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School of Medicine

Professor Anne White PhD. FSB

Photograph of Anne White

Professor of Endocrine Sciences

(3.016) AV Hill Building
University of Manchester
Oxford Road
Manchester M13 9PT

 

Memberships of Committees and Professional Bodies

  • Chair MRC Doctoral Training Grants Panel 2009-2011
  • Chair MRC Capacity Building Studentships Panel 2008-2011
  • Panel member MRC Training & Careers Group 2010-2011
  • Society for Endocrinology
  • The Endocrine Society (USA)
  • British Society for Neuroendocrinology

Research

Hormones and their Precursors in Disease 


Pro-opiomelanocortin (POMC) is the precursor of a number of hormones and neuropeptides. In the pituitary It is processed to ACTH which stimulates the release of glucocorticoids as part of the stress response.

POMC is also produced in the brain where it is processed to neuropeptides involved in the regulation of food intake and energy balance. We are investigating how these peptides are regulated and their involvement in the development of diabetes and obesity.

POMC is also produced by some tumours and we are studying its role as a biomarker in small cell lung cancer


Glucocorticoid Regulation of POMC in Small Cell Lung Cancer

Glucocorticoids have many key roles in physiological processes and their synthetic steroid counterparts are one of the most commonly prescribed medicines especially as anti-inflammatory and immunosuppressive drugs.

This research group has identified aberrant glucocorticoid receptor activity in a number of POMC-secreting small cell lung cancer cell lines (In collaboration with Professor David Ray). We are now elucidating how glucocorticoid signaling abnormalities allow excess secretion of ACTH-related peptides by these lung tumour cells

Glucocorticoid receptors and cell death in small cell lung cancer

Glucocorticoids are important regulators of cell growth and differentiation. At the cellular level they bind to intracellular receptors which act as transcription factors binding to the promoter region of genes to enhance or inhibit transcription.

Abnormalities in glucocorticoid receptors may also contribute to the tumour cell phenotype because it decreases glucocorticoid-mediated apoptosis. Using retrovirally-mediated expression of the glucocorticoid receptor we have markedly increased cell death in human small cell lung cancer cells both in vitro and in xenografts (Sommer et al 2010). Current studies are investigating how overexpression of GR can be used to kill human cancer cells.

 

Methodological Knowledge

  • Molecular Endocrinology techniques including transfection analysis, reporter gene assays, RNAi, microarrays
  • Immunoassay development and immunocytochemistry
  • Monoclonal antibody production
  • Purification and characterisation of peptides by immunoaffinity analysis, HPLC and western blotting
  • Characterisation of human small cell lung cancer cell lines, cloning and stable transfection analysis
 

Biography

Anne White is Professor of Endocrine Sciences in Endocrinology and Diabetes within the School of Biomedicine and holds a joint appointment in the Faculty of Medical and Human Sciences and the Faculty of Life Sciences where until recently she was Associate Dean for Business Development and on the Faculty Management Team.  Anne became a Fellow of the Society of Biology in 2010.

Anne gained her PhD in Cell Biology at the University of Manchester in 1978 and has pursued a translational research career initially as a Lecturer in Clinical Biochemistry in 1989 and then as Senior Lecturer in 1991, Reader in 1995 and was appointed to a personal Chair in 1999. From 1994 to 1998, Anne was Head of the Division of Cells, Immunology and Development in the School of Biological Sciences.

In 2002, Anne became Head of Graduate Education, and subsequently Associate Dean for Graduate Education, in the Faculty of Medical and Human Sciences, with overall responsibility for more than 1000 graduate students. She was a member of the MRC Training and Career Development Board from 20022011 and has since Chaired several of the MRC panels for studentships.

Anne has pursued interests at the interface with cellular/molecular endocrinology and its direct translation to endocrine disorders. This has led to over 130 full publications, chapters and reviews. She has been invited to speak not only at international conferences, but also to clinical groups, and researchers in pharmaceutical and diagnostic companies. The majority of her published work has derived from Wellcome Trust, Research Council and NHS funding. In addition, she has research funding from collaboration with industrial partners to underpin programmes on therapeutic targets and develop diagnostic assays.

As part of a Royal Society Industry Fellowship, Anne worked with AstraZeneca from 1999-2002, extending her interests in prohormone processing to neuropeptides in food intake and obesity. Anne has had a number of roles in the Society for Endocrinology. In 2000 she was elected to a five year appointment on the Executive Board of the Council of the Society and became a Director of BioScientifica.  In 2010 Anne was appointed to the Council of the Society for Endocrinology.

 

Collaborators and affiliated staff

Dr Fiona Blackhall
Paterson Institute for Cancer Research

Professor Frank Bloomfield
University of Auckland

Professor John Challis
University of Toronto

Professor Caroline Dive
Paterson Institute for Cancer Research

Professor Stafford Lightman
Laboratories for Integrative Neuroscience & Endorinology (LINE)
University of Bristol

Professor Lucilla Poston
King’s College, London

Professor David Ray, University of Manchester
Molecular mechanisms of glucocorticoid signalling

Dr A Turnbull
AstraZeneca, CVGI, Alderley Park

Professor Sharon Wardlaw
Columbia University College of Physicians and Surgeons, New York

  

 

Publications

2011

  • Begum G, Stevens, A, Bolton Smith E, Connor K, Challis J, Bloomfield F and White A. (In-press). Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning. FASEB J, eScholarID:142290 | DOI:10.1096/fj.11-198762 fj.11-198762
  • Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum g, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carlin D and Withers D. (2011). Deletion of Lkb1 in Pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice. Diabetes, 60, 735-745. eScholarID:132779 | DOI:10.2337/db10-1055
  • Kay P, Schlossmacher G, Matthews L, Sommer P, Singh D, White A, Ray D. (2011). Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS ONE, 6(10), 1-11. eScholarID:132777 | DOI:10.1371/journal.pone.0024839
  • Murray PG, Read A, Banerjee I, Whatmore AJ, Pritchard LE, Davis, R, Brennand J, White A, Ross RJ and Clayton PE. (2011). Reduced appetite and body mass index with delayed puberty in a mother and son: association with a rare novel sequence variant in the leptin gene. European Journal of Endocrinology, 164, 521-527. eScholarID:125047 | DOI:10.1530/EJE-10-0656
  • Schlossmacher George, Stevens Adam and White Anne. (2011). Glucocorticoid receptor-mediated apoptosis: mechanisms of resitance in cancer cells. Journal of Endocrinology, 211, 17-25. eScholarID:132775 | DOI:10.1530/JOE-11-0135
  • Stevens A, Begum G and White A. (2011). Epigenetic changes in the hypothalamic pro-opiomelanocortin gene: a mechanism linking maternal undernutrition to obesity in the offspring? European Journal of Pharmacology, 660(1), 194-201. eScholarID:108650 | DOI:10.1016/j.ejphar.2010.10.111
  • Whalley NM, Pritchard LE, Smith DE and White A. (2011). Processing of proglucagon to GLP-1 in pancreatic alpha-cells: is this a paracrine mechanism enabling GLP-1 to act on beta-cells? Journal of Endocrinology, 211, 99-106. eScholarID:132776 | DOI:10.1530/JOE-11-0094

2010

  • Stevens A, White A. (2010). ACTH: Cellular Peptide Hormone Synthesis and Secretory Pathways. In Jens F Rehfeld/Jens R Bundgaard (Ed.), Cellular Peptide Hormone Synthesis and Secretory Pathways (Results and Problems in Cell Differentiation). (pp. 63-84). USA: Springer. eScholarID:108640
  • Stevens A, White A. (2010). Adrenocorticotropic Hormone. In J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD (Ed.), Endocrinology. USA: Saunders. eScholarID:108638
  • Harno E and White A. (2010). Will treating diabetes with 11beta-HSD1 Inhibitors affect the HPA axis? Trends in Endocrinology and Metabolism, 21(10), 619-627. eScholarID:91328 | DOI:10.1016/j.tem.2010.06.004
  • Russell GM, Henley DE, Leendertz J, Douthwaite JA, Wood SA, Stevens A, Woltersdorf WW, Peters BWMM, Ruigt Ge SF, White A, Veldhuis JD, Lightman SL. (2010). Rapid glucocorticoid receptor mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males. Journal of Neuroscience, 30(17), 6106-6115. eScholarID:85375 | DOI:10.1523/JNEUROSCI.5332-09.2010
  • Sommer P, Cowen, RL, Berry A, Cookson A, Telfer BA, Williams KJ, Stratford IJ, Kay P, White A and Ray DW. (2010). Glucocorticoid receptor over expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth. Endocrine Related Cancer, 17(1), 203-213. eScholarID:80251 | DOI:10.1677/ERC-09-0241
  • Stevens A, Begum G, Cook A, Connor K, Rumball C, Oliver M, Challis J, Bloomfield F, White A. (2010). Epigenetic changes in the hypothalamic pro-opiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition. Endocrinology, 151(8), 3652-3664. eScholarID:91329 | DOI:10.1210/en.2010-0094

2008

  • Creemers JW, Lee YS, Oliver RL, Bahceci M, Tuzcu A, Gokalp D, Keogh J, Herber S, White A, O'Rahilly S, Farooqi I. (2008). Mutations in the amino-terminal region of proopiomelanocortin (POMC) in patients with early-onset obesity impair POMC sorting to the regulated secretory pathway. J Clin Endocrinol Metab, 93, 4494-4499. eScholarID:1d18980 | DOI:10.1210/jc.2008-0954
  • Freel E, Ingram M, Wallace A, White A, Fraser R, Davies E, Connell J. (2008). Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects. Clin Endocrinol (Oxf), 68( 5), 700-706. eScholarID:1d19245 | DOI:10.1111/j.1365-2265.2007.03116.x
  • Rice L, Waters C, Eccles J, Garside H, Sommer P, Kay P, Blackhall F, Zeef L, Telfer B, Stratford I, Clarke R, Singh D, Stevens A, White A, Ray DW. (2008). Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. The Journal of Endocrinology, 198(3), 499-509. eScholarID:1c8295 | PMID:18583474 | DOI:10.1677/JOE-08-0019

2007

  • Farooqi S, Volders K, Stanhope R, Heuschkel R, White A, Lank E, Keogh J, O’Rahilly S, Creemers JWM. (2007). Hyperphagia and early onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3. J Clin Endocrinol Metab, -(92), 3369-3373. eScholarID:1c7141
  • Gyte A, Pritchard LE, Jones HB, Brennand JC, White A. (2007). Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti related protein in the hypothalami of Zucker Diabetic Fatty rats. Journal of Neuroendocrinology, 19, 941-951. eScholarID:1d27452
  • Pritchard, L. & White, A (2007). Neuropeptide processing and its impact on melanocortin pathways. Endocrinology, 148(9), 4201-7. eScholarID:76146 | PMID:17584964 | DOI:10.1210/en.2006-1686
  • Rousseau, K, Kauser, S, Pritchard, LE, Warhurst, A, Oliver, RL, Slominski, A, Wei, ET, Thody, AJ, Tobin, DJ, White, A. (2007). Proopiomelanocortin (POMC) and the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. Faseb Journal, 21, 1844-1856. eScholarID:1d27449 | DOI:10.1096/fj.06-7398com
  • Sommer P, Le Rouzic P, Gillingham H, Berry A, Kayahara M, Huynh T, White A and Ray DW. (2007). Glucocorticoid Receptor Expression Exerts An Anti-Survival Effect On Human Small Cell Lung Cancer Cells. Oncogene, -(26), 1-11. eScholarID:1c7139

2006

  • Creemers, JWM, Pritchard, LE, Gyte, A, Le Rouzic, PP, Wardlow, SL, Zhu, X, Steiner, DF, Davies, N, Armstrong, D, Lawrence, CC.B., Luckman, S, Schmitz, CA, Brennand, JC, White, A. (2006). Agouti-related protein is post transitionally cleaved by proprotein convertase 1 to generate (AGRP) 83-132: Interaction between AGRP 83-132 and melanocortin receptors cannot be influenced by syndecan-3. Endocrinology, 147(4), 1621-1631. eScholarID:1d26831 | DOI:10.1210/en.2005-1373
  • Garside H, Waters C, Berry A, Rice L, Ardley HC, White A, Robinson PA, Ray DW. (2006). UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. The Journal of endocrinology, 190(3), 621-629. eScholarID:1c7307 | PMID:17003263 | DOI:10.1677/joe.1.06799
  • Heald, A, Karvestedt L, Anderson SG, McLaughlin J, Knowles A, Wong L, Grill V, Cruickshank, (K, White, A, Gibson, JM, Brismar K. (2006). Low insulin-like growth facctor-II levels predict weight gain in normal weight subjects with type 2 diabetes. American Journal Of Medicine, 119(2), 9-15. eScholarID:1d27038

2005

  • Pritchard LE, White A. (2005). Agouti-related protein: more than a melanocortin-4 receptor antagonist? Peptides, 26(10), 1759-1770. eScholarID:1c4918 | PMID:15996791

2004

  • White A. (2004). Adrenocorticotrophic hormone. Endocrinology 5th edition (eds De Groot LJ & Jameson JL). (pp. 323-329). Elsevier Science. eScholarID:3d378
  • Challis BG, Coll AP, Yeo GSH, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Carlton MB, Aparicio SA, Russ AP, Colledge WH, O'Rahilly S. (2004). Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc.Natl.Acad.Sci.U.S.A, 101, 4695-4700. eScholarID:1c2951 | DOI:10.1073/pnas.0306931101
  • Coppock HA, White A, Aplin JD, Westwood M. (2004). Matrix metalloprotease-3 and -9 proteolyze insulin-like growth factor-binding protein-1. Biology of reproduction, 71(2), 438-443. eScholarID:1c4457 | PMID:15070833 | DOI:10.1095/biolreprod.103.023101
  • Pritchard LE, Armstrong D, Davies N, Oliver RL, Schmitz CA, Brennand JC, Wilkinson GF, White A. (2004). Agouti-related protein (83-132) is a competitive antagonist at the human melanocortin-4 receptor: no evidence for differential interactions with pro-opiomelanocortin-derived ligands. The Journal of endocrinology, 180(1), 183-191. eScholarID:1c303 | PMID:14709157 | DOI:10.1677/joe.0.1800183
  • Pritchard LE, White A. (2004). The physiological role of agouti-related peptide in energy homeostasis: more than a melanocortin 4 receptor antagonist? Peptides, eScholarID:1d8813
  • Waters CE, Stevens A, White A, Ray DW. (2004). Analysis of co-factor function in a glucocorticoid resistant small cell carcinoma cell line. Journal of Endocrinology, eScholarID:1d26030

2003

  • White A, Ray DW, GaillardR.C. (2003). ACTH precursors in different pathological conditions. The ACTH axis: Pathogenesis, Diagnosis and Treatment. Kluwer Academic Publ. eScholarID:3d190
  • E Marshman, Green K, Flint DJ, White A, Streuli CC.H, Westwood M. (2003). Insulin-like growth factor binding protein 5 and apoptosis in mammary epithelial cells. Journal of Cell Sciences, 116, 675-682. eScholarID:1d6021 | DOI:10.1242/jcs.00263
  • Jackson R, Creemers JW, Farooqi IS, Raffin-Sanson ML, Varro A, Dockray GJ, Holst JJ, Brubaker PL, Corvol P, Polonsky KS, Ostrega D, Becker KL, Bertagna X, Hutton, JJ.C., Dattani MT, White, A, Hussain K, Middleton SJ, Nicole TM, Milla PJ, Lindley KL, O'Rahilly S. (2003). Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency. Journal of Clinical Investigation, 112 (10), 1550-1560. eScholarID:1d26027
  • Oliver RL, Davis JRE, White A. (2003). Characterisation of ACTH related peptides in ectopic Cushing's Syndrome. Pituitary, 6 (3), 119-126. eScholarID:1d26028
  • Pritchard LE, Oliver RL, McLoughlin JD, Birtles S, Lawrence CB, Turnbull AV, White A. (2003). Proopiomelanocortin-derived peptides in rat cerebrospinal fluid (CSF) and hypothalamic extracts: evidence that secretion is regulated with respect to energy balance. Endocrinology, 144(3), 760-766. eScholarID:1d6017 | DOI:10.1210/en.2002-220866
  • Stevens A, Garside H, Berry A, Waters C, White A, Ray DW. (2003). Dissociation of Steroid Receptor Coactivator 1 and Nuclear Receptor Corepressor Recruitment to the Human Glucocorticoid Receptor by modification of the Ligand-Receptor Interface: the role of Tyrosine 735. Molecular Endocrinology, 17, 845-859. eScholarID:1d25087 | DOI:10.1210/me.2002-0320
  • Talbot JA, Kane JW, White A. (2003). Analytical and clinical aspects of adrenocorticotrophin determination. Annals of Clinical Biochemistry, 40, eScholarID:1d6023
  • White A, Cade JE, Cruickshank JK, Gibson JM, Anderson S, Heald AH. (2003). The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public health nutrition, 6(2), eScholarID:1c300 | PMID:12675960
  • White A, Kane JW, Talbot JA. (2003). Analytical and clinical aspects of adrenocorticotrophin determination. Annals of clinical biochemistry, 40(Pt 5), eScholarID:1c305 | PMID:14503983

2002

  • Ray DW, White A, Davis JRE. (2002). Ectopic pituitary hormone production. Genetics in Endocrinology. eScholarID:3d733
  • White A, Ray DW. (2002). ACTH precursors in different pathological conditions. The ACTH Book. Kluwer Academic Publ. eScholarID:3d671
  • Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S. (2002). A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism. Human molecular genetics, 11(17), 1997-2004. eScholarID:1c306 | PMID:12165561 | DOI:10.1093/hmg/11.17.1997
  • Heald A, Siddals KW, Fraser W, Taylor W, Kaushal K, Morris J, Young RJ, White A, Gibson JM. (2002). Low circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) are closely associated with the presence of macrovascular disease and hypertension in type 2 diabetes. Diabetes, 51, 2629-2636. eScholarID:1d2954
  • Huynh TT, Ray DW, Brogan IJ, Stevens A, Davis JRE, White A. (2002). Failure of steroid regulation of the MMTV promoter in a small cell lung cancer cell line is caused by a DNA sequence flanking the glucocorticoid response element. Journal Of Endocrinology, 172, 295-302. eScholarID:1d25084
  • Pritchard LE, Turnbull AV, White A. (2002). Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. Journal of Endocrinology, 172, eScholarID:1d6024
  • Siddals KW, Westwood M, Gibson JM, White A. (2002). IGF-binding protein-1 inhibits IGF effects on adipocyte function: implications for insulin-like actions at the adipocyte. The Journal of endocrinology, 174(2), eScholarID:1c311 | PMID:12176668 | DOI:10.1677/joe.0.1740289

2001

  • Bano G, Rodin DA, White A, O'Rahilly S, Nussey SS. (2001). Is the defect in pro-hormone processing in type 2 diabetes mellitus restricted to the beta-cell? Diabetic Medicine, 18, 17-21. eScholarID:1d6005
  • Cruickshank, (K, Heald, A, Anderson S, Cade JE, Sampayo, J, Riste, L, Greenhalgh A, Taylor, W, Fraser W, White, A, Gibson, JM. (2001). Epidemiology of the insulin-like growth factor system in three ethnic groups. American Journal of Epidemiology, 154(6), 504-513. eScholarID:1d2610
  • de Lange P, Segeren CM, Koper JW, Wiemer E, Sonneveld P, Brinkmann AO, White, A, Brogan, II.J., de Jong FH, Lamberts SWJ. (2001). Expression in hematological malignancies of a glucocorticoid receptor splice variant which increases glucocorticoid sensitivity in transfected cells. Cancer Research, 61, 3937-3941. eScholarID:1d6009
  • Gibson JM, Aplin JD, White A, Westwood M. (2001). Regulation of IGF bioavailability in pregnancy. Molecular Human Reproduction, 17, 79-87. eScholarID:1d3733 | DOI:10.1093/molehr/7.1.79
  • Heald, A, Cruickshank, (K, Riste, L, Cade, J, Anderson, S, Greenhalgh, A, Sampayo, J, Taylor, W, Fraser, W, White, A, Gibson, JM. (2001). Close relation of fasting insulin-like growth factor binding protein-1 (IGFBP-1) with glucose tolerance and cardiovascular risk in two populations. Diabetologia, 44, 333-339. eScholarID:1d2608
  • Hiroi N, Chrousos GP, Kohn B, Lafferty A, Abu-Asab M, Bonat S, White A, Bornstein SR. (2001). Adrenocortical-pituitary hybrid tumor causing Cushing"s syndrome. The Journal of clinical endocrinology and metabolism, 86(6), 2631-2637. eScholarID:1c307 | PMID:11397864 | DOI:10.1210/jc.86.6.2631
  • Westwood M, Aplin JD, Collinge IA, Gill A, White A, Gibson JM. (2001). alpha 2-Macroglobulin: a new component in the insulin-like growth factor/insulin-like growth factor binding protein-1 axis. Journal of Biological Chemistry, 276(45), 41668-41674. eScholarID:1c297 | PMID:11546760 | DOI:10.1074/jbc.M102793200
  • Wilson HE, Westwood M, White A, Clayton PE. (2001). Monoclonal antibodies to carboxy terminal Ea sequence of Pro-Insulin-like Growth Factor 1-A (proIGF-1A) recognise proIGF-1a secreted by IM9 B-lymphocytes. Growth Hormone & IGF Research, 11, 10-17. eScholarID:1d1769

2000

  • White A, Ray DW. (2000). Adrenocorticotrophic hormone. Endocrinology (4th)edition, section on neuroendocrinology. eScholarID:3d352
  • Heald A, Selby PL, White A, Gibson JM. (2000). Progestins abrogate estrogen induced changes in the insulin-like growth factor axis. American journal of obstetrics and gynecology, 183(3), 593-600. eScholarID:1c309 | PMID:10992179 | DOI:10.1067/mob.2000.106994
  • Hinnie J, Gray CE, McBain A, McNichol AM, White A, Carter E, Campbell IW, Thomson JA. (2000). Cushing's syndrome in a 16 year old girl due to ectopic ACTH precursor production from a pancreatic tumour. Clinical Endocrinology, 53, 539-540. eScholarID:1d6003
  • White A, Ray DW, Talbot A, Abraham P, Thody A, Bevan J. (2000). Cushing's syndrome due to phaeochromocytoma secreting the precursors of ACTH:aberrant regulation by glucocorticoids. J Clin Endocrinol Metab, 85(12), 47771-4775. eScholarID:1d20327

1999

  • Brogan I, Murray I, Needham M, Cerillo G, White A & Davis JRE. (1999). Interaction of glucocorticoid receptor isoforms with transcription factors AP-1 and NF-kB: lack of effect of glucocorticoid receptor B. Molecular and Cellular Endocrinology, 157, 95-104. eScholarID:1d25193
  • Gibson JM, Westwood M, Lauszus FF, Klebe JG, Flyvbjerg A, White A. (1999). Phosphorylated insulin-like growth factor binding protein 1 is increased in pregnant diabetic subjects. Diabetes, 48, 321-326. eScholarID:1d2606
  • Ray DW, Suen CS, Brass A, White A, Soden J, White A. (1999). Structure/function of the human glucocorticoid receptor: tyrosine 735 is important for transactivation. Mol Endocrinol, 13, 1855-1864. eScholarID:1d20328
  • Westwood M, Gibson J, Pennells L, White A. (1999). Modification of plasma insulin-like growth factors and binding proteins during oral contraceptive use and the normal menstrual cycle. Am J Obstet Gynecol, 180, 530-536. eScholarID:1d20198

1998

  • Cerillo G, Rees A, Manchanda N, Brogan I, White A, Needham M. (1998). The oestrogen receptor regulates NFkappaB and AP-1 activity in a cell-specific manner. J Steroid Biochem Mol Biol, 67, 79-88. eScholarID:1d21789
  • Perone M, Murray C, Brown O, Gibson S, White A, Linton E, Perkins A, Lowenstein P, Castro M. (1998). Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells. Mol Cell Endocrinol, 142, 191-202. eScholarID:1d21791
  • Ray DW, Lovering A, Davis JRE, White A. (1998). Rifampicin: a glucocorticoid receptor ligand? Nat Med, 4, 1090-. eScholarID:1d20332 | DOI:10.1038/2575

1997

  • Gill MS, Whatmore AJ, White A, Addison GM, Price DA, Clayton PE. (1997). Urinary insulin-like growth factor (uIGF-l) and IGF binding protein-3 (uLGFBP-3) in children with disordered growth. Clin Endocrinol (Oxf), 46, 438-492. eScholarID:1d21792
  • Leibowitz G, White A, Hadani M, Gross DJ. (1997). Fluctuating hyper-hypocortisolaemia: a variant of Cushing's Syndrome. Clinical Endocrinology, 46, 759-763. eScholarID:1d21794
  • Miell J, Jauniaux E, Langford K, Westwood M, White A, Jones J. (1997). Insulin-like growth factor binding protein concentration and post-translational modification in embryological fluid. Mol Hum Reprod, 3, 343-349. eScholarID:1d20199
  • Miell JP, Langford KS, Jones JS, Noble P, Westwood M, White A, Nicolaides KH. (1997). The maternal insulin-like growth factor (IGF) and IGF-binding protein response to trisomic pregnancy during the first trimester: a possible diagnostic tool for trisomy 18 pregnancies. J Clin Endocrinol Metab, 82, 287-292. eScholarID:1d20201
  • Westwood M, Gibson JM, White A. (1997). Purification and characterisation of the insulin-like growth factor-binding protein-1 phosphoform found in normal plasma. Endocrinology, 138, 1130-1136. eScholarID:1d20200

1996

  • Davis JRE, Ray DW, Clark AJL, White A. (1996). Glucocorticoid signalling in the ectopic ACTH syndrome: towards a molecular understanding. QJM -Oxford, 89, 867-868. eScholarID:51741
  • Gibson JM, Westwood M, Young RJ, White A. (1996). Reduced insulin-like growth factor binding protein-1 (IGFBP-1) levels correlate with increased cardiovascular risk in non-insulin dependent diabetes mellitus (NIDDM). J Clin Endocrinol Metab, 81, 860-863. eScholarID:1d20202
  • Gibson S, Ray DW, Crosby SR, Dornan TL, Jennings AM, Bevan JS, Davis JRE, White A. (1996). Impaired processing of pro-opiomelanocortin in invasive corticotroph adenomas. J Clin Endocrinol Metab, 81, 497-502. eScholarID:1d20340
  • Ray DW, Davis JRE, White A, Clark AJL. (1996). Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells. Cancer Res, 56, 3276-3280. eScholarID:1d20337

1995

  • Carr GA, Jacobs RA, Young IR, Schwartz J, White A, Crosby SR, Thorburn GD. (1995). Development of adrenocorticotropin-(1-39) and precursor peptide secretory responses in the fetal sheep during the last third of gestation. Endocrinology, 136, 5020-5026. eScholarID:1d21854
  • Gibson JM, Westwood M, Crosby SR, Gordon C, Holly JMP, Fraser W, Anderson C, White A, Young RJ. (1995). Choice of treatment affects plasma levels of insulin-like growth factor-binding protein-1 (IGFBP-l) in non insulin-dependent diabetes mellitus. J Clin Endocrinol Metab, 80, 1369-1375. eScholarID:1d20204
  • McMillen I, Merei JJ, White A, Crosby SR, Schwartz J. (1995). Increasing gestational age and cortisol alter the ratio of ACTH precursors:ACTH secreted from the anterior pituitary of the fetal sheep. J Endocrinol, 144, 569-576. eScholarID:1d21810
  • O'Rahilly S, Gray H, Humphreys P, Krook A, Polonsky K, White A, Gibson S, Taylor K, Carr C. (1995). Impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. N Engl J Med, 333, 1386-1390. eScholarID:1d21852
  • Ray DW, Gibson S, Crosby S, Davies D, Davis JRE, White A. (1995). Elevated levels of adrenocorticotropin (ACTH) precursors in post-adrenalectomy Cushing's disease and their regulation by glucocorticoids. J Clin Endocrinol Metab, 80, 2430-2436. eScholarID:1d20341
  • Schwartz J, Kleftogiannis F, Jacobs R, Thorburn GD, Crosby SR, White A. (1995). Biological activity of ACTH precursors in fetal ovine adrenal cells. Am J Physiol, 268, 623-629. eScholarID:1d21819
  • Tsigos C, Gibson S, Crosby SR, White A, Young RJ. (1995). Cerebrospinal fluid levels of beta-endorphin in painful and painless diabetic polyneuropathy. Journal of Diabetes and Its Complications, 9, 92-96. eScholarID:51917
  • Westwood M, Gibson J, Williams AC, Clayton Pe, Hamberg O, Flyvbjerg A, White A. (1995). Hormonal regulation of circulating insulin-like growth factor-binding protein-1 phosphorylation status. J Clin Endocrinol Metab, 80, 3520-3527. eScholarID:1d20203
  • Zehnder T, Valego N, Schwartz J, White A, Rose J. (1995). Regulation of bioactive and immunoreactive ACTH secretion by CRF and AVP in sheep fetuses. Am J Phyiol Endocr & Metab, 269(6), 1076-1082. eScholarID:1d21855

1994

  • Deayton J, Young I, Hollingworth S, White A, Crosby S, Thorburn G. (1994). Effect of late hypothalamo-pituitary disconnection on the development of the HPA axis in the ovine fetus and the initiation of parturition. J Neuroendocrinol, 6, 25-31. eScholarID:1d21856
  • Gibson S, Crosby SR, Stewart MF, Jennings A, McCall E, White A. (1994). Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two-site immunoradiometric assays. J Clin Endocrinol Metab, 78, 835-841. eScholarID:1d21859
  • Mawer EB, Hayes ME, Heys SE, Davies M, White A, Stewart MF. (1994). Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line. J Clin Endocrinol Metab, 79, 554-560. eScholarID:1d21860
  • Ray DW, Littlewood AC, Clark A, Davis JRE, White A. (1994). Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function. J Clin Invest, 93, 1625-1630. eScholarID:1d20342 | DOI:10.1172/JCI117143
  • S Gibson, Ray DW, SR Crosby, Dornan TL, AM Jennings, JS Bevan, Davis JRE, White A. (1994). Impaired processing of proopiomelanocortin in corticotroph macroadenomas. Journal Of Clincal Endocrinology And Metabolism, 81, 497-502. eScholarID:1d24391
  • Schwartz J, Ash P, Ford V, Raff H, Crosby SR, White A. (1994). Secretion of adrenocorticotrophin (ACTH) and ACTH precursors in ovine anterior pituitary cells: actions of corticotrophin-releasing hormone, arginine vasopressin and glucocorticoids. J Endocrinol, 140, 189-195. eScholarID:1d21858
  • Stewart, P, Gibson, S, Crosby, S, Penn, R, Holder, R, Ferry, D, Thatcher, N, Phillips, P, London, D, White, A. (1994). ACTH precursors characterize the ectopic ACTH syndrome. Clin Endocrinol (Oxf), 40, 199-204. eScholarID:1d21857
  • Turnbull AV, Dow RC, Hopkins SJ, White A, Fink G, Rothwell NJ. (1994). Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat. Psychoneuroendocrinology, 19, 165-178. eScholarID:1d28453
  • Westwood M, Gibson J, Davies A, Young R, White A. (1994). The phosphorylation pattern of insulin-like growth factor-binding protein-1 in normal plasma is different from that in amniotic fluid and changes during pregnancy. J Clin Endocrinol Metab, 79, 1735-1741. eScholarID:1d20205
  • White A, S Gibson, Ray DW, Crosby SR. (1994). Progress in measurement of ACTH and related peptides. Proc UK NEQAS Meeting, 1, 72-78. eScholarID:1d33876

1993

  • Crosby SR, Andeerton CA, Westwood M, Holly JMP, Cwyfan-Hughes SC, Gibson M, Morrison C, Young RJ, White A. (1993). Measurement of IGF-II in human plasma using a specific monoclonal antibody based two-site immunoradiometric assay. J Endocrinology, 137, 141-150. eScholarID:57950
  • Dixon MJ, Robinson V, White A, Ferguson MW. (1993). Monoclonal antibodies recognising stage and region specific epitopes in embryonic mouse palatal epithelial cells. J Anat, 183, 423-438. eScholarID:1d21870
  • EC Crowne, WHB Wallace, S Gibson, CM Moore, White A, Shalet SM. (1993). Acth and cortisol secretion in children after low dose cranial irradiation. Clinical Endocrinology, 39, 297-305. eScholarID:1d24667
  • Farrell WE, Stewart MF, Clark AJL Crosby Sr, Davis JRE, White A. (1993). Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells. J Mol Endocrinol, 10, 25-32. eScholarID:1d21861
  • Gibson S, Crosby SR, White A. (1993). Discrimination between beta-endorphin and beta-lipotrophin in human plasma using two-site immunoradiometric assays. Clin Endocrinol (Oxf), 39, 445-453. eScholarID:1d21868
  • Grant Ac, Rodger RSC, Mitchell R, Gibson S, White A, Robertson WR. (1993). Hypothalamo-pituitary-adrenal axis in uraemia: evidence for primary adrenal dysfunction? Nephrol Dial Transplant, 8, 307-310. eScholarID:1d21865
  • Nussey Ss, Soo S-c, Gibson S, Gout I, White A, Bain M, Johnstone AP. (1993). Isolated congenital ACTH deficiency: a cleavage enzyme defect? Clin Endocrinol (Oxf), 39, 381-385. eScholarID:1d21867
  • Tsigos C, Crosby S, Gibson S, Young R, White A. (1993). Proopiomelanocortin is the predominant adrenocorticotropin-related peptide in human cerebrospinal fluid. J Clin Endocrinol Metab, 76, 620-624. eScholarID:1d21841
  • Tsigos C, Diemel LT, White A, Tomlinson DR, Young RJ. (1993). Cerebrospinal fluid levels of substance P and calcitonin-gene-related peptide: correlation with sural nerve levels and neuropathic signs in sensory diabetic polyneuropathy. Clin Sci (Lond), 84, 305-311. eScholarID:1d7834
  • Tsigos C, Reed P, Weinkove C, White A, Young RJ. (1993). Plasma norepinephrine in sensory diabetic polyneuropathy. Diabetes Care, 16, 1-6. eScholarID:1d21842
  • Tsigos C, Young RJ, White A. (1993). Diabetic neuropathy is associated with increased activity of the hypothalamic-pituitary-adrenal axis. J Clin Endocrinol Metab, 76, 554-558. eScholarID:1d21830
  • Winocour PH, Tong P, White J, Edwards A, White A, Gibson GJ, Clark F. (1993). Unusual presentation and course of Cushing's syndrome due to ectopic ACTH secretion by a bronchial carcinoma. Respiratory Medicine, 87, 149-151. eScholarID:57933

1992

  • Al-Damluji S and White A. (1992). Central noradrenergic lesion impairs the adrenocortictrophin response to release of endogenous catcholamines. Journal of Neuroendocrinology, 4, 319-323. eScholarID:61398
  • Crosby SR, Tsigos C, Anderton CD, Gordon C, Young RJ, White A. (1992). Elevated plasma insulin-like growth factor binding protein-1 levels in type 1 (insulin-dependent) diabetic patients with peripheral neuropathy. Diabetologia, 35, 868-872. eScholarID:1d21828
  • Farrell WE, Stewart MF, Clark AJL, Crosby SR, White A. (1992). Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines. J Clin Invest, 90, 705-710. eScholarID:1d21862 | DOI:10.1172/JCI115941
  • Metcalf RA, Crosby SR, White A, Hanford L & MacNeil S. (1992). A simple bioassay for EGF using pig thyrocytes. Journal of Endocrinology, 134, 449-457. eScholarID:61407
  • Tsigos C, White A, Young RJ. (1992). Discrimination between painful and painless diabetic neuropathy based on testing of large somatic nerve and sympathetic nerve function. Diabet Med, 9, 359-365. eScholarID:1d21825

1991

  • Nussey S, Page S, Peterson D, Byrne J, Crosby S, White A, Ang V, Jackson R, Jenkins J. (1991). Corticotrophin releasing hormone (CRH1-41) stimulates the secretion of adrenocorticotrophin, vasopressin and oxytocin but not adrenocorticotrophin precursors: evidence from petrosal sinus sampling in man. Clin Endocrinol (Oxf), 34, 51-56. eScholarID:1d21871
  • Rothwell NJ, Hardwick A, LeFeuvre RA, Crosby S, White A. (1991). Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products. Brain Res, 541, 89-92. eScholarID:1d7833
  • Schwartz J, Gibson S, White A. (1991). Regulation of ACTH secretory pathways in cultured pituitary cells. Am J Physiol, 261, 793-798. eScholarID:1d21872
  • Wallace WHB, Crowne EC, Shalet SM, Moore C, Gibson S, Littley MD, White A. (1991). Episodic ACTH and cortisol secretion in normal children. Clinical Endocrinology, 34, 215-221. eScholarID:1d24648

1990

  • Al-Damluji S, Bouloux P, White A, Besser M. (1990). The role of alpha-2-adrenoceptors in the control of ACTH secretion; interaction with the opioid system. Neuroendocrinology, 51(1), 76-81. eScholarID:1d21873
  • Al-Damluji S, Thomas R, White A, Besser GM. (1990). Vasopressin mediates alpha 1-adrenergic stimulation of adrenocorticotropin secretion. Endocrinology, 126(4), 989-1995. eScholarID:1d21879
  • Al-Damluji S, White A, Besser M. (1990). Brattleboro rats have deficient adrenocorticotropin responses to activation of central alpha 1-adrenoceptors. Endocrinology, 127(6), 2849-2853. eScholarID:1d21878
  • Brooks A, White A. (1990). Activation of pituitary-adrenal function in fetal sheep by corticotrophin-releasing factor and arginine vasopressin. J Endocrinol, 124(1), 27-35. eScholarID:1d21882
  • Clark AJL, Stewart MF, Lavender PM, Farrell WE, Crosby SR, Rees LH, White A. (1990). Defective glucocorticoid regulation of pro-opiomelanocortin gene expression and peptide secretion in a small cell lung cancer cell line. J Clinical Endocrinology and Metabolism, 70(2), 485-490. eScholarID:61449
  • Crosby S, Stewart M, Farrell W, Gibson S, White A. (1990). Comparison of ACTH and ACTH precursor peptides secreted by human pituitary and lung tumour cells in vitro. J Endocrinol, 125(1), 147-152. eScholarID:1d21863
  • Horrocks PM, Jones AS, Ratcliffe WA, Holder G, White A, Holder R, Ratcliffe JG & London DR. (1990). Patterns of ACTH pulsatility over 24 hours in normal males and females. Clinical Endocrinology, 32, 127-134. eScholarID:61454
  • Mawer EB, Berry JL, Cundall JP, Still PE, White A. (1990). A sensitive radioimmunoassay using a monoclonal antibody that is equipotent for ercalcitriol and calcitriol (1,25-dihydroxy vitamin D2 and D3). Clin Chim Acta, 190(3), 199-210. eScholarID:1d21876
  • Mitchell R, Lambert A, Crosby S, White A, Robertson W. (1990). ACTH adrenal cell bioassay: improved sensitivity (12 ng/L) achieved by immunoextraction of ACTH from human plasma by a monoclonal antibody. Ann Clin Biochem, 27, 59-64. eScholarID:1d21874
  • Page S, Peterson D, Crosby S, Ang V, White A, Jenkins J, Nussey S. (1990). The responses of arginine vasopressin and adrenocorticotrophin to nausea induced by ipecacuanha. Clin Endocrinol (Oxf), 33(6), 761-770. eScholarID:1d21875
  • Page SR, Ang VTY, Jackson R, White A, Nussey SS & Jenkins JS. (1990). The effect of oxytocin infusion on adenohypophyseal function in man. Clinical Endocrinology, 32, 307-313. eScholarID:61467
  • Roberts RN, Barton MA, Horan M & White A. (1990). Adrenal function after upper femoral fracture in elderly people: Persistence of stimulation and the roles of adrenocorticotrophic hormone and immobility. Age and Ageing, 19, 304-310. eScholarID:61472
  • White A, Clark AJL, Stewart MF. (1990). The synthesis of ACTH and related peptides by tumors. Baillieres Clinical Endocrinology and Metabolism, 4, 1-27. eScholarID:61477

1989

  • Dobson S, Gibson S, & White A. (1989). Assessment of the potency of different standards in the immunoradiometric assay of ACTH. Annals Clin Biochem, 26, 96-101. eScholarID:61483
  • Gibson S, Pollock A, Littley M, Shalet SM, White A. (1989). Advantages of IRMA over RIA in the measurement of ACTH. Annals of Clinical Biochemistry, 26, 500-507. eScholarID:1d24631
  • Howlett TA, Grossman A, McLoughlin L, Percy L, White A, Coy DH, Rees LH, Besser GM. (1989). The effect of ovine corticotrophin-releasing factor on the hormonal response to insulin-induced hypoglycaemia. Clinical Endocrinology, 30, 185-190. eScholarID:62129
  • Le Feuvre RA, Rothwell NJ & White A. (1989). A comparison of the thermogenic effects of CRF, Sauvagine and urotensin 1 in the rat. Hormone and Metabolic Research, 21, 525-526. eScholarID:62139
  • Littley MD, Gibson S , White A, Shalet SM. (1989). Comparison of the ACTH and cortisol responses to provacative testing with glucagon and insulin hypoglycaemia in normal subjects. Clinical Endocrinology, 31, 527-533. eScholarID:1d24627
  • Stafford PJ, Kopelman PG, Davidson K, McLoughlin L, White A, Rees LH, Besser GM, Coy DH & Grossman A. (1989). The pituitary-adrenal response to CRF-41 is unaltered by intravenous somatostatin in normal subjects. Clinical Endocrinology, 30, 661-666. eScholarID:62148
  • Stewart M, Crosby S, Gibson S, Twentyman P, White A. (1989). Small cell lung cancer cell lines secrete predominantly ACTH precursor peptides not ACTH. Br J Cancer, 60, 20-24. eScholarID:1d21869
  • White A, Stewart MF, Farrell WE, Crosby SR, Lavender PM, Twentyman PR, Rees LH, Clark AJL. (1989). Pro-opiomelanocortin gene expression and peptide secretion in human small-cell lung cancer cell lines. J Mol Endocrinol, 3, 365-370. eScholarID:1d21864

1988

  • Al-Damluji S, Ross G, Touzel R, Perrett D, White A, Besser GM. (1988). Modulation of the actions of tyrosine by alpha 2-adrenoceptor blockade. Br J Pharmacol, 95, 405-412. eScholarID:1d21880
  • Al-Saffar N, White A, Moore M & Hasleton PS. (1988). Immunoreactivity of various peptides in typical and atypical bronchopulmonary carcinoid tumours. Brit J Cancer, 58, 762-766. eScholarID:65192
  • Crosby SR, Stewart MF, Ratcliffe JG & White A. (1988). Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay. Journal of Clinical Endocrinology & Metabolism, 67(6), 1272-1277. eScholarID:65182
  • Nussey FS, Page SR, Ang VTY, Jenkins JS & White A. (1988). The effect of oxytocin infusion on adenohypophyseal and adrenal cortisol responses to insulin-induced hypoglycaemia. Clin Endocrinol, 29, 257-264. eScholarID:65166

1987

  • Dobson S, White A, Hoadley M, Lovgren T & Ratcliffe JG. (1987). Measurement of adrenocorticotrophin in unextracted plasma: comparison of a time-resolved immunofluorometric assay and an immunoradiometric assay using the same monoclonal antibodies. Clinical Chemistry, 33, 1747-1751. eScholarID:65216
  • White A, Smith H, Hoadley M, Dobson SH & Ratcliffe JG. (1987). Clinical evaluation of a two-site immuno-radiometric assay for adrenocorticotrophin in unextracted human plasma using antibodies. Clinical Endocrinology, 26, 41-52. eScholarID:65208

1986

  • Crosby SR, Ratcliffe WA, Smith GN & White A. (1986). Characterisation of monoclonal and polyclonal antibodies to 19-linked conjugates of testosterone in corresponding radioligands. J Steroid Biochem, 25, 957-962. eScholarID:65232
  • Dobson SH, Gray C, Smith H, Baker T, Ratcliffe JG & White A. (1986). Selection and optimisation of monoclonal antibodies for a two-site immunoradiometric assay for ACTH. Immunological Methods, 88, 83-90. eScholarID:65222

1985

  • Mawer EB, Berry JL, Bessone J, Shany S, Smith H, White A. (1985). Selection of high-affinity and high-specificity monoclonal-antibodies for 1-alpha, 25-dihydoxyvitamin-D. Steroids, 46, 741-754. eScholarID:65265
  • White A, Gray C & Corrie JET. (1985). Monoclonal antibodies to testosterone: the effect of immunogen structure on specificity. J Steroid Biochemistry, 22, 169-175. eScholarID:65239
  • White A, Gray C & Ratcliffe JG. (1985). Characterisation of monoclonal antibodies to adrenocorticotrophin. J Immunological Methods, 79, 185-194. eScholarID:65243
  • White A, Smith GN, Crosby SR & Ratcliffe WA. (1985). A study of 19-0-carboxymethyl ether and 19-hemisuccinate derivatives of testosterone: Their immunogenicity and use as iodinated radioligands for radioimmunoassay of testosterone. J Steroid Biochem, 23, 981-989. eScholarID:65258
  • White A, Tan K, Gray C, Roberts I & Ratcliffe JG. (1985). Multiple hormone secretion by a human pancreatic glucagonoma in culture. Regulatory Peptides, 11, 335-347. eScholarID:65247

1982

  • White A, Anderson DC & Daly JR. (1982). Production of a highly specific monoclonal antibody to progesterone. Journal of Clinical Endocrinology & Metabolsim, 54(1), 205-207. eScholarID:65271

1980

  • White A & Ayad SR. (1980). Changes in cAMP and fibronectin concentrations in adherent and suspension forms of a hybrid cell line. Experimental Cell Research, 129, 303-312. eScholarID:65280

1977

  • Ayad SR & White A. (1977). The effect of the local anaesthetic, tetracaine, on the isoprenaline and prostaglandin E1 stimulation of cAMP in normal and malignant cell lines. Experimental Cell Research, 107, 201-206. eScholarID:65285

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