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School of Medicine

Professor Alan Jackson 

Professor of Radiology

 

Research

My research interests have developed from a single objective to optimize the use of modern clinical imaging systems for diagnosis, classification and therapeutic planning in patients with malignancy or other diseases of the head and neck. More recently I have been extensively involved in research related to the use of MRI in Cancer drug development. I am currently chairman elect of the drug development group of theInterntional Society of Magnetic Resonance in Medicine (ISMRM).
 

My major areas of clinical research interest are:

  • Neurodegenerative diseases and dementia in the elderly
  • Microvascular brain disease
  • Neuro-oncology
  • Angiogenesis in tumours

My research group is largely focused on methodlogical developments around image analysis with special interests in:

  • Analysis of dynamic contrast enhanced images
  • Design and optimization of Image analysis techniques for clinical decision support

Links:

The TINA image analysis website

The TINA package is an open source image analysis software package supported by ISBE. It contains a considerable number of analysis tools for medical data including tools for:

  • Coregistration of brain images
  • Correction of image intensity heterogeneity due to MRI coil abnormalities
  • Automated assessment of cerebral atrophy from MRI
  • Automatic identification of Taliarach coordinates and Brodman's areas
  • Measurement of regional cortical thickness
  • Measurement of regional cerebral small vessel blood flow from dynamic susceptibility MRI
  • Measurement of contrast transfer coefficient, cerebral blood volume and extravascular extracellular space volume from dynamic T1 weighted images
 

Biography

  • I hold a tenured Faculty of Human and Medical Sciences post as Professor of Neuroradiology in the Division of Imaging Science and Biomedical Engineering (ISBE). I've been here since 1993, with my current post beginning in September 1995. Prior to this I was a full time NHS clinical neuroradiologist at the Manchester Royal Infirmary
  • I also hold honorary chairs in Neuroimaging at the Universities of Liverpool and Bangor
  • I have honorary clinical consultant contracts at the Salford Hospitals NHS Trust and the Manchester Royal Infirmary
  • I am Research Division Leader for the Division of Imaging Science and Biomedical Engineering (ISBE). One of ten major research divisions within the University of Manchester School of Medicine
  • My wife Susan is an anaesthetist and Intensivist and we have two children. Theodore (3) and Alexandra (2)
 

Collaborators and affiliated staff

Members of the Research Team:

  • Dr Neil Thacker, Senior lecturer in image analysis
  • Dr Geoff Parker, Research Fellow in MR physics
 

Publications

2011

  • Brabant G, Cain J, Jackson A, Kreitschmann-Andermahr I. (2011). Visualizing hormone actions in the brain. Trends in Endocrinology and Metabolism, 22, 153-161. eScholarID:146684 | DOI:10.1016/j.tem.2011.01.004
  • Chrysochou C, Mendichovszky I, Buckley DL, Cheung CM, Jackson A, Kalra PA. (2011). BOLD imaging: a potential biomarker of renal functional outcome following revascularization in atheromatous renovascular disease. Nephrol Dial Transplant, 1-7. eScholarID:146693
  • Kotasidis FA, Matthews JC, Angelis GI, Noonan PJ, Jackson A, Price P, Lionheart WR, Reader AJ. (2011). Single scan parameterization of space-variant point spread functions in image space via a printed array: the impact for two PET/CT scanners. Phys Med Biol, 56, 2917-2942. eScholarID:146683 | DOI:10.1088/0031-9155/56/10/003
  • Li K-L, Buonaccorsi G, Thompson G, Cain JR, Watkins A, Russell D, Qureshi S, Evans DG, Lloyd SK, Zhu X, Jackson A. (In-press). An improved coverage and spatial resolution - Using dual injection dynamic contrast-enhanced (ICE-DICE) MRI: A novel dynamic contrast-enhanced technique for cerebral tumours. Magnetic Resonance In Medicine, eScholarID:148233
  • O'Connor JBP, Rose CJ, Jackson A, Watson Y, Cheung S, Maders F, Whitcher BJ, Roberts C, Buonaccorsi GA, Thompson G, Clamp AR, Jayson GC and Parker GJM. (2011). DCE-MRI biomarkers of tumour heterogeneity predict CRC liver metastasis shrinkage following bevacizumab and FOLFOX-6 . Br J Cancer, 105, 139-145. eScholarID:146688 | DOI:10.1038/bjc.2011.191
  • Shardlow E, Jackson A. (2011). Cerebral blood flow and intracranial pressure. Anaesthesia and Intensive Care Medicine, 12, 220-223. eScholarID:146691 | DOI:10.1016/j.mpaic.2011.02.010

2010

  • 232. Trigonis I, Jackson A. (2010). Imaging pharmacodynamics in oncology: the potential significance of “flares”. Annals of Nuclear Medicine, eScholarID:86594
  • Booth, TC, Jackson A, Wardlaw JM, Taylor SA, and Waldman AD. (2010). Incidental findings found in "healthy" volunteers during imaging performed for research: current legal and ethical implications. British Journal of Radiology, 83, 456-465. eScholarID:86588 | DOI:10.1259/bjr/15877332
  • Buonaccorsi GA, Rose CJ, O'Connor JP, Roberts C, Wtson Y, Jackson A, Jayson GC, Parker GJ. (2010). Cross-visit tumor sub-segmentation and registration with outlier rejection for dynamic contrast-enhanced MRI time series data. Med Image Comput Assist Interv, 13(3), 121-128. eScholarID:111264
  • Greenstein AS, Paranthaman R, Burns A, Jackson A, Malik RA, Baldwin RC, Heagerty AM. (2010). Cerebrovascular damage in late-life depression is associated with structural and functional abnormalities of subcutaneous small arteries. hypertension, 56(4), 734-740. eScholarID:111269 | DOI:10.1161/HYPERTENSIONAHA.110.152801
  • Jackson A. (2010). The impact factor game: the rising impact factor of the British Journal of Radiology--a success story? British Journal of Radiology, 83, 93-97. eScholarID:86589 | DOI:10.1259/bjr/18689409
  • Mills SJ, Soh C, O'Connor JP, Rose CJ, Buonaccorsi G, Cheung S, Zhao S, Parker GJ, Jackson A. (2010). Enhancing fraction in glioma and its relationship to the tumoral vascular microenvironment: A dynamic contrast-enhanced MR imaging study. AJNR, 31(4), 726-731. eScholarID:111280 | DOI:10.3174/ajnr.A1925
  • Mills SJ, Soh C, Rose CJ, Cheung S, Zhao S, Parker GJ, Jackson A. (2010). Candidate biomarkers of extravascular extracellular space: a direct comparison of apparent diffusion coefficient and dynamic contrast-enhanced MR imaging derived measurement of the volume of the extravascular extracellular space in glioblastoma multiforme. AJNR, 31(3), 549-553. eScholarID:111286 | DOI:10.3174/ajnr.A1844
  • Mitchell CL, O'Connor JP, Jackson A, et al. (2010). Identification of early predictive imaging biomarkers and their relationship to serological angiogenic markers in patients with ovarian cancer with residual disease following cytotoxic therapy. Annals of Oncology, eScholarID:86590
  • Mitchell CL, O'Connor JP, Roberts C, Watson Y, Jackson A, Cheung S, Evans J, Spicer J, et al. (2010). A two-part PhaseII study of cediranib in patients with advanced solid tumours: the effect of food on single-dose pharmacokinetics and an evaluation of safety, efficacy and imaging pharmacodynamics. Cancer Chemother Pharmacol, eScholarID:111246
  • Paranthaman R, Greenstein AS, Burns AS, Cruikshank JK, Heagerty AM, Jackson A, Malik RA, Scott MLJ, Baldwin RC. (2010). Vascular function in older adults with depressive disorder. Biological Psychiatry, 68, 133-139. eScholarID:86591 | DOI:10.1016/j.biopsych.2010.04.017
  • Perrin R, Embleton K, Pentreath VW, Jackson A. (2010). Longitudinal MRI shows no cerebral abnormality in chronic fatigue syndrome. British Journal of Radiology, 83, 419-423. eScholarID:86592 | DOI:10.1259/bjr/85621779
  • Petersen ET, Mourisden K, Golay X on behalf of the QUASAR test-retest study (of which A Jackson is a member). (2010). The QUASAR reproducibility study, Part 2: results from a multi center arterial spin labelling test-retest study. Neuroimage, 49, 104-113. eScholarID:86593 | DOI:10.1016/j.neuroimage.2009.07.068
  • Stivaros SM, Gledson A, Nenadic G, Zeng XJ, Keane J, Jackson A. (2010). Decision support systems for clinical radiological practice.. towards the next generation. Br J Radiol, 83(995), 904-914. eScholarID:111259 | DOI:10.1259/bjr/33620087
  • Thompson G, Mills SJ, Stivaros SM, Jackson A. (2010). Imaging of brain tumors: perfusion/permeability. Neuroimaging Clin N Am, 20(3), 337-353. eScholarID:111275 | DOI:10.1016/j.nic.2010.04.008
  • Williams LR, Hutchinson CE,Jackson A, Horan MA, JOnes M, McInnes L, Rabbitt PM, Pendletono N. (2010). Clinical correlates of cererbral white matter hyperintensities in cognitively normal older adults. Arch Gerontol Geriatr, 50(2), 127-131. eScholarID:111292 | DOI:10.1016/j.archger.2009.02.012
  • Zee YK, O'Connor JP, Parker GJ, Jackson A et al. (2010). Imaging angiogenesis of genitourinary tumors. Nat Rev Urol, 7, 69-82. eScholarID:146679 | DOI:10.1038/nrurol.2009.262
  • Zee YK, O'Connor JP, Parker GJ, Jackson A et al. (2010). Imaging angiogenesis of genitourinary tumors. Nature Reviews: Urology, 7, 69-82. eScholarID:86595 | DOI:10.1038/nrurol.2009.262

2009

  • Dodds NI, Atcha AW, Birchall D, Jackson A. (2009). Use of high-resolution MRI of the optic nerve in Graves’ ophthalmology. British Journal of Radiology, 82, 1-4. eScholarID:81533
  • Mills SJ, Soh C, Rose CJ, Cheung S, Zhao, S, Parker GJM, Jackson A. (2009). Candidate biomarkers of extravascular extracellular space: a direct comparison of apparent diffusion coefficient and dynamic contrast-enhanced MR imaging, derived measurement of the volume of the extravascular extracellular space in glioblastoma multiforme. American Journal of Neuroradiology, eScholarID:81545
  • Mills SJ, Thompson G, Buonaccorsi G, Parker GJM, Jackson A. (2009). Enhancing fraction (EnF) in glioblastoma multiforme (GBM): a comparison of contrast agent concentration and signal intensity based methods of measurement. European Radiology, eScholarID:81546
  • Mills, S., Soh, C., O'Connor, J., Rose, C., Buonaccorsi, G., Cheung, S., Zhao, S., Parker, G. & Jackson, A (2009). Tumour enhancing fraction (EnF) in glioma: relationship to tumour grade. Eur Radiol, 19(6), 1489-98. eScholarID:72275 | DOI:10.1007/s00330-008-1288-z
  • Naish JH, Kershaw L, Buckley DL, Jackson A, Waterton JC, Parker GJM. (2009). Modelling of contrast agent kinetics in the lung usin gT1 weighted dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine, 61, 1507-1514. eScholarID:81537 | DOI:10.1002/mrm.21814
  • O’Connor JPB, Buckley DL, Jackson A, Watertson JC, Watson Y, Naish J, Mills SJ, Buonaccorsi GA, Cheung S, McGrath DM, Jayson GC, Hutchinson CE, Parker GJM. (2009). Comparison of normal tissue R1 and R2* modulation by oxygen and carbogen. Magnetic Resonance in Medicine, 61, 75-83. eScholarID:81540 | DOI:10.1002/mrm.21815
  • O’Connor JPB, Clamp AR, Ross J, Ho CK, Parker GJP, Jackson A, Mitchell CL et al. (2009). Quantifying anti-vascular effects of anti-VEGF monoclonal antibodies to vascular endothelial growth factor: Insights from imaging. Clinical Cancer Research, 15, 6674-6682. eScholarID:81542 | DOI:10.1158/1078-0432.CCR-09-0731
  • O'Connor JP, Carano RA, Clamp AR, Ross J, Ho CC, Jackson A, et al. (2009). Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res, 15(21), 6674-6682. eScholarID:111284 | DOI:10.1158/1078-0432.CCR-09-0731
  • O'Connor JP, Naish JH, Parker GJ, Waterton JC, Watson Y, Jayson GC, Buonaccorsi GA, Cheung S, Buckley DL, McGrath DM, West CM, Davidson SE, Roberts C, Mills SJ, MItchell CJ, Hope L, Ton NC, Jackson A. (2009). Preliminary study of oxygen-enhanced longitudinal relaxation in MRI: a potential novel biomarker of oxygenation changes in solid tumours. Int J Radiat Oncol Biol Phys, 75(4), 1209-1215. eScholarID:111294 | DOI:10.1016/j.ijrobp.2008.12.040
  • Rose CJ, Mills SJ, O'Connor JP, Buonaccorsi GA, Roberts C, Watson Y, Cheung S, Zhao S, Whitcher B, Jackson A, Parker GJ. (2009). Quantifying spatial heterogeneity in dynamic contrast-enhanced MRI parameter maps. Mag Reson Med, 62(2), 488-499. eScholarID:111290 | DOI:10.1002/mrm.22003
  • Scott, M., Bromiley, P., Thacker, N., Hutchinson, C. & Jackson, A (2009). A fast, model-independent method for cerebral cortical thickness estimation using MRI. Med Image Anal, 13(2), 269-85. eScholarID:72305 | DOI:10.1016/j.media.2008.10.006
  • Selvarajah, J., Scott, M., Stivaros, S., Hulme, S., Georgiou, R., Rothwell, N., Tyrrell, P. & Jackson, A (2009). Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke. Eur Radiol, 19(4), 1011-8. eScholarID:72307 | DOI:10.1007/s00330-008-1202-8
  • Stivaros S, Harris JN, Adams W, Jackson A. (2009). Does black blood MRA have a role in the assessment of intracerebral aneurysms? European Radiology, 19, 184-192. eScholarID:81526 | DOI:10.1007/s00330-008-1127-2
  • Stivaros SM, Sinclair D, Bromiley PA, Kim J, Thorne J, Jakcson A. (2009). Endoscopic third ventriculostomy: predicting outcome with phase-contrast MR imaging. Radiology, 252(3), 825-832. eScholarID:111289 | DOI:10.1148/radiol.2523081398
  • Waldman, A., Jackson, A., Price, S., Clark, C., Booth, T., Auer, D., Tofts, P., Collins, D., Leach, M. & Rees, J (2009). Quantitative imaging biomarkers in neuro-oncology. Nat Rev Clin Oncol, 6(8), 445-54. eScholarID:72312 | DOI:10.1038/nrclinonc.2009.92

2008

  • Jackson, A., O'Connor, J., Thompson, G. & Mills, S (2008). Magnetic resonance perfusion imaging in neuro-oncology. Cancer Imaging, 8, 186-99. eScholarID:72264 | DOI:10.1102/1470-7330.2008.0019
  • Miyajima, F., Ollier, W., Mayes, A., Jackson, A., Thacker, N., Rabbitt, P., Pendleton, N., Horan, M. & Payton, A (2008). Brain-derived neurotrophic factor polymorphism Val66Met influences cognitive abilities in the elderly. Genes Brain Behav, 7(4), 411-7. eScholarID:72276 | DOI:10.1111/j.1601-183X.2007.00363.x
  • O'Connor, J., Jackson, A., Asselin, M., Buckley, D., Parker, G. & Jayson, G (2008). Quantitative imaging biomarkers in the clinical development of targeted therapeutics: current and future perspectives. Lancet Oncol, 9(8), 766-76. eScholarID:72281 | DOI:10.1016/S1470-2045(08)70196-7
  • Purandare, N., Oude, V., McCollum, C., Jackson, A. & Burns, A (2008). Paradoxical embolisation and cerebral white matter lesions in dementia. Br J Radiol, 81(961), 30-4. eScholarID:72294 | DOI:10.1259/bjr/90498392
  • Rabbitt, P., Ibrahim, S., Lunn, M., Scott, M., Thacker, N., Hutchinson, C., Horan, M., Pendleton, N. & Jackson, A (2008). Age-associated losses of brain volume predict longitudinal cognitive declines over 8 to 20 years. Neuropsychology, 22(1), 3-9. eScholarID:72296 | DOI:10.1037/0894-4105.22.1.3
  • Roberts, C., Parker, G., Rose, C., Watson, Y., O'Connor, J., Stivaros, S., Jackson, A. & Rushton, V (2008). Glandular function in Sjogren syndrome: assessment with dynamic contrast-enhanced MR imaging and tracer kinetic modeling--initial experience. Radiology, 246(3), 845-53. eScholarID:72303 | DOI:10.1148/radiol.2463070298
  • Selvarajah, J., Scott, M., Stivaros, S., Hulme, S., Georgiou, R., Rothwell, N., Tyrrell, P. & Jackson, A (2008). Potential surrogate markers of cerebral microvascular angiopathy in asymptomatic subjects at risk of stroke. Eur Radiol, eScholarID:72306 | DOI:10.1007/s00330-008-1202-8
  • Stivaros, S., Harris, J., Adams, W. & Jackson, A (2008). Does black blood MRA have a role in the assessment of intracerebral aneurysms? Eur Radiol, eScholarID:72308 | DOI:10.1007/s00330-008-1127-2

2007

  • Buonaccorsi, G., O'Connor, J., Caunce, A., Roberts, C., Cheung, S., Watson, Y., Davies, K., Hope, L., Jackson, A., Jayson, G. & Parker, G (2007). Tracer kinetic model-driven registration for dynamic contrast-enhanced MRI time-series data. Magn Reson Med, 58(5), 1010-9. eScholarID:72255
  • Haroon, H., Patankar, T., Zhu, X., Li, K., Thacker, N., Scott, M. & Jackson, A (2007). Comparison of cerebral blood volume maps generated from T2* and T1 weighted MRI data in intra-axial cerebral tumours. Br J Radiol, 80(951), 161-8. eScholarID:72259
  • Herholz, K., Coope, D. & Jackson, A (2007). Metabolic and molecular imaging in neuro-oncology. Lancet Neurol, 6(8), 711-24. eScholarID:72260
  • Jackson, A., O'Connor, J., Parker, G. & Jayson, G (2007). Imaging tumor vascular heterogeneity and angiogenesis using dynamic contrast-enhanced magnetic resonance imaging. Clin Cancer Res, 13(12), 3449-59. eScholarID:72265
  • Jackson, A., Reinsberg, S., Sohaib, S., Charles-Edwards, E., Mangar, S., South, C., Leach, M. & Dearnaley, D (2007). Distortion-corrected T2 weighted MRI: a novel approach to prostate radiotherapy planning. Br J Radiol, 80(959), 926-33. eScholarID:72267
  • Kim, J., Thacker, N., Bromiley, P. & Jackson, A (2007). Prediction of the jugular venous waveform using a model of CSF dynamics. AJNR Am J Neuroradiol, 28(5), 983-9. eScholarID:72272
  • Mills, S., Cain, J., Purandare, N. & Jackson, A (2007). Biomarkers of cerebrovascular disease in dementia. Br J Radiol, 80 Spec No 2, S128-45. eScholarID:72273
  • Mullamitha, S., Ton, N., Parker, G., Jackson, A., Julyan, P., Roberts, C., Buonaccorsi, G., Watson, Y., Davies, K., Cheung, S., Hope, L., Munteanu, M., Nakada, M., Nemeth, J., Davis, H., Jiao, Q., Prabhakar, U., Lang, Z., Corringham, R., Beckman, R. & Jayson, G (2007). Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors. Clinical Cancer Research, 13(7), 2128-2135. eScholarID:72277
  • O'Connor, J., Jackson, A., Buonaccorsi, G., Buckley, D., Roberts, C., Watson, Y., Cheung, S., McGrath, D., Naish, J., Rose, C., Dark, P., Jayson, G. & Parker, G (2007). Organ-specific effects of oxygen and carbogen gas inhalation on tissue longitudinal relaxation times. Magn Reson Med, 58(3), 490-6. eScholarID:72282
  • O'Connor, J., Jackson, A., Parker, G. & Jayson, G (2007). DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents. Br J Cancer, 96(2), 189-95. eScholarID:72283
  • O'Connor, J., Jayson, G., Jackson, A., Ghiorghiu, D., Carrington, B., Rose, C., Mills, S., Swindell, R., Roberts, C., Mitchell, C. & Parker, G (2007). Enhancing fraction predicts clinical outcome following first-line chemotherapy in patients with epithelial ovarian carcinoma. Clin Cancer Res, 13(20), 6130-5. eScholarID:72284
  • Patankar, T., Baldwin, R., Mitra, D., Jeffries, S., Sutcliffe, C., Burns, A. & Jackson, A (2007). Virchow-Robin space dilatation may predict resistance to antidepressant monotherapy in elderly patients with depression. J Affect Disord, 97(1-3), 265-70. eScholarID:72289
  • Quinsac, C., Heil, M., Jackson, A. & Dark, P (2007). Instantaneous versus average wave speed calculation in large mammals under acute hemorrhage. Conf Proc IEEE Eng Med Biol Soc, 2007, 971-2. eScholarID:72295
  • Rabbitt, P., Mogapi, O., Scott, M., Thacker, N., Lowe, C., Horan, M., Pendleton, N., Jackson, A. & Lunn, D (2007). Effects of global atrophy, white matter lesions, and cerebral blood flow on age-related changes in speed, memory, intelligence, vocabulary, and frontal function. Neuropsychology, 21(6), 684-95. eScholarID:72297
  • Rabbitt, P., Scott, M., Lunn, M., Thacker, N., Lowe, C., Pendleton, N., Horan, M. & Jackson, A (2007). White matter lesions account for all age-related declines in speed but not in intelligence. Neuropsychology, 21(3), 363-70. eScholarID:72299
  • Rose, C., Mills, S., O'Connor, J., Buonaccorsi, G., Roberts, C., Watson, Y., Whitcher, B., Jayson, G., Jackson, A. & Parker, G (2007). Quantifying heterogeneity in dynamic contrast-enhanced MRI parameter maps. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv, 10(Pt 2), 376-84. eScholarID:72304
  • Stivaros, S. & Jackson, A (2007). Changing concepts of cerebrospinal fluid hydrodynamics: role of phase-contrast magnetic resonance imaging and implications for cerebral microvascular disease. Neurotherapeutics, 4(3), 511-22. eScholarID:72310
  • Ton, N., Parker, G., Jackson, A., Mullamitha, S., Buonaccorsi, G., Roberts, C., Watson, Y., Davies, K., Cheung, S., Hope, L., Power, F., Lawrance, J., Valle, J., Saunders, M., Felix, R., Soranson, J., Rolfe, L., Zinkewich-Peotti, K. & Jayson, G (2007). Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2. Clin Cancer Res, 13(23), 7113-8. eScholarID:72311

2006

  • Baldwin, R., Gallagley, A., Gourlay, M., Jackson, A. & Burns, A (2006). Prognosis of late life depression: a three-year cohort study of outcome and potential predictors. Int J Geriatr Psychiatry, 21, eScholarID:72253
  • Buonaccorsi, G., Roberts, C., Cheung, S., Watson, Y., O'Connor, J., Davies, K., Jackson, A., Jayson, G. & Parker, G (2006). Comparison of the performance of tracer kinetic model-driven registration for dynamic contrast enhanced MRI using different models of contrast enhancement. Acad Radiol, 13(9), 1112-23. eScholarID:72257
  • Jackson, A., Stivaros, S. & Moore, E (2006). Advances in magnetic resonance imaging. Imaging, 18, 97-109. eScholarID:72266
  • Joubert, J., Reid, C., Joubert, L., Barton, D., Ruth, D., Jackson, D., Sullivan, J. & Davis, S (2006). Risk factor management and depression post-stroke: the value of an integrated model of care. J Clin Neurosci, 13(1), 84-90. eScholarID:72271
  • Mills, S., Patankar, T., Haroon, H., Baleriaux, D., Swindell, R. & Jackson, A (2006). Do cerebral blood volume and contrast transfer coefficient predict prognosis in human glioma? AJNR Am J Neuroradiol, 27(4), 853-8. eScholarID:72274
  • Naish, J., Baldwin, R., Patankar, T., Jeffries, S., Burns, A., Taylor, C., Waterton, J. & Jackson, A (2006). Abnormalities of CSF flow patterns in the cerebral aqueduct in treatment-resistant late-life depression: a potential biomarker of microvascular angiopathy. Magn Reson Med, 56(3), 509-16. eScholarID:72278
  • Parker, G., Roberts, C., Macdonald, A., Buonaccorsi, G., Cheung, S., Buckley, D., Jackson, A., Watson, Y., Davies, K. & Jayson, G (2006). An experimentally-derived functional form for a population-averaged high temporal resolution arterial input function for dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine, 56, 993-1000. eScholarID:72286
  • Parker, G., Roberts, C., Macdonald, A., Buonaccorsi, G., Cheung, S., Buckley, D., Jackson, A., Watson, Y., Davies, K. & Jayson, G (2006). Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI. Magn Reson Med, 56(5), 993-1000. eScholarID:72285
  • Patankar, T., Baldwin, R., Mitra, D., Jeffries, S., Sutcliffe, C., Burns, A. & Jackson, A (2006). Virchow-Robin space dilatation may predict resistance to antidepressant monotherapy in elderly patients with depression. J Affect Disord, eScholarID:72288
  • Patankar, T., Widjaja, E., Chant, H., McCollum, C., Baldwin, R., Jeffries, S., Sutcliffe, C., Burns, A. & Jackson, A (2006). Relationship of deep white matter hyperintensities and cerebral blood flow in severe carotid artery stenosis. Eur J Neurol, 13(1), 10-6. eScholarID:72287
  • Purandare, N., Oude, V., Davidson, Y., Gibbons, L., Hardicre, J., Byrne, J., McCollum, C., Jackson, A., Burns, A. & Mann, D (2006). Deletion/insertion polymorphism of the angiotensin-converting enzyme gene and white matter hyperintensities in dementia: A pilot study. J Am Geriatr Soc, 54(9), 1395-400. eScholarID:72293
  • Rabbitt, P., Lowe, C., Scott, M., Thacker, N., Horan, M., Pendleton, N. & Jackson, A (2006). Balance marks cognitive changes in old age because it reflects global brain atrophy and cerebro-arterial blood-flow. : . Neuropsychologia, 44, 1978-1983. eScholarID:72301
  • Rabbitt, P., Scott, M., Thacker, N., Lowe, C., Jackson, A., Horan, M. & Pendleton, N (2006). Losses in gross brain volume and cerebral blood flow account for age-related differences in speed but not in fluid intelligence. Neuropsychology, 20(5), 549-57. eScholarID:72300
  • Roberts, C., Issa, B., Stone, A., Jackson, A., Waterton, J. & Parker, G (2006). Comparative study into the robustness of compartmental modeling and model-free analysis in DCE-MRI studies. J Magn Reson Imaging, 23(4), 554-63. eScholarID:72302

2005

  • Jackson, A, D L Buckley, and G J Parker. (2005). Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology. Berlin: Springer. eScholarID:72263
  • Jayson, G. & Waterton, J (2005). Applications of Dynamic Contrast-Enhanced MRI in Oncology Drug Development. In Jackson, A., Buckley, D. & Parker, G. (Ed.), Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology. (pp. 281-297). Berlin: Springer. eScholarID:72270
  • Ansari, H., Patankar, T. & Jackson, A (2005). Whispering enigma. Br J Radiol, 78(927), 283-4. eScholarID:72251
  • Baldwin, R., Jeffries, S., Jackson, A., Sutcliffe, C., Thacker, N., Scott, M. & Burns, A (2005). Neurological findings in late-onset depressive disorder: comparison of individuals with and without depression. : ; . British Journal of Psychiatry, 186, 308-313. eScholarID:72254
  • Baldwin, R., Jeffries, S., Jackson, A., Sutcliffe, C., Thacker, N., Scott, M. & Burns, A (2005). Neurological findings in late-onset depressive disorder: comparison of individuals with and without depression. Br J Psychiatry, 186, 308-13. eScholarID:72252
  • Buonaccorsi, G., Roberts, C., Cheung, S., Watson, Y., Davies, K., Jackson, A., Jayson, G. & Parker, G (2005). Tracer kinetic model-driven registration for dynamic contrast enhanced MRI time series. Med Image Comput Comput Assist Interv, 8, 91-98. eScholarID:72256
  • Cheadle, E., O'Donnell, D., Selby, P. & Jackson, A (2005). Closely related mycobacterial strains demonstrate contrasting levels of efficacy as antitumor vaccines and are processed for major histocompatibility complex class I presentation by multiple routes in dendritic cells. Infect Immun, 73(2), 784-94. eScholarID:72258
  • Herwadker, A., Vokurka, E., Evans, D., Ramsden, R. & Jackson, A (2005). Size and growth rate of sporadic vestibular schwannoma: predictive value of information available at presentation. Otol Neurotol, 26(1), 86-92. eScholarID:72262
  • Jayson, G., Mulatero, C., Ranson, M., Zweit, J., Jackson, A., Broughton, L., Wagstaff, J., Hakansson, L., Groenewegen, G., Lawrance, J., Tang, M., Wauk, L., Levitt, D., Marreaud, S., Lehmann, F., Herold, M. & Zwierzina, H (2005). Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer. Eur J Cancer, 41(4), 555-63. eScholarID:72268
  • Jayson, G., Parker, G., Mullamitha, S., Valle, J., Saunders, M., Broughton, L., Lawrance, J., Carrington, B., Roberts, C., Issa, B., Buckley, D., Cheung, S., Davies, K., Watson, Y., Zinkewich-Peotti, K., Rolfe, L. & Jackson, A (2005). Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume. J Clin Oncol, 23(5), 973-81. eScholarID:72269
  • Naish, J., Parker, G., Beatty, P., Jackson, A., Young, S., Waterton, J. & Taylor, C (2005). Improved quantitative dynamic regional oxygen-enhanced pulmonary imaging using image registration. Magn Reson Med, 54(2), 464-9. eScholarID:72279
  • Naish, J., Parker, G., Beatty, P., Jackson, A., Young, S., Waterton, J. & Taylor, C (2005). Improved quantitative dynamic regional oxygen-enhanced pulmonary imaging using image registration. magnetic Resonance in Medicine, 54(2), 464-469. eScholarID:72280
  • Patankar, T., Haroon, H., Mills, S., Baleriaux, D., Buckley, D., Parker, G. & Jackson, A (2005). Is volume transfer coefficient (K(trans)) related to histologic grade in human gliomas? AJNR Am J Neuroradiol, 26(10), 2455-65. eScholarID:72290
  • Patankar, T., Mitra, D., Varma, A., Snowden, J., Neary, D. & Jackson, A (2005). Dilatation of the Virchow-Robin space is a sensitive indicator of cerebral microvascular disease: study in elderly patients with dementia. AJNR Am J Neuroradiol, 26(6), 1512-20. eScholarID:72291

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