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School of Medicine

Dr Clare Murray MBChB, MD, MRCP, MRCPCH

Clinical Senior Lecturer

Address:

2nd Floor, Education and Research Building, University Hospital of South Manchester NHS Trust, Southmoor Road, Wythenshawe, Manchester, M23 9LT

 

Role

I am a HEFCE funded clinical senior lecturer based at the University of Manchester and at Royal Manchester Children's Hospital (50:50 split).

The academic part of my current post comprises of five sessions per week as a Senior Lecturer based at the University Hospital of South Manchester. I am part of the Respiratory Group in the School of Translational Medicicne. My main research interest is the role of environmental factors, in particular diet and obesity, in the development of asthma and allergic sensitisation. In addition I have an interest in treatment options for asthma. I have an active role in the Greater Manchester, Lancashire and Cumbria Medicines for Children's Network (MCRN) and I am PI for 4 respiratory studies. I am a member of the Respiratory and Cystic Fibrosis MCRN Clinical studies group. I am Greater Manchester lead for the Paediatric Non-medicines Research (PNMR) network and am PI for several studies running through this.

The clinical part of my current post comprises of 5 sessions a week as a Consultant Respiratory Paediatrician at Royal Manchester Children’s Hospital. As part of a 4WTE consultant team we offer a secondary and tertiary paediatric respiratory service for the North West of England. This includes the investigation and management of children with conditions such as asthma, bronchiectasis, chronic lung disease of prematurity, tuberculosis and interstitial lung disease. In addition we run the Cystic Fibrosis service for Greater Manchester and offer a shared-care service for all children with Cystic Fibrosis in the North West Region by means of peripatetic clinics.

 

Memberships of Committees and Professional Bodies

Royal College of Paediatrics and Child Health

British Medical Association

British Thoracic Society

British Paediatric Respiratory Society

British Society for Allergy and Clinical Immunology

Research

I entered full time research for a two year period in September 1999 at the University of Manchester , under the supervision of Professors Woodcock and Custovic. Working as part of the Manchester Asthma and Allergy Study (MAAS) team I completed my MD Thesis entitled “Environmental Allergens and Childhood Asthma” (awarded December 2002). After completing my clinical training and gaining my CCST in Respiratory Paediatric Medicine, I returned to work with the same research team as a Senior Clinical Research Fellow on a part time basis (5 sessions).

As an independent investigator I obtained competitive grant funding from independent sources (GSK Respiratory Research Award) to pursue my research interest in the dietary risk factors for the development of asthma and allergic sensitisation.  My project is embedded within the Manchester Asthma and Allergy Study (population-based birth cohort of >1000 children recruited between 1995 and 1997). I currently lead the dietary/obesity aspect of the study and supervise 2 PhD students (year 2 and 3). The cohort is supported by the Asthma UK (Grants 301, 362 and 01/012).

Over the next few years I will continue to build on my expertise in diet and obesity by focusing on:

  • Effect of specific dietary nutrients on asthma and allergic disease including gene by environment interaction

    1. Intake of polyunsaturated fatty acids (PUFA, n3:n6), dietary antioxidants (vitamin A, C and E), antioxidant cofactors (selenium, copper and zinc)

    2. Gene-environment interactions (e.g. Leukotiene pathway and intake of n3 PUFA; Vitamin D intake and genes associated with vitamin D metabolism and signalling; Vitamin E intake and genes associated with cytokine secretion, T-cell cycle related proteins and metalloproteinase).
  • Effect of obesity on childhood/adolescent asthma and allergic disease
    In collaboration with Dr Iain Buchan(Senior Lecturer in Public Health Informatics, University of Manchester) we will use prospective data on weights and heights to investigate the effect of growth and obesity on asthma (severity and new onset disease)
  • Specific diet based allergies
    Peanut - including determination of allergy or sensitisation using component resolved diagnostics.

Keywords

  • Acute illness
  • Epidemiology
  • Health promotion
  • Long-term/chronic illness
 

Methodological Knowledge

  • Audit   
  • Epidemiology
  • Qualitative
  • Quantitative
  • Randomised control trials/experimental studies

I also have expertise in involving children in research

 

Biography

I qualified from Edinburgh University in 1990. I started training as a paediatrician in 1993 and worked/trained as a specialist registrar in paediatrics in the Mersey deanery, specialising in respiratory paediatrics. I took time out from 1999 to 2001 to carry out research and was awarded my MD (Environmental allergens and childhood asthma) in 2002. I completed my training in 2003 and have been a consultant in paediatric respiratory medicine at the Royal Manchester Children's Hospital since then. I was awarded a HEFCE clinical senior lectureship in August 2007 have been working a 50:50 clinical:research split between the University of Manchester and Royal manchester Children's Hospital, since then.

 

Qualifications

MB ChB (University of Edinburgh)

MD (Universityof Manchester)

MRCP (UK)

MRCPCH

CCST in Paediatrics (Subspeciality - Respiratory medicine)

 

Publications

2012

  • Gore, C; Custovic, A; Tannock, G W; Munro, K; Kerry, G; Johnson, K; Peterson, C; Morris, J; Chaloner, C; Murray, C S; Woodcock, A. (2012). Treatment and secondary prevention effects of the probiotics Lactobacillus paracasei or Bifidobacterium lactis on early infant eczema: randomized controlled trial with follow-up until age 3years. Clinical experimental Allergy, 42(1), 112-122. eScholarID:152036 | DOI:10.1111/j.1365-2222.2011.03885.x

2011

  • Clare Murray, Dexter Canoy, Iain Buchan, Ashley Woodcock, Angela Simpson, Adnan Custovic. (2011). Body mass index in young children and allergic disease: gender differences in a longitudinal study. Clinical Experimental allergy, 41(1), 78-85. eScholarID:84380 | DOI:10.1111/j.1365-2222.2010.03598.x
  • Nicolaou N, Murray C, Belgrave D, Poorafshar M, Simpson A, Custovic A. (2011). Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. Journal of Allergy and Clinical Immunology, 127(3), 684-685. eScholarID:127934 | DOI:10.1016/j.jaci.2010.12.012

2010

  • Clare S Murray, Adnan Custovic, Lesley A Lowe, Sarah Aldington, Mathew Williams, Richard Beasley and Ashley Woodcock. (2010). Effect of Addition of Salmeterol versus Doubling the Dose of Fluticasone Propionate on Specific Airway Resistance in Children with asthma. Allergy and Asthma Proceedings, 31(5), 415-421. eScholarID:79594 | DOI:10.2500/aap.2010.31.3362
  • Nicolaou N, Poorafshar M, Murray CS, Simpson A, Winell H, Kerry G, Härlin A, Woodcock A, Ahlstedt S, Custovic A. (2010). Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component resolved diagnostics. Journal of Allergy and Clinical Immunology, 125(1), 191-7. eScholarID:55785 | DOI:10.1016/j.jaci.2009.10.008
  • Semic-Jusufagic A, Gevaert P, Bachert C, Murray CS, Simpson A, Custovic A. (2010). INCREASED SERUM SOLUBLE INTERLEUKIN-5 RECEPTOR ALPHA LEVEL PRECEDES THE DEVELOPMENT OF ECZEMA IN CHILDREN. Pediatric Allergy and Immunology, 21(7), 1052-1058. eScholarID:79593 | DOI:10.1111/j.1399-3038.2010.01077.x

2009

  • Patel S, Murray CS, Woodcock A, Simpson A, Custovic A. (2009). Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy, 64(12), 1766-1772. eScholarID:55744 | DOI:10.1111/j.1398-9995.2009.02099.x

2008

  • Murray CS. (2008). Can inhaled corticosteroids influence the natural history of asthma? Curr Opin Allergy Clin Immunol, 8( 1), 77-81. eScholarID:1d19684 | DOI:10.1097/ACI.0b013e3282f41769
  • Nicolaou NC, Simpson A, Lowe LA, Murray CS, Woodcock A, Custovic A. (2008). Day-care attendance, position in sibship, and early childhood wheezing: a population-based birth cohort study. journal of Allergy and Clinical Immunology, 122(3), 500-506. eScholarID:66633 | DOI:10.1016/j.jaci.2008.06.033

2007

  • Marinho S, Simpson A, Lowe L, Kissen P, Murray CS, Custovic A. (2007). Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study. Allergy, 62(4), 385-393 . eScholarID:1d17522

2006

  • Ahlstedt S, Murray CS. (2006). In vitro diagnosis of allergy: how to interpret IgE antibody results in clinical practice. Prim Care Respir J, 15( 4), eScholarID:1d19962 | DOI:10.1016/j.pcrj.2006.05.004
  • Moore K, David T, Murray CS, Child F, Arkwright P. (2006). Effect of childhood eczema and asthma on parental sleep and well-being: a prospective comparative study. Br J Dermatol, 154( 3), 514-518. eScholarID:1d30823
  • Murray CS, Poletti G, Kebadze T, Morris J, Woodcock AA, Johnston S, Custovic A. (2006). Study of modifiable risk factors for asthma exacerbations: virus infection and allergen exposure increase the risk of asthma hospital admissions in children. Thorax, 61( 5), 376-382. eScholarID:1d13027
  • Murray CS, Simpson B, Kerry G, Woodcock AA, Custovic A. (2006). Dietary intake in sensitized children with recurrent wheeze and healthy controls: a nested case-control study. Allergy, 61( 4), 438-42. eScholarID:1d13023
  • Murray CS, Woodcock AA, Langley S, Morris J, Custovic A. (2006). Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet, 368( 9537), 754-62. eScholarID:1d14398 | DOI:10.1016/S0140-6736(06)69285-4
  • Nicolaou N, Lowe L, Murray CS, Woodcock AA, Simpson A, Custovic A. (2006). Exhaled breath condensate pH and childhood asthma: unselected birth cohort study. Am J Respir Crit Care Med, 174( 3), 254-259. eScholarID:1d14402
  • Thomas M, Custovic A, Woodcock A, Morris J, Simpson A, Murray CS. (2006). Atopic wheezing and early life antibiotic exposure: a nested case-control study. Pediatr Allergy Immunol, 17( 3), 184-188. eScholarID:1d14666

2005

  • Custovic A, Murray CS, Simpson A. (2005). Allergy and infection: understanding their relationship. Allergy, 60 Suppl 79, eScholarID:1d10458
  • Lowe L, Simpson A, Woodcock AA, Morris J, Murray CS, Custovic A. (2005). Wheeze Phenotypes and Lung Function in Pre-School Children. Am J Respir Crit Care Med, 171(3), eScholarID:1d9085 | DOI:10.1164/rccm.200406-695OC
  • Murray CS, Tannock G, Simon M, Harmsen H, Welling G, Custovic A, Woodcock AA. (2005). Fecal microbiota in sensitized wheezy and non-sensitized non-wheezy children: a nested case-control study. Clin Exp Allergy, 35( 6), eScholarID:1d11199
  • Simpson A, Soderstrom L, Ahlstedt S, Murray CS, Woodcock A, Custovic A. (2005). IgE antibody quantification and the probability of wheeze in preschool children. J Allergy Clin Immunol, 116( 4), 744-9. eScholarID:1d12138 | DOI:10.1016/j.jaci.2005.06.032

2004

  • Lowe L, Woodcock AA, Murray CS, Murray CS, Morris J, Simpson A, Custovic A. (2004). Lung function at age 3 years: effect of pet ownership and exposure to indoor allergens. Arch Pediatr Adolesc Med, 158( 10), eScholarID:1d9087
  • Lowe, L, Murray, CS, Martin, L, Deas, J, Cashin, E, Poletti, G, Simpson, A, Woodcock, AA, Custovic, A. (2004). Reported versus confirmed wheeze and lung function in early life. Arch Dis Child, 89( 6), eScholarID:1d9092
  • Murray CS, Murray CS, Woodcock AA, Smillie F, Cain G, Kissen P, Custovic A. (2004). Tobacco smoke exposure, wheeze, and atopy. Pediatr Pulmonol, 37( 6), eScholarID:1d9096
  • Murray CS, Simpson A, Custovic A. (2004). Allergens, viruses, and asthma exacerbations. Proc Am Thorac Soc, 1( 2), eScholarID:1d11197
  • Woodcock AA, Lowe L, Murray CS, Simpson B, Pipis S, Kissen P, Simpson A, Custovic A, NAC Manchester Asthma and Allergy Study Group. (2004). Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med, 170( 4), eScholarID:1d9094 | DOI:10.1164/rccm.200401-083OC
  • Young, S, Simon, M, Baird, M, Tannock, G, Bibiloni, R, Spencely, K, Lane, J, Fitzharris, P, Crane, J, Town, I, Addo-Yobo, E, Murray, CS, Woodcock, AA. (2004). Bifidobacterial species differentially affect expression of cell surface markers and cytokines of dendritic cells harvested from cord blood. Clin Diagn Lab Immunol, 11( 4), eScholarID:1d29362

2002

  • C S Murray and A Custovic. (2002). Lifestyle and indoor air pollution. In G D'Amato, ST Holgate (Ed.), Air pollution and obstructive respiratory diseases. (pp. 133-153). European Respiratory Monograph. eScholarID:55982
  • C S murray and A Woodcock. (2002). Gut microflora and atopic disease. In G W Tannock (Ed.), Probiotics and prebiotics; where are we going?. (pp. 239-263). Norfolk, England: Caister Academic press. eScholarID:56020
  • Clare S Murray and Adnan Custovic. (2002). Tips on avoiding indoor allergens. Journal of Asthma, 7(1), 40-42. eScholarID:55965
  • Custovic A, Murray CS, Gore RB, Woodcock A. (2002). Controlling indoor allergens. Ann Allergy Asthma Immunol, 88( 5), eScholarID:1d10295
  • Custovic A, Murray CS, Gore RB, Woodcock A. (2002). Environmental allergen control. Annals of allergy, asthma and immunology, 88(5), 432-441. eScholarID:55925
  • Custovic A, Murray CS. (2002). The effect of allergen exposure in early childhood on the development of atopy. Curr Allergy Asthma Rep, 2( 5), 417-23. eScholarID:1d10294
  • Custovic A, Simpson B, Murray CS, Lowe L, Woodcock A. (2002). The National Asthma Campaign Manchester Asthma and Allergy Study. Pediatr Allergy Immunol, 13 Suppl 15, 32-7. eScholarID:1d10289
  • Lowe L, Murray CS, Custovic A, Simpson B, Kissen P, Woodcock AA. (2002). Specific airway resistance in 3-year-old children: a prospective cohort study. Lancet, 359( 9321), eScholarID:1d6774 | DOI:10.1016/S0140-6736(02)08781-0
  • Murray CS, Pipis S, McArdle E, Lowe L, Custovic A, Woodcock AA. (2002). Lung function at one month of age as a risk factor for infant respiratory symptoms in a high risk population. Thorax, 57( 5), 388-92. eScholarID:1d6776
  • WoodcockA, MoradiM, SmillieF.I, Murray CS, Burnie JP, Custovic A. (2002). Clostridium difficile, atopy and wheeze during the first year of life. Pediatr.Allergy Immunol, 13, 5, 357-360. eScholarID:1d7128

2001

  • Murray CS, Woodcock A, Custovic A. (2001). The role of indoor allergen exposure in the development of sensitization and asthma. Curr Opin Allergy Clin Immunol, 1( 5), 407-12. eScholarID:1d10297

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