Professor Vaskar Saha MBBS, DCH, MD, FRCP, FRCPath, PhD

2012

• Castro, F., McGinn, O., Krishnan, S., Marinov, G., Li, J., Rutkowski, A., Elkord, E., Burt, D., Holland, M., Vaghjiani, R., Gallego, A., Saha, V. & Stern, P (2012). 5T4 oncofoetal antigen is expressed in high risk of relapse childhood pre-B acute lymphoblastic leukemia and is associated with a more invasive and chemotactic phenotype. Leukemia, eScholarID:153847 | PMID:22266911 | DOI:10.1038/leu.2012.18
• Schrappe M, Hunger SP, Pui CH, Saha V, Gaynon PS, Baruchel A, Conter V, Otten J, Ohara A, Versluys AB, Escherich G, Heyman M, Silverman LB, Horibe K, Mann G, Camitta BM, Harbott J, Riehm H, Richards S, Devidas M, Zimmermann M. (2012). Outcome after Induction Failure in Childhood Acute Lymphoblastic Leukemia. The New England Journal of Medicine, 366(15), 1371-1381. eScholarID:159050

2011

• Saha, V. and Kearns, P. (2011). New Agents for the Treatment of Acute Lymphblastic Leukemia. New York: Springer. eScholarID:156676
• Pamela Kearns and Vaskar Saha. (2011). Nucleoside Analogues. New Agents for the Treatment of Acute Lymphoblastic Leukemia. (pp. 167-187). New York: Springer. eScholarID:156679
• Shekhar Krishnan, Ashish Masurekar, and Vaskar Saha. (2011). Identifying Targets for New Therapies in Children with Acute Lymphoblastic Leukemia. In Vaskar Saha and Pamela Kearns (Ed.), New Agents for the Treatment of Acute Lymphoblastic Leukemia. (pp. 25-37). New York: Springer. eScholarID:156678
• Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgemen J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. (2011). RAC2, AEP and ICAM1 expression are associated with CNS disease in a mouse model of Pre-B childhood acute lymphoblastic leukaemia. Blood, eScholarID:125867 | DOI:10.1182/blood-2010-09-307330
• Offman MN, Krol M, Patel N, Krishnan S, Liu J, Saha V, Bates PA. (2011). Rational engineering of L-Asparaginase reveals importance of dual activity for cancer cell toxicity. Blood, 117(5), 1614-1621. eScholarID:98595 | DOI:10.1182/blood-2010-07-298422
• van Delft FW, Horsley S, Colman S, Anderson K, Bateman C, Kempski H, Zuna J, Eckert C, Saha V, Kearney L, Ford A, Greaves M. (2011). Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukaemia. Blood, 117(23), 6247-6254. eScholarID:125866 | DOI:10.1182/blood-2010-10-314674

2010

• Arico, M. Schrappe, M. Hunger, S. P. Carroll, W. L. Conter, V. Galimberti, S. Manabe, A. Saha, V. Baruchel, A. Vettenranta, K. Horibe, K. Benoit, Y. Pieters, R. Escherich, G. Silverman, L. B. Pui, C. H. Valsecchi, M. G. (2010). Clinical outcome of children with newly diagnosed philadelphia chromosome-positive acute lymphoblastic leukaemia treated between 1995 and 2005. Journal of Clinical Oncology, 28(31), 4755-4761. eScholarID:98596 | DOI:10.1200/JCO.2010.30.1325
• Krishnan, S., Wade, R., Moorman, A., Mitchell, C., Kinsey, S., Eden, T., Parker, C., Vora, A., Richards, S. & Saha, V (2010). Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985-2001. Leukemia, 24(2), 450-9. eScholarID:85940 | PMID:20016529 | DOI:10.1038/leu.2009.264
• Parker C, Waters R, Leighton C, Hancock J, Sutton R, Moorman AV, Ancliff P, Morgan M, Masurekar A, Goulden N, Revesz T, Darbyshire P, Love S, Saha V. (2010). Effect of Mitoxantrone on outcome of children with first relapse of acute lymphoblastic leukaemia (ALL R3): an open-label randomised trial. Lancet, eScholarID:98594 | DOI:10.1016/S0140-6736(10)62002-8
• Saha V, Shanson E, Shankar A, Samuel D, Millar M. (2010). Hospital ventilation, heat and humidity: risk of fungal and other infections. J Hosp Infect, 75(1), 74-75. eScholarID:98593 | DOI:10.1016/j.jhin.2009.11.009

2009

• Patel, N, Krishnan, S, Offman, M, Krol, M, Moss, C, Leighton, C, van Delft, F, Holland, M, Liu, J, Alexander, S, Dempsey, C, Ariffin, H, Essink, M, Eden, T, Watts, C, Bates, P, Saha, V. (2009). A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug l-asparaginase. J Clin Invest, eScholarID:1d32651 | DOI:10.1172/JCI37977

2007

• Saha V. (2007). Simplifying treatment for children with ALL. Lancet, 369( 9556), 82-3. eScholarID:1d31309
• Strefford, J, Worley, H, Barber, K, Wright, S, Stewart, A, Robinson, H, Bettney, G, van Delft, F, Atherton, M, Davies, T, Griffiths, M, Hing, S, Ross, F, Talley, P, Saha, V, Moorman, A, Harrison, C. (2007). Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization. Oncogene, 26( 29), eScholarID:1d32438 | DOI:10.1038/sj.onc.1210190

2006

• Jon C. Strefford, Frederik W. van Delft, Hazel M. Robinson, Helen Worley, Olga Yiannikouris, Rebecca Selzer, Todd Richmond, Ian Hann, Tony Bellotti, Manoj Raghavan, Bryan D. Young, Saha, V, Christine J. Harrison. (2006). Complex genomic alterations and gene expression in acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. PNAS, 103 (21), 8167-8172. eScholarID:1d14892 | DOI:10.1073/pnas.0602360103

2005

• Belloti T, Luo Z, Gammerman A, van Delft F, Saha V. (2005). Qualified predictions for microarray and proteomics pattern diagnostics with confidence machines. Int J Neural Sys, 15, 247-268. eScholarID:1d15460
• Bury J, Hurt C, Roy A, Cheesman L, Bradburn M, Cross S, Fox J, Saha V. (2005). LISA - a web-based trial management and decision support system for childhood acute lymphoblastic leukaemia. Br J Haematol 2005;129: 746-754, 129, 746-754. eScholarID:1d15447
• Jones LK, Saha V. (2005). Philadelphia positive acute lymphoblastic leukaemia of childhood. Br J Haematol, 130, 489-500. eScholarID:1d15459
• Roy, A, Bradburn, M, Moorman, AV, Burrett, J, Love, S, Kinsey, SE, Mitchell, CL, Vora, A, Eden, OB, Lilleyman, JS, Hann, I, Saha, V. (2005). Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 Trial. Br J Haematol, 129, 35-44. eScholarID:1d15433
• Roy, D, Cargill, A, Love, S, Moorman, AV, Stoneham, S, Lim, A, Darbyshire, PJ, Lancaster, D, Hann, I, Eden, OB, Saha, V. (2005). Outcome of first relapse in childhood acute lymphoblastic leukaemia - experiences from the UKALL R2 protocol. Br J Haematol, 130, 60-75. eScholarID:1d15458
• van Delft, FW, Belloti, T, Luo, Z, Jones, LK, Patel, N, Yiannikouris, O, Hill, AS, Hubank, M, Kemspki, H, Fletcher, D, Chaplin, D, Foot, N, Young, BD, Hann, I, Gammerman, A, Saha, V. (2005). Prospective gene expression analysis accurately subtypes acute leukaemia in children and establishes a commonality betweenhyperdiploidy and t(12;21) in acute lymphoblastic leukaemia. Br J Haematol, 130, 26-35. eScholarID:1d15435
• Zuna, J, Ford, AM, Peham, M, Patel, N, Saha, V, Eckert, C, Kockling, J, Panzer-Grumayer, P, Trka, J, Greaves, M. (2005). Adenovirus infection following paediatric bone marrow transplantation: Is treatment always necessary? Clin Infect Dis, 40, 1244-1249. eScholarID:1d15431

2004

• Bury J, Hurt C, Roy A, Bradburn M, Cross S, Fox J, Saha V. (2004). A quantitative and qualitative evaluation of LISA, a decision support system for chemotherapy dosing in childhood acute lymphoblastic leukaemia. Stud Health Technol Inform, 107, 197-201. eScholarID:125868
• Bury J, Hurt C, Roy A, Bradbury M, Cross S, Fox J, Saha V. (2004). A Quantitative and Qualitative Evaluation of LISA, a Decision Support System for Chemotherapy Dosing in Childhood Acute Lymphoblastic Leukaemia. Medinfo, 2004, 197-201. eScholarID:1d15429
• Davis, T. B. Williamson, C. J. Sargent, J. M. van Delft, F. Saha, V. Joel, S. P. (2004). Validation of a 96-well plate based ATP assay for determining chemosensitivity of leukaemic blast cells. British Journal of Cancer, 91, S70-S70. eScholarID:98699
• Jan Zuna, Anthony M. Ford, Martina Peham, Naina Patel, Saha, V, Cornelia Eckert, Joachim Köchling, Renate Panzer-Grümayer, Jan Trka, Mel Greaves. (2004). TEL Deletion Analysis Supports a Novel View of Relapse in Childhood Acute Lymphoblastic Leukemia. Clinical Cancer Research, 10(16), 5355-5360. eScholarID:1d27532
• Roy, A. Bradburn, M. Moorman, A. Burrett, J. Mitchell, C. Kinsey, S. Hann, I. Saha, V. (2004). Outcome of Philadelphia positive (Ph+) childhood acute lymphoblastic leukaemia (ALL) on the MRC ALL 97/01 trial. British Journal of Haematology, 125, 1-1. eScholarID:98697
• Roy, A. Bradburn, M. Moorman, A. V. Burrett, J. Mitchell, C. Kinsey, S. E. Vora, A. J. Lilleyman, J. Eden, O. Hann, I. Saha, V. (2004). Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: Results of the Medical Research Council ALL 97 trial. Blood, 104(11), 51a-51a. eScholarID:98694
• Stoneham, S. Lennard, L. Coen, P. Lilleyman, J. Saha, V. (2004). Chronic hepatotoxicity following 6-thioguanine therapy for childhood acute lymphoblastic leukaemia - Response. British Journal of Haematology, 125(3), 412-412. eScholarID:98599
• Strefford, J. C. van Delft, F. Raghavan, M. Robinson, H. M. Moorman, A. V. Young, B. D. Saha, V. Harrison, C. J. (2004). Molecular characterization of AML1 (RUNX1) amplification: A poor risk chromosomal marker in acute lymphoblastic leukaemia (ALL). Blood, 104(11), 43a-43a. eScholarID:98598
• van Delft F, Saha V. (2004). Molecular techniques to improve outcome in childhood ALL. Methods Mol Med, 91, eScholarID:1d21288
• van Delft, F. W. Bellotti, T. Jones, L. K. Patel, N. Hann, I. Hubank, M. Sargent, J. Daw, S. Gammerman, A. Saha, V. Chauhan, V. Senderovich, S. Kempski, H. Fletcher, D. Taylor, C. (2004). Diagnosis and outcome prediction for childhood acute leukaemia by gene expression profiling. British Journal of Haematology, 125, 67-68. eScholarID:98597

2003

• Jones LK, Saha V. (2003). Fusion proteins and disease. eScholarID:4d195
• Debernardi, S. Van Delft, F. Davies, A. Lillington, D. Smith, M. Lister, T. A. Saha, V. Young, B. D. Fitzgibbon, J. (2003). The Wiskott-Aldrich-Syndrome family member 1 (WASF1) gene on 6q21 is down-regulated in specific AML cytogenetic subtypes. Blood, 102(11), 582a-582a. eScholarID:98712
• Ghandhi M, Rao K, Chua S, Saha V, Lilleyman J, Shankar A. (2003). Routine blood counts in children with acute lymphoblastic leukaemia after completion of therapy: are they necessary? Br J Haematol, 122, eScholarID:1d15427
• Hurt C, Fox J, Bury J, Saha V. (2003). Computerised Advice on Drug Dosage Decisions in Childhood Leukaemia: A Method and a Safety Strategy. Artificial Intelligence in Medicine, 2780, eScholarID:1d15428
• Jones LK, Neat MJ, van Delft FW, Mitchell MP, Adamaki M, Stoneham SJ, Patel N, Saha V. (2003). Cryptic rearrangement involving MLL and AF10 occurring in utero. Leukemia, 17(8), eScholarID:1d15424
• Jones, L. K. Hajibagheri, N. Saha, V. Young, B. D. Toda, T. (2003). Functional analysis of two S. pombe genes which show a structural similarity to the leukaemia associated human MLLT10 gene. British Journal of Cancer, 88, S18-S18. eScholarID:98709
• L K Jones, M J Neat, F W van Delft, M P Mitchell, M Adamaki, S J Stoneham, N Patel, Saha V. (2003). Cryptic rearrangement involving MLL and AF10 occurring in utero. Leukemia, 17(8), 1667-1669. eScholarID:1d27531 | DOI:10.1038/sj.leu.2403039
• Patel N, Goff LK, Clark T, Foot N, Lillington D, Hing S, Pritchard-Jones K, Jones LK, Saha V. (2003). Expression profile of wild-type ETV6 in childhood acute leukaemia. Br J Haematol, 122(1), eScholarID:1d15423
• Saha, V. (2003). Chromosomal translocations, fusions genes and acute leukaemia. British Journal of Cancer, 88, S3-S3. eScholarID:98708
• Sargent, J. M. Elgie, A. W. Williamson, C. J. Taylor, C. G. Van Delft, F. Saha, V. (2003). Validation of the ViaLight HS ATP assay for chemosensitivity testing in childhood ALL. Leukemia, 17(3), 681-681. eScholarID:98706
• Stoneham S, Lennard L, Coen P, Lilleyman JS, Saha V. (2003). Veno-Occlusive Disease in Patients Receiving Thiopurines during Maintenance Therapy for Childhood Acute Lymphoblastic Leukaemia. Br J Haematol, 123, eScholarID:1d15426
• van Delft, F. Belloti, T. Hubank, M. Chaplin, T. Patel, N. Adamaki, M. Fletcher, D. Hann, I. Jones, L. Gammerman, A. Saha, V. (2003). Hierarchical clustering analysis of gene expression profiles accurately identifies subtypes of acute childhood leukaemia. British Journal of Cancer, 88, S54-S54. eScholarID:98705
• van Delft, F. W. Bellotti, T. Jones, L. K. Patel, N. Skinner, M. Hubank, M. Hann, I. Fletcher, D. Sargent, J. Taylor, C. Gammerman, A. (2003). Gene expression profiling in childhood acute leukaemia; a useful classification tool and a first promising insight into drug resistance. Blood, 102(11), 365a-365a. eScholarID:98702
• Zuna, J. Ford, A. Peham, M. Patel, N. Saha, V. Eckert, C. Kochling, J. Panzer-Grumayer, R. Trka, J. Greaves, M. (2003). Recurrence of TEL/AML1-positive ALL - Relapse or a new disease? Blood, 102(11), 140a-140a. eScholarID:98700

2002

• Bury, J. P. Hurt, C. Bateman, C. Atwal, S. Riddy, K. Fox, J. Saha, V. (2002). LISA: A clinical information and decision support system for childhood acute lymphoblastic leukaemia. Amia 2002 Symposium, Proceedings, 988. eScholarID:98718
• Jones LK, Saha V. (2002). Chromatin modification, leukaemia and implications for therapy. Br J Haematol, 118, eScholarID:1d15421
• Lowdell MW, Craston R, Samuel DP, Wood EM, O'Neill E, Saha V, Prentice HG. (2002). Evidence that continued remission in patients treated for acute leukaemia is dependent upon autologous natural killer cells. Br J Haematol, 117, eScholarID:1d15422
• Saha, V. (2002). Making paediatric oncological research relevant. Hosp Med, 63(1), 45-54. eScholarID:98715

2001

• Bury, J. P. Saha, V. Fox, J. (2001). Supporting 'scenarios' in the PROforma guideline modelling format. Journal of the American Medical Informatics Association, 870-870. eScholarID:98740
• Jones LK, Chaplin T, Shankar A, Neat M, Patel N, Samuel DP, Saha V. (2001). Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia. Leukemia, 15(6), eScholarID:1d15420
• L K Jones, T Chaplin, A Shankar, M Neat, N Patel, D P Samuel, A S Hill, S Debernardi, A Bassini, B D Young, Saha, V. (2001). Identification and molecular characterisation of a CALM-AF10 fusion in acute megakaryoblastic leukaemia. Leukemia, 15 (6), 910 - 914. eScholarID:1d27530 | DOI:10.1038/sj.leu.2402140
• Patel, N. Goff, L. K. Clark, T. Foot, N. Lillington, D. Hing, S. Pritchard-Jones, K. Jones, L. K. Saha, V. (2001). Comparative expression profiles of ETV6, CBFA2 and ETV6-CBFA2 in disease and remission states in childhood acute leukemia. Blood, 98(11), 163b-163b. eScholarID:98737
• Patel, N. Goff, L. K. Jones, L. K. Clark, T. Foot, N. Lillington, D. Hing, S. Pritchard-Jones, K. Saha, V. (2001). Expression profile of ETV6, CBFA2 and ETV6-CBFA2 in childhood ALL and AML. British Journal of Cancer, 85, 31-31. eScholarID:98736
• Pitsiouni, M. Patel, N. Goff, L. K. Samuel, D. Wilkes, S. J. Saha, V. (2001). RQ-PCR strategies to detect minimal residual disease in childhood ALL. Leukemia, 15(12), 2008-2008. eScholarID:98734
• Wu, P. J. Bardos, J. I. Sheer, D. Freemont, P. Saha, V. (2001). Expression and association of the human trithorax and polycomb group of proteins. British Journal of Cancer, 85, 109-109. eScholarID:98722

2000

• Lillington, D., Jaju, R., Shankar, A., Neat, M., Kearney, L., Young, B. & Saha, V (2000). Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia. Br J Haematol, 110(3), 547-51. eScholarID:85941 | PMID:10997963
• Linder, B., Newman, R., Jones, L., Debernardi, S., Young, B., Freemont, P., Verrijzer, C. & Saha, V (2000). Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation. J Mol Biol, 299(2), 369-78. eScholarID:85943 | PMID:10860745 | DOI:10.1006/jmbi.2000.3766
• Lowdell, M. W. Wood, M. E. Samuel, D. Craston, R. Saha, V. Prentice, H. G. (2000). Autologous leukaemia-reactive CD8+NK cells are required for long-term survival after treatment for acute leukaemia. Blood, 96(11), 119a-119a. eScholarID:98745
• Rao, K. Saha, V. (2000). Medical management of Aspergillus flavus endocarditis. Pediatr Hematol Oncol, 17(5), 425-427. eScholarID:98742

1999

• Jaju, R., Haas, O., Neat, M., Harbott, J., Saha, V., Boultwood, J., Brown, J., Pirc-Danoewinata, H., Krings, B., Müller, U., Morris, S., Wainscoat, J. & Kearney, L (1999). A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG). Blood, 94(2), 773-80. eScholarID:85945 | PMID:10397745
• McCullagh, P., Chaplin, T., Meerabux, J., Grenzelias, D., Lillington, D., Poulsom, R., Gregorini, A., Saha, V. & Young, B (1999). The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene. Oncogene, 18(52), 7442-52. eScholarID:85944 | PMID:10602503 | DOI:10.1038/sj.onc.1203117
• Tomlinson, R., Ronghe, M., Goodbourne, C., Price, C., Lilleyman, J., Das, S. & Saha, V (1999). Once daily ceftriaxone and gentamicin for the treatment of febrile neutropenia. Arch Dis Child, 80(2), 125-31. eScholarID:85946 | PMID:10325726
• Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, Saha V, Biondi A, Greaves MF. (1999). Prenatal origin of acute lymphoblastic leukaemia in children. Lancet, 354, eScholarID:1d3800

1998

• Attard-Montalto, S., Hadley, J., Kingston, J., Eden, O. & Saha, V (1998). Ongoing assessment of nutritional status in children with malignant disease. Pediatr Hematol Oncol, 15(5), 393-403. eScholarID:85949 | PMID:9783305
• Linder, B., Jones, L., Chaplin, T., Mohd-Sarip, A., Heinlein, U., Young, B. & Saha, V (1998). Expression pattern and cellular distribution of the murine homologue of AF10. Biochim Biophys Acta, 1443(3), 285-96. eScholarID:85948 | PMID:9878787
• Saha, V., Young, B. & Freemont, P (1998). Translocations, fusion genes, and acute leukemia. J Cell Biochem Suppl, 30-31, 264-76. eScholarID:85947 | PMID:9893279

1997

• Goddard, A. & Saha, V (1997). Late-onset hemorrhagic cystitis following bone marrow transplantation: a case report. Pediatr Hematol Oncol, 14(3), 273-5. eScholarID:85950 | PMID:9185212

1996

• Attard-Montalto, S., Saha, V., Kingston, J., Plowman, N., Taylor, M., Arlett, C., Bridges, B. & Eden, O (1996). Increased radiosensitivity in a child with T-cell non-Hodgkin's lymphoma. Med Pediatr Oncol, 27(6), 564-70. eScholarID:85952 | PMID:8888819
• Gregorini, A., Sahin, F., Lillington, D., Meerabux, J., Saha, V., McCullagh, P., Bocci, M., Menevse, S., Papa, S. & Young, B (1996). Gene BR140, which is related to AF10 and AF17, maps to chromosome band 3p25. Genes Chromosomes Cancer, 17(4), 269-72. eScholarID:85951 | PMID:8946209
• Young, B. & Saha, V (1996). Chromosome abnormalities in leukaemia: the 11q23 paradigm. Cancer Surv, 28, 225-45. eScholarID:85953 | PMID:8977038

1995

• Saha, V., Lillington, D., Shelling, A., Chaplin, T., Yaspo, M., Ganesan, T. & Young, B (1995). AF6 gene on chromosome band 6q27 maps distal to the minimal region of deletion in epithelial ovarian cancer. Genes Chromosomes Cancer, 14(3), 220-2. eScholarID:85954 | PMID:8589040