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School of Medicine

Dr Stefan Meyer MD PhD MRCPCH

Photograph of Stefan Meyer

Senior Lecturer / Consultant Paediatric Oncologist

c/o Young Oncology Unit
Christie Hospital
Wilmslow Road
Manchester M20 4BX

 

 

Research

Dr Stefan Meyer works as a Honorary Consultant Paediatric Oncologist at the Royal Manchester Children’s Hospital, where he also leads the multidisciplinary care for children with Fanconi anaemia, and the Young Oncology unit at the Christie Hospital.

Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities and extreme cancer predisposition. FA results from a defect in one of the at least 13 FA genes that encode for proteins interacting in a fundamental DNA damage response pathway with an important role in development, haematopoiesis and cancer prevention. Our research is focused on malignant transformation associated with FA and functional aspects of the FA-pathway in sporadic cancers.

Using FA-derived AML cell lines we have identified amplification and overexpression of the EVI1 oncogene associated with FA characteristic gains in the chromosomal region 3q26q29. EVI1 is an oncogenic transcriptional regulator with a critical role in self renewal. EVI1 overexpression in AML, which is usually associated with balanced translocations confers poor prognosis in sporadic AML. EVI1 function and regulation is complex and includes transforming growth factor (TGF)-ß antagonistic and chromatin remodeling properties. We areexploring EVI1 function in the context of the FA defect.

Our FA-derived AML cell lines derived from the AML associated with bi-allelic disruption of the FANCD1/BRCA2 gene maintain the FA characteristic cross linker hypersensitivity. We explore the characteristics of the DNA damage response using systems biology approaches in order to identify regulatory events that might be therapeutically accessible.


 

 

Methodological Knowledge


 

Teaching

Deputy Lead European Studies, Medical School

Firm Lead Paediatrics / Paediatic Oncology

Year 1 SSC supervsison

PhD, MPH and MRes supervision

Academic Advisor

Dr Meyer's Paediatic Oncology Clinic at RMCH can be booked via MedLea

 

Biography

Graduated in Medicine in Hamburg, Germany. MD University of Hamburg. Basic Paediatric training in Lubeck, Germany, and Manchester. MRCP/MRCPH(UK) 1995. Higher Specialist Training in Paediatrics and Paedriatric Oncology in Manchester. Leukaemia Research Fund Clinical Research Fellow 2000 – 2004, Paediatric Oncology, Manchester. PhD 2004, University of Manchester. CRUK Clinician Scientist 2005 -2010, University of Manchester .

Since 2010 Senior Lecturer / Honorary Consultant Paediatric Oncologist, Stem Cell and Leukaemia Proteomics Laboratory and clinically in the Department of Paediatric and Adoloscent Oncology of the University of Manchester at Royal Manchester Children’s and Christie Hospitals.

 

Collaborators and affiliated staff

Dr Daniel J White  Postdoctoral Research Associate

Ms Joanne Muter Research Assistant

 

Publications

2011

  • Biswas K, Das R, Alter BP, Kuznetsov SG, Stauffer SL, North SLG, Burkett S, Brody LC, Meyer S, Byrd AR, Sharan SK. (2011). A comprehensive study to classify BRCA2 variants associated with Fanconi Anemia using mouse ES cell-based functional assay. Blood, eScholarID:128047 | DOI:10.1182/blood-2010-12-324541
  • Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJM, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. (2011). Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood, 117, 234-241. eScholarID:128049 | DOI:10.1182/blood-2010-04-281337
  • Meyer S, Bristow C, Wappett M, Pepper S, Whetton AD, Hanenberg H, Neitzel H, Wlodarski MW, Ebell W , Tönnies H. (2011). Fanconi Anaemia (FA)-associated 3q gains in leukaemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood, 117, 6047-6050. eScholarID:128048 | DOI:10.1182/blood-2011-03-343897
  • Thathia, S., Ferguson, S., Gautrey, H., van Otterdijk, S., Hili, M., Rand, V., Moorman, A., Meyer, S., Brown, R. & Strathdee, G (2011). Epigenetic inactivation of TWIST2 in acute lymphoblastic leukemia modulates proliferation, cell survival and chemosensitivity. Haematologica, eScholarID:140380 | PMID:22058208 | DOI:10.3324/haematol.2011.049593

2010

  • Clarkson, J., Worthington, H., Furness, S., McCabe, M., Khalid, T. & Meyer, S (2010). Interventions for treating oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev, (8), CD001973. eScholarID:103459 | PMID:20687070 | DOI:10.1002/14651858.CD001973.pub4
  • Worthington, H., Clarkson, J., Bryan, G., Furness, S., Glenny, A., Littlewood, A., McCabe, M., Meyer, S. & Khalid, T (2010). Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev, 12, CD000978. eScholarID:103457 | PMID:21154347 | DOI:10.1002/14651858.CD000978.pub4
  • Worthington, H., Clarkson, J., Khalid, T., Meyer, S. & McCabe, M (2010). Interventions for treating oral candidiasis for patients with cancer receiving treatment. Cochrane Database Syst Rev, (7), CD001972. eScholarID:103460 | PMID:20614427 | DOI:10.1002/14651858.CD001972.pub4

2007

  • Meyer, S, Fergusson, W, Whetton, A, Moreira-Leite F, Pepper SD, Miller, CCJ, Saunders EK, White, DDJ, Will AM, Eden, OB, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. (2007). Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosome Cancer, 46 (4), 359-372. eScholarID:1d27524 | DOI:10.1002/gcc.20417
  • Strathdee, G, Holyoake, T, Sim, A, Parker, A, Oscier, D, Melo, J, Meyer, S, Eden, OB, Dickinson, A, Mountford, J, Jorgensen, H, Soutar, R, Brown, R. (2007). Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis. Clin Cancer Res, 13( 17), eScholarID:1d20073 | DOI:10.1158/1078-0432.CCR-07-0919

2006

  • Isaac H, Patel L, Meyer S, Cusick C, Hall C, Price DA, Clayton PE. (2006). Efficacy of a monthly compared to 3-monthly depot GnRH analogue (goserelin) in the treatment of children with central precocious puberty. Hormone Research, 68, 157-163. eScholarID:1d27670
  • Meyer S, Eden OB, Kalirai H. (2006). Dexamethasone protects against cisplatin-induced activation of the mitochondrial apoptotic pathway in human osteosarcoma cells. Cancer Biol Ther, 5, 915-920. eScholarID:1d15557
  • Meyer S, Eden T, Brennan B, Stevens R, Makin GWJ, Wynn RF, Carr T, Will A. (2006). Acquired chemosensitivity after insect bite in a boy with leukaemia. Br J Haematol, 134( 2), 244-5. eScholarID:1d30545
  • Meyer S, White DDJ, Will AM, Eden OB, Sim A, Brown R, Strathdee G. (2006). No evidence of significant silencing of Fanconi genes FANCF and FANCB or Nijmegen breakage syndrome gene NBS1 by DNA hyper-methylation in sporadic childhood leukaemia. Br J Haematol in press, 134, 61-63. eScholarID:1d13067 | DOI:10.1111/j.1365-2141.2006.06107.x
  • Meyer, S, Barber, L, White, DDJ, Andrew M. Will, Birch, JM, Janice A. Kohler, Ersfeld, KK.., Eric Blom, Hans Joenje, Eden, OB, Taylor, GM. (2006). Spectrum and significance of variants and mutations in the Fanconi anaemia group G gene in children with sporadic acute myeloid leukaemia. British Journal of Haematology, 133, 284-293. eScholarID:1d13048 | DOI:10.1111/j.1365-2141.2006.05985.x
  • Barber L, Meyer S, White DDJ, Andrew MW, Eden OB, Taylor GM. (2006). The association between FANCD1/BRCA2 mutations and leukaemia - response to Alter. British Journal Of Haematology, 133(4), eScholarID:17d389

2005

  • Barber L, Barlow R, Meyer S, White DDJ, Will AM, Eden OB, Taylor GM. (2005). Inherited FANCD1/BRCA2 exon 7 splice mutations associated with acute myeloid leukaemia in Fanconi anaemia D1 are not found in sporadic childhood leukaemia. British Journal Of Haematology, 130 (5), 796-797. eScholarID:1d26679
  • Meyer, S, Fergusson, W, Oostra AB , Medhurst AL, Waisfisz Q, de Winter JP, Chen F, Carr TF, Clayton-Smith, J, Clancy, T, Green M, Barber, L, Eden, OB, Will AM, Joenje H, Taylor, GM. (2005). A cross- linker sensitive myeloid leukaemia cell line from a 2-year-old boy with severe Fanconi Anaemia and bi-allelic FANCD1/BRCA2 mutations. Genes Chromosomes and Cancer, 42(4), 404-415. eScholarID:1d10145 | DOI:10.1002/gcc.20153
  • Meyer, S, Fergusson, W, Oostra, A, Medhurst, A, Waisfisz, Q, de Winter, J, Chen, F, Carr, T, Clayton-Smith, J, Clancy, T, Green, M, Barber, L, Eden, O, Will, A, Joenje, H, Taylor, G. (2005). A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations. Genes Chromosomes Cancer, 42( 4), eScholarID:1d30840

2004

  • Chen F, Medhurst AL, De Winter JP, Waisfisz Q, Rooimans MA, Oostra AB, Meyer, S, Zhang KJ, Xia B, Pals G, Arwert F, Zwaan CM, Joenje H. (2004). Apparent absence of BRCA2 protein in a proportion of acute myeloid leukemia cell lines. Leukemia, 18, eScholarID:1d10143
  • Meyer, S, Kingston, H, Taylor AM, Byrd PJ, Last JIK, Brennan, BMD, Trueman S, Kelsey, A, Taylor, GM, Eden, OB. (2004). Rhabdomyosarcoma in Nijmegen Breakage Syndrome: strong association with perianal primary site. Cancer Genetics and Cytogenetics, 154, 169-174. eScholarID:1d10045
  • Meyer, S, Kingston, H, Taylor, A, Byrd, P, Last, J, Brennan, B, Trueman, S, Kelsey, A, Taylor, G, Eden, O. (2004). Rhabdomyosarcoma in Nijmegen breakage syndrome: strong association with perianal primary site. Cancer Genet Cytogenet, 154( 2), eScholarID:1d29224

2003

  • Barber L, McGrath HEN, Meyer S, Will AM, Birch JM, Eden OB, Taylor GM. (2003). Constitutional sequence variation in the Fanconi anaemia group C (FANCC) gene in childhood acute myeloid leukaemia. British Journal Of Haematology, 121 (1), eScholarID:1d25387

2002

  • Robson H, Meyer S, Shalet SM, Anderson E, Roberts SA, Eden OB. (2002). Platinum agents in the treatment of osteosarcoma: efficacy of cistplatin vs. carboplatin in human osteosarcoma cell lines. Medical & Pediatric Oncology, 39 (6), eScholarID:1d3890
  • Stevens RF, Meyer S. (2002). Fanconi and Glanzmann - the men and their works. Brit J Haematol, 119(4), eScholarID:1d6556

2000

  • Meyer S, Bradbury AJ. (2000). Infant air travel, bronchiolitis and the environment. Archives of Diseases in Childhood, 83, eScholarID:1d3895
  • Meyer S, Bruce J, Kelsey A, Eden OB. (2000). Pseudosarcoma of the bladder associated with residual urachus in a three year old girl. Paediatric Surgery International, 16, eScholarID:1d3892
  • Meyer S, Thornley M, Wynn RF, Brennan BMD, Carr T, Wraith JE, Will AM. (2000). Donor bone marrow from sibling with inborn error of metabolism for treatment of acute leukaemia – clinical and biochemical consequences for the non affected recipient. Bone Marrow Transplantation, 25, eScholarID:1d3894

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