Dr Rainer Hinz

Senior Lecturer in Functional Imaging
- Email: rainer.hinz@manchester.ac.uk
- Telephone: +44 (0)161 2750068
- Alternative Telephone: +44 (0)161 2750000 (switchboard)
- Fax: +44 (0)161 2750003
Wolfson Molecular Imaging Centre
27 Palatine Road
Withington
Manchester
M20 3LJ
Role
For the Research School of Cancer and Imaging Sciences
- Sustained output of high quality peer reviewed research publications.
- Sustained research and professional achievement e.g invited conference contributions, invitations to referee or review publications.
- Success in attracting external grant income.
- Successful postgraduate research supervision.
- Promoting the reputation of the School via conferences and media exposure.
- Contributing to multi-disciplinary team working in applying for major grants.
- Contibuting to undergraduate teaching.
- Making a contribution to the management of the School.
For the Wolfson Molecular Imaging Centre
- Advise on the design, conduct and analysis of clinical and preclinical PET research studies in oncology, neurology and psychiatry.
- Develop novel acquisition and analysis techniques to help establish the WMIC as a centre of excellence in PET methodology.
- Contribute with others in the developments in instrumentation.
- Transfer conventional and new modelling techniques into implementation, working closely with information systems and technology personnel to ensure that such software adheres to appropriate standards of quality assurance.
- Ensure with others that data analysis conducted within the WMIC is performed to an appropriate standard by conforming to internal policies and external regulations.
- Continually learn and educate oneself in biological and medical research via interactions with colleagues and literature reading.
- Educate, advise and supervise clinical fellows and data analysts in the conduct of image analysis.
- Collaborate in projects outside the main areas of image analysis such as physics, image reconstruction, statistics and the analysis of non-PET imaging modalities.
- Present the scientific work of the institute at national and international meetings and conferences.
- Publish in international peer-reviewed journals.
- Establish and maintain collaborations with partners in academia and in industry.
- Contribute to the production of grant applications, centre reports and funding body reviews as appropriate.
- Supervise or co-supervise students undertaking research degrees.
Memberships of Committees and Professional Bodies
- Member of the Institute of Electrical and Electronics Engineers (IEEE), Nuclear and Plasma Sciences Society.
Research
- Please visit my University webpage which provides further material such as slides from presentations and a chronological list of selected publications.
Methodological Knowledge
Biography
- September 1994 – July 1999. Work on the development of a novel positron emission tomography (PET) technique to monitor the radiation therapy with heavy charged particles at the Radiation Physics Department of the Institute of Nuclear and Hadron Physics at the Forschungszentrum Rossendorf.
- August 1999 – February 2001. Work at post-doctoral level at the Institute of Bioinorganic and Radiopharmaceutical Chemistry of the Forschungszentrum Rossendorf.
- March 2001 – February 2002. Research project “Kinetic analysis and modelling of new tracers for the investigation into the serotonergic system by means of positron emission tomography (PET)”, supported by a Research Grant of the Deutsche Forschungsgemeinschaft. Host institutes: Medical Research Council Clinical Sciences Centre and Imaging Research Solutions Ltd. (IRSL) London Hammersmith.
- March 2002 - March 2006. Senior Mathematical Modeller in the PET Biology and Methodology Research and Development group of IRSL (now: Hammersmith Imanet Ltd. – part of General Electric Health Care).
- April 2006 - December 2007. Senior PET Methodologist at the Wolfson Molecular Imaging Centre of the University of Manchester.
- since January 2008. Senior Lecturer in the Research School of Cancer and Enabling Sciences (formerly Cancer and Imaging Sciences) of the University of Manchester.
Qualifications
- 27 September 1995. University degree as engineer (Diplom-Ingenieur) attained with “very good” after studies at the Chemnitz University of Technology in the Department of Electrical Engineering.
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07 February 2000. Doctoral award in engineering (Doktor-Ingenieur) with “magna cum laude” after postgraduate studies at the Dresden University of Technology, Institute of Biomedical Engineering of the Department Electrical Engineering. Thesis entitled Contributions on the introduction of positron emission tomography in heavy ion tumour therapy.
Collaborators and affiliated staff
Collaborators
- The PET Methodology Group at the MRC Clinical Sciences Centre (group head: Dr. Federico E. Turkheimer) on quantification and statistical analysis of neuroimaging data.
- Dr. Peter Brust (Institute of Interdisciplinary Isotope Research at the University of Leipzig) on tracer development and validation in preclinical studies.
- The Psychiatry Group at the MRC Clinical Sciences Centre (formerly headed by Prof. Paul M. Grasby) in collaboration with the Psychopharmacology Research Unit of the University Oxford (Prof. Philip J. Cowen) for investigations into the brain serotonergic system.
- Members of the Neurology Group at the MRC Clinical Sciences Centre (group head: Prof. David J. Brooks) for research in neurodegenerative diseases with PET.
- The Cardiology Group at the MRC Clinical Sciences Centre (group head: Prof. Paolo Camici) investigating in vivo imaging of blood vessel inflammation.
Network
- Please visit my public profile on LinkedIn.
Selected publications
2010
- Meyer, P., Bhagwagar, Z., Cowen, P., Cunningham, V., Grasby, P. & Hinz, R (2010). Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses. Neuroimage, 50(3), 984-993. eScholarID:78731 | PMID:20083209 | DOI:10.1016/j.neuroimage.2010.01.037
2009
- Edison, P., Brooks, D., Turkheimer, F., Archer, H. & Hinz, R (2009). Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility. Neuroimage, 48(2), 329-38. eScholarID:89963 | PMID:19591948 | DOI:10.1016/j.neuroimage.2009.06.079
2008
- Hinz, R., Selvaraj, S., Murthy, N., Bhagwagar, Z., Taylor, M., Cowen, P. & Grasby, P (2008). Effects of citalopram infusion on the serotonin transporter binding of [11C]DASB in healthy controls. J Cereb Blood Flow Metab, 28(8), 1478-90. eScholarID:89960 | PMID:18478022 | DOI:10.1038/jcbfm.2008.41
2007
- Hinz, R., Bhagwagar, Z., Cowen, P., Cunningham, V. & Grasby, P (2007). Validation of a tracer kinetic model for the quantification of 5-HT(2A) receptors in human brain with [(11)C]MDL 100,907. J Cereb Blood Flow Metab, 27(1), 161-72. eScholarID:89971 | PMID:16685260 | DOI:10.1038/sj.jcbfm.9600323
2006
- Hinz R, Turkheimer FE. (2006). Determination of tracer arrival delay with spectral analysis. IEEE Trans Nucl Sci, 53(1), 212-219. eScholarID:1d13876 | DOI:10.1109/TNS.2005.862982
- Turkheimer, F., Aston, J., Asselin, M. & Hinz, R (2006). Multi-resolution Bayesian regression in PET dynamic studies using wavelets. Neuroimage, 32(1), 111-21. eScholarID:89976 | PMID:16644238 | DOI:10.1016/j.neuroimage.2006.03.002