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School of Medicine

Professor Tony Freemont BSc, MD, FRCP, FRCPath

Photograph of Tony Freemont

Head of Undergraduate Medical Education, Professor of Osteoarticular Pathology

Head of Undergraduate Medical Education

Room G16
Stopford Building
The University of Manchester
Oxford Road
Manchester
M13 9PT

 

Research

My research is in two distinct areas:
 

1) Basic Science  - Basic molecular pathology and regenerative medicine. I am a member of the Tissue Injury and Repair Theme in the School of Biomedicine.
2) Clinical practice-based research – Primarily diagnostics. I am research theme leader for the Molecular Diagnostics in the new NIHR Manchester Musculoskeletal BRU.
 

Primary Research

Over the years, my group has pioneered the development of those molecular pathology techniques required to understanding disease mechanisms at the cellular level in human hard tissues (eg. bone, cartilage). Examples include being the first to use: in-situ RT PCR to detect low copy number transcripts (eg. IL-1 and oestrogen receptors) in bone, and in-situ zymography to identify active matrix degrading enzymes in osteoarthritic cartilage.
Currently our primary research focuses on identifying molecular mechanisms underlying discogenic low back pain and designing novel therapies using regenerative medicine techniques (eg. tissue engineering, stem cell manipulation, gene therapy). Key discoveries include showing that: Imbalances in the IL-1 superfamily drive the intervertebral disc (IVD) pathology underlying back pain; IL-1Ra delivered by gene therapy reverses the cellular dysfunction causing this pathology; autologous mesenchymal stem cells can be differentiated into IVD cells.
In addition, because it is difficult to reproduce the disease conditions of IVD degeneration in animal models, we have advanced understanding of the factors precipitating IVD degeneration and preclinical evaluation of novel therapies, by developing novel tissue culture bioreactor systems that mimic the human disease situation in a controlled environment.
 

 

Clinical Practice-based Research

In my role as Professor of Osteoarticular Pathology, I have been responsible for changing clinical practice through research in two particular areas:
• Defining the impact of adynamic bone disease in renal failure patients and reclassifying renal osteodystrophy to facilitate clinical decision-making.
• Defining the scope of synovial fluid microscopy in early management of arthritis.

Keywords

  • Molecular Pathology
  • Regenerative Medicine
  • Intervertebral Disc
  • Stem Cell Biology
  • Cancer Biology
  • Metastasis 
 

Teaching

I teach on the medical MB ChB, Pathology BSc, dental and FLS undergraduate programmes; on the MSc in Clinical Rheumatology and the NowNANO core knowledge programme.

 

Biography

General Background
 

Born in 1953, I was brought up in Ealing, West London. In 1964 I won a scholarship to Latymer Upper School, Hammersmith. After completing A levels in Biology, Physics and Chemistry I entered St Thomas’ Hospital Medical School in London from which I graduated BSc (Anatomy 2:i), MB, BS in 1970.
I trained in General Medicine in Portsmouth and Leicester, passing the MRCP (UK) examination in 1983. I then entered into pathology training in the University of Manchester, passing the MRCPath examination in Histopathology in 1986. I have since been made FRCP(E)(1990), FRCP (1995) and FRCPath (1996). I have specialised in Osteoarticular (bone and joint) pathology since 1983 (when I was awarded an ARC Clinical Lectureship) and was given a personal chair in 1993.
In 1984 I was awarded an MD for work on the migration of lymphocytes into diseased tissue. I was the first person to show vascular specialisation for promoting lymphocyte entry into disease tissues.
 

Clinical Work
 

I am Professor and Honorary Consultant with a large diagnostic histopathology practice in bone and joint disease. I report about 3,500 specimens per annum and am a recognised expert in the diagnostic pathology of joints, metabolic bone disease and soft tissue sarcomas. My clinical research focuses on two aspects of my clinical work:
• Synovial fluid microscopy as a test for the early and accurate diagnosis of joint disease. I have written a book, several chapters in leading Rheumatology and Cytology texts, and in excess of 25 peer-reviewed publications on this subject.
• Bone histomorphometry in the diagnosis, prognosis and management of renal osteodystrophy and other metabolic bone disorders. I have written several book chapters and more than 50 peer-reviewed papers on this subject.

Research
 

My basic scientific and clinical research is detailed above. I am currently funded by the Research Councils, NHS and a number of research charities and hold research grant income of about £1.5M. I have authored or co-authored more than 250 peer reviewed publications, >50 reviews, ≈30 chapters, and 1 book. I have supervised 34 MD/PhD students. I am a member of the College of Experts of the MRC and editorial board member of 4 journals.

Management
 

I am:

  • Head of Undergraduate Medical Education for FMHS
  • a GMC partner and a member of the NIHCE MTAC panel

Hobbies
 

I am a keen bell ringer and collector of brass threepenny bits.

 

Publications

2011

  • Bird, R., Freemont, T. & Saunders, B (2011). Hollow polymer particles that are pH-responsive and redox sensitive: two simple steps to triggered particle swelling, gelation and disassembly. Chem Commun (Camb), 47(5), 1443-5. eScholarID:134427 | PMID:21180719 | DOI:10.1039/c0cc04657d
  • Gilbert, H., Hoyland, J., Freemont, A. & Millward-Sadler, S (2011). The involvement of interleukin-1 and interleukin-4 in the response of human annulus fibrosus cells to cyclic tensile strain: an altered mechanotransduction pathway with degeneration. Arthritis Res Ther, 13(1), R8. eScholarID:134428 | PMID:21276216 | DOI:10.1186/ar3229
  • Lally, S., Freemont, T., Cellesi, F. & Saunders, B (2011). pH-responsive microgels containing hydrophilic crosslinking co-monomers: shell-exploding microgels through design. Colloid and Polymer Science, 289(5-6), 647-658. eScholarID:134431 | DOI:10.1007/s00396-010-2366-8
  • Liu, R., Milani, A., Freemont, T. & Saunders, B (2011). Doubly crosslinked pH-responsive microgels prepared by particle inter-penetration: swelling and mechanical properties. Soft Matter, 7(10), 4696-4704. eScholarID:134430 | DOI:10.1039/c1sm05216k
  • Liu, R., Milani, A., Saunders, J., Freemont, T. & Saunders, B (2011). Tuning the swelling and mechanical properties of pH-responsive doubly crosslinked microgels using particle composition. Soft Matter, 7(19), 9297-9306. eScholarID:134432 | DOI:10.1039/c1sm05922j
  • Rajpura, A., Porter, M., Gambhir, A., Freemont, A. & Board, T (2011). Clinical Experience of Revision of Metal on Metal Hip Arthroplasty for Aseptic Lymphocyte Dominated Vasculitis Associated Lesions (ALVAL). Hip International, 21(1), 43-51. eScholarID:134429 | DOI:10.5301/hip.2011.6276

2010

  • Fraylich, M., Liu, R., Richardson, S., Baird, P., Hoyland, J., Freemont, A., Alexander, C., Shakesheff, K., Cellesi, F. & Saunders, B (2010). Thermally-triggered gelation of PLGA dispersions: towards an injectable colloidal cell delivery system. J Colloid Interface Sci, 344(1), 61-9. eScholarID:94980 | PMID:20070971 | DOI:10.1016/j.jcis.2009.12.030
  • Minogue, B., Richardson, S., Zeef, L., Freemont, A. & Hoyland, J (2010). Characterisation of the human nucleus pulposus cell phenotype and evaluation of novel marker gene expression to define adult stem cell differentiation. Arthritis Rheum, eScholarID:94982 | PMID:20722018 | DOI:10.1002/art.27710
  • Minogue, B., Richardson, S., Zeef, L., Freemont, A. & Hoyland, J (2010). Transcriptional profiling of bovine intervertebral disc cells: implications for identification of normal and degenerate human intervertebral disc cell phenotypes. Arthritis Res Ther, 12(1), R22. eScholarID:94981 | PMID:20149220 | DOI:10.1186/ar2929
  • Strassburg, S., Richardson, S., Freemont, A. & Hoyland, J (2010). Co-culture induces mesenchymal stem cell differentiation and modulation of the degenerate human nucleus pulposus cell phenotype. Regen Med, 5(5), 701-11. eScholarID:94951 | PMID:20868326 | DOI:10.2217/rme.10.59
  • Tolofari, S., Richardson, S., Freemont, A. & Hoyland, J (2010). Expression of semaphorin 3A and its receptors in the human intervertebral disc: potential role in regulating neural ingrowth in the degenerate intervertebral disc. Arthritis Res Ther, 12(1), R1. eScholarID:94960 | PMID:20051117 | DOI:10.1186/ar2898

2009

  • Davies, C., Herrick, A., Cordingley, L., Freemont, A. & Jeziorska, M (2009). Expression of advanced glycation end products and their receptor in skin from patients with systemic sclerosis with and without calcinosis. Rheumatology (Oxford), 48(8), 876-82. eScholarID:94983 | PMID:19542215 | DOI:10.1093/rheumatology/kep151
  • Freemont, A (2009). The cellular pathobiology of the degenerate intervertebral disc and discogenic back pain. Rheumatology (Oxford), 48(1), 5-10. eScholarID:94976 | PMID:18854342 | DOI:10.1093/rheumatology/ken396
  • Johnson, A., Doherty, P. & Freemont, A (2009). Investigation of growth, development, and factors associated with injury in elite schoolboy footballers: prospective study. BMJ, 338, b490. eScholarID:94965 | PMID:19246550 | DOI:10.1136/bmj.b490
  • Kwong, F., Hoyland, J., Evans, C. & Freemont, A (2009). Regional and cellular localisation of BMPs and their inhibitors' expression in human fractures. Int Orthop, 33(1), 281-8. eScholarID:94985 | PMID:19023570 | DOI:10.1007/s00264-008-0691-z
  • Kwong, F., Hoyland, J., Freemont, A. & Evans, C (2009). Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion. J Orthop Res, 27(6), 752-7. eScholarID:94944 | PMID:19058174 | DOI:10.1002/jor.20794
  • Le Maitre, C., Baird, P., Freemont, A. & Hoyland, J (2009). An in vitro study investigating the survival and phenotype of mesenchymal stem cells following injection into nucleus pulposus tissue. Arthritis Res Ther, 11(1), R20. eScholarID:94945 | PMID:19210770 | DOI:10.1186/ar2611
  • Le Maitre, C., Fotheringham, A., Freemont, A. & Hoyland, J (2009). Development of an in vitro model to test the efficacy of novel therapies for IVD degeneration. J Tissue Eng Regen Med, 3(6), 461-9. eScholarID:94953 | PMID:19444863 | DOI:10.1002/term.180
  • Le Maitre, C., Frain, J., Millward-Sadler, J., Fotheringham, A., Freemont, A. & Hoyland, J (2009). Altered integrin mechanotransduction in human nucleus pulposus cells derived from degenerated discs. Arthritis Rheum, 60(2), 460-9. eScholarID:94942 | PMID:19180480 | DOI:10.1002/art.24248
  • Le Maitre, C., Freemont, A. & Hoyland, J (2009). Expression of cartilage-derived morphogenetic protein in human intervertebral discs and its effect on matrix synthesis in degenerate human nucleus pulposus cells. Arthritis Res Ther, 11(5), R137. eScholarID:94956 | PMID:19754961 | DOI:10.1186/ar2808
  • Linton, K., Hey, Y., Dibben, S., Miller, C., Freemont, A., Radford, J. & Pepper, S (2009). Methods comparison for high-resolution transcriptional analysis of archival material on Affymetrix Plus 2.0 and Exon 1.0 microarrays. Biotechniques, 47(1), 587-96. eScholarID:94969 | PMID:19594443 | DOI:10.2144/000113169
  • Millward-Sadler, S., Costello, P., Freemont, A. & Hoyland, J (2009). Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther, 11(3), R65. eScholarID:94974 | PMID:19435506 | DOI:10.1186/ar2693
  • Pockert, A., Richardson, S., Le Maitre, C., Lyon, M., Deakin, J., Buttle, D., Freemont, A. & Hoyland, J (2009). Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum, 60(2), 482-91. eScholarID:94971 | PMID:19180493 | DOI:10.1002/art.24291
  • Whyte, M., Wenkert, D., McAlister, W., Mughal, M., Freemont, A., Whitehouse, R., Baildam, E., Coburn, S., Ryan, L. & Mumm, S (2009). Chronic recurrent multifocal osteomyelitis mimicked in childhood hypophosphatasia. J Bone Miner Res, 24(8), 1493-505. eScholarID:94950 | PMID:19335222 | DOI:10.1359/jbmr.090308

2008

  • Ali, R., Le Maitre, C., Richardson, S., Hoyland, J. & Freemont, A (2008). Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration. Biotech Histochem, 83(5), 239-45. eScholarID:94952 | PMID:19016368 | DOI:10.1080/10520290802539186
  • Hoyland, J., Le Maitre, C. & Freemont, A (2008). Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc. Rheumatology (Oxford), 47(6), 809-14. eScholarID:94984 | PMID:18397957 | DOI:10.1093/rheumatology/ken056
  • Le Maitre, C., Frain, J., Fotheringham, A., Freemont, A. & Hoyland, J (2008). Human cells derived from degenerate intervertebral discs respond differently to those derived from non-degenerate intervertebral discs following application of dynamic hydrostatic pressure. Biorheology, 45(5), 563-75. eScholarID:94959 | PMID:19065005
  • Linton, K., Hey, Y., Saunders, E., Jeziorska, M., Denton, J., Wilson, C., Swindell, R., Dibben, S., Miller, C., Pepper, S., Radford, J. & Freemont, A (2008). Acquisition of biologically relevant gene expression data by Affymetrix microarray analysis of archival formalin-fixed paraffin-embedded tumours. Br J Cancer, 98(8), 1403-14. eScholarID:94943 | PMID:18382428 | DOI:10.1038/sj.bjc.6604316
  • Purmessur, D., Freemont, A. & Hoyland, J (2008). Expression and regulation of neurotrophins in the nondegenerate and degenerate human intervertebral disc. Arthritis Res Ther, 10(4), R99. eScholarID:94955 | PMID:18727839 | DOI:10.1186/ar2487
  • Richardson, S., Hughes, N., Hunt, J., Freemont, A. & Hoyland, J (2008). Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels. Biomaterials, 29(1), 85-93. eScholarID:94963 | PMID:17920676 | DOI:10.1016/j.biomaterials.2007.09.018
  • Thiryayi, W., Thiryayi, S. & Freemont, A (2008). Histopathological perspective on bone marrow oedema, reactive bone change and haemorrhage. Eur J Radiol, 67(1), 62-7. eScholarID:94961 | PMID:18337044 | DOI:10.1016/j.ejrad.2008.01.056
  • Waller, S., Shroff, R., Freemont, A. & Rees, L (2008). Bone histomorphometry in children prior to commencing renal replacement therapy. Pediatr Nephrol, 23(9), 1523-9. eScholarID:94947 | PMID:18481109 | DOI:10.1007/s00467-008-0838-6

2007

  • Ashton, N., Al-Wasil, S., Bond, H., Berry, J., Denton, J. & Freemont, A (2007). The effect of a low-protein diet in pregnancy on offspring renal calcium handling. Am J Physiol Regul Integr Comp Physiol, 293(2), R759-65. eScholarID:94979 | PMID:17567711 | DOI:10.1152/ajpregu.00523.2006
  • Christodoulou, S., Freemont, A., McVey, R. & Vause, S (2007). Prospective comparative case study of uterine collagen in a woman with osteogenesis imperfecta type 1 who had previously ruptured her uterus. J Obstet Gynaecol, 27(7), 738-9. eScholarID:94973 | PMID:17999312 | DOI:10.1080/01443610701667288
  • Freemont, A. & Hoyland, J (2007). Morphology, mechanisms and pathology of musculoskeletal ageing. J Pathol, 211(2), 252-9. eScholarID:94972 | PMID:17200936 | DOI:10.1002/path.2097
  • Lally, S., Mackenzie, P., LeMaitre, C., Freemont, T. & Saunders, B (2007). Microgel particles containing methacrylic acid: pH-triggered swelling behaviour and potential for biomaterial application. J Colloid Interface Sci, 316(2), 367-75. eScholarID:94970 | PMID:17765913 | DOI:10.1016/j.jcis.2007.08.030
  • Le Maitre, C., Freemont, A. & Hoyland, J (2007). Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther, 9(3), R45. eScholarID:94940 | PMID:17498290 | DOI:10.1186/ar2198
  • Le Maitre, C., Hoyland, J. & Freemont, A (2007). Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther, 9(4), R77. eScholarID:94949 | PMID:17688691 | DOI:10.1186/ar2275
  • Le Maitre, C., Hoyland, J. & Freemont, A (2007). Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human intervertebral disc: an in situ zymographic and gene therapy study. Arthritis Res Ther, 9(4), R83. eScholarID:94964 | PMID:17760968 | DOI:10.1186/ar2282
  • Le Maitre, C., Pockert, A., Buttle, D., Freemont, A. & Hoyland, J (2007). Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans, 35(Pt 4), 652-5. eScholarID:94968 | PMID:17635113 | DOI:10.1042/BST0350652
  • Molloy, C., Peck, R., Bonny, S., Jowitt, S., Denton, J., Freemont, A. & Ismail, A (2007). An unusual presentation of multiple myeloma: a case report. J Med Case Reports, 1, 84. eScholarID:94946 | PMID:17845728 | DOI:10.1186/1752-1947-1-84
  • Richardson, S., Mobasheri, A., Freemont, A. & Hoyland, J (2007). Intervertebral disc biology, degeneration and novel tissue engineering and regenerative medicine therapies. Histol Histopathol, 22(9), 1033-41. eScholarID:94966 | PMID:17523081
  • Rogers LC, Armstrong D, Boulton AJM, Freemont AJ, Malik RA. (2007). Malignant melanoma misdiagnosed as a diabetic foot ulcer. Diabetes Care, 30(2), 444-5. eScholarID:1d27879
  • Ward, K., Adams, J., Freemont, T. & Mughal, M (2007). Can bisphosphonate treatment be stopped in a growing child with skeletal fragility? Osteoporos Int, 18(8), 1137-40. eScholarID:94948 | PMID:17279467 | DOI:10.1007/s00198-007-0330-3

2006

  • Davies, C., Jeziorska, M., Freemont, A. & Herrick, A (2006). Expression of osteonectin and matrix Gla protein in scleroderma patients with and without calcinosis. Rheumatology (Oxford), 45(11), 1349-55. eScholarID:94957 | PMID:17050587 | DOI:10.1093/rheumatology/kei277
  • Davies, C., Jeziorska, M., Freemont, A. & Herrick, A (2006). The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis. Hum Pathol, 37(2), 190-7. eScholarID:94977 | PMID:16426919 | DOI:10.1016/j.humpath.2005.10.007
  • Freemont AJ, Hoyland JA. (2006). Lineage plasticity and cell biology of fibrocartilage and hyaline cartilage: its significance in cartilage repair and replacement. Eur J Radiol, 57( 1), eScholarID:1d20641 | DOI:10.1016/j.ejrad.2005.08.008
  • Freemont, A (2006). Lanthanum carbonate. Drugs Today (Barc), 42(12), 759-70. eScholarID:94967 | PMID:17285149 | DOI:10.1358/dot.2006.42.12.1025698
  • Le Maitre CL, Freemont AJ, Hoyland JA. (2006). Human disc degeneration is associated with increased MMP 7 expression. Biotech Histochem, 81( 4-6), 125-31. eScholarID:1d16128
  • Le Maitre, C., Freemont, A. & Hoyland, J (2006). A preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol, 87(1), 17-28. eScholarID:94939 | PMID:16436110 | DOI:10.1111/j.0959-9673.2006.00449.x
  • Le Maitre, C., Freemont, A. & Hoyland, J (2006). Human disc degeneration is associated with increased MMP 7 expression. Biotech Histochem, 81(4-6), 125-31. eScholarID:94962 | PMID:17129995 | DOI:10.1080/10520290601005298
  • Li, C., Mollahan, P., Baguneid, M., McMahon, R., Kumar, P., Walker, M., Freemont, A. & Kumar, S (2006). A comparative study of neovascularisation in atherosclerotic plaques using CD31, CD105 and TGF beta 1. Pathobiology, 73(4), 192-7. eScholarID:94938 | PMID:17119348 | DOI:10.1159/000096020
  • Richardson SM, Walker RV, Parker S, Rhodes NP, Hunt JA, Freemont AJ, Hoyland JA. (2006). Intervertebral Disc Cell Mediated Mesenchymal Stem Cell Differentiation. Stem Cells, 24(3), 707-716. eScholarID:1d12057 | DOI:10.1634/stemcells.2005-0205
  • Richardson, S., Curran, J., Chen, R., Vaughan-Thomas, A., Hunt, J., Freemont, A. & Hoyland, J (2006). The differentiation of bone marrow mesenchymal stem cells into chondrocyte-like cells on poly-L-lactic acid (PLLA) scaffolds. Biomaterials, 27(22), 4069-78. eScholarID:94978 | PMID:16569429 | DOI:10.1016/j.biomaterials.2006.03.017
  • Spasovski, G., Sikole, A., Gelev, S., Masin-Spasovska, J., Freemont, T., Webster, I., Gill, M., Jones, C., De Broe, M. & D'Haese, P (2006). Evolution of bone and plasma concentration of lanthanum in dialysis patients before, during 1 year of treatment with lanthanum carbonate and after 2 years of follow-up. Nephrol Dial Transplant, 21(8), 2217-24. eScholarID:94954 | PMID:16595583 | DOI:10.1093/ndt/gfl146

2005

  • Bond H, Hamilton K, Balment R, Denton J, Freemont AJ, Garland H, Glazier JD, Sibley CP. (2005). Diabetes in rat pregnancy alters renal calcium and magnesium reabsorption and bone formation in adult offspring. Diabetologia, 48(7), 1393-1400. eScholarID:1d11273 | DOI:10.1007/s00125-005-1804-5
  • Brinklow J, Freemont AJ, Zakhour H. (2005). Legislative changes. J Clin Pathol, 58( 4), eScholarID:1d30679
  • Freemont AJ, Malluche H. (2005). Utilization of bone histomorphometry in renal osteodystrophy: demonstration of a new approach using data from a prospective study of lanthanum carbonate. Clin Nephrol, 63( 2), 138-45. eScholarID:1d30680
  • Freemont, A., Hoyland, J., Denton, J. & . (2005). The effects of lanthanum carbonate and calcium carbonate on bone abnormalities in patients with end-stage renal disease. Clin Nephrol, 64(6), 428-37. eScholarID:94986 | PMID:16370155
  • Le Maitre CL, Freemont AJ, Hoyland JA. (2005). The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther, 7( 4), R732-45. eScholarID:1d10886 | DOI:10.1186/ar1732
  • Le Maitre, C., Richardson, S., Baird, P., Freemont, A. & Hoyland, J (2005). Expression of receptors for putative anabolic growth factors in human intervertebral disc: implications for repair and regeneration of the disc. J Pathol, 207(4), 445-52. eScholarID:94958 | PMID:16278806 | DOI:10.1002/path.1862
  • Talwalkar S, Kambhampati S, Whitehouse R, Lang Stevenson A, Freemont AJ. (2005). Intra-articular chondroma of the knee. Skeletal Radiol, 34( 6), 351-4. eScholarID:1d29550
  • Talwalkar, S., Hayton, M., Stilwell, J., Temperley, D. & Freemont, A (2005). Tenosynovial haemangioma of the finger. Acta Orthop Belg, 71(5), 618-21. eScholarID:94975 | PMID:16305091

2004

  • Cooper RG, Freemont AJ. (2004). TNF-alpha blockade for herniated intervertebral disc-induced sciatica: a way forward at last? Rheumatology (Oxford), 43( 2), 119-21. eScholarID:1d10889
  • Le Maitre CL, Freemont AJ, Hoyland JA. (2004). Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol, 204( 1), 47-54. eScholarID:1d9610
  • Le Maitre CL, Hoyland JA, Freemont AJ. (2004). Studies of human intervertebral disc cell function in a constrained in vitro tissue culture system. Spine, 29( 11), 1187-95. eScholarID:1d9611 | DOI:10.1097/00007632-200406010-00006
  • McCarthy CJ, Arnall FA, Nikos Strimpakos, Freemont AJ, Oldham JA. (2004). The biopsychosocial classification of non-specific low back pain: A systematic review. Physical Therapy Reviews, 9, 17-30. eScholarID:1d6402
  • Potts, W, Bowyer, J, Jones, H, Tucker, D, Freemont, AJ, Millest, A, Martin, C, Vernon, W, Neerunjun, D, Slynn, G, Harper, F, Maciewicz, R. (2004). Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy. Int J Exp Pathol, 85( 2), 85-96. eScholarID:1d28786

2003

  • Astuti, D, Hart-Holden, N, Latif, F, Lalloo, F, Black, GCM, Lim, C, Moran, A, Grossman, A, Hodgson, S, Freemont, AJ, Ramsden, R, Eng, C, Evans, DDGR, Maher, E. (2003). Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility. Clin Endocrinol (Oxf), 59( 6), 728-33. eScholarID:1d29418
  • Batra G, Hainey L, Freemont AJ, Andrew G, Saunders P, Hoyland JA, Braidman IP. (2003). Evidence for cell-specific changes with age in expression of oestrogen receptor (ER) alpha and beta in bone fractures from men and women. J Pathol, 200( 1), 65-73. eScholarID:1d10891
  • Cheung J, Grant MME, Jones CJP, Hoyland JA, Freemont AJ, Hillarby M. (2003). Apoptosis of terminal hypertrophic chondrocytes in an in vitro model of endochondral ossification. J Pathol, 201, 3(3), eScholarID:1d7411
  • Cueto-Manzano A, Konel S, Crowley V, France M, Freemont AJ, Adams J, Mawer B, Gokal R, Hutchison A. (2003). Bone histopathology and densitometry comparison between cyclosporine a monotherapy and prednisolone plus azathioprine dual immunosuppression in renal transplant patients. Transplantation, 75( 12)(12), 2053-2058. eScholarID:1d28787
  • D'Haese, PC, Spasovski, GB, Sikole, A, Hutchison, A, Freemont, AJ, Sulkova, S, Swanepoel, C, Pejanovic, S, Djukanovic, L, Balducci, A, Coen, G, Sulowicz, W, Ferreira, A, Torres, A, Curic, S, Popovic, M, Dimkovic, N, De Broe, ME. (2003). A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney International, 63(Supplement 85), S73-S78. eScholarID:1d22181 | DOI:10.1046/j.1523-1755.63.s85.18.x

2002

  • Bryden AAG, Hoyland JA, Freemont AJ, Clarke NW, Schembri Wismayer D, George NJR. (2002). E-cadherin and beta-catenin are down-regulated in prostatic bone metastases. BJU Int, 89( 4)(4), 400-403. eScholarID:1d7257
  • Bryden AAG, Islam S, Freemont AJ, Shanks JH, George NJR, Clarke NW. (2002). Parathyroid hormone-related peptide: expression in prostate cancer bone metastases. Prostate Cancer Prostatic Dis, 5( 1)(1), 59-62. eScholarID:1d29185
  • Bryden, A., Hoyland, J., Freemont, A., Clarke, N. & George, N (2002). Parathyroid hormone related peptide and receptor expression in paired primary prostate cancer and bone metastases. Br J Cancer, 86(3), 322-5. eScholarID:124409 | PMID:11875691 | DOI:10.1038/sj.bjc.6600115
  • Freemont AJ, Jeziorska M, Hoyland JA, Rooney P, Kumar S. (2002). Mast cells in the pathogenesis of chronic back pain: a hypothesis. J Pathol, 197( 3)(3), 281-285. eScholarID:1d10894
  • Freemont AJ, Watkins A, Le Maitre CL, Baird P, Jeziorska M, Knight M, Ross E, O'Brien J, Hoyland JA. (2002). Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol, 197( 3)(3), 286-292. eScholarID:1d9613 | DOI:10.1002/path.1108
  • Freemont AJ, Watkins A, Le Maitre CL, Jeziorska M, Hoyland JA. (2002). Current understanding of cellular and molecular events in intervertebral disc degeneration: implications for therapy. J.Pathol, 196, 374-379. eScholarID:1d6827
  • Freemont AJ. (2002). Bone and the Gulf War. J.Clin.Pathol, 55, 884. eScholarID:1d6823
  • Freemont AJ. (2002). The pathology of dialysis. Semin.Dial, 15, 227-231. eScholarID:1d6824
  • Harrington P, O'Kelly A, Trail I.A, Freemont AJ. (2002). Amelanotic subungual melanoma mimicking pyogenic granuloma in the hand. J.R.Coll.Surg.Edinb, 47, 638-640. eScholarID:1d6829
  • Parker C.R, Blackwell P.J, Freemont AJ, Hosking D.J. (2002). Biochemical measurements in the prediction of histologic subtype of renal transplant bone disease in women. Am.J.Kidney Dis, 40, 2(2), 385-396. eScholarID:1d6833
  • Sive J.I, Baird P, Jeziorska M, Watkins A, Hoyland JA, Freemont AJ. (2002). Expression of chondrocyte markers by cells of normal and degenerate intervertebral discs. Mol.Pathol, 55, 2(2), 91-7. eScholarID:1d6835
  • White A, Watson REB, Newman WG, Freemont AJ, Wallis GA. (2002). Annexin VIII is differentially expressed by chondrocytes in the mammalian growth plate during endochondral ossification and in osteoarthritic cartilage. J Bone Miner Res, 17( 10), 1851-8. eScholarID:1d9640 | DOI:10.1359/jbmr.2002.17.10.1851

2001

  • Bryden AA, Freemont AJ, Clarke N.W, George N.J. (2001). Ki-67 index in metastatic prostate cancer. Eur.Urol, 40, 6, 673-676. eScholarID:1d6816
  • Cueto-Manzano A.M, Freemont AJ, Adams JE, Mawer B, Gokal R, Hutchison A.J. (2001). Association of sex hormone status with the bone loss of renal transplant patients. Nephrol.Dial.Transplant, 16, 6, 1245-1250. eScholarID:1d6822
  • Goel A, Cullen C, Paul A.S, Freemont AJ. (2001). Multiple giant synovial chondromatosis of the knee. Knee, 8, 3, 243-245. eScholarID:1d6828
  • Hollander A.P, Corke K.P, Freemont AJ, Lewis C.E. (2001). Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum, 44, 7, 1540-1544. eScholarID:1d6830
  • Janusz, M.J., Hookfin, E.B., Heitmeyer, S.A., Woessner, J.F., Freemont, AJ, Hoyland, JA, Brown, K.K., Hsieh, L.C., Almstead, N.G., De, B., Natchus, M.G., Pikul, S., Taiwo, Y.O. (2001). Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors. Osteoarthritis.Cartilage, 9, 8, 751-760. eScholarID:1d6831
  • Johnson J.S, Freemont AJ. (2001). A 10 year retrospective comparison of the diagnostic usefulness of synovial fluid and synovial biopsy examination. J.Clin.Pathol, 54, 8, 605-607. eScholarID:1d6832
  • Le Maitre CL, Byers RJ, Liu YinJ.A, Hoyland JA, Freemont AJ. (2001). Dual colour FISH in paraffin wax embedded bone trephines for identification of numerical and structural chromosomal abnormalities in acute myeloid leukaemia and myelodysplasia. J.Clin.Pathol, 54, 9, 730-733. eScholarID:1d7146
  • Robinson P, Whitehouse R.W, Freemont AJ, Ellis D. (2001). Synovial osteochondromatosis complicating pilon fracture of the tibia. Skeletal Radiol, 30, 8, 475-477. eScholarID:1d6834
  • Teh L, Moussa KM, Morris J, Hillarby M, Freemont AJ, Denton J, Sanders PA. (2001). HLA Class II alleles and synovial fluid cytology in rheumatoid arthritis. Annals Of Rheumatic Diseases, 60, 542-544. eScholarID:1d23923

2000

  • Bottomley M, Webb N, Watson C, Holt L, Bukhari M, Denton J, Freemont AJ, Brenchley P. (2000). Placenta growth factor (PlGF) induces vascular endothelial growth factor (VEGF) secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid. Clin Exp Immunol, 119( 1), 182-8. eScholarID:1d29366
  • Braidman I, Baris C, Selby P, Adams J, Freemont AJ, Hoyland J. (2000). Preliminary report of impaired oestrogen receptor-alpha expression in bone, but no involvement of androgen receptor, in male idiopathic osteoporosis. J Pathol, 192( 1), 90-6. eScholarID:1d29637
  • Braidman I, Baris C, Wood L, Selby P, Adams J, Freemont AJ, Hoyland J. (2000). Preliminary evidence for impaired estrogen receptor-alpha protein expression in osteoblasts and osteocytes from men with idiopathic osteoporosis. Bone, 26( 5), 423-7. eScholarID:1d29526
  • Byers R, Hoyland J, Dixon J, Freemont AJ. (2000). Subtractive hybridization--genetic takeaways and the search for meaning. Int J Exp Pathol, 81( 6), 391-404. eScholarID:1d28794
  • Cueto-Manzano A, Konel S, Freemont AJ, Adams J, Mawer B, Gokal R, Hutchison A. (2000). Effect of 1,25-dihydroxyvitamin D3 and calcium carbonate on bone loss associated with long-term renal transplantation. Am J Kidney Dis, 35( 2), 227-36. eScholarID:1d28845
  • Green H, Canfield AE, Hillarby M, Grant M, Boot-Handford RR, Freemont AJ, Wallis GA. (2000). The ribosomal protein QM is expressed differentially during vertebrate endochondral bone development. J Bone Miner Res, 15( 6), 1066-75. eScholarID:1d9645
  • H Green, Canfield AE, Hillarby M, M E Grant, Boot-Handford RR, Freemont AJ, Wallis Gillian. (2000). The ribosomal protein "QM" is differentially expressed during vertebrate endochondral bone development. Journal of Bone Mineral Research, 15, 1066-1075. eScholarID:1d23803
  • Harris M, Coyne J, Tariq M, Eyden B, Atkinson M, Freemont AJ, Varley J, Attwooll C, Telford N. (2000). Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2). Am J Surg Pathol, 24( 7), 1020-6. eScholarID:1d29551
  • Harris M. Coyne J. Tariq M. Eyden B.P. Atkinson M. Attwooll C. Telford N, Freemont AJ, Varley JM. (2000). Extraskeletal myxoid chondrosarcoma with neuroendocrine differentiation: a pathologic, cytogenetic, and molecular study of a case with a novel translocation t(9;17)(q22;q11.2). Am J Surg Pathol, 24, 1020-6. eScholarID:1d1986
  • Iddon J, Bundred N, Hoyland J, Downey S, Baird P, Salter D, McMahon R, Freemont AJ. (2000). Expression of parathyroid hormone-related protein and its receptor in bone metastases from prostate cancer. J Pathol, 191( 2), 170-4. eScholarID:1d29237
  • Kitley R, Hislop A, Hall S, Freemont AJ, Haworth S. (2000). Birth associated changes in pulmonary arterial connective tissue gene expression in the normal and hypertensive lung. Cardiovasc Res, 46( 2), 332-45. eScholarID:1d28838
  • MJ Bottomley, N Webb, CJ Watson, PL Holt, Bukhari MAS, Denton J, Freemont AJ, Brenchley PEC. (2000). Placenta growth factor (PIGF) induces VEGF secretion from mononuclear cells and is co-expressed with VEGF in synovial fluid. Clinical and Experimental Immunology, 119, 182-188. eScholarID:1d24825
  • Núnêz, C, Bashein, A, Brunet, C, Hoyland, J, Freemont, AJ, Buckle, A, Murphy, C, Cross, M, Lucas, G, Bostock, V, Brady, G. (2000). Expression of the imprinted tumour-suppressor gene H19 is tightly regulated during normal haematopoiesis and is reduced in haematopoietic precursors of patients with the myeloproliferative disease polycythaemia vera. J Pathol, 190( 1), 61-8. eScholarID:1d29552
  • Picton M, Moore P, Mawer E, Houghton D, Freemont AJ, Hutchison A, Gokal R, Hoyland J. (2000). Down-regulation of human osteoblast PTH/PTHrP receptor mRNA in end-stage renal failure. Kidney Int, 58( 4), 1440-9. eScholarID:1d29235

1999

  • Bottomley M, Webb N, Watson C, Holt P, Freemont AJ, Brenchley P. (1999). Peripheral blood mononuclear cells from patients with rheumatoid arthritis spontaneously secrete vascular endothelial growth factor (VEGF): specific up-regulation by tumour necrosis factor-alpha (TNF-alpha) in synovial fluid. Clin Exp Immunol, 117( 1), 171-6. eScholarID:1d29645
  • Bryden A, Freemont AJ, Clarke N, George N. (1999). Paradoxical expression of E-cadherin in prostatic bone metastases. BJU Int, 84( 9), 1032-4. eScholarID:1d29644
  • Byers R, Brown J, Brandwood C, Wood P, Staley W, Hainey L, Freemont AJ, Hoyland J. (1999). Osteoblastic differentiation and mRNA analysis of STRO-1-positive human bone marrow stromal cells using primary in vitro culture and poly (A) PCR. J Pathol, 187( 3), 374-81. eScholarID:1d30686
  • Byers R, Denton J, Hoyland J, Freemont AJ. (1999). Differential patterns of altered bone formation in different bone compartments in established osteoporosis. J Clin Pathol, 52( 1), 23-8. eScholarID:1d28846
  • Cotton S, Herrick AL, Jayson M, Freemont AJ. (1999). Endothelial expression of nitric oxide synthases and nitrotyrosine in systemic sclerosis skin. J Pathol, 189( 2), 273-8. eScholarID:1d10896
  • Cueto-Manzano A, Konel S, Hutchison A, Crowley V, France M, Freemont AJ, Adams J, Mawer B, Gokal R. (1999). Bone loss in long-term renal transplantation: histopathology and densitometry analysis. Kidney Int, 55( 5), 2021-9. eScholarID:1d28847
  • Foster J, Maciewicz R, Taberner J, Dieppe P, Freemont AJ, Keen M, Watt I, Waterton JC. (1999). Structural periodicity in human articular cartilage: comparison between magnetic resonance imaging and histological findings. Osteoarthritis Cartilage, 7( 5), 480-5. eScholarID:1d28796
  • Freemont AJ, Byers R, Taiwo Y, Hoyland J. (1999). In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage. Ann Rheum Dis, 58( 6), 357-65. eScholarID:1d29529
  • Haworth C, Freemont AJ, Webb A, Dodd M, Selby P, Mawer E, Adams J. (1999). Hip fracture and bone histomorphometry in a young adult with cystic fibrosis. Eur Respir J, 14( 2), 478-9. eScholarID:1d28795
  • Haworth, C, Selby, P, Webb, A, Dodd, M, Musson, H, McL Niven, R, Economou, G, Horrocks, A, Freemont, AJ, Mawer, E, Adams, J. (1999). Low bone mineral density in adults with cystic fibrosis. Thorax, 54( 11), 961-7. eScholarID:1d29399
  • Hoyland J, Baris C, Wood L, Baird P, Selby P, Freemont AJ, Braidman I. (1999). Effect of ovarian steroid deficiency on oestrogen receptor alpha expression in bone. J Pathol, 188( 3), 294-303. eScholarID:1d30685
  • Kennedy J, Baris C, Hoyland J, Selby P, Freemont AJ, Braidman I. (1999). Immunofluorescent localization of estrogen receptor-alpha in growth plates of rabbits, but not in rats, at sexual maturity. Bone, 24( 1), 9-16. eScholarID:1d29559
  • Lawton D, Andrew J, Marsh D, Hoyland J, Freemont AJ. (1999). Expression of the gene encoding the matrix gla protein by mature osteoblasts in human fracture non-unions. Mol Pathol, 52( 2), 92-6. eScholarID:1d29553
  • MJ Bottomley, NJA Webb, CJ Watson, Freemont AJ, PL Holt, Brenchley PEC. (1999). PBMCs from patients with rheumatoid arthritis spontaneously secrete VEGF: specific upregulation by TNFa in synovial fluid. Clin Exp Immunol, 117, 171-176. eScholarID:1d24821
  • Nicholas J, Dawes P, Davies S, Freemont AJ. (1999). Persisting aluminium-related bone disease after cadaveric renal transplantation. Nephrol Dial Transplant, 14( 1), 202-4. eScholarID:1d29238
  • Parker C, Freemont AJ, Blackwell P, Grainge M, Hosking D. (1999). Cross-sectional analysis of renal transplantation osteoporosis. J Bone Miner Res, 14( 11), 1943-51. eScholarID:1d30684
  • Tetlow L, Freemont AJ, Woolley D. (1999). Bronchial cartilage atrophy in chronic bronchitis: observations on chondrolytic processes. Pathobiology, 67( 4), 196-201. eScholarID:1d29527
  • Sari-Kouzel H, Herrick AL, Freemont AJ, Marcuson R, Jayson MMI. (1999). Giant cell arteritis in a patient with limited cutaneous systemic sclerosis. Rheumatology (Oxford), 38( 5), 479-80. eScholarID:17d851

1998

  • Baris, C., Carter, D., Freemont, A., Thorp, B. & Braidman, I (1998). A method for immunofluorescent localization of oestrogen receptors in bone sections from an egg-laying poultry strain. Avian Pathol, 27(2), 121-8. eScholarID:94941 | PMID:18483977 | DOI:10.1080/03079459808419312
  • Boot-Handford RR, Michaelidis T, Hillarby M, Zambelli A, Denton J, Hoyland J, Freemont AJ, Grant M, Wallis G. (1998). The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. Int J Exp Pathol, 79( 5), 329-35. eScholarID:1d29646
  • Boot-Handford RR, TM Michaelidis, Hillarby M, A Zambeli, Denton J, Freemont AJ, Grant MM.E, Wallis GA. (1998). The bcl-2 knockout mouse exhibits marked changes in osteoblast phenotype and collagen deposition in bone as well as a mild growth plate phenotype. International Journal Of Experimental Pathology, 79, 329-335. eScholarID:1d25567
  • Cotton S, Herrick AL, Jayson M, Freemont AJ. (1998). TGF beta--a role in systemic sclerosis? J Pathol, 184( 1), 4-6. eScholarID:1d10898
  • Freemont AJ. (1998). Demystified ... adhesion molecules. Mol Pathol, 51( 4), 175-84. eScholarID:1d29246
  • Goddard C, Smith A, Hoyland J, Baird P, McMahon R, Freemont AJ, Shomaf M, Haboubi N, Warnes T. (1998). Localisation and semiquantitative assessment of hepatic procollagen mRNA in primary biliary cirrhosis. Gut, 43( 3), 433-40. eScholarID:1d28797
  • Goupille P, Jayson M, Valat J, Freemont AJ. (1998). Matrix metalloproteinases: the clue to intervertebral disc degeneration? Spine, 23( 14), 1612-26. eScholarID:1d28798
  • Goupille P, Jayson M, Valat J, Freemont AJ. (1998). The role of inflammation in disk herniation-associated radiculopathy. Semin Arthritis Rheum, 28( 1), 60-71. eScholarID:1d29401

1997

  • Bukhari M, Freemont AJ, Noble J, Jayson M. (1997). Erosive amyloidosis of the wrist and knee associated with oligoclonal bands. Br J Rheumatol, 36( 4), 494-7. eScholarID:1d30687
  • Byers R, Denton J, Hoyland J, Freemont AJ. (1997). Differential patterns of osteoblast dysfunction in trabecular bone in patients with established osteoporosis. J Clin Pathol, 50( 9), 760-4. eScholarID:1d29247
  • Byers R, Marshall D, Freemont AJ. (1997). Pericardial involvement in systemic sclerosis. Ann Rheum Dis, 56( 6), 393-4. eScholarID:1d29543
  • Deed R, Rooney P, Kumar P, Norton J, Smith J, Freemont AJ, Kumar S. (1997). Early-response gene signalling is induced by angiogenic oligosaccharides of hyaluronan in endothelial cells. Inhibition by non-angiogenic, high-molecular-weight hyaluronan. Int J Cancer, 71( 2), 251-6. eScholarID:1d29561
  • Downey S, Hoyland J, Freemont AJ, Knox F, Walls J, Bundred N. (1997). Expression of the receptor for parathyroid hormone-related protein in normal and malignant breast tissue. J Pathol, 183( 2), 212-7. eScholarID:1d29560
  • Freemont AJ, Hampson V, Tilman R, Goupille P, Taiwo Y, Hoyland J. (1997). Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific. Ann Rheum Dis, 56( 9), 542-9. eScholarID:1d29648
  • Freemont AJ, Peacock T, Goupille P, Hoyland J, O'Brien J, Jayson M. (1997). Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet, 350( 9072), 178-81. eScholarID:1d28849
  • Hoyland J, Mee A, Baird P, Braidman I, Mawer E, Freemont AJ. (1997). Demonstration of estrogen receptor mRNA in bone using in situ reverse-transcriptase polymerase chain reaction. Bone, 20( 2), 87-92. eScholarID:1d29654
  • Lawton D, Andrew J, Marsh D, Hoyland J, Freemont AJ. (1997). Mature osteoblasts in human non-union fractures express collagen type III. Mol Pathol, 50( 4), 194-7. eScholarID:1d28848
  • Shanks J, Harris M, Howat A, Freemont AJ. (1997). Angiotropic lymphoma with endocrine involvement. Histopathology, 31( 2), 161-6. eScholarID:1d29530

1996

  • A Salo, Hoyland JA, S Ayad, Kielty CM, Freemont AJ, T Kantomaa Pirttiniemi. (1996). The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage: response to mastication forces. Acta Odontologica Scandinavica, 54, 295-302. eScholarID:1d24903
  • Benbow E, Freemont AJ. (1996). The scenario paper: an integrated examination for an integrated course. J Pathol, 180( 3), 343-5. eScholarID:1d28805
  • Benbow E, Rutishauser S, Stoddart R, Andrew S, Freemont AJ. (1996). Pathologists and problem-based learning. J Pathol, 180( 3), 340-2. eScholarID:1d28806
  • Freemont AJ. (1996). Microscopic analysis of synovial fluid--the perfect diagnostic test? Ann Rheum Dis, 55( 10), 695-7. eScholarID:1d29409
  • Freemont AJ. (1996). The pathology of osteogenesis imperfecta. J Clin Pathol, 49( 8), 618-9. eScholarID:1d29655
  • Freemont AJ. (1996). The pathophysiology of cartilage and synovium. Br J Rheumatol, 35 Suppl 3, 10-3. eScholarID:1d29408
  • Gerakis A, Hutchison A, Apostolou T, Freemont AJ, Billis A. (1996). Biochemical markers for non-invasive diagnosis of hyperparathyroid bone disease and adynamic bone in patients on haemodialysis. Nephrol Dial Transplant, 11( 12), 2430-8. eScholarID:1d30688
  • Mee A, Hoyland J, Braidman I, Freemont AJ, Davies M, Mawer E. (1996). Demonstration of vitamin D receptor transcripts in actively resorbing osteoclasts in bone sections. Bone, 18( 4), 295-9. eScholarID:1d30689
  • Salo L, Hoyland J, Ayad S, Kielty C, Freemont AJ, Pirttiniemi P, Kantomaa T, Grant M, Thomas J. (1996). The expression of types X and VI collagen and fibrillin in rat mandibular condylar cartilage. Response to mastication forces. Acta Odontol Scand, 54( 5), 295-302. eScholarID:1d29410

1995

  • Andrew J, Hoyland J, Freemont AJ, Marsh D. (1995). Platelet-derived growth factor expression in normally healing human fractures. Bone, 16( 4), 455-60. eScholarID:1d30690
  • Braidman I, Davenport L, Carter D, Selby P, Mawer E, Freemont AJ. (1995). Preliminary in situ identification of estrogen target cells in bone. J Bone Miner Res, 10( 1), 74-80. eScholarID:1d29248
  • Cooper R, Freemont AJ, Hoyland J, Jenkins J, West C, Illingworth K, Jayson M. (1995). Herniated intervertebral disc-associated periradicular fibrosis and vascular abnormalities occur without inflammatory cell infiltration. Spine, 20( 5), 591-8. eScholarID:1d29545
  • Devlin H, Hoyland J, Freemont AJ, Sloan P. (1995). Localization of pro-collagen type II mRNA and collagen type II in the healing tooth socket of the rat. Arch Oral Biol, 40( 3), 181-5. eScholarID:1d28851
  • Priest N, Freemont AJ, Humphreys J, Kathren R. (1995). Histopathology and 241Am microdistribution in skeletal USTER Case 246. Health Phys, 69( 3), 330-7. eScholarID:1d29563
  • Rehman M, Hoyland J, Denton J, Freemont AJ. (1995). Histomorphometric classification of postmenopausal osteoporosis: implications for the management of osteoporosis. J Clin Pathol, 48( 3), 229-35. eScholarID:1d29544
  • Stewart M, Freemont AJ, Richardson T. (1995). Fatal isoniazid poisoning. Ann Clin Biochem, 32 ( Pt 2), 229-31. eScholarID:1d28850

1994

  • Anderson D, Richardson P, Brown J, Freemont AJ, Hollis S, Denton J, Buckler H, Hargreaves S, Cantrill J. (1994). Intravenous pamidronate: evolution of an effective treatment strategy. Semin Arthritis Rheum, 23( 4), 273-5. eScholarID:1d28807
  • Andrew J, Andrew S, Freemont AJ, Marsh D. (1994). Inflammatory cells in normal human fracture healing. Acta Orthop Scand, 65( 4), 462-6. eScholarID:1d29564
  • Byers R, McMahon R, Freemont AJ, Parrott N, Newstead C. (1994). Angiosarcoma at the site of a ligated arteriovenous fistula in a renal transplant recipient. Nephrol Dial Transplant, 9( 1), eScholarID:1d29565
  • Herrick AL, Oogarah P, Freemont AJ, Marcuson R, Haeney M, Jayson MMI. (1994). Vasculitis in patients with systemic sclerosis and severe digital ischaemia requiring amputation. Ann Rheum Dis, 53( 5), 323-6. eScholarID:1d10900
  • Hoyland J, Freemont AJ, Sharpe P. (1994). Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res, 9( 1), 75-80. eScholarID:1d28808
  • Hutchison A, Whitehouse R, Freemont AJ, Adams J, Mawer E, Gokal R. (1994). Histological, radiological, and biochemical features of the adynamic bone lesion in continuous ambulatory peritoneal dialysis patients. Am J Nephrol, 14( 1), 19-29. eScholarID:1d29250
  • Hutchison A, Whitehouse RR W, Freemont AJ, Adams JE, Mawer EB, Gokal RR. (1994). Histological, radiological, and biochemical features of the a dynamic bone lesion in continuous ambulatory peritoneal dialysis patients. American Journal of Nephrology, 14, eScholarID:1d4114
  • Narayanan M, Geary C, Freemont AJ, Kendra J. (1994). Long-term follow-up of aplastic anaemia. Br J Haematol, 86( 4), 837-43. eScholarID:1d29411
  • Rehman M, Hoyland J, Denton J, Freemont AJ. (1994). Age related histomorphometric changes in bone in normal British men and women. J Clin Pathol, 47( 6), 529-34. eScholarID:1d29249
  • Herrick AL, Oogarah P, Brammah T, Freemont AJ, Jayson M. (1994). Nervous system involvement in association with vasculitis and anticardiolipin antibodies in a patient with systemic sclerosis. Ann Rheum Dis, 53( 5), 349-50. eScholarID:17d282

1993

  • Andrew J, Hoyland J, Andrew S, Freemont AJ, Marsh D. (1993). Demonstration of TGF-beta 1 mRNA by in situ hybridization in normal human fracture healing. Calcif Tissue Int, 52( 2), 74-8. eScholarID:1d29568
  • Andrew J, Hoyland J, Freemont AJ, Marsh D. (1993). Insulinlike growth factor gene expression in human fracture callus. Calcif Tissue Int, 53( 2), 97-102. eScholarID:1d28809
  • Andrew S, Freemont AJ. (1993). Juxtacortical malignant schwannoma with heterologous elements. Histopathology, 23( 3), 280-2. eScholarID:1d30692
  • Andrew S, Freemont AJ. (1993). Skeletal mastocytosis. J Clin Pathol, 46( 11), 1033-5. eScholarID:1d28858
  • Cartwright EJ, Gordon M, Freemont AJ, Anderson D, Sharpe P. (1993). Paramyxoviruses and Paget's disease. J Med Virol, 40( 2), 133-41. eScholarID:1d29567
  • Cheras P, Freemont AJ, Sikorski J. (1993). Intraosseous thrombosis in ischemic necrosis of bone and osteoarthritis. Osteoarthritis Cartilage, 1( 4), 219-32. eScholarID:1d29547
  • Das-Gupta E, Lyons T, Hoyland J, Lawton D, Freemont AJ. (1993). New histological observations in spontaneously developing osteoarthritis in the STR/ORT mouse questioning its acceptability as a model of human osteoarthritis. Int J Exp Pathol, 74( 6), 627-34. eScholarID:1d29656
  • Dean G, Hoyland J, Denton J, Donn R, Freemont AJ. (1993). Mast cells in the synovium and synovial fluid in osteoarthritis. Br J Rheumatol, 32( 8), 671-5. eScholarID:1d29413
  • Edwards B, Andrew S, O'Driscoll J, Chalmers R, Ballardie F, Freemont AJ. (1993). Changes in numbers of epidermal cell adhesion molecules caused by oral cyclosporin in psoriasis. J Clin Pathol, 46( 8), 713-7. eScholarID:1d28810
  • Freemont AJ. (1993). Basic bone cell biology. Int J Exp Pathol, 74( 4), 411-6. eScholarID:1d29412
  • Freemont AJ. (1993). Synovial fluid analysis. The forgotten investigation. Eur J Med, 2( 6), 323-6. eScholarID:1d30694
  • Hartley A, Blair V, Harris M, Birch J, Banerjee S, Freemont AJ, McClure J, McWilliam L. (1993). Multiple primary tumours in a population-based series of patients with histopathologically peer-reviewed sarcomas. Br J Cancer, 68( 6), 1243-6. eScholarID:1d29251
  • Herdman R, Charlton A, Hinton A, Freemont AJ. (1993). An in vitro comparison of the Erbium: YAG laser and the carbon dioxide laser in laryngeal surgery. J Laryngol Otol, 107( 10), 908-11. eScholarID:1d29548
  • Holmes A, Hukins D, Freemont AJ. (1993). End-plate displacement during compression of lumbar vertebra-disc-vertebra segments and the mechanism of failure. Spine, 18( 1), 128-35. eScholarID:1d29258
  • Hoyland J, Newson L, Jayson M, Freemont AJ. (1993). The vascular basement membrane in systemic sclerosis skin: heterogeneity of type IV collagen. Br J Dermatol, 129( 4), 384-8. eScholarID:1d29657
  • Hutchison A, Whitehouse RR W, Boulton HF, Adams JE, Mawer EB, Freemont AJ, Gokal R. (1993). Correlation of bone histology with parathyroid hormone, Vitamin D3 and radiology in end stage renal disease. Kidney International, 44, eScholarID:1d24191
  • Jones S, Denton J, Holt P, Freemont AJ. (1993). Possible clearance of effete polymorphonuclear leucocytes from synovial fluid by cytophagocytic mononuclear cells: implications for pathogenesis and chronicity in inflammatory arthritis. Ann Rheum Dis, 52( 2), 121-6. eScholarID:1d28861
  • Jones S, Denton J, Holt P, Freemont AJ. (1993). Refrigeration preserves synovial fluid cytology. Ann Rheum Dis, 52( 5), eScholarID:1d29658
  • McMillan T, Freemont AJ, Herxheimer A, Denton J, Taylor A, Pazianas M, Cummin A, Eastwood J. (1993). Camelford water poisoning accident: serial neuropsychological assessments and further observations on bone aluminium. Hum Exp Toxicol, 12( 1), 37-42. eScholarID:1d29659
  • O'Donovan D, Freemont AJ, Adams J, Markham D. (1993). Malignant pilomatrixoma with bone metastasis. Histopathology, 23( 4), 385-6. eScholarID:1d30691
  • Parrott N, Scott P, Freemont AJ, Johnson R. (1993). Angiosarcoma in an arteriovenous fistula following successful renal transplantation--a case report. Transplantation, 55( 3), 676-7. eScholarID:1d29584
  • Paton R, Freemont AJ. (1993). A clinicopathological study of idiopathic CTEV. J R Coll Surg Edinb, 38( 2), 108-9. eScholarID:1d29583
  • Pitalia A, Liu-Yin J, Freemont AJ, Morris D, Fitzmaurice R. (1993). Immunohistological detection of human herpes virus 6 in formalin-fixed, paraffin-embedded lung tissues. J Med Virol, 41( 2), 103-7. eScholarID:1d28859
  • Shaukat N, Ashraf S, Mebewu A, Freemont AJ, Keenan D. (1993). Myocardial infarction in a young adult due to Kawasaki disease. A case report and review of the late cardiological sequelae of Kawasaki disease. Int J Cardiol, 39( 3), 222-6. eScholarID:1d28860
  • Sugden P, Andrew J, Andrew S, Freemont AJ. (1993). Dermal dendrocytes in Dupuytren's disease: a link between the skin and pathogenesis? J Hand Surg [Br], 18( 5), 662-6. eScholarID:1d29566
  • Walsh L, Freemont AJ, Hoyland J. (1993). The effect of tissue decalcification on mRNA retention within bone for in-situ hybridization studies. Int J Exp Pathol, 74( 3), 237-41. eScholarID:1d30693

1992

  • Byers R, McMahon R, Freemont AJ, Parrott N, Newstead C. (1992). Epithelioid angiosarcoma arising in an arteriovenous fistula. Histopathology, 21( 1), 87-9. eScholarID:1d29414
  • Cooper R, Freemont AJ, Riley M, Holt P, Anderson D, Jayson M. (1992). Bone abnormalities and severe arthritis in pachydermoperiostosis. Ann Rheum Dis, 51( 3), 416-9. eScholarID:1d29585
  • Fitzmaurice R, Pitalia A, Freemont AJ. (1992). Effects of prolonged processing in standard and isotonic trichloroacetic acid (TCA) on cellular preservation in bone marrow trephines. J Clin Pathol, 45( 7), 631-3. eScholarID:1d29420
  • Freemont AJ, Hoyland J, Fielding P, Hodson N, Jayson M. (1992). Studies of the microvascular endothelium in uninvolved skin of patients with systemic sclerosis: direct evidence for a generalized microangiopathy. Br J Dermatol, 126( 6), 561-8. eScholarID:1d29666
  • Freemont AJ. (1992). What is the significance of synovial fluid lipid crystals in a patient with an isolated monoarthritis? Br J Rheumatol, 31( 3), eScholarID:1d28862
  • Hartley A, Blair V, Harris M, Birch J, Banerjee S, Freemont AJ, McClure J, McWilliam L. (1992). Sarcomas in north west England: III. Survival. Br J Cancer, 66( 4), 685-91. eScholarID:1d28811
  • Hayes M, Bayley D, Still P, Palit J, Denton J, Freemont AJ, Cooper R, Mawer E. (1992). Differential metabolism of 25-hydroxyvitamin D3 by cultured synovial fluid macrophages and fibroblast-like cells from patients with arthritis. Ann Rheum Dis, 51( 2), 220-6. eScholarID:1d30695
  • Hayes M, Rai A, Cooper R, Bayley D, Freemont AJ, Mawer E. (1992). Inhibition by prostaglandin E1 and E2 of 1,25-dihydroxyvitamin D3 synthesis by synovial fluid macrophages from arthritic joints. Ann Rheum Dis, 51( 5), 632-7. eScholarID:1d29260
  • Herrick A, Marcuson R, Freemont AJ, Jayson M. (1992). Clinically normal skin becomes sclerodermatous when transplanted into a sclerodermatous area. Br J Rheumatol, 31( 10), 707-9. eScholarID:1d28818
  • Hutchison A, Freemont AJ, Boulton H, Gokal R. (1992). Low-calcium dialysis fluid and oral calcium carbonate in CAPD. A method of controlling hyperphosphataemia whilst minimizing aluminium exposure and hypercalcaemia. Nephrol Dial Transplant, 7( 12), 1219-25. eScholarID:1d29422
  • Morgan K, Reeve-Stephenson J, Denton J, Freemont AJ. (1992). Type II collagen induced arthritis: comparison of histological changes in arthritis-susceptible and arthritis-resistant rats. Clin Exp Rheumatol, 10( 2), 109-16. eScholarID:1d28863
  • Morris G, Freemont AJ. (1992). Direct observation of the magnetization exchange dynamics responsible for magnetization transfer contrast in human cartilage in vitro. Magn Reson Med, 28( 1), 97-104. eScholarID:1d29259
  • Prescott R, Freemont AJ, Jones C, Hoyland J, Fielding P. (1992). Sequential dermal microvascular and perivascular changes in the development of scleroderma. J Pathol, 166( 3), 255-63. eScholarID:1d29586
  • Rate A, Parkinson R, Meadows T, Freemont AJ. (1992). Acute carpal tunnel syndrome due to pseudogout. J Hand Surg [Br], 17( 2), 217-8. eScholarID:1d29261
  • Royle S, Noble J, Parkinson R, Freemont AJ. (1992). The diagnostic potential of synovial effusion in meniscal pathology. Arthroscopy, 8( 2), 254-7. eScholarID:1d29571
  • Wilkinson N, Fitzmaurice R, Turner P, Freemont AJ. (1992). Leiomyosarcoma with osteoclast-like giant cells. Histopathology, 20( 5), 446-9. eScholarID:1d29570
  • Yuan J, Freemont AJ, Mawer E, Hayes M. (1992). Regulation of 1 alpha, 25-dihydroxyvitamin D3 synthesis in macrophages from arthritic joints by phorbol ester, dibutyryl-cAMP and calcium ionophore (A23187). FEBS Lett, 311( 1), 71-4. eScholarID:1d29569

1991

  • Chadwick I, Curry P, Linsley A, Freemont AJ, Doran B. (1991). Ecstasy, 3-4 methylenedioxymethamphetamine (MDMA), a fatality associated with coagulopathy and hyperthermia. J R Soc Med, 84( 6), eScholarID:1d29587
  • Cooper R, Freemont AJ, Fitzmaurice R, Alani S, Jayson M. (1991). Paraspinal muscle fibrosis: a specific pathological component in ankylosing spondylitis. Ann Rheum Dis, 50( 11), 755-9. eScholarID:1d28820
  • Edwards B, Ballardie F, Andrew S, Freemont AJ, O'Driscoll J, Chalmers R. (1991). Epidermal ICAM-1 in psoriasis after long-term cyclosporin. Lancet, 337( 8754), eScholarID:1d29574
  • Fitzmaurice R, Johnson P, Yin J, Freemont AJ. (1991). Rhabdomyosarcoma presenting as 'acute leukaemia'. Histopathology, 18( 2), 173-5. eScholarID:1d28821
  • Freemont AJ, Denton J, Chuck A, Holt P, Davies M. (1991). Diagnostic value of synovial fluid microscopy: a reassessment and rationalisation. Ann Rheum Dis, 50( 2), 101-7. eScholarID:1d29575
  • Freemont AJ. (1991). Role of cytological analysis of synovial fluid in diagnosis and research. Ann Rheum Dis, 50( 2), 120-3. eScholarID:1d29262
  • Harris M, Hartley A, Blair V, Birch J, Banerjee S, Freemont AJ, McClure J, McWilliam L. (1991). Sarcomas in north west England: I. Histopathological peer review. Br J Cancer, 64( 2), 315-20. eScholarID:1d30699
  • Hartley A, Blair V, Harris M, Birch J, Banerjee S, Freemont AJ, McClure J, McWilliam L. (1991). Sarcomas in north west England: II. Incidence. Br J Cancer, 64( 6), 1145-50. eScholarID:1d28819
  • Hayes M, Bayley D, Drayson M, Freemont AJ, Denton J, Davies M, Mawer E. (1991). Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture. J Steroid Biochem Mol Biol, 38( 3), 301-6. eScholarID:1d29669
  • Hoyland J, Freemont AJ. (1991). Investigation of a quantitative post-hybridization signal amplification system for mRNA-oligodeoxyribonucleotide in situ hybridization. J Pathol, 164( 1), 51-8. eScholarID:1d29588
  • Hoyland J, Thomas J, Donn R, Marriott A, Ayad S, Boot-Handford RR, Grant M, Freemont AJ. (1991). Distribution of type X collagen mRNA in normal and osteoarthritic human cartilage. Bone Miner, 15( 2), 151-63. eScholarID:1d30698
  • Hutchison A, Freemont AJ, Lumb G, Gokal R. (1991). Renal osteodystrophy in CAPD. Adv Perit Dial, 7, 237-9. eScholarID:1d29423
  • Marles P, Hoyland J, Parkinson R, Freemont AJ. (1991). Demonstration of variation in chondrocyte activity in different zones of articular cartilage: an assessment of the value of in-situ hybridization. Int J Exp Pathol, 72( 2), 171-82. eScholarID:1d28871
  • Parkinson R, Noble J, Bale R, Freemont AJ. (1991). Rare abnormalities of the scaphoid in association with congenital radial ray defects of the hand: a report of two cases. J Hand Surg [Br], 16( 2), 208-11. eScholarID:1d28870
  • Parkinson R, Paton R, Noble J, Freemont AJ. (1991). Pathologic fracture through a solitary enchondroma of the radial diaphysis: case report. J Trauma, 31( 2), 284-6. eScholarID:1d29263
  • Thomas J, Cresswell C, Rash B, Hoyland J, Freemont AJ, Grant M, Boot-Handford RR. (1991). The human collagen X gene: complete primary sequence and re-expression in osteoarthritis. Biochem Soc Trans, 19( 4), 804-8. eScholarID:1d29573
  • Young M, Freemont AJ. (1991). Primary leiomyosarcoma of bone. Histopathology, 19( 3), 257-62. eScholarID:1d29668

1990

  • Cole P, Jasani M, Wood B, Freemont AJ, Morris G. (1990). High resolution, high field magnetic resonance imaging of joints: unexpected features in proton images of cartilage. Br J Radiol, 63( 755), 907-9. eScholarID:1d29424
  • Eastwood J, Levin G, Pazianas M, Taylor A, Denton J, Freemont AJ. (1990). Aluminium deposition in bone after contamination of drinking water supply. Lancet, 336( 8713), 462-4. eScholarID:1d29270
  • Hay E, Freemont AJ, Kay R, Bernstein R, Holt P, Pumphrey R. (1990). Selective polyclonal increase of immunoglobulin G1 subclass: a link with Sjögren's syndrome. Ann Rheum Dis, 49( 6), 373-7. eScholarID:1d29576

1989

  • Freemont AJ, Denton J. (1989). Demonstration of aluminium on bone using different staining techniques and spectrophotometry. J Clin Pathol, 42( 6), 671-2. eScholarID:1d29589
  • Hayes M, Denton J, Freemont AJ, Mawer E. (1989). Synthesis of the active metabolite of vitamin D, 1,25(OH)2D3, by synovial fluid macrophages in arthritic diseases. Ann Rheum Dis, 48( 9), 723-9. eScholarID:1d29670
  • Hoyland J, Freemont AJ, Jayson M. (1989). Intervertebral foramen venous obstruction. A cause of periradicular fibrosis? Spine, 14( 6), 558-68. eScholarID:1d28872
  • Kay P, Freemont AJ, Davies D. (1989). The aetiology of multiple loose bodies. Snow storm knee. J Bone Joint Surg Br, 71( 3), 501-4. eScholarID:1d30696
  • Kwan A, Dickson I, Freemont AJ, Grant M. (1989). Comparative studies of type X collagen expression in normal and rachitic chicken epiphyseal cartilage. J Cell Biol, 109( 4 Pt 1), 1849-56. eScholarID:1d29271
  • Steven F, Griffin M, Williams L, Freemont AJ, Maier H, Weidauer H. (1989). Inhibition of trypsin-like enzymes on cells with rhodamine-aprotinin. J Enzyme Inhib, 2( 4), 295-303. eScholarID:1d29421
  • Trail I, Noble J, Freemont AJ. (1989). Intraneural leiomyoma: brief report. J Bone Joint Surg Br, 71( 1), eScholarID:1d29667

1988

  • Davis M, Denton J, Freemont AJ, Holt P. (1988). Comparison of serial synovial fluid cytology in rheumatoid arthritis: delineation of subgroups with prognostic implications. Ann Rheum Dis, 47( 7), 559-62. eScholarID:1d30700
  • Freemont AJ, Denton J. (1988). Synovial fluid findings early in traumatic arthritis. J Rheumatol, 15( 5), 881-2. eScholarID:1d28824
  • Freemont AJ. (1988). Functional and biosynthetic changes in endothelial cells of vessels in chronically inflamed tissues: evidence for endothelial control of lymphocyte entry into diseased tissues. J Pathol, 155( 3), 225-30. eScholarID:1d28874
  • Freemont AJ. (1988). HEV-like vessels in lymphoid and non-lymphoid tissues. Int J Tissue React, 10( 2), 85-8. eScholarID:1d28823
  • Freemont AJ. (1988). The histochemical demonstration of aluminum within tissue sections. Contrib Nephrol, 64, 120-3. eScholarID:1d29425
  • Hoyland J, Freemont AJ, Denton J, Thomas A, McMillan J, Jayson M. (1988). Retained surgical swab debris in post-laminectomy arachnoiditis and peridural fibrosis. J Bone Joint Surg Br, 70( 4), 659-62. eScholarID:1d29590
  • MacCallum P, Freemont AJ, Geary C, Liu Yin J. (1988). A case of IgD myeloma presenting as diffuse osteosclerosis. J Clin Pathol, 41( 5), 486-9. eScholarID:1d29671
  • Narayanan M, Liu Yin J, Love E, Geary C, Holt P, Freemont AJ, Feinmann R. (1988). Eosinophilic fasciitis and aplastic anaemia. Clin Lab Haematol, 10( 4), 471-4. eScholarID:1d30701
  • Robinson E, Mackenzie I, Freemont AJ, Jasani M. (1988). High resolution nuclear magnetic resonance imaging of pig knees at 4.7 T. Magn Reson Imaging, 6( 5), 591-4. eScholarID:1d28873
  • Steven F, Griffin M, Freemont AJ, Johnson J. (1988). Inhibition of guanidinobenzoatase: evidence for multiple forms of this protease on different tumour cells. J Enzyme Inhib, 2( 2), 117-27. eScholarID:1d29577

1987

  • Davies M, Clements M, Mawer E, Freemont AJ. (1987). Tumoral calcinosis: clinical and metabolic response to phosphorus deprivation. Q J Med, 63( 242), 493-503. eScholarID:1d29672
  • Freemont AJ. (1987). Molecules controlling lymphocyte-endothelial interactions in lymph nodes are produced in vessels of inflamed synovium. Ann Rheum Dis, 46( 12), 924-8. eScholarID:1d29432

1986

  • Cremin M, Freemont AJ, Tun T. (1986). An unusual case of laryngeal carcinoma. J Laryngol Otol, 100( 4), 477-82. eScholarID:1d28881
  • Davies M, Mawer E, Freemont AJ. (1986). The osteodystrophy of hypervitaminosis D: a metabolic study. Q J Med, 61( 234), 911-9. eScholarID:1d30702
  • Freemont AJ, Rutley C. (1986). Distribution of immunoglobulin heavy chains in diseased synovia. J Clin Pathol, 39( 7), 731-5. eScholarID:1d30703
  • Freemont AJ, Stoddart R, Steven F, Jones C, Matthews S. (1986). The structure of the basement membrane of human lymph node high endothelial venules: an ultrastructural, histochemical and immunocytochemical study. Histochem J, 18( 8), 421-8. eScholarID:1d29578
  • Kwan A, Freemont AJ, Grant M. (1986). Immunoperoxidase localization of type X collagen in chick tibiae. Biosci Rep, 6( 2), 155-62. eScholarID:1d29591
  • Lalor B, Freemont AJ, Carlile S. (1986). An improved transilial crest bone biopsy drill for quantitative histomorphometry. Bone, 7( 4), 273-6. eScholarID:1d28882

1985

  • Ford G, Eady R, Freemont AJ. (1985). Xanthoma disseminatum. J R Soc Med, 78 Suppl 11, 8-9. eScholarID:1d29673
  • Freemont AJ, Denton J. (1985). Disease distribution of synovial fluid mast cells and cytophagocytic mononuclear cells in inflammatory arthritis. Ann Rheum Dis, 44( 5), 312-5. eScholarID:1d29579
  • Freemont AJ, Ford W. (1985). Functional and morphological changes in post-capillary venules in relation to lymphocytic infiltration into BCG-induced granulomata in rat skin. J Pathol, 147( 1), 1-12. eScholarID:1d29592
  • Freemont AJ, Matthews S, Stoddart R, Jones C. (1985). The distribution of cells of the monocytic-lineage in reactive lymph nodes and non-Hodgkin's lymphomata. Characterization using protein histochemistry, lectin binding and monoclonal antibodies. J Pathol, 146( 2), 139-50. eScholarID:1d29272
  • Hopkins S, Freemont AJ, Jayson M. (1985). Pristane-induced arthritis in BALB/c mice. Curr Top Microbiol Immunol, 122, 213-20. eScholarID:1d29273

1984

  • Denton J, Freemont AJ, Ball J. (1984). Detection and distribution of aluminium in bone. J Clin Pathol, 37( 2), 136-42. eScholarID:1d28839
  • Freemont AJ, Porter M, Tomlinson I, Clague R, Jayson M. (1984). Starch synovitis. J Clin Pathol, 37( 9), 990-2. eScholarID:1d29433
  • Hopkins S, Freemont AJ, Jayson M. (1984). Pristane-induced arthritis in Balb/c mice. I. Clinical and histological features of the arthropathy. Rheumatol Int, 5( 1), 21-8. eScholarID:1d29435
  • Newton P, Freemont AJ, Noble J, Scott N, Grennan D, Hilton R. (1984). Secondary malignant synovitis: report of three cases and review of the literature. Q J Med, 53( 209), 135-43. eScholarID:1d28840
  • Williams S, Freemont AJ. (1984). Aerosol antiperspirants and axillary granulomata. Br Med J (Clin Res Ed), 288( 6431), 1651-2. eScholarID:1d29434

1983

  • Freemont AJ, Jones A. (1983). Adenocarcinoma arising in a rectal duplication. Br J Clin Pract, 37( 11-12), eScholarID:1d29674
  • Freemont AJ, Jones C, Bromley M, Andrews P. (1983). Changes in vascular endothelium related to lymphocyte collections in diseased synovia. Arthritis Rheum, 26( 12), 1427-33. eScholarID:1d29274
  • Freemont AJ, Jones C, Denton J. (1983). The synovium and synovial fluid in multicentric reticulohistiocytosis--a light microscopic, electron microscopic and cytochemical analysis of one case. J Clin Pathol, 36( 8), 860-6. eScholarID:1d29580
  • Freemont AJ, Jones C. (1983). Endothelial specialization of salivary gland vessels for accelerated lymphocyte transfer in Sjögren's syndrome. J Rheumatol, 10( 5), 801-4. eScholarID:1d29275
  • Freemont AJ, Jones C. (1983). Light microscopic, histochemical and ultrastructural studies of human lymph node paracortical venules. J Anat, 136( 2), 349-62. eScholarID:1d29593
  • Freemont AJ. (1983). A possible route for lymphocyte migration into diseased tissues. J Clin Pathol, 36( 2), 161-6. eScholarID:1d28884
  • Williams A, Freemont AJ, Barnett D. (1983). Pericarditis and arthritis complicating chickenpox. Br J Clin Pract, 37( 6), 226-7. eScholarID:1d28883

1982

  • Freemont AJ, Davies J. (1982). Acid esterase activity in lymphocytes and other cells: a comparison of six alpha-naphthyl based substrates. Med Lab Sci, 39( 4), 405-7. eScholarID:1d29594
  • Freemont AJ. (1982). The small blood vessels in areas of lymphocytic infiltration around malignant neoplasms. Br J Cancer, 46( 2), 283-8. eScholarID:1d29675

1981

  • Freemont AJ, Millac P. (1981). The place of peripheral neurectomy in the management of trigeminal neuralgia. Postgrad Med J, 57( 664), 75-6. eScholarID:1d30704

1980

  • Williams A, Freemont AJ, Barnett D. (1980). Subclavian vein thrombosis due to external compression. Lancet, 2( 8195 pt 1), 637-8. eScholarID:1d29581

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