Dr Peter Warn PhD

2011

• Al-Barrag, A., Anderson, M., Howard, S., Robson, G., Warn, P., Sanglard, D. & Denning, D (2011). Interrogation of related Clinical Pan-azole Resistant Aspergillus fumigatus strains - G138C, Y431C and G434C SNPs in cyp51A, Upregulation of cyp51A and Integration and Activation of Transposon Atf1 into cyp51A Promoter. Antimicrob Agents Chemother, eScholarID:129943 | PMID:21876055 | DOI:10.1128/AAC.00517-11
• Howard, S., Lestner, J., Sharp, A., Gregson, L., Goodwin, J., Slater, J., Majithiya, J., Warn, P. & Hope, W (2011). Pharmacokinetics and pharmacodynamics of posaconazole for invasive pulmonary aspergillosis: clinical implications for antifungal therapy. J Infect Dis, 203(9), 1324-32. eScholarID:129952 | PMID:21357943 | DOI:10.1093/infdis/jir023
• Italia, J., Sharp, A., Carter, K., Warn, P. & Kumar, M (2011). Peroral amphotericin B polymer nanoparticles lead to comparable or superior in vivo antifungal activity to that of intravenous Ambisome® or Fungizone™. PLoS One, 6(10), e25744. eScholarID:146015 | PMID:21998690 | DOI:10.1371/journal.pone.0025744
• Rajendran, R., Mowat, E., McCulloch, E., Lappin, D., Jones, B., Lang, S., Majithiya, J., Warn, P., Williams, C. & Ramage, G (2011). Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity. Antimicrob Agents Chemother, 55(5), 2092-7. eScholarID:129926 | PMID:21321135 | DOI:10.1128/AAC.01189-10
• Slater, J., Gregson, L., Denning, D. & Warn, P (2011). Pathogenicity of Aspergillus fumigatus mutants assessed in Galleria mellonella matches that in mice. Med Mycol, 49 Suppl 1, S107-13. eScholarID:129947 | PMID:20950221 | DOI:10.3109/13693786.2010.523852
• Slater, J., Howard, S., Sharp, A., Goodwin, J., Gregson, L., Alastruey-Izquierdo, A., Arendrup, M., Warn, P., Perlin, D. & Hope, W (2011). Disseminated Candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin. Antimicrob Agents Chemother, 55(7), 3075-83. eScholarID:129964 | PMID:21502627 | DOI:10.1128/AAC.01686-10
• Warn PA, Livermore J, Howard S, Felton TW, Sharp A, Gregson L, Goodwin J, Petraitiene R, Petraitis V, Cohen-Wolkowiez M, Walsh TJ, Benjamin DK Jr, Hope WW. (2011). Anidulafungin for Neonatal Hematogenous Candida Meningoencephalitis: Identification of Candidate Regimens for Humans Using a Translational Pharmacological Approach. Antimicrob Agents Chemother, eScholarID:146009

2010

• Ann Chai, L., Denning, D. & Warn, P (2010). Candida tropicalis in human disease. Crit Rev Microbiol, 36(4), 282-98. eScholarID:129930 | PMID:20883082 | DOI:10.3109/1040841X.2010.489506
• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2010). Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents, 35(2), 146-51. eScholarID:129922 | PMID:20015618 | DOI:10.1016/j.ijantimicag.2009.09.029
• Zhao, Y., Park, S., Warn, P., Shrief, R., Harrison, E. & Perlin, D (2010). Detection of Aspergillus fumigatus in a rat model of invasive pulmonary aspergillosis by real-time nucleic acid sequence-based amplification. J Clin Microbiol, 48(4), 1378-83. eScholarID:129963 | PMID:20129972 | DOI:10.1128/JCM.02214-09

2009

• Majithiya, J., Sharp, A., Parmar, A., Denning, D. & Warn, P (2009). Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei. J Antimicrob Chemother, 63(1), 161-6. eScholarID:129935 | PMID:19008255 | DOI:10.1093/jac/dkn431
• McCulloch, E., Ramage, G., Jones, B., Warn, P., Kirkpatrick, W., Patterson, T. & Williams, C (2009). Don't throw your blood clots away: use of blood clot may improve sensitivity of PCR diagnosis in invasive aspergillosis. J Clin Pathol, 62(6), 539-41. eScholarID:129931 | PMID:19190008 | DOI:10.1136/jcp.2008.063321
• Verweij, P., González, G., Wiedrhold, N., Lass-Flörl, C., Warn, P., Heep, M., Ghannoum, M. & Guinea, J (2009). In vitro antifungal activity of isavuconazole against 345 mucorales isolates collected at study centers in eight countries. J Chemother, 21(3), 272-81. eScholarID:129938 | PMID:19567347
• Warn, P., Sharp, A., Parmar, A., Majithiya, J., Denning, D. & Hope, W (2009). Pharmacokinetics and pharmacodynamics of a novel triazole, isavuconazole: mathematical modeling, importance of tissue concentrations, and impact of immune status on antifungal effect. Antimicrob Agents Chemother, 53(8), 3453-61. eScholarID:129950 | PMID:19451288 | DOI:10.1128/AAC.01601-08

2007

• Hedayati, M., Pasqualotto, A., Warn, P., Bowyer, P. & Denning, D (2007). Aspergillus flavus: human pathogen, allergen and mycotoxin producer. Microbiology, 153(Pt 6), 1677-92. eScholarID:129924 | PMID:17526826 | DOI:10.1099/mic.0.2007/007641-0
• Hope, W., Drusano, G., Moore, C., Sharp, A., Louie, A., Walsh, T., Denning, D. & Warn, P (2007). Effect of neutropenia and treatment delay on the response to antifungal agents in experimental disseminated candidiasis. Antimicrob Agents Chemother, 51(1), 285-95. eScholarID:129934 | PMID:17088486 | DOI:10.1128/AAC.00601-06
• Hope, W., Warn, P., Sharp, A., Reed, P., Keevil, B., Louie, A., Walsh, T., Denning, D. & Drusano, G (2007). Optimization of the dosage of flucytosine in combination with amphotericin B for disseminated candidiasis: a pharmacodynamic rationale for reduced dosing. Antimicrob Agents Chemother, 51(10), 3760-2. eScholarID:129946 | PMID:17682101 | DOI:10.1128/AAC.00488-07
• Rodriguez-Tudela, J., Donnelly, J., Pfaller, M., Chryssantou, E., Warn, P., Denning, D., Espinel-Ingroff, A., Barchiesi, F. & Cuenca-Estrella, M (2007). Statistical analyses of correlation between fluconazole MICs for Candida spp. assessed by standard methods set forth by the European Committee on Antimicrobial Susceptibility Testing (E.Dis. 7.1) and CLSI (M27-A2). J Clin Microbiol, 45(1), 109-11. eScholarID:129955 | PMID:17093015 | DOI:10.1128/JCM.01969-06
• Warn PA, Sharp AD, Harwood M, Clarke E, Denning DW. In Vitro Model of the Translocation of Candida spp Across Gut Wall. 2007. to be submitted. eScholarID:19d336

2006

• Hope, W., Warn, P., Sharp, A., Howard, S., Kasai, M., Louie, A., Walsh, T., Drusano, G. & Denning, D (2006). Derivation of an in vivo drug exposure breakpoint for flucytosine against Candida albicans and Impact of the MIC, growth rate, and resistance genotype on the antifungal effect. Antimicrob Agents Chemother, 50(11), 3680-8. eScholarID:129962 | PMID:16954320 | DOI:10.1128/AAC.00369-06
• Warn PA, Sharp A, Mosquera J, Spickermann J, Schmitt-Hoffmann A, Heep M, Denning DW. (2006). Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus. J Antimicrob Chemother, 58( 6), 1198-1207. eScholarID:1d14619 | DOI:10.1093/jac/dkl396
• Warn, P., Sharp, A. & Denning, D (2006). In vitro activity of a new triazole BAL4815, the active component of BAL8557 (the water-soluble prodrug), against Aspergillus spp. J Antimicrob Chemother, 57(1), 135-8. eScholarID:129936 | PMID:16284102 | DOI:10.1093/jac/dki399
• Warn, P., Sharp, A., Mosquera, J., Spickermann, J., Schmitt-Hoffmann, A., Heep, M. & Denning, D (2006). Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus. J Antimicrob Chemother, 58(6), 1198-207. eScholarID:129929 | PMID:17071636 | DOI:10.1093/jac/dkl396

2005

• Hope, W., Warn, P., Sharp, A., Reed, P., Keevil, B., Louie, A., Denning, D. & Drusano, G (2005). Surface response modeling to examine the combination of amphotericin B deoxycholate and 5-fluorocytosine for treatment of invasive candidiasis. J Infect Dis, 192(4), 673-80. eScholarID:129956 | PMID:16028137 | DOI:10.1086/432069
• Jung W, Warn PA, Ragni E, Popolo L, Nunn C, Turner M, Stateva L. (2005). Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans. Yeast, 22( 4), 285-94. eScholarID:1d28866
• Jung, W., Warn, P., Ragni, E., Popolo, L., Nunn, C., Turner, M. & Stateva, L (2005). Deletion of PDE2, the gene encoding the high-affinity cAMP phosphodiesterase, results in changes of the cell wall and membrane in Candida albicans. Yeast, 22(4), 285-94. eScholarID:129928 | PMID:15789349 | DOI:10.1002/yea.1199
• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2005). Activity of aminocandin (IP960) compared with amphotericin B and fluconazole in a neutropenic murine model of disseminated infection caused by a fluconazole-resistant strain of Candida tropicalis. J Antimicrob Chemother, 56(3), 590-3. eScholarID:129925 | PMID:16046462 | DOI:10.1093/jac/dki268

2004

• Kamran, M, Calcagno, A, Findon, H, Bignell, E, Jones, M, Warn, PA, Hopkins, P, Denning, DW, Butler, G, Rogers, T, Mühlschlegel, F, Haynes, K. (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3( 2), 546-52. eScholarID:1d28815
• Kamran, M., Calcagno, A., Findon, H., Bignell, E., Jones, M., Warn, P., Hopkins, P., Denning, D., Butler, G., Rogers, T., Mühlschlegel, F. & Haynes, K (2004). Inactivation of transcription factor gene ACE2 in the fungal pathogen Candida glabrata results in hypervirulence. Eukaryot Cell, 3(2), 546-52. eScholarID:129942 | PMID:15075283
• Warn PA, Sharp A, Guinea J, Denning DW. (2004). Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. J Antimicrob Chemother, 53( 5), 743-9. eScholarID:1d29493
• Warn, P., Sharp, A., Guinea, J. & Denning, D (2004). Effect of hypoxic conditions on in vitro susceptibility testing of amphotericin B, itraconazole and micafungin against Aspergillus and Candida. J Antimicrob Chemother, 53(5), 743-9. eScholarID:129933 | PMID:15044422 | DOI:10.1093/jac/dkh153

2003

• Calcagno A, Bignell E, Warn PA, Jones M, Denning DW, Mühlschlegel F, Rogers T, Haynes K. (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50( 4), 1309-18. eScholarID:1d29186
• Calcagno, A., Bignell, E., Warn, P., Jones, M., Denning, D., Mühlschlegel, F., Rogers, T. & Haynes, K (2003). Candida glabrata STE12 is required for wild-type levels of virulence and nitrogen starvation induced filamentation. Mol Microbiol, 50(4), 1309-18. eScholarID:129927 | PMID:14622417
• Warn PA, Brampton M, Sharp A, Morrissey G, Steel N, Denning DW, Priest T. (2003). Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections. Lab Anim, 37( 2), 126-31. eScholarID:1d28430
• Warn PA, Morrissey G, Morrissey J, Denning DW. (2003). Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin B. J Antimicrob Chemother, 51( 4), 913-9. eScholarID:1d29061
• Warn PA, Morrissey G, Morrissey J, Denning DW. (2003). Activity of Micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistence to amphotericin B. Journal of Antimicrobial Chemotherapy, 51, 913-919. eScholarID:1d15580 | DOI:10.1093/jac/dkg185
• Warn, P., Brampton, M., Sharp, A., Morrissey, G., Steel, N., Denning, D. & Priest, T (2003). Infrared body temperature measurement of mice as an early predictor of death in experimental fungal infections. Lab Anim, 37(2), 126-31. eScholarID:129944 | PMID:12689423 | DOI:10.1258/00236770360563769
• Warn, P., Morrissey, G., Morrissey, J. & Denning, D (2003). Activity of micafungin (FK463) against an itraconazole-resistant strain of Aspergillus fumigatus and a strain of Aspergillus terreus demonstrating in vivo resistance to amphotericin B. J Antimicrob Chemother, 51(4), 913-9. eScholarID:129923 | PMID:12654746 | DOI:10.1093/jac/dkg185

2002

• Mosquera J, Sharp A, Moore C, Warn PA, Denning DW. (2002). In vitro interaction of terbinafine with itraconazole, fluconazole, amphotericin B and 5-flucytosine against Aspergillus spp. J Antimicrob Chemother, 50( 2), 189-94. eScholarID:1d29070
• Mosquera, J., Sharp, A., Moore, C., Warn, P. & Denning, D (2002). In vitro interaction of terbinafine with itraconazole, fluconazole, amphotericin B and 5-flucytosine against Aspergillus spp. J Antimicrob Chemother, 50(2), 189-94. eScholarID:129937 | PMID:12161398
• Warn PA, Sharp A, Morrissey G, Denning DW. (2002). In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis. J Antimicrob Chemother, 50( 6), 1071-4. eScholarID:1d28431
• Warn, P., Sharp, A., Morrissey, G. & Denning, D (2002). In vivo activity of micafungin in a persistently neutropenic murine model of disseminated infection caused by Candida tropicalis. J Antimicrob Chemother, 50(6), 1071-4. eScholarID:129940 | PMID:12461036

2001

• Mosquera J, Warn PA, Morrissey J, Moore C, Gil-Lamaignere C, Denning DW. (2001). Susceptibility testing of Aspergillus flavus: inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo. Antimicrob Agents Chemother, 45( 5), 1456-62. eScholarID:1d29713
• Mosquera J, Warn PA, Rodriguez-Tudela J, Denning DW. (2001). Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole. J Antimicrob Chemother, 48( 4), 583-6. eScholarID:1d28465
• Mosquera, J., Warn, P., Morrissey, J., Moore, C., Gil-Lamaignere, C. & Denning, D (2001). Susceptibility testing of Aspergillus flavus: inoculum dependence with itraconazole and lack of correlation between susceptibility to amphotericin B in vitro and outcome in vivo. Antimicrob Agents Chemother, 45(5), 1456-62. eScholarID:129957 | PMID:11302810 | DOI:10.1128/AAC.45.5.1456-1462.2001
• Mosquera, J., Warn, P., Rodriguez-Tudela, J. & Denning, D (2001). Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole. J Antimicrob Chemother, 48(4), 583-6. eScholarID:129961 | PMID:11581243

2000

• Johnson, E., Oakley, K., Radford, S., Moore, C., Warn, P., Warnock, D. & Denning, D (2000). Lack of correlation of in vitro amphotericin B susceptibility testing with outcome in a murine model of Aspergillus infection. J Antimicrob Chemother, 45(1), 85-93. eScholarID:129966 | PMID:10629017
• Warn PA, Morrissey J, Moore C, Denning DW. (2000). In vivo activity of amphotericin B lipid complex in immunocompromised mice against fluconazole-resistant or fluconazole-susceptible Candida tropicalis. Antimicrob Agents Chemother, 44( 10), 2664-71. eScholarID:1d30507
• Warn, P., Morrissey, J., Moore, C. & Denning, D (2000). In vivo activity of amphotericin B lipid complex in immunocompromised mice against fluconazole-resistant or fluconazole-susceptible Candida tropicalis. Antimicrob Agents Chemother, 44(10), 2664-71. eScholarID:129939 | PMID:10991841

1999

• Denning, D. & Warn, P (1999). Dose range evaluation of liposomal nystatin and comparisons with amphotericin B and amphotericin B lipid complex in temporarily neutropenic mice infected with an isolate of Aspergillus fumigatus with reduced susceptibility to amphotericin B. Antimicrob Agents Chemother, 43(11), 2592-9. eScholarID:129932 | PMID:10543734

1997

• Newbold, C., Warn, P., Black, G., Berendt, A., Craig, A., Snow, B., Msobo, M., Peshu, N. & Marsh, K (1997). Receptor-specific adhesion and clinical disease in Plasmodium falciparum. Am J Trop Med Hyg, 57(4), 389-98. eScholarID:129951 | PMID:9347951
• Newton, C., Warn, P., Winstanley, P., Peshu, N., Snow, R., Pasvol, G. & Marsh, K (1997). Severe anaemia in children living in a malaria endemic area of Kenya. Trop Med Int Health, 2(2), 165-78. eScholarID:129954 | PMID:9472302

1996

• Snow, R., Molyneux, C., Warn, P., Omumbo, J., Nevill, C., Gupta, S. & Marsh, K (1996). Infant parasite rates and immunoglobulin M seroprevalence as a measure of exposure to Plasmodium falciparum during a randomized controlled trial of insecticide-treated bed nets on the Kenyan coast. Am J Trop Med Hyg, 55(2), 144-9. eScholarID:129965 | PMID:8780451

1995

• Marsh, K., Forster, D., Waruiru, C., Mwangi, I., Winstanley, M., Marsh, V., Newton, C., Winstanley, P., Warn, P. & Peshu, N (1995). Indicators of life-threatening malaria in African children. N Engl J Med, 332(21), 1399-404. eScholarID:129941 | PMID:7723795 | DOI:10.1056/NEJM199505253322102
• Ruwende, C., Khoo, S., Snow, R., Yates, S., Kwiatkowski, D., Gupta, S., Warn, P., Allsopp, C., Gilbert, S. & Peschu, N (1995). Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature, 376(6537), 246-9. eScholarID:129945 | PMID:7617034 | DOI:10.1038/376246a0

1992

• Winstanley, P., Watkins, W., Newton, C., Nevill, C., Mberu, E., Warn, P., Waruiru, C., Mwangi, I., Warrell, D. & Marsh, K (1992). The disposition of oral and intramuscular pyrimethamine/sulphadoxine in Kenyan children with high parasitaemia but clinically non-severe falciparum malaria. Br J Clin Pharmacol, 33(2), 143-8. eScholarID:129958 | PMID:1550695

• Brooker, S., Peshu, N., Warn, P., Mosobo, M., Guyatt, H., Marsh, K. & Snow, R The epidemiology of hookworm infection and its contribution to anaemia among pre-school children on the Kenyan coast. Trans R Soc Trop Med Hyg, 93(3), 240-6. eScholarID:129959 | PMID:10492749
• Newton, C., Winstanley, P., Watkins, W., Mwangi, I., Waruiru, C., Mberu, E., Warn, P., Nevill, C. & Marsh, K A single dose of intramuscular sulfadoxine-pyrimethamine as an adjunct to quinine in the treatment of severe malaria: pharmacokinetics and efficacy. Trans R Soc Trop Med Hyg, 87(2), 207-10. eScholarID:129921 | PMID:8337731
• Nyakundi, J., Warn, P., Newton, C., Mumo, J. & Jephthah-Ochola, J Serum tumour necrosis factor in children suffering from Plasmodium falciparum infection in Kilifi District, Kenya. Trans R Soc Trop Med Hyg, 88(6), 667-70. eScholarID:129953 | PMID:7886766
• Snow, R., Schellenberg, J., Peshu, N., Forster, D., Newton, C., Winstanley, P., Mwangi, I., Waruiru, C., Warn, P. & Newbold, C Periodicity and space-time clustering of severe childhood malaria on the coast of Kenya. Trans R Soc Trop Med Hyg, 87(4), 386-90. eScholarID:129948 | PMID:8249058
• Winstanley, P., Newton, C., Watkins, W., Mberu, E., Ward, S., Warn, P., Mwangi, I., Waruiru, C., Pasvol, G. & Warrell, D Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: the importance of unbound quinine concentration. Trans R Soc Trop Med Hyg, 87(2), 201-6. eScholarID:129960 | PMID:8337730