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School of Medicine

Professor Tony Whetton 

Photograph of Tony Whetton

Vice Dean of Faculty of Medical and Human Sciences and Professor of Cancer Cell Biology

School of Cancer & Enabling Sciences
1st floor, Wolfson Molecuar Imaging Centre
27 Palatine Road
Withington
Manchester
M20 3LJ 

 

Role

Professor Tony Whetton is currently the Vice Dean of Faculty of Medical and Human Sciences at the University of Manchester (judged the leading University in the UK for cancer research by the Research Assessment Exercise 2008). He is past Director of the Leukaemia Research Fund Cellular Development Unit and is now Director of the Leukaemia Research Fund Mass Spectrometry Unit based at the Wolfson Molecular Imaging Centre, Christie Hospital. He obtained a PhD in signal transduction research and biophysical chemistry. This was followed by one year of research into membrane structure using electron spin resonance techniques. He then moved into a completely different field of experimental haematology, with two years postdoctoral research in the Experimental Haematology section of the Paterson Institute. He left this position to take up a lectureship at UMIST in 1984 where he became the Professor of Cell Biology in 1995 and Head of Department in 2001. He joined the School of Medicine at the University of Manchester in 2003 as Professor of Cancer Cell Biology, based at the Christie Hospital. Here he has established a state of the art biological mass spectrometry facility for stem cell and leukaemia research. He is currently systematically defining the downstream proteomic and phosphoproteomic effects of the protein tyrosine kinases associated with myeloproliferative disorders and myeloid leukaemias to discover common mechanisms for leukaemic transformation. This research has recently expanded and developed to include a clinical proteomics research capability, where the objective is to discover new biomarkers associated with the cancers. He is also Adjunct Professor in the Department of Gene and Cell Medicine at the Mount Sinai School of Medicine in New York, USA where he works with the Black Family Stem Cell Institute, using proteomics to define embryonic stem cell differentiation control.

 

Research

Many leukaemias occur as a result of inappropriate expression of cancer causing genes in hematopoietic stem cells. These stem cells reside in the bone marrow and are able to provide all the white and red blood cells we require throughout our lifetime. Tony Whetton’s group are investigating how stem cells achieve the spectacular feat of maintaining their own numbers during our lifetime whilst acting as the source of the billions of new mature blood cells we each produce every day. They also study how this process is adversely affected by leukaemogenic proteins.

To achieve this objective requires the most advanced technologies. The group has therefore invested much time in developing a new approach to examining leukaemias, proteomics. The human genome sequencing project opened up great opportunities for the study of the types, amount, modification and turnover of proteins in cells. They investigate key mechanistic differences between normal and leukaemic cells using proteomics. Other important cells (such as embryonal stem cells) that may have therapeutic value are also studied using these procedures. In particular the group have devised new methods to look at changes in protein status (phosphorylation, acetylation) that are key in the governance of protein actions within cells. Using the information derived Tony’s group have derived potentially new strategies for the treatment of haematological malignancies.

 

Biography

Tony Whetton obtained his first degree from the University of Manchester and a PhD from the University of Manchester Institute of Science and Technology (UMIST). Since this training in biochemistry he has pursued research in haematology and stem cell biology. This was firstly at Christie Hospital, then UMIST, where he was Professor of Cell Biology, and since 2003 at the Christie Hospital, University of Manchester. He has been the Director of the Leukaemia Research Fund Cellular Development Unit since its inception in 1990 and the Co-Director of the Leukaemia Research Fund (LRF) Proteomics Facility since 1999. He leads a laboratory of about 20 people engaged in both stem cell research and the new exciting area of proteomics research.

The current objective of this work is to combine the incisive techniques of proteomics to understand biological processes in normal and leukaemic stem cells. He has been a consultant to many international pharmaceutical and proteomics companies and has extensive experience advising national and international science funding bodies. He has also served as external examiner to higher education institutes overseas as well as in the UK. He is currently developing, with colleagues overseas, a consortium for proteomic definition of stem cell populations.

 

Publications

2011

  • 1. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. (2011). RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood, 118, 638-649. eScholarID:144112 | DOI:10.1182/blood-2010-09-307330
  • 2. Ramachandran S, Tran, DDH, Klebba-Faerber, Kardinal, C, Whetton AD, Tamura, T. (2011). An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5. RNA, 17(11), 1957-1966. eScholarID:144114 | DOI:10.1261/rna.2820911
  • 4. Wedge DC, Allwood JW, Dunn WB, Vaughan AA, Simpson K, Brown M, Priest L, Blackhall FH, Whetton AD, Dive C, Goodacre R. (2011). Is serum or plasma more appropriate for inter-subject comparisons in metabolomic studies? An assessment in patients with small-cell lung cancer. Anal Chem, 83(17), 6689-6697. eScholarID:144117
  • 5. Meyer S, Bristow C, Wappett M, Pepper S, Whetton AD, Hanenberg H, Neitzel H, Wlodarski MW, Ebell W, Tönnies H. (2011). Fanconi anemia (FA)-associated 3q gains in leukemic transformation consistently target EVI1, but do not affect low TERC expression in FA. Blood, 117(22), 6047-6050. eScholarID:144123 | DOI:10.1182/blood-2011-03-343897
  • 6. Bonadies N, Foster SD, Chan WI, Kvinlaug BT, Spensberger D, Dawson MA, Spooncer E, Whetton AD, Bannister AJ, Huntly BJ, Göttgens B. (2011). Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One, 6(1), eScholarID:144128
  • Williamson AJ, Whetton AD. (2011). The requirement for proteomics to unravel stem cell regulatory mechanisms. J Cell Physiol, 226(10), 2478-2483. eScholarID:144116 | DOI:10.1002/jcp.22610

2010

  • Blankley RT, Robinson NJ, Aplin JD, Crocker IP, Gaskell SJ, Whetton AD, Baker PN, Myers JE. (2010). A Gel-Free Quantitative Proteomics Analysis of Factors Released From Hypoxic-Conditioned Placentae. Reproductive Sciences, 17(3), eScholarID:81800
  • Dobbin E, Graham C, Freeburn RW, Unwin RD, Griffiths JR, Pierce A, Whetton AD, Wheadon H. (2010). Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), 226-243. eScholarID:96768 | DOI:10.1016/j.scr.2010.08.001
  • Lee CF, Griffiths S, Rodríguez-Suárez E, Pierce A, Unwin RD, Jaworska E, Evans CA, J Gaskell S, Whetton AD. (2010). Assessment of downstream effectors of BCR/ABL protein tyrosine kinase using combined proteomic approaches. Proteomics, 10(18), 3321-3342. eScholarID:96769 | DOI:10.1002/pmic.201000176
  • Mancini, A., Niemann-Seyde, S., Pankow, R., El Bounkari, O., Klebba-Färber, S., Koch, A., Jaworska, E., Spooncer, E., Gruber, A., Whetton, A. & Tamura, T (2010). THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo. BMC Biol, 8, 1. eScholarID:81516 | PMID:20051105 | DOI:10.1186/1741-7007-8-1
  • Rees-Unwin, K., Faragher, R., Unwin, R., Adams, J., Brown, P., Buckle, A., Pettitt, A., Hutchinson, C., Johnson, S., Pulford, K., Banham, A., Whetton, A., Lucas, G., Mason, D. & Burthem, J (2010). Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia. Br J Haematol, 148(4), 534-43. eScholarID:81515 | PMID:19961478 | DOI:10.1111/j.1365-2141.2009.07979.x
  • Unwin RD, Griffiths JR, Whetton AD. (2010). Simultaneous analysis of relative protein expression levels across multiple samples using iTRAQ isobaric tags with 2D-nanoLC-MS/MS. Nature Protocols, 5(9), 1574-1582. eScholarID:144161 | DOI:10.1038/nprot.2010.123
  • Williamson, A and Whetton AD. (2010). Development of approaches for systematic analysis of protein networks in stem cells. Advances in Enzyme Regulation, 50(1), 273-284. eScholarID:144165 | DOI:10.1016/j.advenzreg.2009.10.028

2009

  • Blankley R, Gaskell SJ, Whetton A, Dive C, Baker PN, Myers JE. (2009). A proof-of-principle study demonstrates a gel-free proteomics strategy which could be applied to the identification of predictive biomarkers for the onset of pre-eclampsia. British Journal Of Obstetrics And Gynaecology, 116, 1473-1480. eScholarID:1d33580 | DOI:10.1111/j.1471-0528.2009.02283.x
  • Carney L, Pierce A, Rijnen M, Gonzalez Sanchez M, Hamzah H, Zhang L, Tamura T, Whetton A. (2009). THOC5 couples M-CSF receptor signaling to transcription factor expression. Cell Signal, 21( 2), eScholarID:1d19643 | DOI:10.1016/j.cellsig.2008.10.018
  • El Bounkari O, Guria A, Klebba-Faerber S, Claussen M, Pieler T, Griffiths J, Whetton A, Koch A, Tamura T. (2009). Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). FEBS Lett, 583( 1), eScholarID:1d19641 | DOI:10.1016/j.febslet.2008.11.024
  • Leverentz MK, Campbell RN, Connolly Y, Whetton A, Reece RJ. (2009). Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner. J Biol Chem, eScholarID:1d20883 | DOI:10.1074/jbc.M109.030361
  • Lu, R, Markowetz, F, Unwin, RD, Leek, JT, Airoldi, EM, MacArthur, BD, Lachmann, A, Rovov, R, Ma’yan, A, Boyer, LA, Troyanskaya, OG, Whetton, AD, Lemischka, IR. (2009). Systems level dynamic analyses of fate change in murine embryonic stem cells. Nature, 462(7271), 358-362. eScholarID:134764 | DOI:10.1038/nature08575
  • Simpson K, Whetton A, Dive C. (2009). Quantitative mass spectrometry-based techniques for clinical use: biomarker identification and quantification. J Chromatogr B Analyt Technol Biomed Life Sci, 877( 13), eScholarID:1d19642 | DOI:10.1016/j.jchromb.2008.11.023
  • Unwin RD, Griffiths J, Whetton A. (2009). A sensitive mass spectrometric method for hypothesis-driven detection of peptide post-translational modifications: multiple reaction monitoring-initiated detection and sequencing (MIDAS). Nat Protoc, 4( 6), eScholarID:1d19638 | DOI:10.1038/nprot.2009.57
  • Woodcock S, Rooney C, Liontos M, Connolly Y, Zoumpourlis V, Whetton A, Gorgoulis V, Malliri A. (2009). SRC-induced disassembly of adherens junctions requires localized phosphorylation and degradation of the rac activator tiam1. Mol Cell, 33( 5), eScholarID:1d19640 | DOI:10.1016/j.molcel.2009.02.012

2008

  • Krijgsveld J, Whetton A, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). Proteome Biology of Stem Cells: A New Joint HUPO and ISSCR Initiative. Mol Cell Proteomics, 7( 1), eScholarID:1d31843
  • Leech S, Evans C, Shaw L, Wong C, Connolly J, Griffiths J, Whetton A, Corfe B. (2008). Proteomic analyses of intermediate filaments reveals cytokeratin8 is highly acetylated - implications for colorectal epithelial homeostasis. Proteomics, 8( 2), eScholarID:1d31807
  • Pierce, A, Carney, L, Hamza, H, Griffiths, J, Zhang, L, Whetton, B, Gonzalez Sanchez, M, Tamura, T, Sternberg, D, Whetton, A. (2008). THOC5 spliceosome protein: a target for leukaemogenic tyrosine kinases that affects inositol lipid turnover. Br J Haematol, 141( 5), eScholarID:1d19645 | DOI:10.1111/j.1365-2141.2008.07090.x
  • Pierce, A, Unwin, RD, Evans, C, Griffiths, S, Carney, L, Zhang, L, Jaworska, E, Lee, C, Blinco, D, Okoniewski, M, Miller, C, Bitton, D, Spooncer, E, Whetton, A, Whetton, A. (2008). Eight-channel iTRAQ enables comparison of the activity of 6 leukaemogenic tyrosine kinases. Mol Cell Proteomics, eScholarID:1d16932 | DOI:10.1074/mcp.M700251-MCP200
  • Spooncer, E, Brouard, N, Nilsson, S, Williams, B, Liu, M, Unwin, R, Unwin, RD, Blinco, D, Jaworska, E, Simmons, P, Whetton, A, Whetton, A. (2008). Developmental fate determination and marker discovery in hematopoietic stem cell biology using proteomic fingerprinting. Mol Cell Proteomics, eScholarID:1d16931 | DOI:10.1074/mcp.M700292-MCP200
  • Whetton A, Williamson A, Krijgsveld J, Lee B, Lemischka I, Oh S, Pera M, Mummery C, Heck A. (2008). The time is right: proteome biology of stem cells. Cell Stem Cell, 2( 3), eScholarID:1d19644
  • Williamson, A, Smith, D, Blinco, D, Unwin, RD, Pearson, S, Wilson, C, Miller, C, Lancashire, L, Lacaud, G, Kouskoff, V, Whetton, A, Whetton, A. (2008). Quantitative proteomic analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis. Mol Cell Proteomics, 7, 459-72. eScholarID:1d16956 | DOI:10.1074/mcp.M700370-MCP200

2007

  • Burthem J, Rees-Unwin KKS, Mottram R, Adams J, Lucas GS, Spooncer E, Whetton A, Whetton AD. (2007). The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells. Leukemia, eScholarID:1d31663
  • Griffiths J, Unwin RD, Evans C, Leech S, Corfe B, Whetton A. (2007). The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues. J Am Soc Mass Spectrom, 18( 8), eScholarID:1d16959
  • Griffiths S, Burthem J, Unwin RD, Holyoake T, Melo J, Lucas G, Whetton A. (2007). The use of isobaric tag peptide labeling (iTRAQ) and mass spectrometry to examine rare, primitive hematopoietic cells from patients with chronic myeloid leukemia. Mol Biotechnol, 36( 2), eScholarID:1d16961
  • Mancini, A, El Bounkari, O, Norrenbrock, A, Scherr, M, Schaefer, D, Eder, M, Banham, A, Pulford, K, Lyne, L, Whetton, A, Tamura, T. (2007). FMIP controls the adipocyte lineage commitment of C2C12 cells by downmodulation of C/EBP alpha. Oncogene, 26( 7), eScholarID:1d20884 | DOI:10.1038/sj.onc.1209853
  • Meyer, S, Fergusson, W, Whetton, A, Moreira-Leite F, Pepper SD, Miller, CCJ, Saunders EK, White, DDJ, Will AM, Eden, OB, Ikeda H, Ullmann R, Tuerkmen S, Gerlach A, Klopocki E, Tönnies H. (2007). Amplification and translocation of 3q26 with overexpression of EVI1 in Fanconi anemia derived childhood acute myeloid leukemia with biallelic FANCD1/BRCA2 disruption. Genes Chromosome Cancer, 46 (4), 359-372. eScholarID:1d27524 | DOI:10.1002/gcc.20417
  • Unwin RD, Whetton A. (2007). How will haematologists use proteomics? Blood Rev, 21( 6), eScholarID:1d16957
  • Welman A, Griffiths J, Whetton A, Dive C. (2007). Protein kinase C delta is phosphorylated on five novel Ser/Thr sites following inducible overexpression in human colorectal cancer cells. Protein Sci, 16( 12), eScholarID:1d31844

2006

  • Bashamboo A, Taylor A, Samuel K, Panthier J, Whetton A, Forrester L. (2006). The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway. J Cell Sci, 119( Pt 15), eScholarID:1d20885 | DOI:10.1242/jcs.03038
  • McCallum L, Price S, Planque N, Perbal B, Pierce A, Whetton A, Irvine A. (2006). A novel mechanism for BCR-ABL action: stimulated secretion of CCN3 is involved in growth and differentiation regulation. Blood, 108( 5), eScholarID:1d20886 | DOI:10.1182/blood-2006-04-016113
  • Pierce A, Lu Y, Hamzah H, Thompson S, Owen-Lynch P, Whetton A, Spooncer E. (2006). Differential effect of leukaemogenic tyrosine kinases on cell motility is governed by subcellular localisation. Br J Haematol, 133( 3), 345-52. eScholarID:1d31038
  • Underhill-Day N, Pierce A, Thompson S, Xenaki D, Whetton A, Owen-Lynch P. (2006). Role of the C-terminal actin binding domain in BCR/ABL-mediated survival and drug resistance. Br J Haematol, 132( 6), 774-83. eScholarID:1d30366
  • Unwin RD, Evans CL, Whetton A. (2006). Relative quantification in proteomics: new approaches for biochemistry. Trends in Biochemical Sciences, 31, 473-84. eScholarID:1d13562
  • Unwin RD, Whetton A. (2006). Systematic proteome and transcriptome analysis of stem cell populations. Cell Cycle, 5( 15), 1587-91. eScholarID:1d14854
  • Unwin, RD, Smith, D, Blinco, D, Wilson, C, Miller, C, Evans, C, Jaworska, E, Baldwin, S, Barnes, K, Pierce, A, Spooncer, E, Whetton, A. (2006). Quantitative proteomics reveals post-translational control as a regulatory factor in primary hematopoietic stem cells. Blood, eScholarID:1d12944 | DOI:10.1182/blood-2005-12-4995
  • Warwood S, Mohammed S, Cristea I, Evans C, Whetton A, Gaskell S. (2006). Guanidination chemistry for qualitative and quantitative proteomics. Rapid Commun Mass Spectrom, 20( 21), 3245-56. eScholarID:1d31078

2005

  • Barnes K, McIntosh E, Whetton A, Daley G, Bentley J, Baldwin S. (2005). Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene, 24( 20), 3257-67. eScholarID:1d28909
  • Chen C, Boylan M, Evans C, Whetton A, Wright E. (2005). Application of two-dimensional difference gel electrophoresis to studying bone marrow macrophages and their in vivo responses to ionizing radiation. J Proteome Res, 4( 4), 1371-80. eScholarID:1d29850
  • Chen C, Lorimore SA, Evans CA, Whetton A, Wright EG. (2005). A proteomic analysis of murine bone marrow and its response to ionizing radiation. Proteomics, eScholarID:1d30722
  • Hamzah H, Pierce A, Stewart W, Peter Downes C, Gray A, Irvine A, Spooncer E, Whetton A. (2005). Chronic myeloid leukemia CD34+ cells have elevated levels of phosphatidylinositol 3,4,5 trisphosphate (PtdIns(3,4,5)P(3)) and lack a PtdIns(3,4,5)P(3) response to cytokines and chemotactic factors; effects reversed by imatinib. Leukemia, 19( 10), 1851-3. eScholarID:1d30714
  • Unwin RD, Griffiths J, Leverentz M, Grallert A, Hagan IM, Whetton A. (2005). Multiple reaction monitoring to identify sites of protein phosphorylation with high sensitivity. Mol Cell Proteomics, 4( 8), 1134-44. eScholarID:1d11460
  • Unwin RD, Pierce A, Watson R, Sternberg D, Whetton A. (2005). Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol Cell Proteomics, 4( 7), 924-35. eScholarID:1d11633
  • Unwin RD, Sternberg DW, Lu Y, Pierce A, Gilliland DG, Whetton A. (2005). Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: Identification of the Rho pathway as a target of BCR/ABL. J Biol Chem, 280(8), 6316-6326. eScholarID:1d9392 | DOI:10.1074/jbc.M410598200

2004

  • Cristea I, Gaskell S, Whetton A. (2004). Proteomics techniques and their application to hematology. Blood, 103( 10), 3624-34. eScholarID:1d29499
  • Evans, C, Tonge, R, Blinco, D, Pierce, A, Shaw, J, Lu, Y, Hamzah, H, Gray, A, Downes, C, Gaskell, S, Spooncer, E, Whetton, A. (2004). Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood, 103( 10), 3751-9. eScholarID:1d28781
  • Garwood, K, McLaughlin, T, Garwood, C, Joens, S, Morrison, N, Taylor, C, Carroll, K, Evans, C, Whetton, A, Hart, S, Stead, D, Yin, Z, Brown, A, Hesketh, A, Chater, K, Hansson, L, Mewissen, M, Ghazal, P, Howard, J, Lilley, K, Gaskell, S, Brass, A, Hubbard, S, Oliver, S, Paton, N. (2004). PEDRo: a database for storing, searching and disseminating experimental proteomics data. BMC Genomics, 5( 1), eScholarID:1d29405
  • Mancini A, Koch A, Whetton A, Tamura T. (2004). The M-CSF receptor substrate and interacting protein FMIP is governed in its subcellular localization by protein kinase C-mediated phosphorylation, and thereby potentiates M-CSF-mediated differentiation. Oncogene, 23( 39), 6581-9. eScholarID:1d28780
  • Whetton A. (2004). Stem cells bank on ATM machine. Nat Med, 10( 11), 1166-8. eScholarID:1d29036
  • Xenaki D, Pierce A, Underhill-Day N, Whetton A, Owen-Lynch P. (2004). Bcr-Abl-mediated molecular mechanism for apoptotic suppression in multipotent haemopoietic cells: a role for PKCbetaII. Cell Signal, 16( 2), 145-56. eScholarID:1d29037

2003

  • Bentley, J, Itchayanan, D, Barnes, K, McIntosh, E, Tang, X, Downes, C, Holman, G, Whetton, A, Owen-Lynch, P, Baldwin, S. (2003). Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J Biol Chem, 278( 41), 39337-48. eScholarID:1d29329
  • Cochran DA, Evans CA, Blinco D, Burthem J, Burthem J, Stevenson FK, Gaskell SJ, Whetton A. (2003). Proteomic Analysis of Chronic Lymphocytic Leukemia Subtypes with Mutated or Unmutated Ig VH Genes. Mol Cell Proteomics, 2( 12), 1331-1341. eScholarID:1d29153
  • Lee C, Evans C, Spooncer E, Pierce A, Mottram R, Whetton A. (2003). Generation of a conditionally immortalized myeloid progenitor cell line requiring the presence of both interleukin-3 and stem cell factor to survive and proliferate. Br J Haematol, 122( 6), 985-95. eScholarID:1d28728
  • Smith D, Burthem J, Whetton A. (2003). Molecular pathogenesis of chronic myeloid leukaemia. Expert Rev Mol Med, 2003, eScholarID:1d29406
  • Unwin RD, Gaskell S, Evans C, Whetton A. (2003). The potential for proteomic definition of stem cell populations. Exp Hematol, 31( 12), 1147-59. eScholarID:1d9393
  • Whetton A, Lu Y, Pierce A, Carney L, Spooncer E. (2003). Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood, 102( 8), 2798-802. eScholarID:1d9394 | DOI:10.1182/blood-2002-12-3635

2002

  • Evans C, Ariffin S, Pierce A, Whetton A. (2002). Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors. Blood, 100( 9), 3164-74. eScholarID:1d9395 | DOI:10.1182/blood-2001-12-0235
  • Pierce A, Spooncer E, Ainsworth S, Whetton A. (2002). BCR-ABL alters the proliferation and differentiation response of multipotent hematopoietic cells to stem cell factor. Oncogene, 21( 19), eScholarID:1d29160
  • Ross A, Lee P, Smith D, Langridge J, Whetton A, Gaskell S. (2002). Identification of proteins from two-dimensional polyacrylamide gels using a novel acid-labile surfactant. Proteomics, 2( 7), 928-36. eScholarID:1d29038
  • Smith D, Evans C, Pierce A, Gaskell S, Whetton A. (2002). Changes in the proteome associated with the action of Bcr-Abl tyrosine kinase are not related to transcriptional regulation. Mol Cell Proteomics, 1( 11), 876-84. eScholarID:1d28729

2001

  • Bentley J, Walker I, McIntosh E, Whetton A, Owen-Lynch P, Baldwin S. (2001). Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model. Br J Haematol, 112( 1), 212-5. eScholarID:1d28788
  • Pierce A, Smith D, Jakobsen L, Whetton A, Spooncer E. (2001). The specific enhancement of interferon alpha induced growth inhibition by BCR/ABL only occurs in multipotent cells. Hematol J, 2( 4), 257-64. eScholarID:1d29501

2000

  • Broome CS, Whetton AD and Miyan JA. (2000). Neuropeptide control of bone marrow neutrophil production is mediated by both direct and indirect effects on CFU-GM. Brit J Haematol, 108(1), 140-150. eScholarID:146276
  • Buckle A.-M, Mottram R, Pierce, A, Lucas, GS, Russell, N, Miyan, JA, and Whetton, AD. (2000). The effect of the Bcr-Abl protein tyrosine kinase on maturation and proliferation of human primitive hematopoietic cells. Molecular Medicine, 6(10), 892-902. eScholarID:146272
  • Francis JM, Heyworth, CM, Spooncer, E, Pierce A, Dexter, TM and Whetton A. (2000). Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells. Journal of Biological Chemistry, 275(50), 39137-39145. eScholarID:146277
  • Pierce, A, Spooncer, E, Woolley, S, Dive, C, Francis, JM, Miyan, J, Owen-Lynch, PJ, Dexter, TM, and Whetton, AD. (2000). Bcr-Abl tyrosine kinase activity induces a loss of p53 protein that mediates a delay in differentiation. Oncogene, 19(48), 5487-5497. eScholarID:146323
  • Tang, X, Downes, CP, Whetton, AD and Owen-Lynch, PJ. (2000). Role of Phosphatidylinositol 3 Kinase and specific PKB isoforms in the suppression of apoptosis mediated by the Abelson protein tyrosine kinase. J Biol Chem, 275(17), 13142-13148. eScholarID:146270

1999

  • Evans, CA, Pierce, A, Winter, SA, Spooncer, E, Heyworth, CM and Whetton AD. (1999). Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development. Blood, 94(5), 1504-1514. eScholarID:146326
  • Nicholls SE, Lucas G, Graham GJ, Russell NH, Mottram R, Whetton AD, and Buckle AM. (1999). Macrophage-inflammatory protein-1 alpha receptor expression on normal and chronic myeloid leukemia CD34(+) cells. J Immunol, 162(10), 6191-6199. eScholarID:146324
  • Whetton AD, and Graham GJ. (1999). Homing and mobilization in the stem cell niche. Trends Cell Biol, 9(6), 233-238. eScholarID:146327

1998

  • Nicholls, S.E., S. Winter, R. Mottram, J.A. Miyan, and A.D. Whetton. (1998). The Flt3 ligand can promote survival and macrophage development without proliferation in myeloid progenitor cells. Experimental Hematology, 27(4), 663-672. eScholarID:146343
  • Pearson M.A., O'Farrell A-M, Dexter T.M., Whetton A.D., Owen-Lynch, P.J. and Heyworth C.M. (1998). Investigation of the molecular mechanisms underlying growth factor synergy: The role of MAPK activation in synergy. Growth Factors, 15(4), 293-306. eScholarID:146337
  • Pierce, A, A.D. Whetton, P.J. Owen-Lynch, J. Tavernier, E. Spooncer, T.M. Dexter, C.M. Heyworth. (1998). Ectopic interleukin-5 receptor expression promotes proliferation without development in a multipotent hematopoietic cell line. J Cell Science, 111(pt 6), 815-823. eScholarID:146334
  • Pierce, A, Heyworth, CM, Nicholls, SN, Spooncer, E, Dexter, TM, Lord, JM, Owen-Lynch, PJ Wark, G, Whetton AD. (1998). An activated protein kinase C alpha gives a differentiation signal for hematopoietic progenitor cells and mimicks Macrophage-Colony Stimulating Factor-stimulated signalling events. J Cell Biol, 140(6), 1511-1518. eScholarID:146333
  • Pierce, A., P. J. Owen-Lynch, E. Spooncer. T.M. Dexter, and A.D. Whetton. (1998). p210 Bcr-Abl expression in a primitive multipotent haematopoietic cell line models the development of chronic myeloid leukaemia. Oncogene, 17(5), 667-672. eScholarID:146340
  • Wark.G., Heyworth, C.M., Spooncer, E., Czaplewski, L., Francis, J.M., Dexter, T.M., and A.D. Whetton. (1998). Abl protein kinase abrogates the response of multipotent haemopoietic cells to the growth inhibitor macrophage inflammatory protein-1 alpha. Oncogene, 16(10), 1319-1324. eScholarID:146328
  • Whetton, A.D., Spooncer, E. (1998). Role of cytokines and extracellular matrix in the regulation of haemopoietic stem cells. Current Opinions in Cell Biology, 10(6), 721-726. eScholarID:146331

1997

  • A.M. Afan, C.S. Broome, S.E. Nicholls, A.D. Whetton, and J.A. Miyan. (1997). Bone marrow innervation regulates cellular retention in the murine haemopoietic system. British Journal of Haematology, 98(3), 569-572. eScholarID:146349
  • Chen, Q., Benson, R.S.P., Whetton, A.D., Brant, S.R., Donowitz, M., Montrose, M.H., Dive, C., and Watson, A.J.M. (1997). Role of acid/base homeostasis in the suppression of apoptosis in haemopoietic cells by v-Abl protein tyrosine kinase. J Cell Science, 110(pt 3), 379-387. eScholarID:146365

1996

  • Chasty, R, and Whetton, A D and Lucas, G. (1996). A comparison of the effect of bcr\abl breakpoint specific phosphothiorate oligodeoxynucleotides on colony formation by bcr\abl positive and negative , CD34 enriched mononuclear cell populations. Leukaemia Res, 20(5), 391-395. eScholarID:146369

1993

  • Whetton, A.D. and Dexter T.M. (1993). Influence of growth factors and substrates on the differentiation of haemopoietic stem cells. Current Opinions in Cell Biology, 5(6), 1044-1049. eScholarID:146361

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