professor of Child Health & Paediatric Endocrinology, School of Biomedicine, Faculty of Medical & Human Sciences

Honorary Consultant in Paediatrics & Paediatric Endocrinology at Central Manchester & Manchester Children's University Hospitals NHS Foundation Trust (Royal manchester Children's Hospital, 1 of 7 Consultants running the Tertiary Paediatric Endocrine service for the North West).

Honorary Consultant Paediatrician at the Christie Hospital

Director of the Greater Manchester, Lancashire and South Cumbria Medicines for Children Local Research Network

Lead for the Faculty of Medical & Human Sciences Clinical Lecturer programme

Member of the Executive Committee of the Greater Manchester Comprehensive Local Research Network

Lead for Paediatrics, Manchester Biomedical Research Centre, Central Manchester & Manchester Children's (CMFT) University Hospitals NHS Foundation Trust

Divisional Research Lead for Children, Central Manchester University Hospitals NHS Foundation Trust

Member of the Governing Board of Central Manchester University Hospitals NHS Foundation Trust 

 

Memberships of Committees and Professional Bodies

The British Society of Paediatric Endocrinology & Diabetes

The Society for Endocrinology (served on Council)

The Pituitary Foundation Medical Committee

The European Society of Paediatric Endocrinology (served on Drugs & Therapeutics committee)

The Growth Hormone Research Society (On Council)

The Endocrine Society (US)

Research

  • Normal & disordered growth
  • Pharmacogenetics
  • Growth hormone signaling
  • Genetic causes for being born small and pathophysiological mechanisms
  • Congenital Hyperinsulinism
  • Information needs and Communication in paediatric disorders

I run a paediatric endocrine research group with both clinical and basic research interests, the broad remit being – Clinical, biochemical and molecular study of growth & development

Our present projects include:

  • Characterising the role of ubiquitination in growth disorders, using the 3M syndrome as a model disorder
  • Genomic and metabolomic approaches to understanding why some children born small fail to show catch-up growth 
  • Using pharmacogenomics to predict clinical responses to human growth hormone treatment
  • The Manchester Growth & Vascular Health Study – follow-up of normal infants to assess growth, growth factors and CVS parameters in White European and Pakistani children
  • The Ibadan (Nigeria) Growth & Vascular Health Study
  • Pathphysiological mechanisms in children with congenital hyperinsulinism
  • Information needs in Turner Syndrome
  • Information needs for young people involved in pharmacogenetic studies
  • Promoting better communication in young people with endocrine disorders

 

    Keywords
  • Growth Hormone
  • Insulin-like Growth Factor-1
  • Pharmacogenomics
  • Basic Science
  • Clinical investigation
  • Genetics
  • High-risk groups (eg ethnic minorities)
  • Long-term/chronic illness
  • Childhood obesity
 

Methodological Knowledge

 

  • Cohort studies

  • Laboratory Science

  • Randomised control trials/experimental studies

  • Research in Children & Adolescents

    •  

    Teaching

    MB ChB:

    Supervisor for Yr 1 SSCs

    Supervisor for Yr 3, 4 and 5 SSCs

    Academic Advisor

    Supervisor for Yr 4 Project options

    Teacher for Family & Children Module in Yr 4

    OSCE & OSLA examiner

    Postgraduate:

    Supervisor & Mentor for junior staff in paediatrics and paediatric endocrinology

    Supervisor for Medcial MRes / MPhil / MD / PhD students

     

    Biography

    Professor Clayton graduated from Manchester University Medical School in 1984 (Distinction in Paediatrics), having obtained a first class degree in Physiology & Pharmacology in 1981. He did his early paediatric training around Manchester before embarking on an academic career in Paediatric Endocrinology. His MD thesis was on "Growth Patterns after Neuroaxis Irradiation in Childhood". He spent time at the University of Virginia, USA as a MRC Travelling Fellow in 1990/1 with his work there primarily directed at molecular endocrinology in the laboratory.

    He returned to Manchester to establish a research group of both clinicians and scientists, working under the broad remit of investigating normal and abnormal growth from clinical, biochemical and molecular perspectives. He took up a Senior Lectureship in Child Health in 1994, and was promoted to Professor of Child Health and Paediatric Endocrinology in 2001. He was lead for the Division of Human Development in the Manchester Medical School from 2001-2007.

    He has >200 publications on clinical and basic science aspects of paediatric endocrinology. He has served on the editorial boards of a number of endocrine journals, and is currently an associate editor of Hormone Research and on the board of Clinical Endocrinology. He is on the councils of the Growth Hormone Research Society and the Society for Endocrinology. He is on the medical committee of the UK Pituitary Foundation.

     

    Qualifications

    • BSc Hons 1st Class Physiology and Pharmacology University of Manchester 1981
    • MB ChB (Distinction Paediatrics) University of Manchester 1984
    • MRCP London 1989
    • MD (Growth Patterns after Neuroaxis Irradiation) University of Manchester 1990
    • FRCPCH 1998
     

    Collaborators and affiliated staff

    Collaborators
    • Professor Graeme Black, Genetic Medicine (UoM)
    • Professor Peter Callery, School of Nursing (UoM)
    • Professor Kennedy Cruickshank, Diabetes, Cardiovascular Medicine & Nutrition, Kings College University of London
    • Professor Mark Dunne, Faculty of Life Sciences
    • Dr Karen Cosgrove, Faculty of Life Sciences
    • MerckSerono, Geneva
    • Ipsen, Paris
     

    Affiliated Academic staff & students
    • Dr Leena Patel, Senior Lecturer in Child Health
    • Dr Andy Whatmore, Senior Experimental Officer
    • Dr Adam Stevens, Post-doctoral Research Associate
    • Dr Daniel Hanson, Post-doctoral Research Associate
    • Ms Jenny Downing, Research Assistant
    • Ms Aysha Khan, research Assistant
    • Mrs Jacquie Collin, Lecturer in Nursing, University of Keele, PhD student
    • Ms Alisha Gibson, PhD Student
    • Dr Claire Bonshek, MPhil Student (Clinical)
    • Dr Sophia Khan, MPhil Student (Clinical)
    • Dr Bindu Avatapalle, MPhil Student (Clinical)
     

     

    Selected publications

    2011

    • Banerjee, I., Skae, M., Flanagan, S., Rigby, L., Patel, L., Didi, M., Blair, J., Ehtisham, S., Ellard, S., Cosgrove, K., Dunne, M. & Clayton, P (2011). The contribution of rapid KATP channel gene mutation analysis to the clinical management of children with congenital hyperinsulinism. Eur J Endocrinol, 164(5), 733-40. eScholarID:126048 | PMID:21378087 | DOI:10.1530/EJE-10-1136
    • Bansal, N., Anderson, S., Vyas, A., Gemmell, I., Charlton-Menys, V., Oldroyd, J., Pemberton, P., Durrington, P., Clayton, P. & Cruickshank, J (2011). Adiponectin and Lipid Profiles Compared with Insulins in Relation to Early Growth of British South Asian and European Children: The Manchester Children's Growth and Vascular Health Study. J Clin Endocrinol Metab, eScholarID:126041 | PMID:21632814 | DOI:10.1210/jc.2011-0046
    • Clayton, P., Banerjee, I., Murray, P. & Renehan, A (2011). Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol, 7(1), 11-24. eScholarID:126046 | PMID:20956999 | DOI:10.1038/nrendo.2010.171
    • Hanson, D., Murray, P., O'Sullivan, J., Urquhart, J., Daly, S., Bhaskar, S., Biesecker, L., Skae, M., Smith, C., Cole, T., Kirk, J., Chandler, K., Kingston, H., Donnai, D., Clayton, P. & Black, G (2011). Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth. Am J Hum Genet, 89(1), 148-53. eScholarID:134265 | PMID:21737058 | DOI:10.1016/j.ajhg.2011.05.028
    • Murray, P., Read, A., Banerjee, I., Whatmore, A., Pritchard, L., Davies, R., Brennand, J., White, A., Ross, R. & Clayton, P (2011). Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene. Eur J Endocrinol, 164(4), 521-7. eScholarID:126049 | PMID:21296922 | DOI:10.1530/EJE-10-0656
    • Powell, P., Bellanné-Chantelot, C., Flanagan, S., Ellard, S., Rooman, R., Hussain, K., Skae, M., Clayton, P., de Lonlay, P., Dunne, M. & Cosgrove, K (2011). In vitro recovery of ATP-sensitive potassium channels in β-cells from patients with congenital hyperinsulinism of infancy. Diabetes, 60(4), 1223-8. eScholarID:126045 | PMID:21411514 | DOI:10.2337/db10-1443
    • Westwood, M., Tajbakhsh, S., Siddals, K., Whatmore, A. & Clayton, P (2011). Reduced Pericellular Sensitivity to IGF-I in Fibroblasts From Girls With Turner Syndrome: A Mechanism to Impair Clinical Responses to GH. Pediatr Res, 70(1), 25-30. eScholarID:126047 | PMID:21430600 | DOI:10.1203/PDR.0b013e31821b570b

    2010

    • Westwood, M., Maqsood, A., Solomon, M., Whatmore, A., Davis, J., Baxter, R., Gevers, E., Robinson, I. & Clayton, P (2010). The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat. Am J Physiol Endocrinol Metab, 298(3), E467-76. eScholarID:81165 | PMID:19861588 | DOI:10.1152/ajpendo.00234.2009

    2009

    • Hanson, D, Murray, P, Sud, A, Temtamy, S, Aglan, M, Superti-Furga, A, Holder, S, Urquhart, JE, Hilton, E, Manson, FDC, Scambler, P, Black, GCM, Clayton, PE. (2009). The primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1. Am J Hum Genet, 84( 6), eScholarID:1d20102 | DOI:10.1016/j.ajhg.2009.04.021
    • Oldroyd JC, Heald A, Bansal N, Vyas A, Siddals K, Gibson M, Clayton PE, Cruickshank JK. (2009). Inflammatory markers and growth in South Asian and European origin infants in Britain: The Manchester Children's Growth and Vascular Health Study. Atherosclerosis, eScholarID:1d19172 | DOI:10.1016/j.atherosclerosis.2009.03.045
    • Shimomura, K., Flanagan, S., Zadek, B., Lethby, M., Zubcevic, L., Girard, C., Petz, O., Mannikko, R., Kapoor, R., Hussain, K., Skae, M., Clayton, P., Hattersley, A., Ellard, S. & Ashcroft, F (2009). Adjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism. EMBO Mol Med, 1(3), 166-77. eScholarID:81164 | PMID:20049716 | DOI:10.1002/emmm.200900018
    • Whatmore AJ, Patel L, Clayton PE. (2009). A pilot study to evaluate gene expression profiles in peripheral blood mononuclear cells (PBMCs) from children with GH deficiency and Turner syndrome in response to GH treatment. Clin Endocrinol (Oxf), 70( 3), 429-34. eScholarID:1d18723 | DOI:10.1111/j.1365-2265.2008.03477.x

    2007

    • Patel L, Cavazzoni E, Whatmore AJ, Carney S, Wales J, Clayton PE, Gibson A. (2007). The contributions of plasma IGF-I, IGFBP-3 and leptin to growth in extremely premature infants during the first two years. Pediatr Res, 61( 1), 99-104. eScholarID:1d18736 | DOI:10.1203/01.pdr.0000250036.34522.f1

    2005

    • Huber, C, Dias-Santagata, D, Glaser, A, O'Sullivan, J, Brauner, R, Wu, K, Xu, X, Pearce, K, Wang, R, Uzielli, M, Dagoneau, N, Chemaitilly, W, Superti-Furga, A, Dos Santos, H, Mégarbané, A, Morin, G, Gillessen-Kaesbach, G, Hennekam, R, Van der Burgt, I, Black, GCM, Clayton, PE, Read, A, Le Merrer, M, Scambler, P, Munnich, A, Pan, Z, Winter, R, Cormier-Daire, V. (2005). Identification of mutations in CUL7 in 3-M syndrome. Nat Genet, 37( 10), 1119-24. eScholarID:1d30314

    View all Publications

    Top of page

    | Skip to main content | Skip to navigation | Skip to Search |